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PubMed Journal Database | IET nanobiotechnology RSS

08:07 EST 27th February 2020 | BioPortfolio

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Showing PubMed Articles 1–25 of 72 from IET nanobiotechnology

Toxicity of copper oxide nanoparticles: a review study.

Copper oxide nanoparticles (CuO NPs) use has exponentially increased in various applications (such as industrial catalyst, gas sensors, electronic materials, biomedicines, environmental remediation) due to their flexible properties, i.e. large surface area to volume ratio. These broad applications, however, have increased human exposure and thus the potential risk related to their short- and long-term toxicity. Their release in environment has drawn considerable attention which has become an eminent area of...

Studies on antimicrobial and wound healing applications of gauze coated with CHX-Ag hybrid NPs.

In this study, chlorhexidine (CHX)-silver (Ag) hybrid nanoparticles (NPs) coated gauze was developed, and their bactericidal effect and wound healing capacities were tested. A new method was developed to synthesise the NPs, wherein Ag nitrate mixed with sodium (Na) metaphosphate and reduced using Na borohydride. Finally, CHX digluconate was added to form the hybrid NPs. To study the antibacterial efficacy of particles, the minimal inhibition concentration and biofilm degradation capacity against Gram-posit...

Colorimetric-based detection of using gold nanoparticles.

(uu) is one of the most common agents of urogenital infections and is associated with complications such as infertility, spontaneous abortion and other sexually transmitted diseases. Here, a DNA sensor based on oligonucleotide target-specific gold nanoparticles (AuNPs) was developed, in which the dispersed and aggregated states of oligonucleotide-functionalised AuNPs were optimised for the colorimetric detection of a polymerase chain reaction (PCR) amplicon of DNA. A non-cross-linking approach utilising a ...

Effects of saponin capped triangular silver nanocrystals on the germination of , , seeds & their subsequent growth study.

In this study, saponin capped triangular silver nanocrystals have been synthesised using fenugreek seed extract, where the extract acts both as a reducing and capping agent. X-ray diffraction study confirms the purity and crystalline nature of the prepared nanocrystals and transmission electron microscopic study shows the triangular morphology with the average edge length of 72 nm, along with the atomic force microscopy study for the height or the width of the triangular nanocrystals. These nanocrystals h...

Co-encapsulating CoFeO and MTX for hyperthermia.

Magnetic manotheranostics can be a fascinating charm to diagnose a tumour with MRI, and treatment through hyperthermia. This study aims to synthesise and characterise magnetically responsive polymer colloids (MRPCs). Healthy tissue damage done by chemotherapy session could be minimised by MRPCs. For the colloidal formulation of MRPCs, the oil in water emulsion technique was employed with the aid of sonication and stirring. The organic phase of emulsion contained methotrexate (MTX) drug, Eudragit E100 and Co...

Catalytic hydrolysis of cellobiose using different acid-functionalised FeO magnetic nanoparticles.

The present study demonstrated the preparation of three different acid-functionalised magnetic nanoparticles (MNPs) and evaluation for their catalytic efficacy in hydrolysis of cellobiose. Initially, iron oxide (FeO)MNPs were synthesised, which further modified by applying silica coating (FeO-MNPs@Si) and functionalised with alkylsulfonic acid (FeO-MNPs@Si@AS), butylcarboxylic acid (FeO-MNPs@Si@BCOOH) and sulphonic acid (FeO-MNPs@Si@SOH) groups. The Fourier transform infrared analysis confirmed the presence...

Facile hydrothermal bio-synthesis of cellulose acetate templated CuS nanorods like fibres: antibacterial, cytotoxicity effects and DNA cleavage properties against A549 lung cancer cells.

In this research, the hydrothermal method was used for synthesising cellulose acetate (CA) templated nanorods like CuS fibres using vegetable extract (). These extracts act as a reducing agent in the presence of CA. Surprisingly, when the same reaction was carried out in the absence of CA and broccoli extract, structural morphology disappeared and was found as agglomerated. In the presence of cellulose templated extract mediated CuS has revealed as nanorods like fibres and was confirmed by field emission sc...

Wing-kinematics measurement and flight modelling of the bamboo weevil .

Insects are one of the most agile flyers in nature, and studying the kinematics of their wings can provide important data for the design of insect-like wing-flapping micro aerial vehicles. This study integrates high-speed photogrammetry and three-dimensional (3D) force measurement system to explore the kinematics of during the wing-flapping flight. The tracking point at the wing tip of the hind wing was recorded using high-speed videography. The lift-thrust force characteristic of wing-flapping motion was ...

Biosynthesis of eco-friendly and recyclable Pd/LDHs catalyst using the withered leaves extract for Suzuki coupling reaction.

