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To assess the cost-effectiveness of increased consistent HIV testing among men who have sex with men (MSM) in the Netherlands.
Lung cancer is the leading cause of cancer death in people living with HIV (PWH). Surgical resection is a key component of potentially curative treatment regimens for early-stage lung cancers, but its safety is unclear in the setting of HIV. From a national cohort, we assessed potential differences in the risk of major lung cancer surgery complications by HIV status.
This study aimed to understand epidemiological feature and critical factors associated with pathogenesis of CRF01_AE strains in Northeast China.
Investigate whether cerebral small vessel disease (CSVD) is more common in virologically-suppressed HIV-positive participants compared to HIV-negative controls and examine the potential synergistic effects of HIV and CSVD on brain structure and cognition.
: We evaluated efficacy and safety of a two-drug regimen including dolutegravir (DTG) and unboosted atazanavir (uATV) in 151 HIV-1 infected patients with HIV-RNA > 50 copies/ml.During a median follow-up of 62 (42-97) weeks, 2 VFs (1%) and 13 treatment discontinuations (9%) occurred; the 48-week probability of VF was 0.8% (95% CI = 0.2%-5.6%).Switch to DTG + uATV may represent a boosting and RTIs sparing option in subjects with long exposure to ART and risk of cardiovascular disease.
The influence of confounding neurocognitive comorbidities in persons living with HIV (PLWH) on neuroimaging has not been systematically evaluated. We determined associations between comorbidity burden and brain integrity and examined the moderating effect of age on these relationships.
To determine the precision of new and established methods for estimating duration of HIV infection.
To examine whether experienced poverty stigma is associated with worse HIV care and treatment outcomes.
Characterize virologic and immunologic outcomes of INSTI-based antiretroviral therapy (ART) in experienced patients with and without virologic failure.
HIV controllers (HIC) are rare HIV-infected individuals able to maintain undetectable viremia in the absence of antiretroviral treatment. While HIV-specific cytotoxic T cells have been well deciphered in HIC, γδ T lymphocytes remain largely uncharacterized. The aim of this study was to analyze phenotypic and functional characteristics of γδ T cells and their relationship with immune activation, which remain abnormally elevated and associated with comorbidities in HIC.
To explore the contribution of blood and colon myeloid cells to HIV persistence during antiretroviral therapy (ART).
In 2015, Malawi piloted the HIV Diagnostic Assistant (HDA), a cadre of lay health worker focused primarily on HIV testing services. Our objective is to measure the effect of HDA deployment on country-level HIV testing measures.
To assess the impact of HIV-coinfection on the risk of developing liver related complications in HCV-infected patients with advanced fibrosis treated with direct-acting antivirals (DAA) after sustained virological response (SVR).
HIV-2 may slow progression of a subsequently acquired HIV-1 infection through cross-neutralizing antibodies and polyfunctional CD8+ T cells. We hypothesized that HIV-1/2 dually infected patients compared to HIV-1 infected patients had more preserved immune maturation subsets and less immune activation of T and B-cells.
For unknown reasons, HIV-2 is less pathogenic than HIV-1, and HIV-2 induced immunodeficiency may be different from that caused by HIV-1. Previous immunological studies have hinted at possible shifts in both T and B-cell subsets, which we aimed to characterize further.
Histone deacetylase inhibitors (HDACi) have proven to induce HIV-RNA and antigen expression in resting CD4 T cells of antiretroviral therapy (ART)-treated HIV-infected individuals. However, to achieve viral eradication, immune clearance must follow latency reversal, and thus it is essential to understand the impact of latency reversal agents on immune function.
Urinary biomarkers of kidney injury may have potential to identify subclinical injury attributable to tenofovir disoproxil fumarate (TDF) toxicity.
: Transgender women have recently been acknowledged as a unique and important risk group in HIV research and care. Although transgender men also face specific problems related to HIV infection, less is known about the risk behaviours and HIV prevalence of this important population. This article highlights key issues relating to the epidemiology, prevention, treatment and management of complications of HIV infection in transgender adults living with HIV, and explores future areas for HIV-related research, wi...
Early steps of HIV infection are mediated by the binding of the envelope to mucosal receptors as α4β7 and the C-type lectins DC-SIGN and langerin. Previously Env-specific B-cell responses have been reported in highly exposed seronegative individuals (HESN).
Calculating national rates of HIV diagnosis, incidence, and prevalence can quantify disease burden and is important for planning and evaluating programs. We calculated HIV rates among men who have sex with men (MSM), persons who inject drugs (PWID), and heterosexuals in 2010 and 2015.
We sought to identify optimal strategies for integrating HIV- and opioid use disorder-(OUD) screening and treatment in diverse settings.
We analyzed HCV reinfection among participants in a prospective registry of HIV/HCV-coinfected patients treated with all-oral DAA-based therapy in the region of Madrid.
Molecular epidemiology is applied to various aspects of HIV transmission analyses. With ultra-deep sequencing (UDS), in-depth characterisation of transmission episodes involving minority variants are permitted. We explored HIV-1 epidemiological linkage and evaluated characteristics of transmission dynamics and transmitted drug resistance (TDR) detection through the added value of UDS.
Thymidine analogues (TA) and didanosine (ddI) have been associated with redistribution of body fat from subcutaneous (SAT) to visceral (VAT) adipose tissue, which, in turn, is a risk factor for cardiovascular disease (CVD). We explored differences in adipose tissue distribution between people living with HIV (PLWH) with prior exposure to TA and/or ddI, without exposure, and uninfected controls and the association with CVD risk factors.