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We present a reproducible technique to assess motor recovery after nerve injury via neuromuscular junction (NMJ) immunostaining and electrodiagnostic testing.
Golden retriever muscular dystrophy (GRMD) is a spontaneous X-linked canine model of Duchenne muscular dystrophy (DMD) that resembles the human condition. Muscle percentage index (MPI) is proposed as an imaging biomarker of disease severity in GRMD.
The objective of this study is to assess the efficacy of local FK506 delivery to improve outcomes in the setting of nerve transection injury.
This study assesses the burden, distribution and evolution of muscle inflammation and damage on magnetic resonance imaging (MRI) amongst subtypes of idiopathic inflammatory myopathy (IIM).
Our pilot study tested the feasibility and performance of an eye-controlled power wheelchair for amyotrophic lateral sclerosis (ALS) patients.
Neuro-enhancing therapies are desired, as repair of nerve injuries can fail to achieve recovery. We compared two neuro-enhancing therapies, electrical stimulation (ES) and systemic tacrolimus (FK506), for their capabilities to enhance regeneration in the context of a rat model.
Poor recovery following nerve repair is due to progressive temporal loss of muscle function. Follistatin, a glycoprotein with anabolic properties, may enhance muscle recovery following reinnervation.
Recent investigations have questioned the role of hydration and electrolytes in cramp susceptibility and thus the efficacy of consuming electrolyte-rich beverages (EB) to control/prevent cramping.
Neuromuscular ultrasound has become an essential tool in the diagnostic evaluation of various neuromuscular disorders, and as such, there is growing interest in neuromuscular ultrasound training. Effective training is critical in mastering this modality. Our aim was to develop consensus-based guidelines for neuromuscular ultrasound training courses. A total of 18 experts participated. Expert opinion was sought through the Delphi method using 4 consecutive electronic surveys. A high degree of consensus was a...
The sarcolemmal resting membrane potential (RMP) affects muscle excitability, contractility and force generation. There is however limited in vivo data on the normal RMP of the human sarcolemma between muscles. We hypothesize that the in vivo RMP may differ between human muscles with different physiological roles.
The aim of this study was to determine compound muscle action potential (CMAP) scan parameters and MScanFit motor unit number estimation (MUNE) in patients with amyotrophic lateral sclerosis (ALS) and to compare the results of the abductor pollicis brevis (APB) to the abductor digiti minimi (ADM).
An absent H-reflex, the electrophysiological equivalent of the Achilles reflex, is assumed to be one of the first detectable signs of polyneuropathy (PNP). This study compares the H- and Achilles reflexes in patients with suspected PNP to evaluate the diagnostic utility of the H-reflex.
Reliable measurement of functional recovery is critical in translational peripheral nerve regeneration research. Behavioral functional assessments such as volitional grip strength testing (vGST) are limited by inherent behavioral variability. Isometric tetanic force testing (ITFT) is highly reliable but precludes serial measurements. Combining elements of vGST and ITFT, stimulated grip strength testing (sGST) involves percutaneous median nerve stimulation to elicit maximal tetanic contraction of digital fle...
Muscle herniation is a muscle protrusion through a fascial defect. It is a rarely reported cause of nerve entrapment.
Dysferlin loss-of-function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin-like growth factor 1 (IGF-1) could provide benefit, but may cause strength loss or be ineffective. This study's goal was to determine if locally increased IGF-1 promoted functional muscle hypertrophy in dysferlin-null mice.
Muscle fiber denervation increases with age and yet studies at the tissue level are sparse, due to the challenging nature of establishing the relative role of regeneration and denervation.
Limb-girdle muscular dystrophy (LGMD) consists of over 30 genetic conditions with varying clinical phenotypes primarily affecting pelvic girdle, shoulder girdle, and other proximal limb muscles. Studies focusing on the physical, mental, and social effects of this disease from the patient's perspective are limited.
The prevalence and impact of symptoms affecting individuals with pediatric forms of myotonic dystrophy type-1 (DM1) are not well understood.
Statins have been linked to myasthenia gravis (MG) in recent case reports. However, MG is not currently listed as an adverse drug reaction (ADR) in the summary of product characteristics.
Ambulatory individuals with spinal muscular atrophy (SMA) experience muscle weakness, gait impairments and fatigue that affect their walking ability. Improvements have been observed in motor function in children treated with nusinersen but its impact on fatigue has not been studied.
Suprascapular neuropathy (SSN) is rare, with an estimated prevalence of 4.3% in patients with shoulder pain.