PubMed Journal Database | International journal of radiation oncology, biology, physics RSS

01:39 EDT 25th March 2019 | BioPortfolio

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Showing PubMed Articles 1–25 of 424 from International journal of radiation oncology, biology, physics

Optimal Sequence of Local and EGFR-TKI Therapy for EGFR-mutant NSCLC with Brain Metastases Stratified by Number of Brain Metastases.

It is unclear if local therapy or EGFR-TKI should take precedence for EGFR-mutant non-small cell lung cancer (NSCLC) patients with brain metastases (BMs). The number of BMs is important in the choice of local therapy including Whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS) and surgery.

Outcomes of curative-intent treatment for breast cancer patients presenting with sternal or mediastinal involvement.

Optimal treatment of patients diagnosed with de novo metastatic breast cancer limited to the mediastinum or sternum has never been delineated. Herein the authors sought to determine the efficacy of multimodality treatment, including metastasis-directed radiotherapy (RT), in curing patients with this presentation.

Characterisation of deubiquitylating enzymes in the cellular response to high-LET ionising radiation and complex DNA damage.

Ionising radiation, particular high linear energy transfer (LET) radiation, can induce complex DNA damage (CDD) where two or more DNA lesions are induced in close proximity which contributes significantly to the cell killing effects. However knowledge of the enzymes and mechanisms involved in co-ordinating the recognition and processing of CDD in cellular DNA are currently lacking.

Daily Fractionation of External Beam Accelerated Partial Breast Irradiation to 40Gy is Well Tolerated and Locally Effective.

HOPON (Hyperbaric Oxygen for the Prevention of Osteoradionecrosis): a randomised controlled trial of hyperbaric oxygen to prevent osteoradionecrosis of the irradiated mandible after dentoalveolar surgery.

Hyperbaric oxygen (HBO) has been advocated in the prevention and treatment of osteoradionecrosis of the jaws following head and neck radiotherapy, but supporting evidence is weak. The aim of this randomized trial was to establish the benefit of HBO in prevention of osteoradionecrosis following high risk surgical procedures to the irradiated mandible.

Phenylephrine Alleviates I Radiation Damage in Submandibular Gland through Maintaining Mitochondrial Homeostasis.

The impairment of the salivary glands is a permanent side effect of I ablation therapy for patients with differentiated thyroid cancer (DTC). Effective and safe treatments for protecting the salivary glands against I are currently not available. Mitochondria are susceptible to ionizing radiation, but its alterations after I exposure are unknown. Here we investigated the mechanisms of I damage in submandibular glands (SMGs) and evaluated the cytoprotective effect of phenylephrine (PE) on the mitochondrial ra...

Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death.

To review the radiobiological mechanisms of SBRT and SRS.

Dose Escalation for Prostate Adenocarcinoma: A Long-Term Update on the Outcomes of a Phase III, Single Institution Randomized Clinical Trial.

To determine the long-term outcomes for prostate adenocarcinoma when escalating radiation dose from 70 Gy to 78 Gy.

Deep learning-based delineation of head and neck organs-at-risk: geometric and dosimetric evaluation.

Organ-at-risk (OAR) delineation is a key step in treatment planning, but can be time-consuming, resource intensive, subject to variability and dependent on anatomical knowledge. We studied deep learning (DL) for automated delineation of multiple OARs, and in addition to geometric evaluation, the dosimetric impact of using DL contours for treatment planning was investigated.

Immunomodulatory Effects of Stereotactic Body Radiation Therapy (SBRT): Preclinical Insights and Clinical Opportunities.

Preclinical evidence suggests that stereotactic body radiation therapy (SBRT) is immunomodulatory. Given the potential to augment local and systemic anti-tumor responses there is significant interest in the combination of SBRT with various immunotherapies to improve clinical outcomes. Additional preclinical and clinical investigation will be needed to better understand the radiobiological and immunological mechanisms of this potential synergy and to define the most appropriate application of SBRT to optimiz...

A Phase 1/2 Study of Carbon Ion Radiotherapy with Concurrent Chemotherapy for Locally Advanced Uterine Cervical Squamous Cell Carcinoma (Protocol 1302).

This study evaluated the safety and efficacy of carbon-ion radiotherapy (C-ion RT) with concurrent chemotherapy (chemo-C-ion RT) for locally advanced uterine cervical squamous cell carcinoma in a phase 1/2 clinical trial.

Re-Irradiation of Locally Recurrent Prostate Cancer with Volumetric Modulated Arc Therapy (Vmat).

This study explores the efficacy and safety of re-irradiation with modern radiotherapy technique in patients previously irradiated for prostate cancer and affected by local relapse of disease.

Spatial Dose Patterns Associated with Radiation Pneumonitis in a Randomized Trial Comparing Intensity-Modulated Radiation Therapy with Passive Scattering Proton Therapy for Locally Advanced Non-Small Cell Lung Cancer.

