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The optimal treatment of streptococcal prosthetic joint infections (PJIs) is unclear.
A 21-year-old man developed an infectious keratitis after swimming in Spain whilst wearing contact lenses. Mycelial growth from a corneal sample suggested keratomycosis but a drastic worsening of the patient's condition was observed on antifungal drugs. At day 38, the Pan-fungal PCR identified P. insidiosum, which is an aquatic organism belonging to the oomycete family. Based on recent literature, our patient was promptly prescribed systemic and local antibiotic regimen and cure was ultimately achieved. In ...
Little is known about the birth prevalence and characteristics of congenital cytomegalovirus (CMV) infection in developing countries. To determine the prevalence and characteristics of congenital CMV infection in Indonesia, we conducted a prospective study in an urban birth cohort of neonates at a national referral hospital in 2016 - 2017, Jakarta, Indonesia METHODS: Consecutively born neonates were screened for the presence of CMV by using pan-herpesvirus nested-PCR and Sanger sequencing in saliva and/...
Histoplasma capsulatum and Pneumocystis jirovecii are respiratory fungal pathogens that principally cause pulmonary disease. Coinfection with both pathogens is scarcely reported. This study detected this coinfection using specific molecular methods for each fungus in the bronchoalveolar lavage (BAL) of patients from a tertiary care hospital.
The United Arab Emirates (UAE) is a rapidly developing high-income country that has experienced significant population growth, urbanisation, and improvements in the standard of living since formation in 1971. Published estimates on the prevalence of intestinal infectious diseases (IID) in the UAE are scarce and exclusively based on hospital data. The aim of this study was to provide the first prevalence estimates of IID in the UAE.
Nucleic acid-based polymerase chain reaction (PCR) assay is commonly applied to detect infection with Zika virus (ZIKV). However, time- and labor-intensive sample pretreatment to remove inhibitors that cause false-negative results in clinical samples is impractical for use in resource-limited area. We aim to develop a direct reverse-transcription quantitative PCR (dirRT-qPCR) assay for ZIKV diagnosis directly from clinical samples.
Bioaerosols from pulmonary tuberculosis (PTB) patients are a quantitative predictor of transmission. Current methods involve sophisticated instruments and time-consuming techniques to assess viable TB bacteria in bioaerosols. We tested the feasibility of detecting Mycobacterium tuberculosis (Mtb) specific RNA from bioaerosols retained on TB patients' masks.
Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality, however, little is known about the prevalence and distribution of HBV in some populations and regions.
Candida auris emerged as a human pathogen in 2009 and has subsequently been identified around the world as a cause of invasive candidiasis. We did an analysis from a single institution in order to analyze risk factors and outcomes for C. auris candidemia.
Pneumonia is the largest single contributor to child mortality and the problem is more acute in low and middle income countries. The World Health Organization (WHO) currently recommends oral antibiotic treatment for all children with fast breathing pneumonia without danger signs. It is, however, widely acknowledged that most such infections are viral and self-limiting and that the evidence for the guidance is weak.
Following the launch of the Global Antimicrobial Resistance Surveillance System (GLASS), antimicrobial resistance (AMR) rates in many countries remain poorly described. This review provides an overview of published AMR data from Cambodia in the context of recently initiated national human and food-animal surveillance.
Tuberculosis of the chest wall represents less than 5% of cases of musculoskeletal tuberculosis.
Mycobacterium tuberculosis produces high-affinity siderophores that play essential roles in iron acquisition and TB pathogenesis. In response, host cells secrete a siderophore binding protein, siderocalin, to limit the bacteria's access to iron. The objective of the present study was to evaluate the levels of siderocalin in patients with TB with or without HIV infection compared to controls.
Catheter-related bloodstream infections (CR-BSI) is one of the various complications related to haemodialysis (HD). As a result of the high rate of infection, the lock solutions (LS) has been studied to prevent CRB. However, adverse effects of LS, such as increased emergence of strains resistant to antibiotics, which is an important concern, need to be further investigated. This study aimed to compare the efﬁcacy of LS using a combination of cefazolin and gentamicin versus taurolidine and citrate in reduc...
Meningococcal serogroup B (MenB) has become the main cause of invasive meningococcal disease in industrialized countries in recent years. The diversity of MenB strains and poor immunogenicity of the MenB capsular polysaccharide made vaccine development challenging. Two MenB vaccines, including factor H binding protein (fHbp) as a major antigenic component, are now licensed for use. In addition to fHbp variant 1, the multicomponent vaccine 4CMenB contains Neisserial heparin binding antigen, Neisseria adhesin...
Hand, foot, and mouth disease (HFMD) was rare among adults, whereas its clinical significance was underestimated. This study tried to systematically elucidate the epidemiological characteristics of adult HFMD.
Prevalence and 30-day all-cause mortality of carbapenem and colistin resistant bacteraemias caused by Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae: A description of a decade long trend.
Bacteraemias due to carbapenem resistant Gram-negative bacteria are challenging. This study examined the burden of carbapenem and colistin resistance in Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii bacteraemias in Oman.
Pertussis is a highly contagious respiratory illness mainly caused by the Gram-negative bacterium Bordetella pertussis. The infection of Bordetella pertussis was increasing and the current diagnosis of children pertussis is challenging, especially little is known of Bordetella pertussis infection in Chongqing.
Treatment outcomes of extensively drug-resistant tuberculosis (XDR-TB) patients are sub-optimal and treatment options remain limited. Linezolid is associated with improved outcomes but also substantial toxicity, and details about the relationship between these are lacking from resource-poor HIV-endemic settings.
Staphylococcal scarlet fever (SSF) is characterized by an exanthem without enanthem, bullae, or exfoliation, and is known to be related to Staphylococcus aureus toxins, especially superantigens. It has been reported in children and young adults. Herein, we report the first case of an elderly patient with SSF caused by staphylococcal enterotoxin M (SEM), associated with otitis externa. The patient presented with maculopapular rashes on both arms, thighs, and abdomen and with erythroderma on the face, both ea...
Scrub typhus has emerged as a major cause of acute febrile illness in India in recent years. The causative agent, Orientiatsutsugamushi has more than 20 prototypes strains due to a variable 56-kDa outer membrane protein. It is crucial to know the prevailing types in India for the success of diagnostic immunoassays and prospective vaccine candidates. In north India, the principal types circulating are largely unknown. Our tertiary care hospital caters to a large area of north India (around 7 states and one u...
The aim of this study was to estimate the impact of antimicrobial resistance (AMR) in secondary pneumococcal pneumonia infections on global mortality during the 2009 influenza pandemic, to estimate future pandemic mortality risk and to inform pandemic preparedness.