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PubMed Journal Database | High altitude medicine & biology RSS

23:42 EDT 19th September 2019 | BioPortfolio

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Showing PubMed Articles 1–25 of 113 from High altitude medicine & biology

Venous Thromboembolism at High Altitude: Our Approach to Patients at Risk.

Trunk, Andrew D., Matthew T. Rondina, and David A. Kaplan. Venous thromboembolism at high altitude: our approach to patients at risk. 00:000-000, 2019.-Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a prevalent disorder that confers substantial cardiovascular morbidity and, in serious cases, death. VTE has a complex and incompletely understood etiopathogenesis with genetic, acquired, and environmental risk factors. As the focus of this review, one environmental risk...

Development of a Self-Administered Questionnaire to Detect Psychosis at High Altitude: The HAPSY Questionnaire.

Hüfner, Katharina, Hermann Brugger, Fabio Caramazza, Agnieszka Elzbieta Stawinoga, Monika Brodmann-Maeder, Hannes Gatterer, Rachel Turner, Iztok Tomazin, Paolo Fusar-Poli, and Barbara Sperner-Unterweger. Development of a self-administered questionnaire to detect psychosis at high altitude: the HAPSY questionnaire. 00:000-000, 2019. Psychotic symptoms during exposure to high altitude (HA) have been linked to accidents or near accidents on the mountains. It is thus of great importance to directly identify ...

Are Pre-ascent Low-Altitude Saliva Cortisol Levels Related to the Subsequent Acute Mountain Sickness Score? Observations from a Field Study.

The associations among cortisol levels, body water status, and acute mountain sickness (AMS) remain unclear. We investigated associations between AMS prevalence and severity with resting saliva cortisol levels at low altitude (LA) and high altitude (HA) and with fluid balance during a HA stay. Twenty-two physically fit and healthy participants (12 women, 10 men) were transported to HA (Testa Grigia, 3480 m). In the late afternoon at LA, on the next day 3-4 hours after arrival at HA and in the morning aft...

Effect of Acute Altitude Exposure on Serum Markers of Platelet Activation.

Platelets are the key factor in primary hemostasis. It has been shown that chronic altitude exposure increases platelets' aggregability. Nevertheless, data about acute effects and the underlying mechanisms are sparse. Sixteen healthy volunteers were examined in our hospital (519 m alt.) and 30 minutes after arrival in the environmental research station on the Zugspitze Mountain (2656 m alt.). Serum levels of soluble p-selectin were examined to elucidate platelet activation. In addition, serum levels of...

Splenic Infarct on Exposure to Extreme High Altitude in Individuals with Sickle Trait: A Single-Center Experience.

Sickle cell trait (SCT) is a common genetic abnormality in the so-called "sickle belts" in India. Splenic infarction often brings to medical attention an underlying SCT, when appropriately looked for. The hypoxic environment of an extreme high-altitude area (HAA) is conducive for developing a splenic infarct in an SCT individual not a native of these areas. We studied retrospectively 27 cases who presented with a splenic infarction during the last 4 years. Twenty-five patients (92.5%) were diagnosed to ha...

Swiss Mountain Guides: Medical Education, Knowledge, and Practice.

Mountain guides work daily in remote areas and high-altitude locations where specific hypoxia-related and common medical problems may occur. Arrival of rescue teams can be delayed, so mountain guides often have to rely on their own capabilities to provide first aid. Therefore, IFMGA-recognized Swiss mountain guides receive a specific medical education and are equipped with a dedicated medical kit. This specific education has never been evaluated. A questionnaire was sent to all Swiss mountain guides throug...

A Case of Chronic Thromboembolic Pulmonary Hypertension in a High-Altitude Dweller.

Chronic hypoxia causes sustained pulmonary vasoconstriction and vascular remodeling leading to development of pulmonary hypertension in high-altitude residents. Although pulmonary hypertension is of mild to moderate degrees in most cases, some high-altitude residents may develop severe pulmonary hypertension. We report a case of a 47-year-old female highlander of Kyrgyz ethnicity who presented with exertional breathlessness and echocardiographic signs of severe pulmonary hypertension, who was diagnosed as h...

