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The quadrivalent influenza vaccine (QIV) contains two influenza B antigens (one of each B lineage), while the trivalent vaccine (TIV) contains solely one. As a result, a mismatch between the circulating B lineage and the lineage in the TIV occurs frequently. We aimed to compare the frequency of clinically significant outcomes in a large cohort of vaccinees receiving either TIV or QIV.
Until recently, the European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommended the cefoxitin disk to screen for mecA-mediated betalactam resistance in Staphylococcus pseudintermedius. A recent study indicated that cefoxitin was inferior to oxacillin in this respect. We have re-evaluated cefoxitin and oxacillin disks for screening for methicillin resistance in S. pseudintermedius.
During medical congresses Twitter allows discussions to disseminate beyond the congress hall and reach a wider audience. Insights into the dynamics of social media interactions during congresses, dissemination of scientific information and the determinants of a successful tweet may allow us to better understand social media's role in science communication.
Severe pulmonary infections are among the most common reasons for admission to ICU. Within the last decade increasing reports of severe influenza pneumonia resulting in acute respiratory distress syndrome (ARDS) complicated by Aspergillus infection were published.
Infections are common among patients treated for haematological malignancies and are associated with significant morbidity and mortality. The completeness of reporting infectious complications in randomized controlled trials (RCTs) assessing treatments for haematological malignancies is unknown.
Streptococcus pneumoniae is the most common pathogen causing bacterial meningitis. The routine use of multivalent conjugate pneumococcal vaccines has led to a decline of invasive pneumococcal disease caused by serotypes included in the vaccine serotypes. Recently, several reports have described a concomitant rise in the incidence of non-vaccine serotypes, suggesting serotype replacement.
TB-EASM (Howsome, Shanghai, China), an automated system combining smear preparation, staining and microscopy in a single platform, was evaluated for tuberculosis (TB) diagnostic value in a high disease-burden setting.
Zika virus (ZIKV) is mostly mosquito borne but can also be transmitted by the sexual route, and persist in semen for prolonged time. Moreover, viral RNA has been detected in breastmilk, saliva, lacrimal fluids and urines, suggesting other possible transmission routes. The aim of our research is to better define ZIKV tropism.
Sample preparation for High-throughput sequencing (HTS) includes treatment with various laboratory components, potentially carrying viral nucleic acids, the extent of which has not been thoroughly investigated. Our aim was to systematically examine a diverse repertoire of laboratory components used to prepare samples for HTS in order to identify contaminating viral sequences.
Microbial whole genome sequencing (WGS) has many advantages over standard microbiological methods. However, it is not yet widely implemented in routine hospital diagnostics due to notable challenges.
Candidemia is a serious hazard to hospitalized patients, but European epidemiological data is restricted to national studies focusing on Northern Europe, population-based surveillance programs or studies conducted in distinct local areas.
To investigate the impact of colonization with carbapenemase producing Enterobacteriaceae (CPE) on the CPE infection risk after liver transplantation (LT).
The increasing prevalence of ventilator-associated pneumonia (VAP) due to either multidrug resistant (MDR) organisms or infections with limited treatment options (i.e., susceptible to only aminoglycosides or colisitin) coupled with a dearth of new antimicrobials has led clinicians to pursue alternative management strategies including the use of inhaled antibiotics (IA).
This study aimed to estimate the prevalence of Hepatitis B, D, and C viruses and syphilis in the population of illegal gold miners in French Guiana. The prevalence of HBsAg carriage was high (4.6%, 95%CI= 2.6-6.6) among this hard to reach population as well as the seropositivity for treponemal antibodies (11.5%, 95%CI=8.5-14.6), with higher prevalence in women (p=0,009). This population may represent key population in French Guiana, needing appropriate strategies for prevention, screening and treatment.
Non-cystic fibrosis bronchiectasis (NCFBE) with Pseudomonas aeruginosa (Pa) has been associated with increased pulmonary exacerbation (PEx) and mortality risk. European Respiratory Society guidelines conditionally recommend inhaled antimicrobials for persons with NCFBE, Pa, and ≥3 PEx/year. We report microbiologic results of two randomized, 48-week placebo-controlled trials of ARD-3150 (inhaled liposomal ciprofloxacin) in NCFBE subjects with Pa and PEx history [Lancet Respir Med 2019;7:213-26].
In this multicenter, factorial (2x2), randomized, double-blind, placebocontrolled trial of uva-ursi 3600 mg daily for 3 to 5 days with an open, pragmatic component of advice versus no advice to take ibuprofen 1200 mg daily for the treatment of uncomplicated cystitis in 382 women, there was no difference in symptom severity between the groups of uva-ursi versus placebo (difference = -0.06, 95% CI: -0.33, 0.21; p=0.661) or advice versus no advice to take ibuprofen (difference = -0.01, 95% CI:- 0.27, 0.26; p=...
Carbapenem resistance is defined as in vitro nonsusceptibility to any carbapenem and/or documented production of a carbapenemase. This feature has rapidly spread worldwide among clinical isolates of Enterobacteriaceae, mostly Klebsiella spp, and is associated with diverse molecular mechanisms. Carbapenem resistance is often associated with resistance to all traditional beta-lactams and other classes of antibiotics, denoting a typical example of extensively drug-resistant phenotype.
We aimed to determine the viral epidemiology and clinical characteristics of patients with and those without clinically-apparent respiratory tract infection.
Pseudomonas aeruginosa is mostly a nosocomial pathogen affecting predisposed patients. However, community-onset bloodstream infections (CO-BSI) caused by this organism are not exceptional.
To provide species distribution and antifungal susceptibility profiles of 358 Trichosporon clinical isolates collected from 24 tertiary care hospitals.
Methanogenic archaea are considered as extremely oxygen-sensitive organisms and their culture is fastidious, requiring specific equipment. We report here the conditions allowing the cultivation of M. smithii in an anaerobic chamber without hydrogen addition.
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are serious complications in transplant patients.
This year, the World Health Organization is launching a global survey with self-assessment tools in Infection Prevention and Control and Hand Hygiene. Despite evidence for the effectiveness of hand-hygiene, HCWs' compliance is unacceptably low. It is important to understand the relevance of these tools and their value to institutions and health systems.