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Diabetes Mellitus is an established risk factor for stroke and maybe associated with poorer outcomes following stroke.
Recent studies advocate that omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have direct antioxidative and anti-inflammatory effects in the vasculature; however, the role of ω-3 PUFAs in Schwann cells remains undetermined.
To prospectively investigate whether simultaneous elevation of gamma-glutamyl transferase (GGT) and alanine aminotransferase (ALT) is associated with the increase of type 2 diabetes mellitus (T2DM) incidence independent of drinking, body mass index (BMI), and triglycerides.
To determine the current clinical preferences of anti-vascular endothelial growth factor (VEGF) treatment protocols for diabetic macular edema (DME) in Japan.
Which is better, high-dose metformin monotherapy or low-dose metformin/ linagliptin combination therapy, in improving glycemic variability in type 2 diabetes patients with insufficient glycemic control despite low-dose metformin monotherapy: A randomized, crossover, CGM-based, pilot study.
This study investigates the effect of high-dose metformin or low-dose metformin/linagliptin combination therapy on glycemic variability (GV) in type 2 diabetes (T2D) patients with insufficient glycemic control despite low-dose metformin monotherapy in a crossover study using continuous glucose monitoring (CGM).
Insulin resistance has long been established as the key metabolic defect linking obesity with its related cardio-metabolic diseases including type 2 diabetes, hypertension, dyslipidaemia, accelerated atherosclerosis and even cancers. In recent years, it has also been increasingly recognized that insulin resistance in obesity is closely related to adipose tissue inflammation, following the demonstration of macrophage infiltration of the adipose tissue in obese rodents and humans. In one of the seminal studie...
Feasibility and safety of using an automated decision support system for insulin therapy in the treatment of steroid-induced hyperglycemia in patients with acute graft-versus-host disease - a randomized trial.
Steroid-induced hyperglycemia (SIHG) has shown to independently increase the risk for mortality in patients with acute Graft-versus-host disease (aGvHD) and it is still unclear whether SIHG might be a modifiable risk factor. Therefore a feasibility trial was conducted aiming to evaluate the performance of a standardized decision support system (GlucoTab) for insulin therapy in patients with SIHG. 10 hyperglycemic aGvHD patients were included and treated either with GlucoTab (GT) or standard of care (SOC) du...
To investigate the prevalence of sarcopenia, its related factors, and indicators of physical evaluation in elderly diabetic patients.
We compared treatment satisfaction in type 2 diabetes patients taking daily and weekly glucagon-like peptide-1 (GLP-1) receptor agonists.
Diabetic polyneuropathy (DPN) is one of the most frequent diabetic complications, and impairs patients' quality of life. We evaluated the efficacy and safety of ranirestat (40 mg/day) in patients with DPN.
To compare the effects of gliclazide, liraglutide, and metformin on body composition in patients with type 2 diabetes mellitus patients with non-alcoholic fatty liver disease.
Vitamin D deficiency can lead to male hypogonadism in diabetes mellitus,but the target organs and the mechanism driving the disorder are unclear. This experiment was designed to study the relationship between vitamin D deficiency and hypogonadism in diabetes mellitus.
Bullous pemphigoid (BP) may be drug-induced. This study evaluated the relation between BP and dipeptidyl peptidase-4 inhibitors (DPP4Is).
Glucagon secreted by pancreatic α-cells plays pivotal roles in the systemic energy homeostasis mainly by regulating systemic glucose mobilization together with another important metabolic hormone, insulin. Recent application of the incretin-based therapies to clinical diabetes refocused on the central roles of glucagon in the development of diabetic hyperglycemia. This revival of glucagon also enhanced the progress of basic research in α-cell biology, as targeting glucagon is now expected to be the next t...
Dipeptidyl Peptidase-4 Inhibitor was proved to improve glycemic control and βcell function in latent autoimmune diabetes in adults (LADA). The potential immune modulation mechanism is still unknown. Thus we tested T lymphocyte subsets and expression of relevant transcription factors in LADA patients with sitagliptin intervention for up to one-year study.
Obesity and type 2 diabetes mellitus are prevalent all over the world. Obese patients with more visceral fat are more likely to suffer from type 2 diabetes mellitus, hypertension, dyslipidemia and obstructive sleep apnea. Obese patients with type 2 diabetes mellitus have higher risk of obesity and diabetes related complications (especially arteriosclerotic cardiovascular disease). This article is protected by copyright. All rights reserved.
Genetic and epigenetic mechanisms have been implicated in the pathogenesis of type 1 diabetes (T1D), and histone acetylation is an epigenetic modification pattern that activates gene transcription. However, the genome-wide histone H3 acetylation in newly onset T1D patients has been less described. Accordingly, we aimed to unveil the genome-wide promoter acetylation profile in CD4 T lymphocytes from T1D patients, especially for those with glutamate decarboxylase antibody (GADA) positive.
To investigate the effect of endurance training on Hippocampus DJ-1 and CB protein and blood glucose concentration in diabetic rats.
Older people with diabetes mellitus (DM) are at high risk for cognitive impairment or dementia. The clinical predictors for cognitive decline in older people with DM were elucidated.
One hundred years have passed since guanidine, a precursor compound of biguanides and thus of metformin, was found to have a glucose-lowering effect in live animals . In this historical study, C. K. Watanabe did not set out to identify glucose-lowering agents but rather to understand the mechanism underlying the development of tetany in animals that have undergone parathyroidectomy. Watanabe concluded that guanidine is a pathogenic factor responsible for tetany because its administration in rabbits resulte...
Currently, the clinical dynamics of glucagon needs to be revised based on previous data obtained from conventional glucagon radioimmunoassays. In this study, we evaluated plasma glucagon levels in type 1 diabetes patients using a newly-developed sandwich enzyme-linked immunosorbent assay (ELISA), and its association with clinical parameters and markers of diabetes complications were statistically assessed. The plasma glucagon level in 77 Japanese type 1 diabetes patients was 28.1±17.7 pg/mL, and comparable...
Recent data showed that DPP-4 inhibitors exert a lipid-lowering effect in diabetic patients. However, the mechanism of action is not yet clearly understood. We investigated the effect of anagliptin on cholesterol metabolism and transport in the small intestine using non-diabetic hyperlipidemic animals, to clarify the mechanisms underlying the cholesterol-lowering action.
To investigate the correlation between snoring and chronic kidney disease (CKD) and explore whether metabolic syndrome (MetS) plays an important role in this relationship among middle-aged and elderly Chinese.
Hypertension is one of the most significant risk factors for diabetes. The present study aimed to investigate the associations of lipid profiles, including the ratio of low-density lipoprotein cholesterol (LDL-C) to high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels, as well as their interactions, with type 2 diabetes in hypertensive patients.