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The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 21 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books. BioPortfolio aims to publish relevant information on published papers, clinical trials and news associated with users selected topics.
For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.
Intracranial tumors are one of the most frightening and difficult to treat tumor types. In addition to surgery, additional protocols such as chemotherapy and radiotherapy also take place in the treatment. Glutathione S-transferase (GST) and cytochrome P450 (CYP) enzymes are prominent drug metabolizing enzymes in human body. The aim of the present study is to show the expression of GSTP1, GSTM1, CYP1A1 and CYP1B1 in different types of brain tumors and to compare the results with current literature.
Dementia is one of the most common neurodegenerative disorder among older populations around the world, and the incidence is increasing. Many epidemiologic studies have considered the association between proton-pump inhibitors and dementia, yet the relationship is still controversial.The objective of this study was to validate whether or not proton-pump inhibitors is indeed associated with dementia.Materials (Subjects) and Methods: We searched for articles on clinical studies of dementia and proton pump inh...
To report on a case of intravesical explosion during transurethral resection of prostate (TURP) which was managed laparoscopically and to review the relevant literature.
Sinus floor evelation and augmentation surgery is widely used as a reliable procedure to increase insufficient bone height in the posterior maxillary area. The purpose of the present clinical study was to determine the associations between periodontal bone loss (PBL), maxillary sinus lateral bone wall thickness, age, and gender using cone beam computerized tomography (CBCT).
Polycystic ovary syndrome (PCOS) is a serious endocrine disorder. In the present study, we investigated the therapeutic effects of erdosteine in letrozole induced-PCOS in rats. Methods: Thirty two wistar albino female rats were grouped as control group (C), PCOS group (PCOS), PCOS-metformin group (PCOS+MET), PCOS-erdosteine group (PCOS+Erd). Polycystic ovary syndrome was induced by administering letrozole; such rats presented with sex hormone disorder, abnormal estrous cycles determined by daily vaginal sme...
Patients with Turner syndrome (TS) have an unfavorable cardiometabolic profile. Hyperhomocysteinemia is a potential cardiovascular risk factor influenced by genetic and environmental factors, therapies, unbalanced diets and other lifestyle factors. We retrospectively studied the relationship between total plasma homocysteine (Hcy), serum vitamin B12 (B12) and folate concentration (s-F) in TS patients, taking into account the genetic profile, diet, smoking habits, hormonal therapies and dietary supplements o...
This study compares the effect of the white mineral trioxide aggregate (WMTA) accelerators including disodium hydrogen orthophosphate (Na2HPO4) (2.5 wt%), calcium chloride (CaCl2) (5 wt% and 10 wt%), and KY jelly, on the push-out bond strength of WMTA. The null hypothesis was that the WMTA accelerators would not affect the push-out strength of WMTA.
We evaluated whether gamma gap is associated with cognitive function among older adults and whether physical activity is favorably associated with cognition among those with an elevated gamma gap. Materials (Subjects) and MethodsData from the 1999-2002 NHANES were used to identify 2,352 older adults, ages 60-85. The gamma gap was evaluated from subtracting albumin from total protein (i.e., Gamma Gap = Total Protein (g/dl) - Albumin (g/dl). Those at or above 3.1 g/dl (31.0 g/L) were considered to have an el...
To compare characteristics of pain in terms of neuropathic pain and to assess association between neuropathic component and quality of life (QoL) in patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA).
To measure plasma GLN levels in systemic and portal circulation after combined enteral and parenteral administration in early endotoxemic swine. We hypothesized that this combination will be more efficient than intravenous alone in restoring plasma levels during the course of endotoxemia.
Spexin is a novel peptide which has a potential role as a biomarker of insulin resistance, diabetes and obesity. We aimed to measure levels of spexin in lean type 1 diabetic patients and its relevance to glycemic parameters without the presence of obesity or insulin resistance.
Candida albicans and Candida dubliniensis are germ tube-positive pathogenic yeast species. Accurate identification of these two species is warranted since C. albicans is a highly pathogenic species while C. dubliniensis exhibits increased adherence to buccal epithelial cells, reduced susceptibility to azoles and resistance to flucytosine. We have developed a duplex real-time PCR assay for rapid detection and differentiation between clinical C. albicans and C. dubliniensis isolates.
Lysozyme and lactoferrin have anti-candidal activity. Candida dubliniensis is associated with oral candidiasis. Candida infections are managed with nystatin, amphotericin B, caspofungin, ketoconazole, fluconazole and chlorhexidine. Candida undergo a brief exposure to therapeutic agents in the mouth. There is no data on the influence of limited exposure to antimycotics on the sensitivity of C. dubliniensis to lactoferrin and lysozymes. Hence, this study observed the changes in the sensitivity of C. dublinien...
Sauna bathing has been suggested to promote mental well-being and relaxation, but the evidence is uncertain with respect to mental disorders. We aimed to assess the association of frequency of sauna bathing with risk of psychosis in the Kuopio Ischemic Heart Disease prospective population-based study.
Rheumatoid arthritis (RA) is a chronic inflammatory systemic autoimmune disease, affecting the joints with varying severity among patients. The risk factors include age, gender, genetics and environmental exposure (cigarette smoking, air pollutants and occupational). Many complications can follow such as permanent joint damage requiring arthroplasty, rheumatoid vasculitis and elty's syndrome requiring splenectomy if it remains unaddressed. As there is no cure for RA, the treatment goals are to reduce the pa...
The cesarean delivery rate has increased worldwide. The aim of our study was to assess the events associated with the second cesarean deliveries in our institution.
The aim of this study was to examine the effect of volume status on the progressions of renal disease in normovolemic or hypervolemic patients with advanced non-dialysis-dependent CKD who were apparently normovolemic in conventional physical examination.
To study available data on the prevalence of atopic diseases and food allergy in children living on the Arabian Peninsula.
To evaluate the anti-inflammatory effectiveness of celecoxib and its effect on the rehabilitation of joint function after total knee arthroplasty.
Non-selective β-blockers (NSBBs) are used in liver cirrhosis (LC) to prevent variceal bleeding because they decrease portal pressure. A main risk factor for the development of portal vein thrombosis (PVT) in LC is decreased portal vein inflow velocity. The aim of our study was to examine retrospectively the incidence of PVT and its correlation with the use of β-blockers in a cohort of LC patients.
One of the most important side effects of opioids is their influence on the electrical activity of the heart. This review focusses on the effects of opioids on QT interval prolongation and their arrhythmogenic liability.
Arterial myointimal hyperplasia (MIH) has a significant impact on long-term outcomes of vascular procedures such as bypass surgery and angioplasty. In this study, we describe a new and innovative technique to induce MIH by using a dental flossing cachet in Wistar rats.