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We investigated for the first time whether patients with recent-onset, uncomplicated hypertension and different hypertension phenotypes exhibit altered values of SEVR, a surrogate measure of myocardial perfusion that correlates with the ratio of subendocardial to subepicardial blood flow. We additionally explored whether SEVR correlates with arterial stiffness in a population free from the long-term effects of essential hypertension.
Acetylcholinesterase inhibition prevents autonomic imbalance, reduces inflammation and attenuates the development of hypertension. Considering that vascular dysfunction is a crucial feature of arterial hypertension, we investigated the effects of chronic administration of acetylcholinesterase inhibitors - pyridostigmine or donepezil - on vascular reactivity of spontaneously hypertensive rats (SHR).
Our objective of this study was to determine if rate of eGFR decline and its intensity was associated with cardiovascular risk and death in hypertensive patients whose baseline estimated glomerular filtration rate (eGFR) was higher than 60 mL/min/1.73m2.
Pregnancy hypertensive disorders have impaired neurodevelopment in offspring. We aimed to explore the association of normal range maternal blood pressure (BP) with child neurodevelopment, as well as the possible role of placental 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2) therein.
Activation of beta-1 adrenoreceptors (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure. Genetic variation in the β1-AR could therefore alter the physiological and clinical effects of this hormone. We tested this hypothesis in patients from a primary care cohort being screened for primary hyperaldosteronism, PHA (n=465).
Inter-individual variability in blood pressure (BP) response to antihypertensives has been reported. Although plasma renin activity (PRA) is a potential biomarker for personalizing antihypertensive therapy in European-American (EA) and African-American (AA) hypertensives, clinical utility of PRA-guided prescribing is incompletely understood.
Aldosterone has been linked with obesity, metabolic syndrome (MetS), pro-inflammatory and pro-thrombotic states; however, most studies relate these indicators with primary aldosteronism (PA), excluding non-PA patients.
The attenuation of physiological nocturnal decline of blood pressure (BP) - called nondipper pattern - has previously been reported to be associated with target organ damage in hypertensive subjects. However, this association remains debated and poorly studied in normotensive patients. The present study aimed to investigate the association between nondipper pattern and subclinical cardiovascular and renal damage in an initially healthy population-based cohort study.
Self-monitoring of blood pressure better predicts prognosis than clinic measurement, is popular with patients, and endorsed in hypertension guidelines. However, there is uncertainty over the optimal self-monitoring schedule. We therefore aimed to determine the optimum schedule to predict future cardiovascular events and determine "true" underlying blood pressure.
Hypertension is a growing problem worldwide and can often result in a variety of negative health outcomes. The aim of this study was to assess the effects of age at diagnosis, calendar period, and birth cohort on the change in the prevalence rate of hypertension in Guangzhou from 2004 to 2013.
The 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline lowers the blood pressure (BP) thresholds for defining brachial hypertension. We therefore aimed to investigate how the new guideline influences the prevalence of brachial hypertension and whether it improves the identification of central hypertension in an Asian national representative population.
Coronary heart disease (CHD) is among the main causes of death in the world. Individual study of cardiovascular risk is an important way to a predict CHD risk. The aim of this study was to evaluate the added role of the aortic pulse wave velocity (PWV) index in the prediction of CHD risk.
Several studies assessed maternal gestational diabetes mellitus (GDM) with the risk of childhood high blood pressure, and the results were inconsistent. We investigated the association between maternal GDM and high blood pressure risk in offspring during early childhood.
Elevations of fasting glucose (FG) levels are frequently encountered in people treated with thiazide diuretics. The risk is lower in people treated with ACE inhibitors (ACEi). To determine if genetic factors play a role in FG elevation we examined the interaction of a diabetes gene risk score (GRS) with the use of three different antihypertensive medications.
Millions of Americans have uncontrolled hypertension and are low-income or uninsured. Health Resources and Services Administration-funded health centers (HCs) are primary providers of care to these patients and a majority have adopted the Patient-Centered Medical Home (PCMH). PCMH includes principles of care coordination or integration and care management-support important to the treatment of hypertension. We examined whether the receipt of PCMH concordant care by HC patients improved hypertension outcomes.
The mechanism explaining the inverse association between renal urate and albumin excretion remains unclear. First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e., SLC2A9, SLC22A12, ABCG2) on the association between fractional excretion of uric acid (FEUA) and urinary albumin/creatinine ratio (uACR). Second, we examined uromodulin and sodium excretion as mediators of the association between FEUA and uACR.
Multiple cross-sectional epidemiologic studies have suggested an association between periodontal disease and tooth loss and hypertension, but the temporality of these associations remains unclear. The objective of our study was to evaluate the association of baseline self-reported periodontal disease and edentulism with incident hypertension.
Several formulas using spot urine have been developed to estimate 24-hour sodium excretion, but none of them have been validated in pediatrics. We aimed to evaluate the performance of eight formulas, including Kawasaki, Tanaka, International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT1), INTERSALT without potassium (INTERSALT2), Mage, Whitton, Uechi simple-mean, and Uechi regression, in estimating 24-hour sodium excretion at both population and individual levels in Chinese young ...
The contribution of steady-state pressures and the forward (Pf) and backward (reflected) (Pb) wave pressure components of pulse pressure (PP) to risk prediction have produced contrasting results. We hypothesized that the independent contribution of steady-state pressures (mean arterial pressure [MAP]), Pf and Pb to cardiovascular damage is organ-specific and age-dependent.
Primary aldosteronism (PA) may cause myocardial injury. We investigated myocardial dysfunction using speckle tracking echocardiographic (STE) layer-specific strain in patients with PA.