Extrication Times During Avalanche Companion Rescue: A Randomized Single-Blinded Manikin Study.

This study aimed to determine the time needed for one or two companion rescuers to access, extricate, and deliver cardiopulmonary resuscitation (CPR) to a fully buried manikin during a simulated avalanche burial scenario. In this randomized, single-blinded study, 18 medical students were required to extricate a manikin manually from a simulated avalanche burial of 1 m in depth, either alone or in teams of two. Each participant performed three consecutive tests with the manikin in three different position...

The Complexity of Diagnosing High-Altitude Pulmonary Edema: A Case Report and Review of the Differential Diagnosis of Greater Than Expected Hypoxemia at Altitude.

High-altitude pulmonary edema (HAPE) is a common presumptive diagnosis for a patient who experiences significant dyspnea and cyanosis at altitude. In this study, we present a case of a 58-year-old woman who was initially diagnosed with HAPE, although further evaluation revealed the presence of two underlying contributors to her significant hypoxemia at altitude. We discuss the medical workup for causes of greater than expected hypoxemia at altitude and the role some relevant medical comorbidities may play.

Effect of Altitude on Veteran Suicide Rates by Sabic et al. (From: Sabic H, Kious B, Boxer D, Fitzgerald C, Riley C, Scholl L, McGlade E, Yurgelun-Todd D, Renshaw PF, Kondo DG. High Alt Med Biol 2019;20:171-177; DOI: 10.1089/ham.2018.0130).

Inhibition of Suicidal Erythrocyte Death by Chronic Hypoxia by Tang et al. (From: Tang F, Feng L, Li R, Wang W, Liu H, Yang Q, Ge R-L. High Alt Med Biol 2019;20:112-119; DOI: 10.1089/ham.2017.0159).

Influence of Altitude on Elite Biathlon Performances.

Lunghi, Alex, Franck Brocherie, and Grégoire P. Millet. Influence of altitude on elite biathlon performances. 00:000-000, 2019.-Biathlon is a complex sport subjected to large performance variability. Among the environmental conditions (e.g., temperature, wind, snow conditions) susceptible to influence performance, altitude is likely a detrimental factor for skiing (i.e., due to decreased aerobic capacity) as well as for prone and/or-to a larger extent-standing shooting (i.e., due to altered postural contr...

Clinician's Corner: Ultrasound in Austere Environments.

Canepa, Carlo A. and N. Stuart Harris. Clinician's corner: ultrasound in austere environments. 00:000-000, 2019.-Ultrasonography is a noninvasive, reliable, repeatable, and inexpensive technology that has dramatically changed the practice of medicine. The clinical use of portable ultrasound devices has grown tremendously over the last 10 years in the fields of intensive care, emergency medicine, and anesthesiology. In this review we present the various ways that handheld portable ultrasound devices can be ...

Urbanization and Altitude Are Associated with Low Kidney Function in Peru.

Carrillo-Larco, Rodrigo M., J. Jaime Miranda, Robert H. Gilman, Offdan Narvaez-Guerra, Karela Herrera-Enriquez, Josefina Medina-Lezama, Liam Smeeth, William Checkley, and Antonio Bernabe-Ortiz; on behalf of the CRONICAS Cohort Study Group. Urbanization and altitude are associated with low kidney function in Peru. 00:000-000, 2019. Kidney health needs to be studied in low- and middle-income countries with populations living at high altitude and undergoing urbanization. We studied whether greater level of u...

Impact of Hanging Motionless in Harness on Respiratory and Blood Pressure Reflex Modulation in Mountain Climbers.

Lanfranconi, Francesca, Alessandra Ferri, Luca Pollastri, Manuela Bartesaghi, Massimiliano Novarina, Giovanni De Vito, Egidio Beretta, and Lucio Tremolizzo. Impact of hanging motionless in harness on respiratory and blood pressure reflex modulation in mountain climbers. 16:000-000, 2019.-Harness hang syncope (HHS) is a risk that specifically affects safety of harness' users in mountain climbing. To evaluate individual patterns of breathing resulting from deranged cardiovascular reflexes triggering a synco...

