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PubMed Journal Database | Clinical and experimental immunology RSS

16:21 EDT 16th July 2019 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.

BioPortfolio aims to cross reference relevant information on published papers, clinical trials and news associated with selected topics - speciality.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 203 from Clinical and experimental immunology

Interstitial lung disease in patients with Common Variable Immunodeficiency Disorders: several different pathologies?

Various reports of disease-related lung pathologies in Common Variable Immunodeficiency Disorder (CVID) patients have been published, with differing histological and HRCT findings. Data was extracted from the validated Oxford PID database (1986 to 2016) on adult sporadic CVID patients with suspected interstitial lung disease (ILD). Histology of lung biopsies was studied in relation to length of follow-up, clinical outcomes, HRCT findings and chest symptoms, to look for evidence for different pathological pr...

T- Cell Functionality in HIV-1, HIV-2 and Dually Infected Individuals: Correlates of Disease Progression and Immune Restoration.

The role of suppressive antiretroviral therapy (ART) in eliciting restoration of dysregulated immune function remains unclear in HIV-1 infection. Also, due to tailoring of therapeutic regimens towards HIV-1, this possible impairment of therapy may be even more pronounced in HIV-2 and dual (HIV-D) infection. Thus, we evaluated the impact of ART on immune restoration by assessing T cell functions including HIV specific responses in HIV-1, HIV-2 and HIV-D infected individuals. Both ART-treated and naive infect...

Experimental colitis in IL-10-deficient mice ameliorates in the absence of PTPN22.

Interleukin (IL)-10 plays key role in controlling intestinal inflammation. IL-10-deficient mice and patients with mutations in IL-10 or its receptor, IL-10R, show increased susceptibility to inflammatory bowel diseases (IBD). Protein tyrosine phosphatase PTPN22 controls immune cell activation and the equilibrium between regulatory and effector T cells, playing important role in controlling immune homeostasis of the gut. Here, we examined the role of PTPN22 in intestinal inflammation of IL-10-deficient (IL-1...

Regulatory T cells: exploring mechanisms for future therapies.

In this two-part Review Series for Clinical & Experimental Immunology, we have invited experts in their fields to contribute review articles on the recent progress in understanding the genetic basis of regulatory T cell functional development, their role in ensuring tolerance in health, the underlying mechanisms underlying their dysfunction in diseased states, and their use in cellular therapies for the treatment of a host inflammatory conditions in humans. This article is protected by copyright. All rights...

Influence of maternal microbiota during pregnancy on infant immunity.

Microbiota from various maternal sites including the gut, vagina and breastmilk, are known to influence colonization in infants. However, emerging evidence suggests that these sites may exert their influence prior to delivery, in turn influencing fetal immune development. The dogma of a sterile womb continues to be challenged. Regardless, there is convincing evidence that the composition of the maternal gut prior to delivery influences neonatal immunity. Therefore, while the presence and function of placent...

A study of 51 subtypes of peripheral blood immune cells in newly diagnosed young type 1 diabetes patients.

Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta cells in pancreatic islets. Various immune cell populations are involved in disease development and natural course. However, to our knowledge, so far there are no comprehensive comparative investigations of all main immune cell populations and their most important subsets at the onset of the disease. Therefore, in the current study, we analyzed 51 peripheral blood immune cell populations in 22 young T1D patients and in 25 ag...

Metabolism at the centre of the host-microbe relationship.

Maintaining homeostatic host-microbe interactions is vital for host immune function. The gut microbiota shapes the host immune system and the immune system reciprocally shapes and modifies the gut microbiota. Yet, our understanding of how these microbes are tolerated and how individual, or communities of, gut microbes influence host function is limited. This review will focus on metabolites as key mediators of this complex host-microbe relationship. It will look at the central role of epithelial metabolism ...

Circulating lectin pathway proteins do not predict short-term cardiac outcomes after myocardial infarction.

In spite of improvements in treatment, coronary artery disease is still responsible for one third of all deaths globally, predominantly due to myocardial infarction (MI) and stroke. There is an important potential in developing new strategies for treatment of patients with these conditions. Inflammation, and in particular the actions of the complement system, has emerged as part of the pathogenesis in the reperfusion injury in patients with MI. To further qualify this, we examined the association between th...

IL-17 and TNFα cooperation contributes to the pro-inflammatory response of hepatic stellate cells.

