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PubMed Journal Database | Colloids and surfaces. B, Biointerfaces RSS

07:42 EDT 21st March 2019 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.

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For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 1,800+ from Colloids and surfaces. B, Biointerfaces

Microalgae harvesting with the novel flocculant hairy cationic nanocrystalline cellulose.

This paper investigates the flocculation of Chlorella sorokiniana suspensions with a novel cellulose derivative, namely hairy cationic nanocrystalline cellulose (CNCC). CNCC are a brand new family of nanocellulose characterized by having two positively charged amorphous ends joint through a common crystalline shaft. Flocculation was monitored through laser reflectance and its mechanism was studied by means of zeta potential, fractal dimension and turbidity removal. CNCC dosage and shear rate were varied and...

Multi-targeted approach by 2-benzimidazolylquinoxalines-loaded cationic arginine liposomes against сervical cancer cells in vitro.

Multi-targeted approaches for inhibition of сervical cancer cells in vitro were developed by implementing two different strategies and drug combination for creation of new therapeutic target agents and for nanotechnological-enhancement of intracellular delivery. New 2-benzimidazolylquinoxalines derivatives were synthesized and characterized by combining two different pharmacophores - benzimidazole and quinoxaline rings directly bonded in their structures. Spectrophotometric technique for determination of c...

Optimal construction and pharmacokinetic study of CZ48-loaded poly (lactic acid) microbubbles for controlled drug delivery.

CZ48, a prodrug of camptothecin (CPT) with derivative resistant to lactone hydrolysis, suffers from limited application for cancer treatment due to poor water-solubility, thus causing its low bioavailability and absorption in vivo. To echo this problem, CZ48 was incorporated into poly (lactic acid) (PLA) microbubbles via a double emulsion technique (W/O/W), and the successful loading was confirmed by X-ray diffraction (XRD) patterns and confocal laser scanning microscope (CLSM). The obtained CZ48-loaded mic...

Early hMSC morphology and proliferation on model polyelectrolyte multilayers.

Polyelectrolyte multilayers (PEMs) are a category of materials commonly used as coatings on surfaces that interact with cells. The properties of PEMs have been established to be controlled by not only polyelectrolyte choice, but by the identity of the initially applied (bottom) layer. In this work, 5-bilayer PEMs consisting of poly(diallyldimethylammonium chloride) (PDADMAC) and poly(sodium 4-styrenesulfonate) (PSS) were coated on gold-sputtered quartz substrates with different first layer materials. A fina...

Biosurfactant production by a rhizosphere bacteria Bacillus altitudinis MS16 and its promising emulsification and antifungal activity.

Generally, most of the biosurfactant producing microbes are the common inhabitants of hydrocarbon contaminated sites. However, there are a very few literatures that report the existence of biosurfactant producing microbes in rhizosphere soil of plants involved in remediation of pesticide laden agricultural soil and in general welfare of the plants indicating the necessity of further research. A total of twenty three morphologically distinct rhizosphere strains were isolated and were screened for biosurfacta...

Supramolecular nanoassembly of lysozyme and α-lactalbumin (apo α-LA) exhibits selective cytotoxicity and enhanced bioavailability of curcumin to cancer cells.

Hybrid supramolecular spherical nanoassembly of hen egg white lysozyme and bovine apo α lactalbumin (SN) was prepared with a mean size of ˜55.2 nm using an optimized desolvation method via chemical crosslinking. The nanoassembly, SN demonstrated dose-dependent reactive oxygen species (ROS) mediated cytotoxicity in multiple cancer cells such as MCF-7, MDA-MB231, HeLa and MG 63. It also demonstrated high loading capacity of a phytochemical based anticancer agent, curcumin (248.8 mg/g) and target-based p...

Erythropoietin-loaded solid lipid nanoparticles: Preparation, optimization, and in vivo evaluation.

Solid lipid nanoparticle (SLN) is a promising approach for delivery of various drugs including proteins and peptides. However, the loading of hydrophilic drugs into the lipoid matrix of SLNs is challenging. The statistical design is a potential method facilitating the optimization of nanoparticles characteristics. In this study, the Box-Behnken design was conducted to optimize the preparation of Erythropoietin (EPO) loaded SLNs. Circular dichroism, size exclusion chromatography, SDS-PAGE, and ELISA tests we...

Preparation, microstructure and function of liposome with light responsive switch.

A novel liposome with photo-responsiveness was prepared by a combined method of thin film hydration and supercritical carbon dioxide technique. In liposomes, curcumin and 4-butylazobenzene-4-hexyloxy-trimethyl-ammoniumtrifluoro-acetate (BHA) were used as model drug and photo-responsive reversible switch, respectively. Optimum incubation temperature of drug was determined by using phase transition temperature of the liposomes. Morphology and size of liposomes were obtained by transmission electron microscop...

