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The voltage-gated sodium (Na ) channel is required for cardiomyocyte function. In heart, its major, pore-forming, α-subunit is Na 1.5, encoded by SCN5A, which maps to chromosome 3p21. The Na channel plays a key role in myocardial excitability, since it is responsible for generating the rising phase of the cardiac action potential. Na 1.5 often shows alterations in inherited channelopathies causing cardiac arrhythmias. Two well-known arrhythmias in which pathogenic variants of Na 1.5 are implicated are Brug...
Sleep disordered breathing (SDB) is a common obesity-related co-morbidity with strong associations to cardiometabolic disease. The risk of SDB is increased during pregnancy, particularly amongst obese pregnant women. Accumulating evidence suggests that an association exists between maternal SDB and the development of adverse pregnancy outcomes, particularly gestational diabetes and hypertensive disorders of pregnancy. Intermittent hypoxia, a central characteristic of SDB, has been shown in animal and clinic...
How to best measure journal performance remains a controversial issue. Routinely, the impact factor of the journal is taken, although this measure was never designed to reflect journal performance. The impact factor was developed as a tool for librarians in academia to sort out, which of the many very different journals may best suit the demands of their readers. As the annual impact factors are released in the middle of the year, we cannot yet share this value with you. However, our estimates indicate a si...
The annual Winter School of the Danish Diabetes Academy (DDA) in November 2019 challenged postdoctoral researchers with tough questions regarding research culture that scientists around the world are discussing. The complexity and competitiveness of modern research makes it increasingly difficult for junior researchers to navigate in the science community. This editorial reflects the voices of nearly 200 international researchers ranging from early-career scientists to professors and medical doctors discuss...
Much has been written on how various issues unrelated to science can affect acceptance or rejection of your manuscripts, for instance in Acta Physiologica.[1, 2] For many, journal rankings are becoming a matter of feast or famine as national funding agencies assess scientific output to efficiently distribute their limited resources. Yet, how do agencies objectively value scientific output? There are several very different approaches.
Obesity and obesity-related diseases have turned into a major global health risk. This is no longer restricted to highly developed countries  and has reached epidemic degrees in many regions. A diversity of metabolic and inflammatory pathophysiological phenotypes can be related to obesity, which represent a burden for healthcare and insurance systems, but particularly to affected people.
We thank Sandal et al. for taking an interest in our paper and the intriguing question on the determinants of mean arterial blood pressure (MAP) in mammals. Sandal et al. present a correlation between MAP and the vertical distance between the heart and the brain in 16 different species of (predominantly large) mammals.
Cellular plasticity is a topical subject with interest spanning a wide range of fields from developmental biology to regenerative medicine. Even the nomenclature is a subject of debate, and the underlying mechanisms are still under investigation. On top of injury repair, cell plasticity is a constant, physiological process in adult organisms and tissues, in response to homeostatic challenges. In this review we discuss two examples of plasticity for the maintenance of homeostasis in the renal system - namely...
Cardiovascular complications, including cardiac arrhythmias, result in high morbidity and mortality in patients with type-2 diabetes mellitus (T2DM). Clinical and experimental data suggest electrophysiological impairment of the natural pacemaker of the diabetic heart. The present study examined sinoatrial node (SAN) arrhythmias in a mouse model of T2DM and physiologically probed their underlying cause.
Astroglial connexins (Cxs) 30 and 43 are engaged in gap junction and hemichannel activities. Evidence suggests that these functional entities contribute to regulating neurotransmission, thereby influencing brain functions. In particular, preclinical and clinical findings highlight a role of Cx43 in animal models of depression. However, the role of these proteins in response to currently available psychotropic drugs is still unknown.
In the current issue of Acta Physiologica, Larsson and colleagues examined the effect of chaperone co-inducer BGP-15 on impaired contractile function of the slow-twitch soleus muscles in a rat intensive care unit (ICU) model. They found that BGP-15 improves myofibrillar function in the soleus muscle after 5 days exposure to the ICU condition, which is accompanied by improved mitochondrial morphology/biogenesis and reduced oxidative post-translational modifications (PTMs) of myosin molecules.
To explore the role of the histidine triad nucleotide-binding 2 (HINT2) protein in heart failure.
