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To evaluate calcitonin (CT) levels in sporadic primary hyperparathyroidism (PHPT), which has to date rarely been considered.
It is still controversial whether differentiated thyroid carcinoma (DTC) in patients with Graves' disease (GD) can be more aggressive than non-Graves' DTC. We conducted a systematic review and meta-analysis to examine the association between GD and prognosis in patients with DTC. We comprehensively searched the databases of MEDLINE and EMBASE from inception to March 2019. We included published studies that compared the risk of mortality and prognosis between DTC patients with GD and those with non-GD. Data...
: Choosing Wisely is a campaign of the American Board of Internal Medicine that aims to promote evidence-based practices to reduce unnecessary ordering of tests or procedures. As part of this campaign, the Endocrine Society advises against ordering a serum total or free triiodothyronine (T3) level when assessing levothyroxine dosing in hypothyroid patients. This study was performed to assess and reduce inappropriate laboratory ordering practices among providers who manage patients with hypothyroidism within...
De-intensification of diabetes treatment is recommended in elderly patients with tight glycemic control at high risk of hypoglycemia. However, rates of de-intensification in endocrine practice are unknown. We conducted a retrospective study to evaluate the rate of de-intensification of anti-diabetic treatment in elderly patients with type 2 diabetes mellitus (T2DM) and tight glycemic control.
In this descriptive study, we evaluated perceptions and knowledge of inpatient glycemic control among resident physicians. We performed this study at four academic medical centers: the University of Mississippi Medical Center, University of Virginia Health System, University of Louisville Health Sciences Center, and Emory University. We designed a questionnaire and Institutional Review Board approval was granted at each institution prior to study initiation. We then administered the questionnaire to Intern...
Regional nodal metastases carry prognostic significance in papillary thyroid cancer (PTC). However, whether different locational nodal metastases correlate with different therapeutic responses remains controversial. We innovatively applied the response to therapy re-stratification system (RTRS) to evaluate the dynamic disease status after surgery and radioiodine (RAI) therapy in PTC patients with different locational nodal metastases. A total of 585 non-distant-metastatic PTC patients who underwent total t...
Differentiated thyroid cancer patients uncommonly present with bone metastasis as initial manifestation. Their molecular profile is largely unknown. The aim of this study was to evaluate histopathology, molecular profiles, and response to radioactive iodine therapy in these patients. Eight patients presented with symptomatic bone metastasis from an unknown primary tumor. We identified these patients by performing a retrospective chart review. Pathology slides were reviewed and molecular analysis of 112 thy...
Falls are a common and costly source of injury and death in elderly adults. A large proportion of injurious falls are due to a trip or slip, suggesting that muscular factors are major determinants of both fall risk and the risk for fall related injury. Sarcopenia is the loss of muscle strength and mass that occurs with advancing age, and an increasing body of evidence links this condition with an increased risk for falls. Nutritional factors, as well as exercise can help with both prevention and treatment o...
Early mammary tissue development occurs prenatally. This process is hormone-independent, and occurs similarly in males and females. Breast tissue is quiescent until puberty at which time surging estrogen levels in cisgender girls mediate breast development and growth. Adult breast tissue composition further evolves in cisgender women during pregnancy, lactation and menopause revealing the ever-changing interplay between breast structure and hormonal environment. Breast growth is a significant physical endpo...
: Studies have demonstrated that HbA1c is a significant predictor of hearing impairment in type 1 diabetes. We identified additional factors associated with hearing impairment in participants with type 1 diabetes from the Diabetes Control and Complications Trial and its observational follow-up, Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. : 1,150 DCCT/EDIC participants were recruited for the Hearing Study. A medical history, physical measurements, and a self-administered heari...
The prevalence of post-bariatric surgery hypoglycemia (PBH) remains unclear due to diagnostic criteria variability, types of bariatric procedures and possible unawareness. To determine the frequency, pattern and severity of symptomatic and asymptomatic hypoglycemia in subjects post three different bariatric procedures performed >1 year before evaluation and a group of obese subjects before surgery. Observational cohort study. Fifty-one consecutive patients participated: post Roux-en-Y gastric-bypass (RYGB...
To correlate the size of autonomously functioning thyroid nodules (AFTN) with thyroid function tests. A retrospective analysis of data from patients with a diagnosis of a single AFTN who were seen in a university-based endocrinology clinic between January 1, 2003 and December 31, 2015 was performed. Patients with a nuclear thyroid scan confirming the presence of an AFTN without significant cystic degeneration were included in the study. The volume of the AFTN and the corresponding thyroid function tests w...
RE: CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2019 EXECUTIVE SUMMARY.