Radiation pneumonitis (RP) is commonly associated with thoracic radiation therapy (RT), and its incidence is related to dose and volume of the normal lung in the path of radiation. Our aim was to investigate dose patterns associated with RP in patients enrolled in a randomized trial of intensity-modulated RT (IMRT) versus passive scattering proton therapy (PSPT) for locally advanced non-small-cell lung cancer (NSCLC).

Higher Reported Lung Dose Received during Total Body Irradiation for Allogeneic Hematopoietic Stem Cell Transplantation in Children with Acute Lymphoblastic Leukemia is Associated with Inferior Survival: A Report from the Children's Oncology Group.

To examine the relationship between lung radiation dose and survival outcomes in children undergoing total body irradiation (TBI)-based hematopoietic stem cell transplantation (HSCT) for acute lymphoblastic leukemia (ALL) on Children's Oncology Group (COG) trial.

A Prospective Analysis of Radiation Oncologist Compliance to Early Peer Review Recommendations.

We conducted a prospective observational cohort study of physician compliance to daily early pre-treatment planning peer review recommendations and quantified factors associated with compliance.

Predictors of Radiation-Induced Liver Disease in Eastern and Western Patients with Hepatocellular Carcinoma Undergoing Proton Beam Therapy.

To identify predictors of radiation-induced liver disease (RILD) in hepatocellular carcinoma (HCC) patients treated with proton beam therapy (PBT).

Phenotype-Oriented Ablation of Oligometastatic Cancer With Single Dose Radiotherapy.

The current oligometastatic (OM) model postulates the disease evolves dynamically with Sequential emergence of OM (SOM) lesions requiring successive rounds of SOM ablation (SOMA) to afford tumor cure. The present Phase II study explores the ablative efficacy of 24Gy single dose radiotherapy (SDRT), its feasibility in diverse OM settings, and the impact of radioablation on polymetastatic (PM) dissemination.

Optimized Hypofractionation can Markedly Improve Tumor Control and Decrease Late Effects for Head and Neck Cancer.

Treatment of fast-growing HPV-negative head-and-neck cancers (HNC) remains challenging, both from the perspective of tumor control and late sequelae. Here we use systematic radiobiological optimization to identify fractionation schemes that markedly improve the radiotherapeutic effectiveness balance between tumor control probability (TCP) and late normal-tissue complication probability (LNTCP), as compared with standard fractionation.

Pravastatin Reverses Established Radiation-Induced Cutaneous and Subcutaneous Fibrosis in Patients with Head and Neck Cancer: Results of the Biology-Driven Phase Ii Clinical Trial Pravacur.

The "xxx" phase II trial (NCTxxx) assessed the efficacy of pravastatin as anti-fibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiotherapy and/or radio-chemotherapy.

5-Year Outcomes of a Single Institution Prospective Trial of 19 Gy Single-Fraction HDR Brachytherapy for Low- and Intermediate-Risk Prostate Cancer.

To update outcome and toxicity results of a prospective trial of 19 Gy single-fraction high-dose-rate (HDR) brachytherapy for men with low- and intermediate-risk prostate cancer.

Hyperthyroidism Following Radiation Therapy for Childhood Cancer: A Report from the Childhood Cancer Survivor Study.

The association of hyperthyroidism with exposure to ionizing radiation is poorly understood. This study addresses the risk of hyperthyroidism in relation to incidental therapeutic radiation dose to the thyroid and pituitary glands in a large cohort of survivors of childhood cancer.

Outcomes After Reduced-Dose Intensity Modulated Radiation Therapy for Gastric Mucosa- Associated Lymphoid Tissue (MALT) Lymphoma.

In patients with gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma (MALT lymphoma), the standard radiation therapy (RT) dose is ≥ 30 Gy. We report the outcome of patients treated with reduced 24 Gy compared with ≥ 30 Gy.

Corneal Substructure Dosimetry Predicts Corneal Toxicity in Patients with Uveal Melanoma Treated with Proton Beam Therapy.

The present study examines the relationship between dose to corneal substructures and incidence of corneal toxicity within six months of proton beam therapy (PBT) for uveal melanoma. We aim to develop clinically meaningful dose constraints that can be used to mitigate corneal toxicity.

Cardiac Function After Radiotherapy for Breast Cancer.

The main purpose of this study was to test the hypothesis that incidental cardiac irradiation is associated with changes in cardiac function in breast cancer (BC) survivors treated with radiotherapy (RT).

Patterns of Failure and Survival Outcomes After Total Lymphoid Irradiation and High-Dose Chemotherapy With Autologous Stem Cell Transplantation for Relapsed or Refractory Classical Hodgkin Lymphoma.

The patterns of failure and long-term outcomes of patients with relapsed or refractory classical Hodgkin lymphoma (cHL) treated with total lymphoid irradiation (TLI) and high-dose chemotherapy (HDCT) followed by autologous stem cell transplantation (aSCT) is reported.

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