Hepatic stellate cells (HSCs) have a central role in liver inflammation and fibrosis by producing inflammatory and fibrotic mediators. Their activation is regulated through direct cell-cell interactions but also through systemic and local effects of soluble factors, such as cytokines. The effects of the pro-inflammatory cytokines IL-17 and TNFα and cell interactions with hepatocytes on HSC activation were assessed. Human HSC and HepaRG cells were exposed to IL-17 and/or TNFα. IL-17 and TNFα contribution ...

Neutrophils develop rapid proinflammatory response after engulfing Hb-activated platelets under intravascular hemolysis.

Neutrophils maintain immune homeostasis by engulfing apoptotic cells and debris. We describe the rapid activation of neutrophils after engulfing hemoglobin (Hb)-activated platelets, which are abundant in circulation of hemolytic patients. Neutrophils from healthy individuals after engulfing Hb-activated express elevated CD11b and secrete significant amounts of TNF-α, IL-1β, IL-6, MPO and elastase within 4 hr platelets but not with only free-Hb in vitro. These neutrophils exhibit early onset of apoptosis a...

Mitigating placental injuries through up-regulating DAF in experimental APS mice:new mechanism of progesterone.

Antiphospholipid syndrome (APS) is characterized by recurrent pathological pregnancy, arterial or venous thrombosis in the presence of antiphospholipid antibody (aPL). Complement activation is recognized as an intermediate link leading to placental thrombosis and placental inflammation in APS model mice. Decay accelerating factor (DAF, CD55), MAC-inhibitory protein (MAC-IP, CD59) and membrane cofactor protein (MCP, CD46) are important complement inhibitory proteins (CIPs) highly expressed in normal placenta...

Overview of procalcitonin in pregnancy and in pre-eclampsia.

Procalcitonin (PCT), a precursor for calcitonin, is a pro-hormone involved in the inflammatory processes, which has been poorly studied in the context of pregnancy. During severe inflammation, PCT derives from almost all cell types, including monocytes and parenchymal tissues, making it as a good predictive and diagnostic marker of an inflammatory state with rapidly increased serum levels in inflammation or sepsis.

MicroRNA-466a-3p attenuates allergic nasal inflammation in mice by targeting GATA3.

Allergic rhinitis is thought to be an allergic disease associated with IgE-mediated immune response, characterized by increased Th2 cytokine production, elevated eosinophil levels in the nasal mucosa and induced nasal secretions. MicroRNA microarray data revealed that the expression level of miR-466a-3p was significantly decreased. Notably, GATA3 was identified as one of its target genes through miRNA target prediction web tools. The expression levels of miR-466a-3p were altered by mimics and lentivirus bot...

Disrupted regulation of serpinB9 in circulating T cells is associated with an increased risk for post-transplant skin cancer.

Cutaneous squamous cell carcinoma (cSCC) is a serious complication after organ transplantation and patients benefit from an early risk assessment. We hypothesized that functional differences in circulating T cells may represent risk factors for post-transplant cSCC development. Here we analyzed genome-wide DNA methylation of circulating T cells of kidney transplant recipients before the clinical onset of cSCC, to identify differences associated with post-transplant cSCC development. This analysis identified...

T cell metabolism in chronic viral infection.

T cells are a fundamental component of the adaptive immune response in the context of both acute and chronic viral infection. Tight control over the metabolic processes within T cells provides an additional level of immune regulation that is interlinked with nutrient sensing and the continued balancing of co-stimulatory and co-inhibitory signals. Underpinning T cell responsiveness for viral control are a number of phenotypic and functional adaptations ensuring adequate nutrient uptake and their utilisation....

Protein-engineered molecules carrying GAD65 epitopes and targeting CD35 selectively down-modulate disease-associated human B lymphocytes.

Type 1 diabetes mellitus is an autoimmune metabolic disorder characterized by chronic hyperglycemia, presence of autoreactive T and B cells and autoantibodies against self-antigens. A membrane-bound enzyme on the pancreatic beta-cells, GAD 65, is one of the main autoantigens in type 1 diabetes. Autoantibodies against GAD65 are potentially involved in beta-cells destruction and decline of pancreatic functions.

Patients with TNF Receptor Associated Periodic Syndrome (TRAPS) are hypersensitive to Toll-like receptor 9 stimulation.

Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) is an hereditary autoinflammatory disorder characterised by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, which encodes tumour necrosis factor receptor-1 (TNFR1). Our aim was to understand the influence of TRAPS mutations on the response to stimulation of the pattern recognition receptor TLR9. Peripheral blood mononuclear cells (PBMCs) and serum were isolated from TRAPS patien...

