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22:23 EDT 21st March 2019 | BioPortfolio

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Showing PubMed Articles 1–25 of 63 from Acta neurologica Scandinavica

Prestige of neurological disorders among future neurologists in Norway.

Neurology has increasing subspecialisation. Some disorders, such as cerebrovascular diseases, dementia and headache are highly prevalent in the general population, while others, such as movement disorders and multiple sclerosis, are rarer. Thus, there may be a mismatch between neurologists' interests and the population needs.

Investigative practice into sudden death in epilepsy: A global survey.

Sudden death is a recognised consequence of epilepsy. Little is known about the practice of confirming the cause of sudden death from most nations. We sought to determine how often autopsy is undertaken, clinician confidence in cause of death, and identify the factors which may influence autopsy utilization.

Structural and functional connectivity in newly diagnosed juvenile myoclonic epilepsy.

We aimed to evaluate structural and functional connectivity of patients with newly diagnosed juvenile myoclonic epilepsy (JME) compared to healthy subjects.

Depression and risk of Cognitive Dysfunctions in Amyotrophic Lateral Sclerosis.

ALS is not only a motor disorder: more than 50% of patients have cognitive dysfunctions over the course of the disease. At the same time, mood disorders may also occur in ALS patients following diagnosis due to the fatal prognosis; however little data is available on any depression beforehand. Starting from these considerations, the aim of our study was to investigate the occurrence of depression in Italian ALS patients prior to diagnosis, evaluating its prevalence in the subjects who have developed cogniti...

Treatment of Medication Overuse Headache - a review.

Medication overuse headache (MOH) is the most prevalent chronic headache disorder with a prevalence between 1-2% worldwide. The disease has been acknowledged for almost 30 years, yet experts still disagree on how best to treat MOH. By performing a search in PubMed on the terms "medication overuse headache", "analgesics abuse headache", "rebound headache", "drug induced headache", and "headache AND drug misuse" limited to human studies published in English between January 1 2004 and November 1 2017, we aimed...

Therapeutic drug monitoring of gabapentin in various indications.

Gabapentin has been increasingly used in various indications in recent years. Despite variable pharmacokinetics, therapeutic drug monitoring (TDM) is scarcely described in other indications than epilepsy. The aim of the study was to investigate the use and pharmacokinetic variability of gabapentin in epilepsy and non-epilepsy indications, and to further evaluate the use of TDM in patients with restless legs syndrome (RLS).

Distribution of Migraine Attacks over the Days of the Week: Preliminary Results from a Web-Based Questionnaire.

The purpose of this work is the analysis of migraine attack reports collected online within the project Migraine Radar in respect to the distribution of the migraine attacks over the week on a single-participant level.

Intravenous metoclopramide in the treatment of acute migraines: a randomized, placebo-controlled trial.

The present study aimed to evaluate the efficacy and safety of intravenous metoclopramide for acute migraine treatment.

Restless legs syndrome and its variants in acute ischemic stroke.

The clinical-radiological correlation between restless legs syndrome (RLS) or its variants and acute ischemic stroke remains unclear.

Do Elevated Autoantibodies in Patients With Multiple Sclerosis Matter ?

The incidence and clinical impact of serum autoantibodies in patients with multiple sclerosis (MS) is controversially discussed. The aim of the study is to reassess the value of elevated serum autoantibodies in our MS study cohort.

Combination of flunarizine and transcutaneous supraorbital neurostimulation improves migraine prophylaxis.

This study is aimed to access the efficacy and safety of combination therapy of flunarizine plus transcutaneous supraorbital neurostimulation (tSNS) compared with either flunarizine or tSNS alone for migraine prophylaxis.

Efficacy of Co Q10 as Supplementation for Migraine: A Meta-Analysis.

Migraine ranks among the most frequent neurological disorders globally. Co-enzyme Q10 (CoQ10) is a nutritional agent that might play a preventative role in migraine. This meta-analysis aimed to investigate the effects of CoQ10 as a supplemental agent in migraine.

Structural correlates of cognitive impairment in normal pressure hydrocephalus.

The pathological bases for the cognitive and neuropsychiatric symptoms in normal pressure hydrocephalus (NPH) have not been elucidated. However, the symptoms may indicate dysfunction of subcortical regions. Previously, volume reductions of subcortical deep grey matter (SDGM) structures have been observed in NPH patients. The present study used automated segmentation methods to investigate whether SDGM structure volumes are associated with cognitive and neuropsychiatric measures.

Distribution of disease courses in familial versus sporadic multiple sclerosis.