Doxorubicin loaded tumor-triggered targeting ammonium bicarbonate liposomes for tumor-specific drug delivery.

Ammonium bicarbonate (ABC) liposomes can only release drugs extracellularly while intracellular drug delivery could be more promising than extracellular release in chemotherapy. The purpose of this work was to endow the ABC liposomes with tumor-triggered targeting effect, to realize the intracellular drug release and retain the long circulation characteristics of the liposomes. The tumor-triggered targeting ABC (TT-ABC) liposomes were proposed to improve uptake of tumor cells owing to folate (FA) - specific...

A pH-sensitive microemulsion-filled gellan gum hydrogel encapsulated apigenin: Characterization and in vitro release kinetics.

In this work, the incorporation of O/W microemulsion in gellan gum hydrogels was performed to prepare the composite hydrogel as the carrier of apigenin. In vitro release studies resulted that the composite hydrogels could control the drug release under acidic (pH 1.2) and weak alkaline conditions (pH 7.4). This was due to the increase of crosslinking degree under acidic medium and degradation under weak alkaline medium, observed by SEM technique. The FT-IR analysis further confirmed that the hydrogen ions (...

Temperature-modulated cell-separation column using temperature-responsive cationic copolymer hydrogel-modified silica beads.

There is strong demand for cell separation methods that do not decrease cell activity or modify cell surfaces. Here, new temperature-modulated cell-separation columns not requiring cell-surface premodification are described. The columns were packed with temperature-responsive cationic polymer hydrogel-modified silica beads. Poly(N-isopropylacrylamide-co-n-butyl methacrylate-co-N,N-dimethylaminopropyl acrylamide) hydrogels with various cationic moieties were attached to silica-bead surfaces by radical polyme...

Transforming an inert nanopolymer into broad-spectrum bactericidal by superstructure tuning.

Poloxamer block copolymers (also known as Pluronic®) are particularly useful for drug delivery and self-assembly techniques. These nanopolymers are generally considered to be biologically inert and they were used to generate only bacteria repellent surfaces but keeps bacteria alive and as a latent threat. However, the inherent capabilities of these nanopolymers to kill bacteria have been largely overlooked. Here, we report that Pluronic shaped as superstructures (self-organized array of micelles) in fact p...

Biomimetic mineralization on natural and synthetic polymers to prepare hybrid scaffolds for bone tissue engineering.

To mimic the mineral component and the microstructure of natural bone, nanohydroxyapatite (nHAP)/polymer (natural and synthetic materials) composite scaffolds with micropore structures and good mechanical performance were prepared via the assistance of sonication and amidation. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) showed the biomimetic homogeneous formation of nHAP in the polymer matrix. Fourier transform infrared spectroscopy (FTIR) indicated that the polymer matrix regulated the ...

Quercetin mediated gold nanoclusters explored as a dual functional nanomaterial in anticancer and bio-imaging disciplines.

Quercetin-mediated gold nanoclusters (Qu-GNCs) were prepared for the first time by employing bovine serum albumin (BSA) as a stabilizer with a natural flavonoid, "quercetin" as a reducing agent. Interestingly, quercetin (Qu) forms a cluster by reacting with gold under alkali conditions in the presence of BSA. Transmission electron microscopy (TEM) images of obtained nanoclusters exhibit the optimal size with homogenous distribution. Similarly, Fourier transform infrared spectroscopy (FTIR) confirmed the con...

Targeted release mechanism of λ-cyhalothrin nanocapsules using dopamine-conjugated silica as carrier materials.

Based on the specific binding between the receptors and ligands, novel targeted nanocapsules were prepared by using silica covalently bonded with dopamine to increase the insecticidal efficacy of λ-cyhalothrin. The targeted release mechanism of λ-cyhalothrin nanocapsules (NC) nanocapsules was verified by enzymatic analysis, fluorescent marking method and high performance liquid chromatograph. The results showed NC had uniform particle size (800 nm) and approximately 31% (w/w) loading efficiency of λ-cy...

Effect of surface modification on the peroxidase-like behaviors of carbon dots.

Carbon dots (CDs) have drawn much attention in recent decades due to their outstanding biocompatibility and environmental friendliness. In this work, the surface modifications of peroxidase-like carbon dots were carried out to show the influence of surface structure on the catalytic activity. Poly(ethyleneimine) and citric acid modified CDs, i.e. PEI-CDs and CA-CDs, were obtained and used in the catalytic oxidation of two different substrates 3,3',5,5'-tetramethylbenzidine (TMB) and 2,2'-azino-bis(3-ethylbe...

Interaction of DNA with likely-charged lipid monolayers: An experimental study.

