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The risk of cardiovascular (CV) disease is higher in patients with psoriatic arthritis (PsA) versus the general population. Tofacitinib is an oral Janus kinase inhibitor for the treatment of PsA. As tofacitinib increases circulating lipid levels in some patients, we evaluated CV risk factors and major adverse cardiovascular events (MACE) in patients with active PsA receiving tofacitinib 5 or 10 mg twice daily plus conventional synthetic disease-modifying antirheumatic drugs.
To assess "real-word" practice patterns surrounding treatment initiation and treatment adjustments over time for methotrexate (MTX) and non-MTX-based treatments strategies in early rheumatoid arthritis (ERA).
To evaluate the course of impaired spinal mobility in patients with long-standing well-defined ankylosing spondylitis (AS).
This study ascertains whether Latina and African American women with arthritis-related knee pain and primary care providers who treat them believe their treatment decisions would benefit from having more information about the impact of treatment on their quality of life, medical care costs and work productivity.
Hand osteoarthritis (OA) trials often target exclusively the thumb base joint although concomitant widespread interphalangeal (IP) involvement is frequent. We aimed to compare hand strength and function between individuals with isolated thumb base OA and those with co-existent IP joint pain and erosive OA.
We conducted a systematic review and appraisal of the cross-cultural adaptation and cross-cultural validity of the Health Assessment Questionnaire (HAQ) and its derivatives, and the more recent Patient-Reported Outcomes Measurement Information System (PROMIS) Functional Status Assessment Measures (FSAMs) in rheumatoid arthritis (RA).
Evaluate safety and efficacy of intravenous golimumab in patients with active psoriatic arthritis (PsA) through 1 year.
To estimate the cumulative incidence of arthritis-induced orofacial symptoms, dysfunctions, and dentofacial deformities in growing individuals with juvenile idiopathic arthritis (JIA) in a 36 month regional cohort study, and to identify predictors for the development of arthritis-induced dentofacial deformities.
The relapse rate of patients with giant cell arteritis (GCA) treated with glucocorticoids (GC) alone varied widely in observational series and randomized controlled trials (RCT). The purpose of this systematic review was to evaluate the prevalence of relapse and predisposing factors in patients receiving GC alone.
To identify depression subtypes in participants with or at-risk for symptomatic knee osteoarthritis (OA) and to evaluate differences in pain and disability trajectories between groups.
Treating early, intensively and to target leads to rapid disease control, preventing joint damage and loss of function in early rheumatoid arthritis (RA). We report the effect of such approach on patient-reported outcomes and explore the contribution of rapid and persistent disease control on wellbeing after 1 year of treatment.
To describe the range and depth of perspectives and experiences of patients with psoriasis and psoriatic arthritis to inform gaps in patient centred care.
Explore therapeutic alliance between physiotherapists and patients with knee osteoarthritis during telephone consultations. Specifically, i) describe and compare physiotherapist and patient ratings; ii) determine if alliance changes over time, and; iii) evaluate if individual characteristics are associated with alliance.
Caldwell and colleagues, in their Letter to the Editor entitled "Training Nurse Practitioners and Physicians' Assistants in a University Fellowship Program: Implementation and Challenges", describe the establishment of a rheumatology training program for nurse practitioners (NPs) and physician assistants (PAs). We read with interest the training model outlined and applaud their efforts for the work that has been accomplished at their institution. Their described plan of immersing NP and PA fellows in the cl...
In response to the article "Core Curriculum to Facilitate the Expansion of a Rheumatology Practice to Include Nurse Practitioners and Physicians' Assistants" by Benjamin J. Smith, et al., Vol. 70(5), May 2018: pp 672-678, we write to share the experiences of the Duke Rheumatology Nurse Practitioner/Physicians' Assistant (NP/PA) Fellowship Program. After two years of discussion and planning, we launched a one-year fellowship in rheumatology for NP/PAs in October, 2017. This article is protected by copyright...
Health information technology has enabled efficient measurement of patient reported outcomes (PROs). The NIH PROMIS system (The Patient-Reported Outcomes Measurement Information System) is becoming more widely adopted for research and routine care, and some PROMIS instruments might be substituted for lengthier, legacy PRO instruments.
Demonstrate the effectiveness of Project ECHO (Extension for Community Healthcare Outcomes) in educating primary care clinicians (PCCs) to provide best practice rheumatology care to patients in under-resourced communities in New Mexico (NM).
Supervised group exercise (SGE) is proven effective in patients with axial spondyloarthritis (axSpA), but its contents and dosage do not always comply with current scientific insights. This study aimed to describe axSpA patients' satisfaction with current SGE and perspective on potential, evidence-based SGE enhancements.
To assess the comparative responsiveness of outcome measures used for the assessment of pain and function in individuals with first metatarsophalangeal joint osteoarthritis (1 MTPJ OA).
To explore the feasibility, fidelity, safety, and preliminary outcomes of a physical therapist-administered physical activity (PA) intervention after total knee replacement (TKR).
The goal of this paper is to describe approaches for the joint analysis of repeatedly measured data with time-to-event endpoints, first separately and then in the framework of a single comprehensive model, emphasizing the efficiency of the latter approach. Data from the Johnston County Osteoarthritis Project (JoCo OA) will be used as an example to investigate the relationship between the change in repeatedly measured body mass index (BMI) and the time-to-event endpoint of incident worsening of radiographic ...
Despite an extensive body of research on NSAIDs in osteoarthritis, the duration of their efficacy and timeline of adverse event (AE) onset have been understudied. We conducted a systematic review and meta-analyses from 2 to 26 weeks to characterize the efficacy and AE trajectories of oral NSAIDs in knee osteoarthritis.
Glucocorticoids (GCs) are widely used to effectively treat inflammatory disease, however GCs have a number of recognised side effects. It has been shown that patients and clinicians view these side effects differently, with clinicians most concerned with serious side effects such as osteoporosis and diabetes. Consequently these side effects are well researched with clinical guidelines and recommendations. A side effect shown to be of particular concern to patients is weight gain, however this topic has not ...
Little is known about if and how rheumatologists provide family planning counseling and reproductive health care (FPCC) to reproductive-age women with rheumatic diseases. This qualitative study sought to assess rheumatologists' perspectives, attitudes, and practices regarding FPCC.
We performed a systematic review and meta-analysis to evaluate the comparative effects of tumor necrosis factor-α inhibitors (TNFi), non-TNFi biologic and conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) on cardiovascular risk in rheumatoid arthritis (RA).