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Triadin is a protein expressed in cardiac and skeletal muscle with an essential role in the structure and functional regulation of calcium release units and excitation-contraction coupling. Mutations in the triadin gene (TRDN) have been described in different forms of human arrhythmia syndromes with early onset and severe arrhythmogenic phenotype, among which the triadin knockout syndrome.
The use of coronary sinus sheaths to deliver stylet-driven leads for His bundle pacing (HBP) has not been described. Conventionally, HBP is achieved using a styletless lead delivered through a customized catheter.
Although pediatric catheter ablation therapy has often been described, there are few reports on outcomes in a large series of patients at a single center.
Percutaneous left atrial appendage (LAA) occlusion with Lariat has emerged as a viable alternative to oral anticoagulation (OAC) to prevent thromboembolic (TE) events in patients with atrial fibrillation (AF).
Pregnancy is a period of heightened cardiovascular risk in a woman's life. In the setting of an inherited arrhythmia syndrome (IAS), cardiologists and obstetricians may be unfamiliar with cardiovascular optimization and risk stratification in pregnancy. Historically, there were few data addressing the safety of pregnancy in these rare disorders. Recent advances suggest that no type of IAS represents an absolute contraindication to pregnancy. However, it is imperative that obstetric and cardiovascular clinic...
High power, shorter duration (HPSD) ablation strategies have been advocated to increase efficacy and minimize posterior wall deep tissue thermal injury during atrial fibrillation (AF) ablation.
Programming of His bundle pacing may be challenging because current implantable pulse generators are not specifically designed for this pacing modality.
The right ventricular outflow tract is the most common source of ventricular arrhythmias in non-structural heart disease. Most of these arrhythmias are of endocardial origin, but their morphological substrate is mostly unknown.
Dual antiplatelet therapy (DAPT) with aspirin plus clopidogrel is used for stroke prevention in patients with atrial fibrillation (AF) when patients refuse to use oral anticoagulants (OAC) in clinical practice. However, there are limited clinical data comparing these treatments.
The introduction of quadripolar (QP) cardiac resynchronization therapy (CRT) leads aimed to improve procedural and clinical outcomes.
Renal artery catheter ablation has been reported as a possible therapeutic option for drug-refractory ventricular arrhythmias (VA) associated with structural heart diseases.
Antitachycardia pacing (ATP) is routinely used to terminate ventricular tachyarrhythmias. However, little guidance exists on the most effective programming of ATP.
Atrial fibrillation (AF) remains the most relevant arrhythmia with a prevalence of 2%. The treatment options are either highly invasive and cost-intensive or limited by potential side effects or insufficient efficacy. However, no direct means of prevention that could reduce the burden of AF have been tested.
Catheter ablation on ganglionated plexus (GP) as cardioneuroablation in left atrium (LA) has been used to treat the vasovagal syncope (VVS).
Endocardial cardiac resynchronization therapy (eCRT) avoids the limitations and failures of coronary sinus (CS) resynchronization. However, data regarding long-term outcomes are lacking.
Implantable loop recorder (ILR) is preferred strategy for prolonged rhythm monitoring.