Track topics on Twitter Track topics that are important to you
The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books.
BioPortfolio aims to cross reference relevant information on published papers, clinical trials and news associated with selected topics - speciality.
For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.
It is unclear if local therapy or EGFR-TKI should take precedence for EGFR-mutant non-small cell lung cancer (NSCLC) patients with brain metastases (BMs). The number of BMs is important in the choice of local therapy including Whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS) and surgery.
Optimal treatment of patients diagnosed with de novo metastatic breast cancer limited to the mediastinum or sternum has never been delineated. Herein the authors sought to determine the efficacy of multimodality treatment, including metastasis-directed radiotherapy (RT), in curing patients with this presentation.
Ionising radiation, particular high linear energy transfer (LET) radiation, can induce complex DNA damage (CDD) where two or more DNA lesions are induced in close proximity which contributes significantly to the cell killing effects. However knowledge of the enzymes and mechanisms involved in co-ordinating the recognition and processing of CDD in cellular DNA are currently lacking.
HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible after dentoalveolar surgery.
Hyperbaric oxygen (HBO) has been advocated in the prevention and treatment of osteoradionecrosis of the jaws following head and neck radiotherapy, but supporting evidence is weak. The aim of this randomized trial was to establish the benefit of HBO in prevention of osteoradionecrosis following high risk surgical procedures to the irradiated mandible.
The impairment of the salivary glands is a permanent side effect of I ablation therapy for patients with differentiated thyroid cancer (DTC). Effective and safe treatments for protecting the salivary glands against I are currently not available. Mitochondria are susceptible to ionizing radiation, but its alterations after I exposure are unknown. Here we investigated the mechanisms of I damage in submandibular glands (SMGs) and evaluated the cytoprotective effect of phenylephrine (PE) on the mitochondrial ra...
To review the radiobiological mechanisms of SBRT and SRS.
To determine the long-term outcomes for prostate adenocarcinoma when escalating radiation dose from 70 Gy to 78 Gy.
Organ-at-risk (OAR) delineation is a key step in treatment planning, but can be time-consuming, resource intensive, subject to variability and dependent on anatomical knowledge. We studied deep learning (DL) for automated delineation of multiple OARs, and in addition to geometric evaluation, the dosimetric impact of using DL contours for treatment planning was investigated.
Preclinical evidence suggests that stereotactic body radiation therapy (SBRT) is immunomodulatory. Given the potential to augment local and systemic anti-tumor responses there is significant interest in the combination of SBRT with various immunotherapies to improve clinical outcomes. Additional preclinical and clinical investigation will be needed to better understand the radiobiological and immunological mechanisms of this potential synergy and to define the most appropriate application of SBRT to optimiz...
This study evaluated the safety and efficacy of carbon-ion radiotherapy (C-ion RT) with concurrent chemotherapy (chemo-C-ion RT) for locally advanced uterine cervical squamous cell carcinoma in a phase 1/2 clinical trial.
This study explores the efficacy and safety of re-irradiation with modern radiotherapy technique in patients previously irradiated for prostate cancer and affected by local relapse of disease.
Spatial Dose Patterns Associated with Radiation Pneumonitis in a Randomized Trial Comparing Intensity-Modulated Radiation Therapy with Passive Scattering Proton Therapy for Locally Advanced Non-Small Cell Lung Cancer.
Radiation pneumonitis (RP) is commonly associated with thoracic radiation therapy (RT), and its incidence is related to dose and volume of the normal lung in the path of radiation. Our aim was to investigate dose patterns associated with RP in patients enrolled in a randomized trial of intensity-modulated RT (IMRT) versus passive scattering proton therapy (PSPT) for locally advanced non-small-cell lung cancer (NSCLC).
Higher Reported Lung Dose Received during Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children with Acute Lymphoblastic Leukemia is Associated with Inferior Survival: A Report from the Children's Oncology Group.
To examine the relationship between lung radiation dose and survival outcomes in children undergoing total body irradiation (TBI)-based hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL) on Children's Oncology Group (COG) trial.
We conducted a prospective observational cohort study of physician compliance to daily early pre-treatment planning peer review recommendations and quantified factors associated with compliance.
To identify predictors of radiation-induced liver disease (RILD) in hepatocellular carcinoma (HCC) patients treated with proton beam therapy (PBT).
The current oligometastatic (OM) model postulates the disease evolves dynamically with Sequential emergence of OM (SOM) lesions requiring successive rounds of SOM ablation (SOMA) to afford tumor cure. The present Phase II study explores the ablative efficacy of 24Gy single dose radiotherapy (SDRT), its feasibility in diverse OM settings, and the impact of radioablation on polymetastatic (PM) dissemination.
Treatment of fast-growing HPV-negative head-and-neck cancers (HNC) remains challenging, both from the perspective of tumor control and late sequelae. Here we use systematic radiobiological optimization to identify fractionation schemes that markedly improve the radiotherapeutic effectiveness balance between tumor control probability (TCP) and late normal-tissue complication probability (LNTCP), as compared with standard fractionation.
The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy.
To update outcome and toxicity results of a prospective trial of 19 Gy single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer.
The association of hyperthyroidism with exposure to ionizing radiation is poorly understood. This study addresses the risk of hyperthyroidism in relation to incidental therapeutic radiation dose to the thyroid and pituitary glands in a large cohort of survivors of childhood cancer.
In patients with gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), the standard radiation therapy (RT) dose is ≥ 30 Gy. We report the outcome of patients treated with reduced 24 Gy compared with ≥ 30 Gy.
The present study examines the relationship between dose to corneal substructures and incidence of corneal toxicity within six months of proton beam therapy (PBT) for uveal melanoma. We aim to develop clinically meaningful dose constraints that can be used to mitigate corneal toxicity.
The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT).
The patterns of failure and long-term outcomes of patients with relapsed or refractory classical Hodgkin lymphoma (cHL) treated with total lymphoid irradiation (TLI) and high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (aSCT) is reported.