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The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books.
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Many of the signaling pathways and growth factors involved with pulmonary fibrosis are well-described but little is known about why the fibroproliferative process progresses over time. Ventilation-induced lung injury occurs as a result of epithelial stress and strain from atelectrauma and volutrauma, respectively, both of which occur in the setting of alveolar collapse. We suggest that ventilation-induced lung injury may be a unifying process explaining perpetuation of the fibrosis on the basis that (a) alv...
Traditionally, the presence and severity of obstructive sleep apnea (OSA) has been defined by the apnea-hypopnea index (AHI). Continuous positive airway pressure (CPAP) is generally first line therapy despite low adherence as it reliably reduces the AHI when used, and the response to other therapies is variable. However, there is growing appreciation that the underlying etiologies (i.e. endotype) and clinical manifestations (i.e. phenotype) of OSA in an individual are not well described by the AHI. We defin...