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PubMed Journal Database | Behavioural brain research RSS

07:00 EDT 26th May 2019 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.

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Showing PubMed Articles 1–25 of 751 from Behavioural brain research

Somatotopic representation of tactile duration: evidence from tactile duration aftereffect.

Accurate perception of sub-second tactile duration is critical for successful human-machine interaction and human daily life. However, it remains debated where the cortical processing of tactile duration takes place. Previous studies have shown that prolonged adaptation to a relatively long or short auditory or visual stimulus leads to a repulsive duration aftereffect such that the durations of subsequent test stimuli within a certain range appear to be contracted or expanded. Here, we demonstrated a robust...

Behavioral consequences of co-administration of MTEP and the COX-2 inhibitor NS398 in mice. Part 1.

The immunologic modulation of glutamate (Glu) neurotransmission is a topic of great interest. Neuroinflammation is an intrinsic component of neurodegenerative diseases, as well as a factor responsible for cognitive and behavioral changes. Cyclooxygenase-2 (COX-2) expression in the brain was shown to be associated with inflammation. COX-2 is also widely expressed in the brain including neurons and glia and participates in fundamental brain functions, e.g. in synaptic plasticity or memory consolidation. Furth...

Age and Sex Differences in Motivation and Spatial Working Memory in 3xTg-AD Mice in the Hebb-Williams Maze.

The 3xTg-AD mouse model of Alzheimer's disease (AD) has both amyloid beta plaque and tau tangle pathology. However, the results of behavioural testing with these mice have been inconsistent due to age- and sex-related differences, as well as differences in the difficulty of the tests used to measure cognitive function. In order to better understand the sex- and age-related spatial working memory deficits in the 3xTg-AD mice compared to their B6129S/F2 wildtype controls, we tested 4 and 7-month-old males and...

Enhancing effect of aerobic training on learning and memory performance in rats after long-term treatment with Lacosamide via BDNF-TrkB signaling pathway.

Aerobic training has a neuroprotective effect, reduces the risk of developing neurodegenerative diseases and facilitates functional recovery. The present study assesses the effect of aerobic training on cognitive functions, hippocampal BDNF/TrkB ligand receptor system expression and serum levels of BDNF and corticosterone in intact rats after chronic treatment with Lacosamide (LCM). Male Wistar rats were randomly divided into two groups. One group was exercised on a treadmill (Ex) and the other one was sede...

Effects of prenatal exposure to chrysotile asbestos on hippocampal neurogenesis and long-term behavioral changes in adult male rat offspring.

Prenatal development is a critical period of life that many environmental pollutants have been suggested to influence fetal growth. Nevertheless, there are still a few investigations into the prenatal exposure to chrysotile asbestos and its neurodevelopmental and behavioral outcome in offspring. In this study, twenty-eight pregnant Wistar rats were divided into four groups and received three-times repeated intraperitoneal injections of normal saline, chrysotile, ascorbic acid and the combination of chrysoti...

Prenatal immune activation induces age-related alterations in rat offspring: Effects upon NMDA receptors and behaviors.

Prenatal exposure to polyriboinosinic-polyribocytidylic acid (poly I:C) results in psychotic-like behavior in mature rat offspring as well as enduring modifications of glutamatergic excitatory synaptic transmission. However, little is known about the dynamic behavioral and glutamate N-methyl-D-aspartate (NMDA) receptor changes in rat offspring following poly I:C treatment of pregnant dams. In this study, poly I:C was administered to rats intravenously at a dose of 10 mg/kg on gestational day 9 in order to...

Examining the equivalence between imagery and execution - do imagined and executed movements code relative environmental features?

Imagined actions engage some of the same neural substrates and related sensorimotor codes as executed actions. The equivalency between imagined and executed actions has been frequently demonstrated by the mental and physical chronometry of movements; namely, the imagination and execution of aiming movements in a Fitts paradigm. The present study aimed to examine the nature or extent of this equivalence, and more specifically, whether imagined movements encompass the relative environmental features as do exe...

The effect of depressive-like behavior and antidepressant therapy on social behavior and hierarchy in rats.

Depression is common and results in a significant morbidity and economic burden. Depression is associated with pervasive impairments in social functioning, and antidepressant treatments are highly variable in improving these impairments. The objectives of this study were to test the effects of depression on social organization and behavior in a rodent model of depression, and to study the effectiveness of antidepressant medication in improving both symptoms of depression and the social function of depressed...

Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus.

Existing evidence from clinical and animal experiments all indicated that fluoxetine, selective serotonin-reuptake inhibitor (SSRI) and anti-depressant drug, has neuroprotection and improve functional outcomes after stroke. Endoplasmic reticulum stress (ERS) inducing apoptosis after cerebral ischemia reperfusion injury was demonstrated in our previous. This trial was examined whether fluoxetine mitigates ERS-induced neuron apoptosis. Male sprague-dawley rats of cerebral ischemia reperfusion injury was produ...

Dysfunction of astrocytic connexins 30 and 43 in the medial prefrontal cortex and hippocampus mediates depressive-like behaviours.

Astrocytic connexin dysfunction is closely associated with synaptic impairment and contributes to the pathological development of depressive-like behaviours. However, little is known about the expression of connexins in astrocytes from different brain regions, or how tissue specific connexin expression affects local neuronal activity. Here, we established a mouse model of chronic social defeated stress (CSDS), from which we isolated astrocytes from the medial prefrontal cortex (mPFC), hippocampus, amygdala,...

Social context influences sensorimotor gating in female African cichlid fish Astatotilapia burtoni.

Disruption in prepulse inhibition (PPI), a sensorimotor gating phenomenon found in many species has been associated with various psychiatric disorders in humans. Social defeat has been identified as a mediator of naturally evoked reductions of PPI in African cichlid fish Astatotilapia burtoni where males reversibly alter social status and their sensorimotor gating abilities. Here we investigated A. burtoni females, which establish a male-like social hierarchy with dominant (DOM) and subordinate (SUB) indivi...

Renewal of extinguished behavior in pigeons (Columba livia) does not require memory consolidation of acquisition or extinction in one-day free-operant appetitive conditioning paradigms.

Extinction learning is a fundamental capacity for adaptive and flexible behavior. As extinguished conditioned responding is prone to relapse under certain conditions, the necessity of memory consolidation for recovery phenomena to occur has been highlighted recently. Several studies have demonstrated that both acquisition and extinction training need to be properly consolidated for a relapse of the original acquired memory trace to occur. Does this imply that extinguished responses can't relapse before memo...

Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone.

Literature data show diverse vulnerability to the rewarding effects of cocaine in human as well as in laboratory animals. The molecular mechanisms of these differences have not been discovered yet. While the initial effects of cocaine depend primarily on the dopamine system, numerous studies have shown that adaptation within the glutamatergic system is responsible for the development of addiction. In this paper, we used the unbiased conditioned place preference (CPP) to identify rats showing a vulnerable or...

The formation of compensatory contextual fear memory in the absence of dorsal hippocampus does not change sleep architecture.

Although the dorsal hippocampus (DH) plays an essential role in the consolidation of contextual fear-conditioned (CxFC) memory, this consolidation may also occur in the absence of DH. It is, however, not known if the development of a compensatory circuit for CxFC memory is time-dependent. The DH-dependent contextual fear memory influences sleep architecture, but whether the compensatory fear memory can influence sleep, is not known. Here, we have studied (a) the temporal progression of compensatory contextu...

Voluntary alcohol access during adolescence/early adulthood, but not during adulthood, causes faster omission contingency learning.

In omission contingency training, rodents learn to suppress their natural tendency to approach or touch a reward-predictive cue (termed "autoshaping" or "sign-tracking" responses) if the approach/touching responses lead to the omission of the reward. Previous research has shown that high levels of alcohol exposure (through alcohol vapor exposure) or adolescent alcohol consumption (with some versions of the omission contingency task) can lead to faster omission contingency learning. However, the alcohol expo...

Chronic caffeine exposure in adolescence promotes diurnal, biphasic mood-cycling and enhanced motivation for reward in adult mice.

Adolescent's consumption of caffeine and caffeinated beverage is increasing, yet little is known about the consequences of chronic caffeine exposure during the critical development period of adolescence. In the present study, we investigated the effect of beginning chronic caffeine consumption in adolescence on locomotor, mood, sensorimotor gating, and reward seeking behaviors through adolescence and in adulthood. During the light cycle, caffeine exposed mice exhibited hypoactivity in a novel open-field box...

tDCS RECOVERS DEPTH PERCEPTION IN ADULT AMBLYOPIC RATS AND REORGANIZES VISUAL CORTEX ACTIVITY.

