PubMed Journal Database | American journal of respiratory cell and molecular biology RSS

02:54 EDT 25th May 2019 | BioPortfolio

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Showing PubMed Articles 1–25 of 425 from American journal of respiratory cell and molecular biology

Activated Fibroblasts: Gluttonous for Glutamine.

Linking VEGF deficiency and IL-33 upregulation in COPD.

Combination therapy targeting platelet activation and virus replication protects mice against lethal influenza pneumonia.

Excessive neutrophils recruited during influenza pneumonia contribute to severe lung pathology through induction of neutrophil extracellular traps (NETs) and release of extracellular histones. We have recently shown that activation of platelets during influenza enhances pulmonary microvascular thrombosis leading to vascular injury and hemorrhage. Emerging evidence indicates that activated platelets also interact with neutrophils forming neutrophil-platelet aggregates (NPAs), which contribute to tissue injur...

Escalating mucus inhibition to the top of our priorities.

Microbiota-dependent regulation of antimicrobial immunity in the lung.

Several body sites including the intestinal and respiratory tracts are colonized with a myriad of bacteria, archaea, fungi and viruses, which are collectively referred to as the microbiota. The bacterial component of the microbiota in particular has been recognized to influence a multitude of physiological functions including innate and adaptive immune responses. Germ-free and microbiota-depleted animals display an impaired antimicrobial defense and are therefore highly susceptible to various infections inc...

Genetic Deletion of Semaphorin 3E Aggravates Airway Contraction in a Mouse Model of Allergic Asthma.

May Highlights/Papers by Junior Investigators/NIH News.

Recommended Reading from the Johns Hopkins University Pulmonary and Critical Care Medicine Research Fellows.

Preventing Glutaminolysis: A Potential Therapy for Pulmonary Fibrosis.

Preterm Lung Exhibits Distinct Spatiotemporal Proteome Expression at Initiation of Lung Injury.

To characterize time-dependent and regionally-specific injury patterns associated with early ventilation of the preterm lung using a mass-spectrometry based proteomic approach. Preterm lambs delivered at gestational age 124-127d were randomized to receive 15-min (n=7) or 90-min (n=10) of mechanical ventilation at standardized settings (positive end-expiratory pressure 8 cmHO, tidal volume 6-8 mL/kg) and were compared with unventilated control lambs (n=7). At study completion, lung tissue was taken from sta...

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variatio...

Transcriptomic responses to Ivacaftor and prediction of Ivacaftor clinical responsiveness.

Ivacaftor is a recently FDA-approved drug for the treatment of cystic fibrosis (CF) patients with at least one copy of the G511D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The transcriptomic effect of Ivacaftor in CF patients remains unclear. We aim to examine if and how the transcriptome of patients is influenced by Ivacaftor treatment and to determine if these data allow prediction of Ivacaftor responsiveness. Our data originate from the GOAL-G551D Observational Study...

CRACking the Beat of Cilia: Calcium Rocks.

CD44 and xCT: The Silver Bullet for Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension?

To Bet or Not To Bet on T-Bet As A Therapeutic Target in Emphysema?

Smoking Impairs the Immunomodulatory Capacity of Lung Resident Mesenchymal Stem Cells in COPD.

Tobacco smoking is the main environmental risk factor of Chronic Obstructive Pulmonary Disease (COPD), but not all smokers develop the disease. A population of lung resident mesenchymal stem cells (LR-MSC) exist in healthy lungs, but how tobacco smoking affects them and their role in COPD have not been assessed yet. Using a sphere based culture technique, LR-MSC were isolated from lung tissue obtained from non-smokers, current and former smokers with and without COPD (n=53). Cells were characterized by flow...

Organophosphorus Pesticides Induce Cytokine Release from Differentiated Human THP1 Cells.

Epidemiologic studies link organophosphorus pesticides (OPs) to increased incidence of asthma. In guinea pigs, OP-induced airway hyperreactivity requires macrophages and TNFα. Here, we determine whether OPs interact directly with macrophages to alter cytokine expression or release. Human THP1 cells differentiated into macrophages were exposed to parathion, chlorpyrifos, diazinon, or their oxon, phosphate or phosphorothioate metabolites for 24 h, in the absence or presence of reagents that block cholinergic...

Beyond Fibroblast Heterogeneity: What Single-Cell RNA-Seq Tells Us.

Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts.

Idiopathic pulmonary fibrosis is characterized by the TGF-β-dependent differentiation of lung fibroblasts into myofibroblasts, leading to excessive deposition of extracellular matrix proteins, which distort lung architecture and function. Metabolic reprogramming in myofibroblasts is emerging as an important mechanism in the pathogenesis IPF and recent evidence suggests that glutamine metabolism is required in myofibroblasts although the exact role of glutamine in myofibroblasts is unclear. Here we demonstr...

CA Dreamin': Carbonic Anhydrase Inhibitors, Macrophages and Pulmonary Hypertension.

Cigarette Smoke Triggers IL-33-Associated Inflammation in a Model of Late Stage COPD.

Chronic Obstructive Pulmonary Disease (COPD) is a worldwide threat. Cigarette smoke (CS) exposure causes cardiopulmonary disease, COPD and increases the risk for pulmonary tumors. In addition to poor lung function, those with COPD are susceptible to bouts of dangerous inflammation triggered by pollutants or infection. These severe inflammatory episodes can lead to additional exacerbations, hospitalization, further deterioration of lung function and reduced survival. Suitable models of the inflammatory condi...

Cellular Senescence: The Trojan Horse in Chronic Lung Diseases.

Senescence is a cell-fate decision characterized by irreversible arrest of proliferation accompanied by senescence associated secretory phenotype (SASP). Traditionally, cellular senescence was recognized as a beneficial physiological mechanism during development, wound healing, and in tumor suppression. However, in recent years identification of negative consequences of cellular senescence has emerged, illuminating its role in several chronic pathologies. In this context, senescent cells persist or accumula...

Transcription Factor T-Bet Attenuates the Development of Elastase-Induced Emphysema in Mice.

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by peripheral airways inflammation and emphysema. Emerging evidence indicates a contribution of both innate and adaptive immune cells to the development of COPD. Transcription factor T-bet modulates the function of immune cells and therefore might be involved in the pathogenesis of COPD. To elucidate the role for T-bet in elastase-induced emphysema, pathological phenotypes were compared between wild-type and T-bet-/- mi...

Microbial Metabolites in Cystic Fibrosis: a Target for Future Therapy?

A Need for Targeted Immunosuppression Following Lung Transplantation.

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