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PubMed Journal Database | Current pharmaceutical design RSS

17:21 EDT 2nd April 2020 | BioPortfolio

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Showing PubMed Articles 1–25 of 101 from Current pharmaceutical design

MAGNOLIA OFFICINALIS REDUCES INFLAMMATION AND DAMAGE INDUCED BY RECURRENT STATUS EPILEPTICUS IN IMMATURE RATS.

Neuroinflammation induced in response to damage caused by status epilepticus (SE) activates the interleukin (IL)1-β pathway and proinflammatory proteins that increase vulnerability to the development of spontaneous seizure activity and/or epilepsy.

Multiple risk factors: A challenge in the management of Autism.

Autism Spectrum Disorder (ASD) is an emerging health problem involving 1 out of every 68 children. The incidence rate of autism has increased 3 folds during last 3 decades. Due to the illusive picture of aetiology a considerable number of autistic children fail to receive proper behavioural and medicational treatment. The present study provides a cumulative account of autism risk factors. Several factors including the gene expression and gene mutations, environmental pollution, metal ion accumulation, expos...

The Effect of PDE5 Inhibitors on the Male Reproductive Tract.

The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albugine...

Manipulation of pharmaceutical polymorphic transformation process using excipients.

In pharmaceutical field, it is vital to ensure a consistent product containing a single solid-state form of the active pharmaceutical ingredient (API) in the drug product. However, some APIs are suffering from the risk of transformation of their target forms during processing, formulation and storage.

Molecular mechanisms and therapeutic targets of inflammatory-related Cardiovascular diseases: from molecular mechanisms to therapeutic targets.

Inflammation is a pathogenic response to multiple factors, that cause over activation of different molecules and pro-inflammatory cellular lines. Different behavioral factors and risk factors might enhance the inflammatory stress, and this might cause cardiovascular disease (CVD). CVD is the world's leading cause of morbidity and mortality, and it is represented by hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital h...

Common neural mechanisms of palatable food intake and drug abuse: knowledge obtained with animal models.

Eating is necessary for survival, but it is also one of the great pleasures enjoyed by human beings. Research to date shows that palatable food can be rewarding in a similar way to drugs of abuse, indicating a considerable comorbidity between eating disorders and substance-use disorders. Analysis of the common characteristics of both types of disorder has led to a new wave of studies proposing a Gateway Theory of food as a vulnerability factor that modulates the development of drug addiction. The homeostati...

Administration of pharmaceutical agents prior to testicular sperm extraction procedures: A meaningful or meaningless approach?

To date, no randomized and controlled study has demonstrated effect of adjuvant medical therapy on testicular sperm production before the sperm retrieval procedures in men with non-obstructive azoospermia (NOA).

A novel sentinel lymph node approach in oral squamous cell carcinoma.

Occult metastases are common in patients with oral squamous cell carcinoma (OSCC) which is why elective neck dissection, adjuvant radiotherapy or watchful waiting have been treatment options after surgical removal of the primary tumour. Sentinel lymph node biopsy (SLNB), has lately emerged as a novel possibility in treatment planning. Even though the SLNB technique is constantly improving, it has not yet been firmly established in the assessment of head and neck cancer.

DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier.

The use of peptides as drug carriers across the blood-brain barrier (BBB) has increased significantly during the last decades. PepH3, a seven residue sequence (AGILKRW) derived from the α-helical domain of the dengue virus type-2 capsid protein, translocates across the BBB with very low toxicity. Somehow predictably from its size and sequence, PepH3 is degraded in serum relatively fast. Among strategies to increase peptide half-life (t1/2), use of the enantiomer (wholly made of D-amino acid residues) can b...

Stimulation of Leydig and Sertoli cellular secretory function by anti-oestrogens: Tamoxifen.

Tamoxifen is a selective oestrogen receptor modulator (SERM). SERMs act on oestrogen receptors to inhibit oestradiol mediated negative feedback on the hypothalamic-pituitary-gonadal (HPG) axis, thereby upregulating gonadotrophin secretion and release from the pituitary. Hence, Tamoxifen is used to upregulate activation of the HPG axis in the treatment of male-factor infertility. However, due to a lack of robust evidence, Tamoxifen has not been FDA approved for use in male-factor infertility and so its use i...

A hidden human proteome signature characterizes the epithelial mesenchymal transition program.

Molecular changes associated with the initiation of the epithelial to mesenchymal transition (EMT) program involve alterations of large proteome-based networks. The role of protein products mapping to non-coding genomic regions is still unexplored.

Acute Kidney Injury after Endovascular Procedures: How to Avoid this Old Foe.

Recent advances on anti-tumor agents-loaded polymeric and lipid based nano-carriers for the treatment of brain cancer.

In 2016, there were 17.2 million of cancer cases which caused 8.9 million of deaths worldwide. Of all cancers, ranked by absolute years of life lost, brain and central nervous system cancer were classified in the nine position between 2006 and 2016. Glioblastoma is the most common malignant primary brain tumour and comprises 80% of malignant tumours. Therapeutic approach usually involves the combination of surgery and radiotherapy, which present a high risk for the patient and are not always effective in th...

