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01:26 EDT 25th March 2019 | BioPortfolio

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Showing PubMed Articles 1–25 of 845 from AIDS (London, England)

Cost-effectiveness of increased hiv testing among men who have sex with men in the netherlands.

To assess the cost-effectiveness of increased consistent HIV testing among men who have sex with men (MSM) in the Netherlands.

Short-term outcomes for lung cancer resection surgery in HIV infection.

Lung cancer is the leading cause of cancer death in people living with HIV (PWH). Surgical resection is a key component of potentially curative treatment regimens for early-stage lung cancers, but its safety is unclear in the setting of HIV. From a national cohort, we assessed potential differences in the risk of major lung cancer surgery complications by HIV status.

Critical amino acid residues and potential N-linked glycosylation sites contribute to CRF01_AE pathogenesis in Northeast China.

This study aimed to understand epidemiological feature and critical factors associated with pathogenesis of CRF01_AE strains in Northeast China.

HIV infection and cerebral small vessel disease are independently associated with brain atrophy and cognitive impairment.

Investigate whether cerebral small vessel disease (CSVD) is more common in virologically-suppressed HIV-positive participants compared to HIV-negative controls and examine the potential synergistic effects of HIV and CSVD on brain structure and cognition.

Switch to dolutegravir and unboosted atazanavir in HIV-1 infected patients with undetectable viral load and long exposure to antiretroviral therapy.

: We evaluated efficacy and safety of a two-drug regimen including dolutegravir (DTG) and unboosted atazanavir (uATV) in 151 HIV-1 infected patients with HIV-RNA > 50 copies/ml.During a median follow-up of 62 (42-97) weeks, 2 VFs (1%) and 13 treatment discontinuations (9%) occurred; the 48-week probability of VF was 0.8% (95% CI = 0.2%-5.6%).Switch to DTG + uATV may represent a boosting and RTIs sparing option in subjects with long exposure to ART and risk of cardiovascular disease.

Effects of comorbidity burden and Age on brain integrity in HIV.

The influence of confounding neurocognitive comorbidities in persons living with HIV (PLWH) on neuroimaging has not been systematically evaluated. We determined associations between comorbidity burden and brain integrity and examined the moderating effect of age on these relationships.

A generalizable method for estimating duration of HIV infections using clinical testing history and HIV test results.

To determine the precision of new and established methods for estimating duration of HIV infection.

Poverty stigma is associated with suboptimal HIV care and treatment outcomes among women living with HIV in the U.S.

To examine whether experienced poverty stigma is associated with worse HIV care and treatment outcomes.

Effectiveness of integrase strand transfer inhibitors among treatment-experienced patients in a clinical setting.

Characterize virologic and immunologic outcomes of INSTI-based antiretroviral therapy (ART) in experienced patients with and without virologic failure.

γδ T-cell subsets in HIV controllers: potential role of Tγδ17 cells in the regulation of chronic immune activation.

HIV controllers (HIC) are rare HIV-infected individuals able to maintain undetectable viremia in the absence of antiretroviral treatment. While HIV-specific cytotoxic T cells have been well deciphered in HIC, γδ T lymphocytes remain largely uncharacterized. The aim of this study was to analyze phenotypic and functional characteristics of γδ T cells and their relationship with immune activation, which remain abnormally elevated and associated with comorbidities in HIC.

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

To explore the contribution of blood and colon myeloid cells to HIV persistence during antiretroviral therapy (ART).

The HIV diagnostic assistant-early findings from a novel HIV testing cadre in Malawi.

In 2015, Malawi piloted the HIV Diagnostic Assistant (HDA), a cadre of lay health worker focused primarily on HIV testing services. Our objective is to measure the effect of HDA deployment on country-level HIV testing measures.

HIV infection does not impact on the risk of liver complications in HCV-infected patient with advanced fibrosis, after sustained virological response with DAA.

To assess the impact of HIV-coinfection on the risk of developing liver related complications in HCV-infected patients with advanced fibrosis treated with direct-acting antivirals (DAA) after sustained virological response (SVR).