Anionic lipids are increasingly being used in lipoplexes for synthetic gene vectors as an alternative to cationic lipids. This is primarily due to their lower toxicity, which makes them biocompatible and adaptable to be tissue specific. However, anionic lipoplexes require the presence of multivalent cations to promote the electrostatic attraction between DNA and anionic lipid mono- and bilayers. In this work we provide for the first time experimental results of the adsorption of linear DNA onto anionic/zwit...

In vitro and in vivo performance of a propolis-coated polyurethane wound dressing with high porosity and antibacterial efficacy.

Wound dressings with antimicrobial and wound healing accelerating properties are emerging as valuable options to prevent wound infection and improve the wound healing process. In this study, high porous polyurethane (PU) foams were successfully prepared using salt leaching/solvent casting method and were coated with propolis as a well-known anti-bacterial agent. The wound dressings were subjected to detail analyzes using electron microscopy, reflectance Fourier transform infrared spectroscopy, mechanical pr...

Potential of chitosan-based carrier for periodontal drug delivery.

Periodontal diseases are chronic infectious diseases and are a major oral health burden. With the progress in the understanding of etiology, epidemiology and pathogenesis of periodontal diseases coupled with the understanding of the polymicrobial synergy in the dysbiotic oral microbial flora, several new therapeutic targets have been identified. The strategies to curb bacterial growth and production of factors that gradually destroy the tissue surrounding and supporting the teeth have been the cornerstone f...

Cisplatin-loaded PLGA nanoparticles for HER2 targeted ovarian cancer therapy.

The conventional treatment (cytoreduction combined with cisplatin/carboplatin and taxane drugs) of ovarian cancer has a high rate of failure and recurrence despite a favorable initial response. This lack of success is usually attributed to the development of multidrug resistance mechanisms by cancer cells and avoidance of the anti-growth effects of monoclonal targeted therapeutic antibodies. The disease, like other cancers, is characterized by the overexpression of molecular markers, including HER2 receptor...

Bio-orthogonal fluorinated resist for biomolecules patterning applications.

The patterning of organic materials on solid substrate surfaces has been demonstrated by several methods, such as photolithography, soft lithography, imprint lithography and ink-jet printing. Fluorinated polymers and solvents provide attractive material systems to develop new patterning approaches, as they are chemically orthogonal to non-fluorinated organic molecules, allowing their efficient incorporation in different devices and systems. Moreover, fluorinated polymers are soluble in hydrofluoroether solv...

Anti-biofouling activity of Ranaspumin-2 bio-surfactant immobilized on catechol-functional PMMA thin layers prepared by atmospheric plasma deposition.

The deposition of polymeric thin layers bearing reactive functional groups is a promising solution to provide functionality on otherwise inert surfaces, for instance, for bioconjugation purposes. Atmospheric pressure plasma (AP plasma) deposition technology offers many advantages, such as fast deposition rates, low costs, low waste generation and suitability for coating various kind of material surfaces. In this work, the AP plasma-assisted copolymerization of methyl methacrylate (MMA) with a vinyl derivati...

Fast-dissolving electrospun gelatin nanofibers encapsulating ciprofloxacin/cyclodextrin inclusion complex.

Electrospun gelatin nanofibrous matrix encapsulating ciprofloxacin (CIP)/hydroxypropyl-beta-cyclodextrin (HPβCD)-inclusion complex (IC) was produced via electrospinning method. Computational modeling indicated that van der Waals forces are the most significant driving forces for the complexation and hydrophobic moiety (piperazinyl) of CIP, which was included in the cavity of HPβCD. The FTIR and XRD studies indicated the formation of CIP/HPβCD host/guest complexation, FTIR also suggested that hydrophobic ...

Facile strategy to prepare a metalloporphyrin-based hydrophilic porous organic polymer with enhanced peroxidase-like activity and high stability for colorimetric detection of HO and glucose.

Nanozymes, nanomaterial-based artificial enzymes, have attracted researchers' enormous interest due to their unique properties compared with natural enzymes. To mimic the catalytic function of natural enzymes, designing high-efficient, novel nanozymes is crucial yet challenging task. In this article, we described the synthesis and functions of a metalloporphyrin-based porous organic polymer, namely FePPOPs-SOH. FePPOPs-SOH was synthesized effortlessly via an extensive aromatic electrophilic substitution and...

Dendritic polylysine based ανβ3 integrin targeted probe for near-infrared fluorescent imaging of glioma.

The difficulty in identifying tumor tissues from healthy brain tissues is a major challenge for the accurate resection of glioma in clinical practice. Many efforts have been made to develop targeting probes to precisely visualize and resect glioma. However, most of these probes are hindered by non-degradation, intolerable toxicity, complicated and costly preparation procedures. In this work, we report an ανβ3 integrin-targeted near-infrared (NIR) fluorescent probe DP-RGD for detection of glioma. Consider...


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