The overall distribution of disease courses in multiple sclerosis (MS) is well established, but little is known about the distribution among familial MS cases. We examine the frequency of the different MS courses among familial and sporadic MS cases and determine whether MS cases within the same family had the same age at diagnosis and have experienced the same disease course.

Response Heterogeneity in Fitness, Mobility, and Cognition with Exercise-Training in MS.

Exercise-training is a beneficial approach for improving function in persons with multiple sclerosis(MS). However, it is unlikely that every participant who engages in an exercise-training intervention will demonstrate similar benefits. Identifying factors that may influence the accrual of specific exercise-training benefits can aid in the development of optimized rehabilitation interventions for improving specific outcomes in MS.

Association between muscle strength, histopathology and MRI in sIBM.

Inclusion body myositis is characterized by inflammatory and degenerative changes, but the temporal relation of these events is unknown.

Movement disorders associated with neuronal antibodies.

Movement disorders are one of the common clinical feature of neurological disease associated with neuronal antibodies. which is a group of potentially reversible disorder. They can present with hypokinetic or hyperkinetic types of involuntary movements and may have other associated neurological symptoms. The spectrum of abnormal movements associated with neuronal antibodies is widening. Some specific phenomenology of movement disorders are likely to give clue about the type of antibody, for instance presenc...

Cerebral small vessel disease and systemic arteriopathy in intracranial arterial dolichoectasia patients.

To investigate clinical and demographic characteristics of patients with intracranial arterial dolichoectasia (IADE) and describe the possible coexistence of cerebral small vessel disease (SVD) and systemic arteriopathy.

Vitamin D supplementation and neurofilament light chain in multiple sclerosis.

The effect of vitamin D supplementation on the disease course of multiple sclerosis (MS) is not established. Neurofilament light chain (NFL) is a sensitive marker of axonal degeneration. The aim of this study was to establish whether high-dose vitamin D supplementation reduces serum levels of NFL.

Patients with MELAS not only require treatment of stroke-like episodes but a comprehensive individual and family management.

With interest we read the article by Hovsepian et al. about a 46 years-old female with MELAS syndrome due to the common variant m.3243A>G in the tRNA(Leu) gene [1]. The patient experienced a stroke-like episode (SLE), which was treated with L-arginine (0.5g/kg/d) intravenously during 7 days, followed by oral administration thereafter. Therapy with L-arginine not only resulted in clinical improvement but also in improvement of cerebral imaging and the NAA/Cho ratio and cerebral lactate levels on MR-spectros...

Hereditary transthyretin-related amyloidosis.

Hereditary transthyretin(TTR)-related amyloidosis (ATTRm amyloidosis) is an endemic/non-endemic, autosomal-dominant, early- and late-onset, rare, progressive disorder, predominantly manifesting as length-dependent, small-fiber dominant, axonal polyneuropathy and frequently associated with cardiac disorders and other multisystem diseases. ATTRm amyloidosis is due to variants in the TTR gene, with the substitution Val30Met as the most frequent mutation. TTR mutations lead to destabilisation and dissociation o...

Neurostimulation for the treatment of chronic migraine and cluster headache - a review article.

Small subsets of patients who fail to respond to pharmacological treatment may benefit from alternative treatment methods. In the last decade, neurostimulation is being explored as a potential treatment option for the patients with chronic, severely disabling refractory primary headaches. To alleviate pain, specific nerves and brain areas have been stimulated, and various methods have been explored: deep brain stimulation, occipital nerve stimulation and sphenopalatine ganglion stimulation are among the...

Single antiepileptic drug levels do not predict adherence and non-adherence.

To investigate the significance of "subtherapeutic" versus "therapeutic" antiepileptic drug (AED) plasma levels with respect to treatment adherence.

Early-SEPs'amplitude reduction is reliable for poor-outcome prediction after cardiac arrest?

The bilateral absence of cortical Somatosensory Evoked Potentials(SEPs), after cardiac arrest(CA), is a high reliable predictor of poor outcome but it is present in no more than 40% of patients. An amplitude reduction of cortical SEPs was found in about 30% of subjects but few papers analysed its prognostic significance. The aim of our study is to identify a value of SEP amplitude reduction below which all the CA patients had poor outcome and the relationship between SEP and Electroencephalogram(EEG) patter...

MELAS: Monitoring treatment with Magnetic Resonance Spectroscopy.

To assess the utility of Magnetic Resonance Spectroscopy (MRS) as a biomarker of response to L-arginine in mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS).

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