Amblyopia or lazy eye is a neurodevelopmental disorder that arises during the infancy and is caused by the interruption of binocular sensory activity before maturation of the nervous system. This impairment causes long-term deterioration of visual skills, particularly visual acuity and depth perception. Although visual function recovery has been supposed to be decreased with age as consequence of reduced neuronal plasticity, recent studies have shown that it is possible to promote plasticity and neurorestor...

Morning stimulant administration reduces sleep and overnight working memory improvement.

The goal of cognitive enhancement is to improve mental functions using interventions including cognitive training, brain stimulation and pharmacology. Indeed, psychostimulants, commonly used for cognitive enhancement purposes, while preventing sleep, have been shown to increase working memory (WM) and attention. Sleep, however, is also important for cognitive function; thus, understanding the interaction between stimulants, sleep and cognition may inform current approaches to cognitive enhancement. We used ...

Pathological Attenuation of the Right Prefrontal Cortex Activity Predicts Speech and Limb Motor Timing Disorder in Parkinson's Disease.

Neurological deficits can cause a wide range of motor symptoms in patients with Parkinson's disease (PD). However, our understanding about the effects of PD on the underlying neural mechanisms of motor function has remained elusive. In the present study, we investigated the relationship between PD pathology and neurological deficits in planning and execution mechanisms of motor timing during speech production and limb movement. We used a combination of behavioral and event-related potential (ERP) measures t...

The Orbitofrontal Cortex Processes Neurofeedback Failure Signals.

Receiving feedback from neural activity, dubbed neurofeedback, can reinforce brain self-regulation. In a real-time functional magnetic resonance imaging (fMRI) experiment, healthy participants received amygdala neurofeedback via a visual brain computer interface. The brain response to signals of reward and failure was modeled. In contrast to previous analyses, we take into account feedback that immediately preceded these signals. That means we tested whether responses were modulated while participants obser...

Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats.

Phf24 is known as Gαi-interacting protein (GINIP) and is associated with the GABA receptor. To study the function of Phf24 protein in the central nervous system (CNS), we have newly developed Phf24-null rats and investigated their behavioral phenotypes, especially changes in seizure sensitivity, emotional responses and cognitive functions. Phf24-null rats did not exhibit any spontaneous seizures. However, they showed a higher sensitivity to pentylenetetrazol (PTZ)- or pilocarpine-induced convulsive seizure...

Retrosplenial cortex damage produces retrograde and anterograde context amnesia using strong fear conditioning procedures.

Contextual fear conditioning relies upon a network of cortical and subcortical structures, including the hippocampus and the retrosplenial cortex (RSC). However, the contribution of the hippocampus is parameter-dependent. For example, with "weak" training procedures, lesions of the hippocampus produce both retrograde and anterograde context amnesia. However, with "strong" training procedures (e.g., more trials and/or higher levels of footshock), lesions of the hippocampus produce retrograde context amnesia ...

Long-Lasting Effects of Repeated Ketamine Administration in Adult and Adolescent Rats.

Initiation of ketamine use often occurs in adolescence, yet little is known about long-term consequences when use begins in this developmental period. The current experiments were designed to examine the effects of repeated exposure to ketamine in adolescence on behavior in adulthood. We examined locomotor activity, as well as cognitive function, in animals that received repeated administration of ketamine. Groups of adolescent and adult male rats were treated with ketamine (25 mg/kg) once daily for 10 da...

Limited effects of early life manipulations on sex-specific gene expression and behavior in adulthood.

Exposure to childhood adversity is associated with increased vulnerability to stress-related disorders in adulthood which has been replicated in rodent stress models, whereas environmental enrichment has been suggested to have beneficial effects. However, the exact neurobiological mechanisms underlying these environment influences on adult brain and behavior are not well understood. Therefore, we investigated the long-term effects of maternal separation (MS) or environmental enrichment (EE) in male and fema...

Social housing promotes cognitive function through enhancing synaptic plasticity in APP/PS1 mice.

Previous studies have shown that loneliness increases the risk of AD (Alzheimer's disease) onset, while active and frequent social housing delays the onset of cognitive impairment. The mechanism of how this occurs remains unclear. In this study, we investigated how social interaction affected cognitive function and AD pathology in APP/PS1 (amyloid precursor protein/presenilin-1) mice. APP/PS1 mice were divided into either a social isolation (SI) group, a social contact with one mouse (SCO) group, or a socia...


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