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The relationship between borderline personality disorder (BPD) and bipolar II disorder (BIP-II) is disputed but understudied. Here, we investigated brain glucose metabolism in these patient groups and healthy control subjects (HCs).
The role of serotonin (5-HT) in human aggression has been the subject a large number of studies, mostly with adults. Meta-analyses indicate a small but significant inverse relationship between central nervous 5-HT availability and aggression, but genetically-informed studies suggest two pathways: one to reactive aggression, the other to proactive aggression.
Depression shows a large heterogeneity of symptoms between and within persons over time. However, most outcome studies have assessed depression as a single underlying latent construct, using the sum score on psychometric scales as an indicator for severity. This study assesses longitudinal symptom-specific trajectories and within-person variability of major depressive disorder over a 9-year period.
I would like to comment on an interesting article by Kessing et al. entitled 'New drug candidates for depression - a nationwide population-based study'(1). It presents a long-term study aimed to screen the Danish population register for the possible association between the exposure to certain clinically approved drugs: such as statins, high-dose aspirin and non aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), which possess anti-inflammatory or neuroprotective properties, and the rate of incident depr...
Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the "leaky gut hypothesis", increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation.
In February 2018, a 14-year-old boy from Rome died by asphyxiation, strangling himself with a cable of his PlayStation. On September 6th, a same-aged free climber from Milan died similarly after hanging a climbing rope around his neck. In both cases, suicidal intention was ruled out after careful interviews with family and friends of the victims: the deaths were classified as accidental, and the parents of the two boys soon discovered that they had watched on the Internet videos related to the so-called "Bl...
Several studies have observed that dissociative experiences are frequently reported by individuals with severe mental illness (SMI), especially amongst patients that report a history of adverse/traumatic life experiences. This review examined the magnitude and consistency of the relationship between childhood adversity (sexual abuse, physical abuse, emotional abuse, neglect, bullying, natural disasters and mass violence) and dissociation across three SMI diagnostic groups: schizophrenia, bipolar disorder an...
Clinical variables were investigated in the 'treatment resistant depression (TRD)- III' sample to replicate earlier findings by the European research consortium 'Group for the Study of Resistant Depression' (GSRD) and enable cross-sample prediction of treatment outcome in TRD.
This study aimed to assess the heterogeneity and stability of cognition in patients with a non-affective psychotic disorder and their unaffected siblings. In addition, we aimed to predict the cognitive subtypes of siblings by their probands.
Structural MRI (sMRI) increasingly offers insight into abnormalities inherent to schizophrenia. Previous machine learning applications suggest that individual classification is feasible and reliable and, however, is focused on the predictive performance of the clinical status in cross-sectional designs, which has limited biological perspectives. Moreover, most studies depend on relatively small cohorts or single recruiting site. Finally, no study controlled for disease stage or medication's effect. These el...
No consensus exists on whether clozapine should be prescribed in early stages of psychosis. This systematic review and meta-analysis therefore focus on the use of clozapine as first-line or second-line treatment in non-treatment-resistant patients.
Bipolar disorder carries a high risk of suicide. Identification of risk factors is important. The aim of this study was to study risk factors for suicide in a large cohort of men and women with bipolar disorder.
We conducted a 12-week double-blind study of stabilization pharmacotherapy in patients with remitted psychotic depression (PD).
Frontal cortical abnormalities and executive function impairment co-occur in bipolar disorder. Recent studies have shown that bipolar subtypes differ in the degree of structural and functional impairments. The relationships between cognitive performance and cortical integrity have not been clarified and might differ across patients with bipolar disorder type I, II, and healthy subjects.