The hydrotalcite-supported palladium (Pd) catalyst is prepared with a green and environmentally friendly route, introducing the extract of withered leaves as a dispersant and reducing agent (Pd/LDHs-B). Compared with the as-prepared catalyst (Pd/LDHs-P with the average diameter of 4.3 nm) using a chemical synthesis method with polyvinylpyrrolidone as a dispersant and ascorbic acid (Vc) as a reductant, the results indicate that the size of Pd nanoparticles in Pd/LDHs-B is smaller (ca. 3.6 nm). The Pd-LHD...

High-efficiency Ni-NTA/PAA magnetic beads with specific separation on His-tagged protein.

To effective capture and universal enrichment of His-tagged protein, polyacrylic acid (PAA) brushes were used to encapsulate FeO nanoparticles, connect NTA, and Ni to prepare magnetic beads. These materials provide many advantages, such as excellent stability, tuneable particle size, and a surface for further functionalisation with biomolecules. His-tagged green fluorescence protein (GFP) was separated efficiently, and the binding capacity of FeO/MPS@PAA/NTA-Ni was 93.4 mg/g. Compared with High-Affinity N...

Efficient co-cultivation of human fibroblast cells (HFCs) and adipose-derived stem cells (ADSs) on gelatin/PLCL nanofiber.

In this study, we investigated whether the nanofibers produced by natural-synthetic polymers can probably promote the proliferation of co-cultured adipose-derived stem cells/human fibroblast cells (ADSs/HFCs) and synthesis of collagen. Nanofiber was fabricated by blending gelatin and poly (L-lactide co-ɛ-caprolactone) (PLCL) polymer nanofiber (Gel/PLCL). Cell morphology and the interaction between cells and Gel/PLCL nanofiber were evaluated by FESEM and fluorescent microscopy. MTS assay and quantitative re...

Enhancement of secondary metabolites in (L.) Pennell plants treated with copper-based nanoparticles .

The study aims to document the effect of starch-stabilised copper-based nanoparticles (CuNPs) on the biosynthesis of pharmaceutically valuable secondary metabolites, especially saponins, of the reputed nootropic herb (L.) Pennell. CuNPs were synthesised chemically by the reduction of cupric sulphate pentahydrate with ascorbic acid using starch as the capping agent. They were characterised by UV-visible spectrophotometry, Fourier-transform infra-red spectroscopy, X-ray diffraction, high-resolution transmiss...

Synthesis, physicochemical characterisation and biological activity of anandamide/ɛ-polycaprolactone nanoparticles obtained by electrospraying.

Drug encapsulation in nanocarriers such as polymeric nanoparticles (Nps) may help to overcome the limitations associated with cannabinoids. In this study, the authors' work aimed to highlight the use of electrospraying techniques for the development of carrier Nps of anandamide (AEA), an endocannabinoid with attractive pharmacological effects but underestimated due to its unfavourable physicochemical and pharmacokinetic properties added to its undesirable effects at the level of the central nervous system. ...

Synthesis and characterisation of magnetite nanoparticles using gelatin and starch as capping agents.

Nanoparticles of magnetite passivated with gelatin and starch were synthesised using a co-precipitation technique. The nanoparticles were characterised using ultraviolet-visible (UV-vis), dynamic light scattering (DLS), Zeta potential, transmission electron microscope (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The UV-vis spectra showed characteristic surface plasmon resonance of magnetite nanoparticles. The DLS results showed the nanoparticles to have average hydrodyn...

Serum analysis method combining cellulose acetate membrane purification with surface-enhanced Raman spectroscopy for non-invasive HBV screening.

A highly sensitive, non-invasive, and rapid HBV (Hepatitis B virus) screening method combining membrane protein purification with silver nanoparticle-based surface-enhanced Raman scattering (SERS) spectroscopy was developed in this study. Reproducible serum protein SERS spectra were obtained from cellulose acetate membrane-purified human serum from 94 HBV patients and 89 normal groups. Tentative assignments of serum protein SERS spectra showed that the HBV patients primarily led to specific biomedical chang...

Improvement of efficacy and decrement cytotoxicity of oxaliplatin anticancer drug using bovine serum albumin nanoparticles: synthesis, characterisation and release behaviour.

To sustained release of an anticancer drug, oxaliplatin (OX), a non-toxic and biocompatible nanocarrier based on bovine serum albumin (BSA) were synthesised by desolvation method and characterised using Fourier-transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), atomic force microscopy (AFM) and dynamic light scattering. The results showed that the BSA nanoparticles (BSANPs) with a mean magnitude of 187.9 ± 1.2 nm have spherical morphology with a smooth surfac...

Effect of green GO/Au nanocomposite on in-vitro amplification of human DNA.

Recently nanomaterials have attracted interest for increasing efficiency of polymerase chain reaction (PCR) systems. Here, the authors report on the usefulness of green graphene oxide/gold (GO/Au) nanocomposites for enhancement of PCR reactions. In this study, green GO/Au nanocomposite was prepared with Matricaria chamomilla extract as reducing/capping agent for site-directed nucleation of Au atoms on surface of GO sheets. The as-prepared green GO/Au nanocomposites were then characterised with UV-VIS spectr...