Adhesion Molecules as Potential Novel Biomarkers for Opioid Dependence.

Cell-cell adhesion is essential in maintaining the structure and function of an organ. Several adhesion molecules have recently been identified as associated with heroin dependence in both genetic and peripheral plasma studies.

A Survey of Network Representation Learning Methods for Link Prediction in Biological Network.

Networks are powerful resources for describing complex systems. Link prediction is an important issue in network analysis and has important practical application value. Network representation learning has proven to be useful for network analysis, especially for link prediction tasks.

A Review of Recent Developments and Progress in Computational Drug Repositioning.

Computational drug repositioning is an efficient approach towards discovering new indications for existing drugs. In recent years, with the accumulation of online health-related information and the extensive use of biomedical databases, computational drug repositioning approaches have achieved significant progress in drug discovery. In this review, we summarize recent advancements in drug repositioning. Firstly, we detailed demonstrate available data source information which is conducive to identifying nove...

Polymer-Lipid Hybrid Nanoparticles: A Next-Generation Nanocarrier for Targeted Treatment of Solid Tumors.

At present, cancer is the most deadly disease and one of the most common causes of death worldwide providing different obstacles to chemotherapy including non-specific biodistribution of chemotherapeutic drugs, dose-related adverse effects, development of metastasis and chemoresistance. Nanoparticle-based targeted delivery of chemotherapeutics gained enormous attention in the treatment of solid tumors as they provide many significant advantages including prolonged drug release, enhanced systemic half-life, ...

Recent Nano-based therapeutic intervention of Bioactive Sesquiterpenes: Prospects in cancer therapeutics.

In recent scenario, nanotechnology based therapeutics intervention has gained tremendous impetus all across the globe. Nano-based pharmacological intervention of various bioactive compounds has been explored on an increasing scale. Sesquiterpenes are major constituents of essential oils (EOs) present in various plant species which embodies intriguing therapeutic potentials. However, owing to their poor physico-chemical properties; they have pharmacological limitations. Recent advances in nano-based therapeu...

A Current Nanoparticles approaches in Nose to Brain Drug Delivery and Anticancer Therapy - A Review.

Nanoparticles (NPs) are unique may be organic, or inorganic, play a vital role in the development of drug delivery targeting the brain and central nervous system (CNS). Intranasal drug delivery has shown to be an efficient strategy and attractive application for drug delivery to the brain and CNS disorders and related diseases such as Parkinson's disease, Alzhemier's disease and brain solid tumors. Blood brain barrier (BBB) and blood cerebrospinal fluid barriers are natural protective hindrances to enter an...

Vaccines and Neurological Disease.

Role of miRNA and Long Non-Coding RNA in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) accounts for about 80-90% of all liver cancers and is found to be the third most common cause of cancer mortality in the Asia-Pacific region. Risk factors include hepatitis B and C virus, cirrhosis, aflatoxin-contaminated food, alcohol, and diabetes. Surgically removing the tumor tissue seems effective but a high chance of recurrence has led to an urgent need to develop novel molecules for the treatment of HCC. Clinical management with sorafenib is found to be effective but it...

Critical View on the Usage of Ribavirin in Already Existing Psychostimulant-Use Disorde.

Substance-use disorder represents a frequently hidden non-communicable chronic disease. Patients with intravenous drug addiction are at high risk of direct exposure to a variety of viral infections and are considered to be the largest subpopulation infected with the hepatitis C virus. Ribavirin is a synthetic nucleoside analog that has been used as an integral component of hepatitis C therapy. However, ribavirin medication is quite often associated with pronounced psychiatric adverse effects. It is not well...

Exploring Dysregulated Signaling Pathways in Cancer.

Cancer cell biology takes the advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. Signaling pathways are an important means of communication from exterior of cell to intracellular mediators, as well as intracellular interactions that governs diverse cellular processes. Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apop...

Inflammatory biomarkers for mood disorders.

The nervous system and the immune system interact consistently in the brain and peripheries. Inflammation in the brain not only alters the metabolism of neurotransmitters, but also causes network dysfunction, structural changes, and the development of mood symptomology in patients with mood disorders. In addition, the dysregulation of the neuroimmune axis in mood disorders drives multiple-system comorbidities. Furthermore, patients with low-grade inflammation are more likely to exhibit treatment resistance ...

Nose-to-brain Delivery of Natural Compounds for the Treatment of Central Nervous System Disorders.

Several natural compounds have demonstrated potential for the treatment of central nervous system disorders such as ischemic cerebrovascular disease, glioblastoma, neuropathic pain, neurodegenerative diseases, multiple sclerosis and migraine. This is due to their well-known antioxidant, anti-inflammatory, neuroprotective, anti-tumor, anti-ischemic and analgesic properties. Nevertheless, many of these molecules have poor aqueous solubility, low bioavailability and extensive gastrointestinal and/or hepatic fi...


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