Embryonic extracellular vesicles as informers to the immune cells at the maternal-fetal interface.

Extracellular vesicle exchange is emerging as a novel way of communication at the maternal-fetal interface. The presence of the EVs has been demonstrated in the pre-implantation embryo culture medium from different species, such as bovines, porcines and humans. Pre-implantation embryo-derived EVs have been shown to carry molecules potentially able to modulate the local endometrial immune system. The nonclassical MHC class I molecule HLA-G, the immunomodulatory molecule progesterone-induced blocking factor a...

Relation of HLA-DRB1 to IgG4 autoantibody and cytokine production in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG).

A small subset of myasthenia gravis (MG) patients develop autoantibodies against muscle-specific kinase (MuSK) which are predominantly of the IgG4 isotype. MuSK-MG is strongly associated with HLA-DRB1*14, HLA-DRB1*16 and HLA-DQB1*05. In this study, the possible effects of these HLA associations on MuSK IgG autoantibody or cytokine production were investigated. Samples from 80 MG patients with MuSK antibodies were studied. The disease-associated HLA types were screened in the DNA samples. The IgG1, IgG2, IgG...

Regulatory T cell features in Chronic Granulomatous Disease.

Chronic Granulomatous Disease (CGD) is a primary immunodeficiency caused by mutations in any of the genes encoding the phagocyte NADPH oxidase system, responsible for the production of reactive oxygen species (ROS). CGD is marked by invasive bacterial and fungal infections and by auto-inflammation/autoimmunity of which the exact pathophysiology remains elusive. Contributing factors include decreased neutrophil apoptosis, impaired apoptotic neutrophil clearance, increased pro-inflammatory protein expression ...

Identification of susceptibility SNPs in CTLA4 and PTPN22 for scleritis in Han Chinese.

To determine the association between 13 single nucleotide polymorphisms (SNPs) in the Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) genes with scleritis in a Chinese Han population. We recruited 432 scleritis patients and 710 healthy controls. Four tag SNPs of CTLA4 and 9 tag SNPs of PTPN22 were selected using Haploview. Genotyping was performed with the Sequenom MassArray iPLEX GOLD Assay. Genotype and allele frequency differences were ana...

Tissue Talks: Immunophenotype of Cells Infiltrating the Graft Explains Histological Findings and the Benefits of Belatacept at 10 years.

Previously, we found a substantial number of Tregs and fewer senescent and Th17; and a decrease in interstitial fibrosis (IF) in 12-month graft biopsies in belatacept- versus cyclosporine (CNI)-treated patients (BENEFIT study). Seven years after kidney transplantation (KT), mean eGFR, patient and graft survival were significantly higher with belatacept versus CNI treatment. The aim of this study was to determine whether the immunophenotypes of inflammatory and regulatory cell subsets infiltrating the grafts...

Methods to manufacture regulatory T cells for cell therapy.

Regulatory T cell (Treg) therapy has shown promise in early clinical trials for treating graft-versus-host disease, transplant rejection and autoimmune disorders. A challenge has been to isolate sufficiently pure Tregs and expand them to a clinical dose. However, there has been considerable progress in the development and optimization of these methods, resulting in a variety of manufacturing protocols being tested in clinical trials. In this review, we summarize methods that have been used to manufacture Tr...

Distinct patterns of naïve, activated and memory T and B cells in blood of patients with ulcerative colitis or Crohn's disease.

Both major subcategories of inflammatory bowel disease (IBD), ulcerative colitis and Crohn's disease are characterized by infiltration of the gut wall by inflammatory effector cells, and elevated biomarkers of inflammation in blood and faeces. We investigated the phenotypes of circulating lymphocytes in the two types of IBD in treatment-naïve pediatric patients by analysis of blood samples by flow cytometry. Multivariate analysis was used to compare the phenotypes of the blood lymphocytes of children with ...

The role of FOXP3 regulatory T cells in human autoimmune and inflammatory diseases.

CD4 T Regulatory cells expressing the FOXP3 transcription factor (Treg cells) are instrumental for the prevention of autoimmune diseases. There is increasing evidence that the human T regulatory population is highly heterogeneous in phenotype and function. Numerous studies conducted in human autoimmune diseases have shown that Treg cells are impaired either in their suppressive function or in number or both. Hence, the contribution of the FOXP3 Treg subpopulations to the development of autoimmunity has not ...


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