PubMed Journal Database | Experimental gerontology RSS

16:07 EST 20th January 2020 | BioPortfolio

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Showing PubMed Articles 1–25 of 482 from Experimental gerontology

Kynurenine pathway, NAD synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan.

Aging is characterized by a progressive decline in the normal physiological functions of an organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD) is an essential cofactor that plays a critical role in mitochondrial energy production as well as many enzymatic redox reactions. Age-associated decline in NAD is implicated as a driving factor in several categories of age-associated disease, including metabolic and neurodegenerative disease, as well as deficiency in the mechanisms of ...

Effects of aquatic exercise on insulin-like growth factor-1, brain-derived neurotrophic factor, vascular endothelial growth factor, and cognitive function in elderly women.

The purpose of this study was to investigate the effects of a 16-week aquatic exercise program on brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF) levels, as well as cognitive function in elderly women. The subjects were 20 elderly women aged 68-80 years, randomly divided into an aquatic exercise group (n = 10) and a control group (n = 10). The aquatic exercises were performed for 60 min, three times per week for 16 w...

Difference in sarcopenia prevalence and associated factors according to 2010 and 2018 European consensus (EWGSOP) in elderly patients with type 2 diabetes mellitus.

The aim of this study was to establish the prevalence of sarcopenia and associated factors in elderly patients with type 2 diabetes mellitus (DM) according to 2010 (EWGSOP1) and 2018 (EWGSOP2) European consensus.

Inflammatory markers associated with fall recurrence and severity: The Bambuí Cohort Study of Aging.

The aim of this study was to analyze the association between inflammatory markers and recurrent and severe falls in 1304 community-dwelling older adults from the Bambuí Cohort Study of Aging.

The effect of a mentally fatiguing task on postural balance control in young and older women.

The purpose of this study was to examine the effect of a mentally fatiguing task on postural responses to unexpected backward perturbations in sixteen young and sixteen older women. Postural responses were characterized by center of pressure (COP) displacement, corrective COP peak velocity, and electromyography (EMG) of the medial gastrocnemius. Older women had slower reaction time (p = .002), longer EMG onset times (p = .03), larger COP displacement (p = .001), and faster COP velocity (p = ...

Age-related changes in muscle volume and intramuscular fat content in quadriceps femoris and hamstrings.

Whether age-related changes in muscle components differ between the quadriceps femoris and hamstrings has remained unclear. This study aimed to compare the muscle volume and echo intensity-estimated intramuscular adipose tissue content of the vastus lateralis (VL) and long head of biceps femoris (BF) muscles between young and older adults. Thirty young adults (n = 15; mean age, 21 years) and older adults (n = 15; mean age, 71 years) participated in this study. Magnetic resonance imaging was perf...

Foot web pentosidine does not covary strongly with age in four species of wild seabirds.

Age is an important parameter for a variety of ecological applications, including population viability analyses, contaminants monitoring and targeting of individuals for conservation. While many organisms can be aged by annual rings, dentition and other techniques (i.e., fish otoliths, clam growth rings, mammal tooth wear), there are no minimally invasive biomarkers for accurately aging birds in the wild. For the past century, banding has been the only way to identify a bird of known age, which requires con...

Sex-different associations between serum homocysteine, high-sensitivity C-reactive protein and sarcopenia: Results from I-Lan Longitudinal Aging Study.

Both serum homocysteine and high sensitivity C - reactive protein (hsCRP) are inflammatory markers related to vascular aging. Little was known about relationship between hsCRP and homocysteine and sarcopenia. The study aimed to explore the association between these two biomarkers and sarcopenia and its components.

NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.

Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of biological processes including energy production, DNA repair, gene expression, calcium-dependent secondary messenger signalling and immunoregulatory roles. The de novo synthesis of NAD+ is primarily dependent on the kynurenine pathway (KP), although NAD+ can also be recycled from nicotinic acid (NA), nicotinamide (NAM) and nicot...

l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation.

Redox and inflammation imbalances are associated with increased levels of advanced glycation end products (AGEs), leading to the degeneration of body function. l-Theanine, derived from tea, reportedly inhibits AGE formation in vitro. We investigated the effects on AGE content, oxidative stress, and inflammatory factors in d-galactose-induced aging rats for prevention and treatment of age-related liver dysfunction. l-Theanine increased activities of antioxidant enzymes such as superoxide dismutase, catalase,...

Aftereffects of prolonged Achilles tendon vibration on postural control are reduced in older adults.

To assess the change in the contribution of proprioceptive signal from leg muscles in postural control with ageing.

Cycle exercise improves vascular function and neuropathic symptoms in patients with type 2 diabetes and peripheral neuropathy: A randomized controlled trial.

Diabetic peripheral neuropathy (DPN) is associated with peripheral arterial disease and endothelial dysfunction. We investigated the effect of exercise training on the measures of superficial femoral artery (SFA) and neuropathic symptoms in patients with DPN. In a randomized-controlled trial, 31 volunteers with established DPN were randomly assigned to experimental or control groups. Experimental group performed exercise training (50%-70% of heart rate reserve, 30-45 min, 3 sessions/week) over 12 weeks....

Higher dose of resveratrol elevated cardiovascular disease risk biomarker levels in overweight older adults - A pilot study.

Older adults are at high risk of developing cardiovascular disease (CVD). Pre-clinical studies indicate that resveratrol (RSV), a polyphenol commonly found in grapes and red wine, may help prevent development of CVD. Based on our previous reports where the 300 mg and 1000 mg doses appeared safe and improved psychomotor function in a dose-dependent manner, our hypothesis was that RSV would reduce biomarkers of CVD risk in overweight, but otherwise healthy older adults and that 1000 mg would lower CVD b...

