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PubMed Journal Database | Journal of applied clinical medical physics RSS

12:02 EDT 18th March 2019 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.

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Showing PubMed Articles 1–25 of 296 from Journal of applied clinical medical physics

MR-based treatment planning in radiation therapy using a deep learning approach.

To develop and evaluate the feasibility of deep learning approaches for MR-based treatment planning (deepMTP) in brain tumor radiation therapy.

AlignRT and Catalyst™ in whole-breast radiotherapy with DIBH: Is IGRT still needed?

Surface guided radiotherapy (SGRT) is reported as a feasible setup technique for whole-breast radiotherapy in deep inspiration breath hold (DIBH), but position errors of bony structures related to deeper parts of the target are not fully known. The aim of this study was to estimate patient setup accuracy and margins obtained with two different SGRT workflows with and without daily kV- and/or MV-based image guidance (IGRT).

Simulation analysis for tumor radiotherapy based on three-component mathematical models.

To setup a three-component tumor growth mathematical model and discuss its basic application in tumor fractional radiotherapy with computer simulation.

Image quality evaluation of ultrasound imaging systems: advanced B-modes.

The Quality assurance of ultrasound clinical imaging systems is essential for maintaining their performance to the highest level and for complying with the requirements by various regulatory and accrediting agencies. Although there is no standardization yet, most of the quality assessment procedures available in literature are proposed for B-mode and Doppler imaging. However, ultrasound imaging systems offer a variety of advanced imaging modes, besides B-mode and Doppler, which are primarily aimed at improv...

Clinical practice workflow in Radiation Oncology should be highly standardized.

Evaluation of mixed energy partial arcs for volumetric modulated arc therapy for prostate cancer.

The purpose of this work was to investigate the dosimetric impact of mixed energy (6-MV, 15-MV) partial arcs (MEPAs) technique on prostate cancer VMAT plans.

Technical Note: The use of DirectDensity and dual-energy CT in the radiation oncology clinic.

Two new tools available in Radiation Oncology clinics are Dual-energy CT (DECT) and Siemens' DirectDensity™ (DD) reconstruction algorithm, which allows scans of any kV setting to use the same calibration. This study demonstrates why DD scans should not be used in combination with DECT and quantifies the magnitude of potential errors in image quality and dose.

Development and validation of an open source Monte Carlo dosimetry model for wide-beam CT scanners using Fluka.

Development and validation of an open source Fluka-based Monte Carlo source model for diagnostic patient dose calculations.

Geometric and dosimetric impact of anatomical changes for MR-only radiation therapy for the prostate.

With the move towards magnetic resonance imaging (MRI) as a primary treatment planning modality option for men with prostate cancer, it becomes critical to quantify the potential uncertainties introduced for MR-only planning. This work characterized geometric and dosimetric intra-fractional changes between the prostate, seminal vesicles (SVs), and organs at risk (OARs) in response to bladder filling conditions.

Development and validation of a 3D-printed bolus cap for total scalp irradiation.

The goal of total scalp irradiation (TSI) is to deliver a uniform dose to the scalp, which requires the use of a bolus cap. Most current methods for fabricating bolus caps are laborious, yet still result in nonconformity and low reproducibility, which can lead to nonuniform irradiation of the scalp. We developed and validated patient-specific bolus caps for TSI using three-dimensional (3D) printing.

A multi-institutional evaluation of machine performance check system on treatment beam output and symmetry using statistical process control.

The automated and integrated machine performance check (MPC) tool was verified against independent detectors to evaluate its beam uniformity and output detection abilities to consider it suitable for daily quality assurance (QA).

Three discipline collaborative radiation therapy (3DCRT) special debate: The United States should build additional proton therapy facilities.

Dose evaluation indices for total body irradiation using TomoDirect with different numbers of ports: A comparison with the TomoHelical method.

TomoDirect has been reported to have some advantages over TomoHelical in delivering total body irradiation (TBI). This study aimed to investigate the relationships between the number of ports and the dose evaluation indices in low-dose TBI in TomoDirect mode using 2-12 ports and to compare these data with those for the TomoHelical mode in a simulation study. Thirteen patients underwent low-dose TBI in TomoHelical mode from June 2015 to June 2016. We used the same computed tomography data sets for these pati...

Assessment of prostate cancer prognostic Gleason grade group using zonal-specific features extracted from biparametric MRI using a KNN classifier.

To automatically assess the aggressiveness of prostate cancer (PCa) lesions using zonal-specific image features extracted from diffusion weighted imaging (DWI) and T2W MRI.

Radiation dose and image quality comparison during spine surgery with two different, intraoperative 3D imaging navigation systems.

Careful protocol selection is required during intraoperative three-dimensional (3D) imaging for spine surgery to manage patient radiation dose and achieve clinical image quality. Radiation dose and image quality of a Medtronic O-arm commonly used during spine surgery, and a Philips hybrid operating room equipped with XperCT C-arm 3D cone-beam CT (hCBCT) are compared. The mobile O-arm (mCBCT) offers three different radiation dose settings (low, standard, and high), for four different patient sizes (small, me...