Self-repair behaviour of the neuronal cell membrane by conductive atomic force indentation.

Conductive atomic force indentation (CAFI) was proposed to study the self-repair behaviour of the neuronal cell membrane here. CAFI was used to detect the changes of membrane potentials by performing the mechanical indentation on neurons with a conductive atomic force microscope. In the experiment, a special insulation treatment was made on the conductive probe, which turned out to be a conductive nanoelectrode, to implement the CAFI function. The mechanical properties of the neuronal cell membrane surface ...

Silver nanoparticles and silver salt (AgNO) elicits morphogenic and biochemical variations in callus cultures of sugarcane.

The research work was arranged to check the role of AgNPs and silver ions on callus cells of sugarcane ( spp. cv CP-77,400). AgNPs were synthesized chemically and characterized by UV-Vis spectra, XRD and SEM. AgNPs and silver ions were applied in various concentrations (0, 20, 40, 60 ppm) to sugarcane calli and the induced stress was characterized by studying various morphological and biochemical parameters. AgNPs and silver ions treatments produced high levels of malondialdehyde, proline, proteins, TP an...

Surface stress-induced membrane biosensor based on double-layer stable gold nanostructures for detection.

The surface stress-based biosensor has been applied in fast and sensitive identification of ()with significance for public health, food, and water safety. However, the stable sensitive element of flexible biosensor based on surface stress is still crucial and challengeable. Here, the authors reported surface stress-induced biosensors based on double-layer stable gold nanostructures (D-AuNS-SSMB) for O157:H7 detection. Bacterial detection demonstrates the high stability of the biosensor. The resistance cha...

Estimation of magnetohydrodynamic radiative nanofluid flow over a porous non-linear stretching surface: application in biomedical research.

The present study investigates the effects of thermal radiation and chemical reaction on magnetohydrodynamic flow, heat, and mass transfer characteristics of nanofluids such as Cu-water and Ag-water over a non-linear porous stretching surface in the presence of viscous dissipation and heat generation. Using similarity transformation, the governing boundary layer equations of the problem are transformed into non-linear ordinary differential equations and solved numerically by the shooting method along with t...

Micro RNA-30b (inhibitor) nanoparticles suppressed the lipopolysaccharide (LPS)-induced acute kidney injury.

The main aim of present study is to evaluate the effect of miR-30b on the function of human proximal tubular epithelial cell line HK-2 cells. For this purpose, miRNA was loaded in an ionically cross-linked polysaccharide nanoparticle. The authors have demonstrated the influence of miR-30b mimic and inhibitor in HK-2 cell killing effect. Lipopolysaccharide (LPS) significantly increased the level of inflammatory cytokines of TNF-α, IL-1β and level was further increased with the treatment of PAg-miR mimic co...

Nucleic acid detection strategy using gold nanoprobe of two diverse origin.

In recent years, nanoparticles especially with gold and silver nanoparticles based point of care diagnostic methods is being developed for the lethal diseases like dengue. This study focused to work on the dengue virus detection in a simplest method using gold nanoparticles probe (AuNPs) with thiol tagged single strand DNA (ss-DNA). A sensitive, fluorescence-based detection strategy was designed to examine and quantified the hybridisation process and also elucidated the behaviour of AuNPs before and after i...

Atorvastatin lipid nanocapsules and gold nanoparticles embedded in injectable thermo-gelling hydrogel scaffold containing adipose tissue extracellular matrix for myocardial tissue regeneration.

This study aimed to prepare, optimise, and characterise the novel hybrid hydrogel scaffold containing atorvastatin lipid nanocapsules (LNCs) and gold nanoparticles (NPs) to improve cardiomyoblasts proliferation and regeneration of myocardium. A thermo-responsive aminated guaran (AGG) hydrogel was prepared to encompass extracellular matrix (ECM) fetched from human adipose tissue. Emulsion phase-inversion technique was used to obtain LNCs. Biocompatibility, tensile strength, conductivity, and proliferation of...

Human blood test based on surface-enhanced Raman spectroscopy technology using different excitation light for nasopharyngeal cancer detection.

Nasopharyngeal carcinoma (NPC), a kind of squamous cell carcinoma, occurs in the top and the side wall of nasopharyngeal, which harms human health and life. In this study, a novel blood test (SERS) was carried out for 30 NPC patients and 30 normal ones. Using multi-variate statistical analysis for spectral data, the diagnostic sensitivities of 89.3% (50/56) and 85.7% (48/56) can be achieved for 633 and 785 nm exciting wavelength, respectively. Also corresponding specificities are 71.4% (41/56) and 78.6% (...


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