Prevalence of sarcopenia as a comorbid disease: A systematic review and meta-analysis.

Sarcopenia shares risk factors with various other age-related diseases. This meta-analysis aimed to determine the prevalence of sarcopenia as a comorbid disease.

Haplotype analysis on association between variants of interleukin 6 (IL-6) and late-onset Alzheimer's disease in a Chinese Han population.

The aim of this study was to evaluate the influence of single nucleotide polymorphisms (SNPs) in interleukin-6 (IL-6) gene and the haplotype on late-onset Alzheimer's disease (LOAD).

Oxidative stress, inflammatory cytokines and body composition of master athletes: The interplay.

Unhealthy aging is associated with increased adiposity, inflammation and oxidative stress (OS), but the interactions between them have been poorly investigated in people growing old under vigorous lifelong exercise regimens. Therefore, we compared and analyzed the relationships between markers of inflammation, OS and adiposity in master athletes (MA), young (YC) and middle-aged controls (MC). Fifty-nine participants (MA, n = 30, 51.56 ± 8.61 yrs, minimum of 20 yrs of training; YC, n = 17, 2...

Comparison of revised EWGSOP criteria and four other diagnostic criteria of sarcopenia in Chinese community-dwelling elderly residents.

To compare the prevalence and associated factors of sarcopenia defined by the revised European Working Group on Sarcopenia in Older People (EWGSOP2) criteria with the initial European Working Group on Sarcopenia in Older People (EWGSOP1) criteria, the Asia Working Group for Sarcopenia (AWGS), the International Working Group on Sarcopenia (IWGS), and the National Institutes of Health (FNIH) Sarcopenia Project criteria among Chinese community-dwelling older adults.

Chair-based exercise programs in institutionalized older women: Salivary steroid hormones, disabilities and frailty changes.

Many people experience aging-related losses in different physical domains, which leads to a condition often called physical frailty (PF). The aim of this study was to analyse the effects of two different, 28-weeks, class chair-exercise protocols on salivary steroid hormones (SH), PF, and functional disabilities (FD) in frail older women.

Role of 7-chloro-4-(phenylselanyl) quinoline as an anti-aging drug fighting oxidative damage in different tissues of aged rats.

This study investigated whether subacute treatment with 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) presented antioxidant action in oxidative stress associated with aging in different rat tissues. We also investigated whether plasma selenium levels were altered by aging, as well as the contribution of 4-PSQ administration to these levels. Aged Wistar male rats (23 month old) were intragastrically treated with 4-PSQ (5 mg/kg) for seven days. On the 14th day of the experimental protocol, plasma was colle...

SOD1 deficiency alters gastrointestinal microbiota and metabolites in mice.

Redox imbalance induces oxidative damage and causes age-related pathologies. Mice lacking the antioxidant enzyme SOD1 (Sod1) exhibit various aging-like phenotypes throughout the body and are used as aging model mice. Recent reports suggested that age-related changes in the intestinal environment are involved in various diseases. We investigated cecal microbiota profiles and gastrointestinal metabolites in wild-type (Sod1) and Sod1 mice. Firmicutes and Bacteroidetes were dominant in Sod1 mice, and most of th...

Balance and motor functioning in subjects with different stages of cognitive disorders.

Approximately 30% of the elderly population is falling each year, resulting in a major health problem. Cognitive decline is an independent risk factor for fall. Mild cognitive impairment (MCI) is a cognitive decline that is higher than expected in the subjects' age but does not affect the activities of daily living OBJECTIVE: In the study, vestibulo-ocular reflexes, dynamic visual acuities and postural balances of subjects with mild cognitive impairment were evaluated and compared with the healthy control g...

Are depression and anxiety disorders associated with adductor pollicis muscle thickness, sleep duration, and protein intake in cancer patients?

Psychological disturbances may be associated with compromised body composition and food intake. However, this has not been elucidated totally. Thus, this study aimed to evaluate the prevalence of anxiety and depression, and whether there is an association between these disorders and adductor pollicis muscle thickness (APMT), protein intake and sleep duration, in gastrointestinal cancer patients.

Cell aging and cellular senescence in skin aging - Recent advances in fibroblast and keratinocyte biology.

The aging of the skin is the most visible and obvious manifestation of organismal aging and may serve as a predictor of life expectancy and health. It is, however, also the human desire for long-lasting beauty that further raises interests in the topic, and thus considerable means and efforts are put into studying the mechanisms of skin aging in basic and applied research. Both medical und non-medical interests are of benefit for skin research in general because the results from these studies help to deepen...

Analysis of inflammatory markers and hormones in old cancer patients: A descriptive study.

Advanced cancers are associated with a chronic inflammation, especially high interleukin-6 (IL-6) and with various levels of adipokines (leptin and adiponectin), while ghrelin counteracts the anorexigenic effect of leptin in cancer-induced anorexia-cachexia syndrome. We aimed to understand how IL-6, adipokines and ghrelin plasma levels could be influenced by cancer on the one hand, and by age, frailty, and nutritional status in old cancer patients on the other hand. Ninety-nine patients aged 79[76-83] years...

Okra polysaccharides can reverse the metabolic disorder induced by high-fat diet and cognitive function injury in Aβ mice.

Epidemiological studies showed that a high-fat diet threatened human health seriously. It can induce various diseases, such as obesity, metabolic disturbance and cognitive dysfunction which also related to insulin signaling. In the present study, Aβ induced AD model mice and normal mice were given a standard diet and high-fat diet, respectively. Meanwhile, Okra polysaccharides were used to treat AD mice to explore the possible mechanism between Alzheimer's disease and insulin signals. Weight and blood gluc...

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