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In recent years, neutrophil-lymphocyte ratio and platelet-lymphocyte ratio have been studied in many dermatological diseases as various parameters indicating inflammation, and found to be associated with disease activity, prognosis and spread of disease 2,3. In the present study, authors found a significant decrease in the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and C-Reactive Protein after omalizumab treatment. However, a limited number of patients had C-Reactive Protein levels. Since no cor...
To investigate the efficiency of intravitreal octreotide, which has previously been shown to have benefits in the treatment of proliferative vitreoretinopathy (PVR), and intravitreal infliximab as a novel option in an experimental dispase-induced PVR model. A total of 28 pigmented guinea pigs were divided into four groups, and each group consisted of seven subjects. Group 1 (control) was treated with a 0.2 ml saline solution intravitreally from 1.5 mm behind the limbus. Group 2 (sham) was treated with 0...
Oral isotretinoin can effect markers of inflammation in patients with acne vulgaris. To our knowledge, there is no data on the relationship between ISO and monocyte to HDL cholesterol ratio (MHR). In this study, it is aimed to examine the effect of the ISO treatment on the MHR and other inflammatory markers in patients with acne vulgaris. In this study, 89 out of 120 patients with severe/very severe acne vulgaris according to the Global Acne Grading Scale who received at least 3 months of ISO treatment were...
Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan®; OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation.
The aim of this study was to evaluate and compare the toxicity of six different types of titanium dioxide (TiO) nanoparticles (NP) on human epidermal keratinocytes (HEK).
Type 2 diabetes mellitus (DM) induces various dermatological conditions that can affect patient quality of life, including increased susceptibility to skin infections and dry skin. While the mechanisms that underlie the causes of dry skin in type 1 DM have been widely studied, how type 2 DM elicits similar effects is unclear. The purpose of this study was therefore to evaluate skin barrier and hydration function using a KK-A/TaJcl mouse model of type 2 DM.
The mechanism of action of omalizumab in chronic spontaneous urticaria (CSU) is not exactly known. In previous studies, D-dimer which is a fibrin-degradation product and interleukin-31 which has a role in inflammation were found to be decreased in patients with chronic urticaria (CU) treated with omalizumab. However, to our knowledge, there is no study on the effects of omalizumab on the ratio of neutrophil to lymphocyte (NLR) and the ratio of platelet to lymphocyte (PLR) which are inflammatory parameters i...
To determine the effects of Pycnogenol on cisplatin induced optic nerve damage.
Sulfur mustard (SM) is a chemical compound that preferentially targets ocular, cutaneous and pulmonary tissues. Although pathologic effect of SM has been extensively considered, molecular and cellular mechanism of its toxicity, especially at the chronic phase of injury is not well-understood. Excessive production of reactive oxygen species (ROS) and oxidative stress (OS) appear to be involved in SM-induced injuries. SM may trigger several molecular and cellular pathways linked to OS and inflammation that ca...
Exposure to oxidative stress will lead to the progression of retinal degenerative diseases, and unfortunately the exact mechanisms have not been fully understood. In this study, the protective effects of (3R)-5,6,7-trihydroxy-3-isopropyl-3-methylisochroman-1-one (TIM) against the lipoteichoic acid (LTA)-induced cell damage in mouse photoreceptor-derived 661W cells were investigated. 661W cells were pre-treated with TIM at different concentrations (0.1-2.5 μM) before exposure to LTA. The oxidative stress an...
The purpose of this experimental study was to investigate the role of vitamin supplements (Ocuvite, Vitalux Omega and Nutrof Total) as possible inhibitors of the onset of Age-Related Macular Degeneration (AMD).
Chronic exposure to inorganic arsenic is an important public health problem and leads to hyperpigmentation, hyperkeratosis, Bowen's disease and non-melanoma skin cancers in humans. Arsenic keratosis is the most common skin change that is associated with arsenic exposure. It may be an indicator of arsenic induced health hazards.
To assess the results of intravitreal ranibizumab treatment for retinopathy of prematurity (ROP) in infants.
To compare the thicknesses of the retinal layers in smokers with those of non smoking healthy subjects using spectral-domain optical coherence tomography (SD-OCT).
Crude 4-methylcyclohexanemethanol (MCHM) is an industrial chemical used to wash and clean coal. On January 9(th), 2014 approximately 10,000 gallons of a mixture containing crude MCHM were released into the Elk River near Charleston, West Virginia, contaminating the local water supply. Following the spill, residents reported numerous health complaints, and sought medical attention for ailments including rashes and itching. The relationship between the complaints and the spill were unknown, as such symptoms a...