Short-Term High-Altitude Exposure (3600 m) Alters the Type Distribution of Sperm Deformity.

Zheng, Shanjun, Yunsheng Liu, Peng Li, and Huaijun Tian. Short-term high-altitude exposure (3600 m) alters the type distribution of sperm deformity. High Alt Med Biol. 00:000-000, 2019.

Physiological Responses in Humans Acutely Exposed to High Altitude (3480 m): Minute Ventilation and Oxygenation Are Predictive for the Development of Acute Mountain Sickness.

Burtscher, Martin, Michael Philadelphy, Hannes Gatterer, Johannes Burtscher, Martin Faulhaber, Werner Nachbauer, and Rudolf Likar. Physiological responses in humans acutely exposed to high altitude (3480 m): Minute ventilation and oxygenation are predictive for the development of acute mountain sickness. High Alt Med Biol. 00:000-000, 2019.-The importance of arterial oxygen saturation for the prediction of acute mountain sickness (AMS) is still a matter of debate. Reasons for discrepancies may result from...

Acute Hypobaric Hypoxia-Mediated Biochemical/Metabolic Shuffling and Differential Modulation of S1PR-SphK in Cardiac and Skeletal Muscles.

High altitude exposure alters biochemical, metabolic, and physiological features of heart and skeletal muscles, and hence has pathological consequences in these tissues. Central to these hypoxia-associated biochemical/metabolic shuffling are energy deficit accumulation of free radicals and ensuing oxidative damage in the tissue. Recent preclinical/clinical studies indicate sphingosine-1-phosphate (S1P) axis, comprising S1P G protein coupled receptors (S1PR) and its synthesizing enzyme-sphingosine kinase (Sp...

Mountain Rescue Operations Facilitated with Drone Usage.

Differences in Cardiorespiratory Responses in Winter Mountaineering According to the Pathway Snow Conditions.

Carceller, Anna, Casimiro Javierre, Jordi Corominas, and Ginés Viscor. Differences in cardiorespiratory responses in winter mountaineering according to the pathway snow conditions. High Alt Med Biol 20:000-000, 2019.-Locomotion during ascent requires higher energy consumption than on flat terrain. Locomotion efficiency decreases in snowy terrain, with changes in the biomechanical pattern of walking. This study aims to evaluate differences in both cardiorespiratory responses and energy expenditure between l...

The Effect of a 300 mBar Increase in Barometric Pressure on Digital Microcirculation in Healthy Subjects Exposed to High Altitude: Is the Use of a Portable Hyperbaric Chamber to Treat Frostbite and/or Hypothermia in the Field Indicated? (Flow_Pulse Study).

Savina, Yann, Sandra Leal, Pascal Zellner, François Becker, Monica Piris, and Emmanuel Cauchy. The effect of a 300 mbar increase in barometric pressure on digital microcirculation in healthy subjects exposed to high altitude: Is the use of a portable hyperbaric chamber to treat frostbite and/or hypothermia in the field indicated? (Flow_Pulse Study). High Alt Med Biol. 18:000-000, 2019.

A Deeply Hypothermic Patient Presenting with Vital Signs.

Re: "Drug Use and Misuse in the Mountains: A UIAA MedCom Consensus Guide for Medical Professionals" by Donegani et al. (High Alt Med Biol 17:157-184).

Re: "High Altitude and Cancer Mortality" by Thiersch and Swenson (High Alt Med Biol 2018;19:116-123).

Acute Mountain Sickness is Reduced Following 2 Days of Staging During Subsequent Ascent to 4300 m.

Beidleman, Beth A., Charles S. Fulco, Ellen L. Glickman, Allen Cymerman, Robert W. Kenefick, Bruce S. Cadarette, Sean P. Andrew, Janet E. Staab, Ingrid V. Sils, and Stephen R. Muza. Acute mountain sickness is reduced following 2 days of staging during subsequent ascent to 4300 m. High Alt Med Biol 00:000-000, 2018.


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