Neurons in the arcuate nucleus of the hypothalamus are involved in regulation of food intake and energy expenditure, and dysregulation of signaling in these neurons promotes development of obesity. The role of the rate-limiting enzyme in the NAD salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT), for regulation energy homeostasis by the hypothalamus has not been extensively studied.
Pathogenic variants of the SCN5A gene can cause Brugada syndrome (BrS) and long QT syndrome (LQTS), which predispose individuals to potentially fatal ventricular arrhythmias and sudden cardiac death. SCN5A encodes the Na 1.5 protein, the pore forming α-subunit of the voltage-dependent cardiac Na channel. Using a WW domain, the E3 ubiquitin ligase Nedd4-2 binds to the PY-motif ((L/P)PxY) within the C-terminus of Na 1.5, which results in decreased protein expression and current through Na 1.5 ubiquitination....
Heart failure (HF) is the end-stage syndrome for most cardiac diseases, and the five-year morbidity and mortality of HF remain high. Malignant arrhythmia is the main cause of sudden death in the progression of HF. Recently, bridging integrator 1 (BIN1) was discovered as a regulator of transverse-tubule (T-tubule) function and calcium signaling in cardiomyocytes. BIN1 downregulation is linked to abnormal cardiac contraction, and it increases the possibility of malignant arrhythmias preceding heart failure. D...
We welcome the opportunity to reply to the elegant editorial of Prof. Ehmke in which he highlights contradicting conclusions reached by Hinrichs et al. and by us in two recently published articles in Acta Physiologica. In our reply, we first comment on some technical aspects discussed by Prof. Ehmke as possible explanations for the discrepant conclusions reached in the two studies. In addition, we highlight some in vivo data reported by Hinrichs et al. which in our view do not oppose but rather support ...
It is widely accepted that the exocytosis of synaptic and secretory vesicles is triggered by Ca entry through voltage-dependent Ca channels. However, there is evidence of an alternative mode of exocytosis induced by membrane depolarization but lacking Ca current and intracellular Ca increase. In this work we investigated if such a mechanism contributes to secretory vesicle exocytosis in mouse chromaffin cells.
According to the World health organization (WHO) elevated blood pressure, known as arterial Hypertension, is a condition in which the arterial blood vessels have persistently raised pressure, putting them under increased stress. The higher the blood pressure, the higher the risk of damage to the heart and blood vessels in major organs such as the brain and kidneys. Hypertension is the most important preventable cause of heart disease and stroke worldwide.
Mechanisms of cross organ communication is vital for our bodies to maintain homeostasis. Secreted peptides, proteins and the autonomic nervous system have been the major regulators in metabolic adaptation. During the last decade significant scientific evidence has accumulated that extracellular vesicles (EVs), secreted by all cells, are involved cellular signaling [1, 2]. The EVs consists of different types, e.g. exosomes from the endosomal pathway, microvesicles from the cell surface and apoptotic bodies. ...
Abstracts of the 4th Congress of Physiology and Integrative Biology (CBPI) and 86th Congress of French Physiological Society (SFP), Nouvelle Faculté de Médecine, Montpellier, France, 12-14 June, 2019.
Air-breathing and amphibious fishes are essential study organisms to shed insight into the required physiological shifts that supported the full transition from aquatic water-breathing fishes to terrestrial air-breathing tetrapods. While the origin of air-breathing in the evolutionary history of the tetrapods has received considerable focus, much less is known about the evolutionary physiology of air-breathing among fishes. This review summarises recent advances within the field with specific emphasis on th...
In the following, novel developments in biomedical publishing important to all of our authors, reviewers and editors involved in the publication process at Acta Physiologica will be highlighted. Acta Physiologica's recommendations for authors focus on (a) the current implications of the revised ICMJE Guidelines, (b) the still recent European General Data Protection Regulation (GDPR) and (c) guidelines for experimental biomedical research involving animals. In addition, (d) Acta Physiologica follows the COPE...
When in late autumn 1944 the failed allied operation Market Garden trapped allied forces fighting in the Netherlands on one side of the river Rhine, it shattered all their hopes of ending WWII by Christmas 1944. For the Dutch civil population, however, the consequences were devastating, and resulted in a historically unprecedented famine descending upon a modern, highly developed and highly educated functional society. The Hongerwinter affected mostly the densely populated Western provinces, killing thousan...