T and B-cell perturbations are similar in ART-naïve HIV-1 and HIV-1/2 dually infected patients.

HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8+ T cells. We hypothesized that HIV-1/2 dually infected patients compared to HIV-1 infected patients had more preserved immune maturation subsets and less immune activation of T and B-cells.

T and B-cell perturbations identify distinct differences in HIV-2 compared with HIV-1 induced immunodeficiency.

For unknown reasons, HIV-2 is less pathogenic than HIV-1, and HIV-2 induced immunodeficiency may be different from that caused by HIV-1. Previous immunological studies have hinted at possible shifts in both T and B-cell subsets, which we aimed to characterize further.

In-vivo administration of histone deacetylase inhibitors does not impair natural killer cell function in HIV+ individuals.

Histone deacetylase inhibitors (HDACi) have proven to induce HIV-RNA and antigen expression in resting CD4 T cells of antiretroviral therapy (ART)-treated HIV-infected individuals. However, to achieve viral eradication, immune clearance must follow latency reversal, and thus it is essential to understand the impact of latency reversal agents on immune function.

Tenofovir disoproxil fumarate initiation and changes in urinary biomarker concentrations among HIV-infected men and women.

Urinary biomarkers of kidney injury may have potential to identify subclinical injury attributable to tenofovir disoproxil fumarate (TDF) toxicity.

Optimizing HIV prevention and care for transgender adults.

: Transgender women have recently been acknowledged as a unique and important risk group in HIV research and care. Although transgender men also face specific problems related to HIV infection, less is known about the risk behaviours and HIV prevalence of this important population. This article highlights key issues relating to the epidemiology, prevention, treatment and management of complications of HIV infection in transgender adults living with HIV, and explores future areas for HIV-related research, wi...

A high mucosal blocking score is associated with HIV protection.

Early steps of HIV infection are mediated by the binding of the envelope to mucosal receptors as α4β7 and the C-type lectins DC-SIGN and langerin. Previously Env-specific B-cell responses have been reported in highly exposed seronegative individuals (HESN).

One step closer to ultra-long-acting PREP?

Estimating national rates of HIV infection among men who have sex with men, persons who inject drugs and heterosexuals in the United States.

Calculating national rates of HIV diagnosis, incidence, and prevalence can quantify disease burden and is important for planning and evaluating programs. We calculated HIV rates among men who have sex with men (MSM), persons who inject drugs (PWID), and heterosexuals in 2010 and 2015.

Integration of care for HIV and opioid use disorder: a systematic review of interventions in clinical and community-based settings.

We sought to identify optimal strategies for integrating HIV- and opioid use disorder-(OUD) screening and treatment in diverse settings.

Reinfection by HCV following effective all-oral DAA therapy in HIV/HCV-coinfected individuals.

We analyzed HCV reinfection among participants in a prospective registry of HIV/HCV-coinfected patients treated with all-oral DAA-based therapy in the region of Madrid.

Caution is needed in interpreting HIV transmission chains by ultra-deep sequencing.

Molecular epidemiology is applied to various aspects of HIV transmission analyses. With ultra-deep sequencing (UDS), in-depth characterisation of transmission episodes involving minority variants are permitted. We explored HIV-1 epidemiological linkage and evaluated characteristics of transmission dynamics and transmitted drug resistance (TDR) detection through the added value of UDS.

Prior exposure to thymidine analogues and didanosine is associated with long-lasting alterations in adipose tissue distribution and cardiovascular risk factors.

Thymidine analogues (TA) and didanosine (ddI) have been associated with redistribution of body fat from subcutaneous (SAT) to visceral (VAT) adipose tissue, which, in turn, is a risk factor for cardiovascular disease (CVD). We explored differences in adipose tissue distribution between people living with HIV (PLWH) with prior exposure to TA and/or ddI, without exposure, and uninfected controls and the association with CVD risk factors.

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