Dosimetric verification of IMPT using a commercial heterogeneous phantom.

The purpose of this study was to propose a verification method and results of intensity-modulated proton therapy (IMPT), using a commercially available heterogeneous phantom. We used a simple simulated head and neck and prostate phantom. An ionization chamber and radiochromic film were used for measurements of absolute dose and relative dose distribution. The measured doses were compared with calculated doses using a treatment planning system. We defined the uncertainty of the measurement point of the ioniz...

Dosimetric comparison of VMAT with integrated skin flash to 3D field-in-field tangents for left breast irradiation.

Volumetric modulated arc therapy (VMAT) has been implemented for left breast irradiation to reduce prescription dose to the heart and improve dose homogeneity across the targeted breast. Our in-house method requires application of a bolus during the optimization process with a target outside of the body, then removing the bolus during the final calculation in order to incorporate skin flash in VMAT plans. To quantify the dosimetric trade-offs between traditional 3D field-in-field tangents and VMAT with inte...

Do the representative beam data for TrueBeam linear accelerators represent average data?

If the vendor's representative beam data (RBD) for TrueBeam linear accelerators are to be valid for use in clinical practice, the variations in the beam data used for beam modeling must be small. Although a few studies have reported the variation of the beam data of the TrueBeam machines, the numbers of machines analyzed in those studies were small. In this study, we investigated the variation in the beam data for 21 TrueBeam machines collected from 17 institutions with their agreement. In the exponential r...

Elective nodal irradiation with simultaneous integrated boost stereotactic body radiotherapy for pancreatic cancer: Analyses of planning feasibility and geometrically driven DVH prediction model.

We evaluate the feasibility of the elective nodal irradiation strategy in stereotactic body radiotherapy (SBRT) for pancreatic cancer.

Improvements in treatment planning calculations motivated by tightening IMRT QA tolerances.

Implementing tighter intensity modulated radiation therapy (IMRT) quality assurance (QA) tolerances initially resulted in high numbers of marginal or failing QA results and motivated a number of improvements to our calculational processes. This work details those improvements and their effect on results. One hundred eighty IMRT plans analyzed previously were collected and new gamma criteria were applied and compared to the original results. The results were used to obtain an estimate for the number of plans...

An additional tilted-scan-based CT metal-artifact-reduction method for radiation therapy planning.

As computed tomography (CT) imaging is the most commonly used modality for treatment planning in radiation therapy, metal artifacts in the planning CT images may complicate the target delineation and reduce the dose calculation accuracy. Although current CT scanners do provide certain correction steps, it is a common understanding that there is not a universal solution yet to the metal artifact reduction (MAR) in general. Particularly noting the importance of MAR for radiation treatment planning, we propose...

Remote dosimetric auditing of clinical trials: The need for vendor specific models to convert images to dose.

A previous pilot study has demonstrated the feasibility of a novel image-based approach for remote dosimetric auditing of clinical trials. The approach uses a model to convert in-air acquired intensity modulated radiotherapy (IMRT) images to delivered dose inside a virtual phantom. The model was developed using images from an electronic portal imaging device (EPID) on a Varian linear accelerator. It was tuned using beam profiles and field size factors (FSFs) of a series of square fields measured in water ta...

A quality assurance for respiratory gated proton irradiation with range modulation wheel.

The purpose of this study was to provide periodic quality assurance (QA) methods for respiratory-gated proton beam with a range modulation wheel (RMW) and to clarify the characteristics and long-term stability of the respiratory-gated proton beam. A two-dimensional detector array and a solid water phantom were used to measure absolute dose, spread-out Bragg peak (SOBP) width and proton range for monthly QA. SOBP width and proton range were measured using an oblique incidence beam to the lateral side of a so...

Usefulness of hybrid deformable image registration algorithms in prostate radiation therapy.

To evaluate the accuracy of commercially available hybrid deformable image registration (DIR) algorithms when using planning CT (pCT) and daily cone-beam computed tomography (CBCT) in radiation therapy for prostate cancer. The hybrid DIR algorithms in RayStation and MIM Maestro were evaluated. Contours of the prostate, bladder, rectum, and seminal vesicles (SVs) were used as region-of-interest (ROIs) to guide image deformation in the hybrid DIR and to compare the DIR accuracy. To evaluate robustness of the ...

Extended SSD VMAT treatment for total body irradiation.

In this work, we develop a total body irradiation technique that utilizes arc delivery, a buildup spoiler, and inverse optimized multileaf collimator (MLC) motion to shield organs at risk. The current treatment beam model is verified to confirm its applicability at extended source-to-surface distance (SSD). The delivery involves 7-8 volumetric modulated arc therapy arcs delivered to the patient in the supine and prone positions. The patient is positioned at a 90° couch angle on a custom bed with a 1 cm ac...


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