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PubMed Journal Database | Photodiagnosis and photodynamic therapy RSS

11:10 EST 6th December 2019 | BioPortfolio

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Showing PubMed Articles 1–25 of 435 from Photodiagnosis and photodynamic therapy

Comparison of efficacy, adverse effects and costs between 20% ALA-PDT and 10% ALA-PDT for the treatment of actinic keratosis in Chinese patients.

5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) is a reliable treatment for actinic keratosis (AK), and the concentration of ALA for this treatment is 20% in most studies, but it was found that 10% ALA could achieve similar outcome during clinical practice while reducing the costs. However, there are limited reports comparing the efficacy and the safety of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) with different ALA doses.

Repeated application of adjunctive photodynamic and antibiotic therapy as an adjunct to root surface debridement in patients with grade C and stage III or IV aggressive periodontitis.

To evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) and antimicrobial therapy on clinical and immunological outcomes of periodontal treatment in patients with periodontitis grade C and stage III or IV.

Clinical Effectiveness Of Indocyanine Green Mediated Antimicrobial Photodynamic Therapy As An Adjunct To Scaling Root Planning In Treatment Of Chronic Periodontitis- A Randomized Controlled Clinical Trial.

Antimicrobial photodynamic therapy (aPDT) along with scaling and root planing has been studied for treatment of periodontitis. Various photosensitizers have been utilized for the same. The present study was conducted to assess the clinical efficacy of indocyanine green (ICG), a photosensitizer with better tissue absorption and low toxicity, as an aPDT adjuvant to scaling and root planing (SRP).

Performance of ICDAS II and fluorescence methods on detection of occlusal caries-An ex vivo study.

The aim of the ex vivo study was to compare the performance of the visual ICDAS II scale and two fluorescence methods (DIAGNOdent Pen and VistaCam iX) in detecting occlusal caries lesions in permanent teeth using cone beam computed tomography (CBCT) as a reference test.

Acetophenone substituted phthalocyanines and their graphene quantum dots conjugates as photosensitizers for photodynamic antimicrobial chemotherapy against Staphylococcus aureus.

This work reports on the synthesis and characterization of novel acetophenone substituted phthalocyanines along with the self-assembled nanoconjugates formed via π-π stacking interaction between the synthesized unmetalated (2), zinc (3) and indium (4) phthalocyanines and graphene quantum dots (GQDs) to form 2@GQDs, 3@GQDs and 4@GQDs. The complexes and conjugates exhibited high singlet oxygen ranging from 0.20 to 0.79 in DMSO for Pcs alone and for the nanoconjugates where in all cases, the indium complexes...

Clinical efficacy of photodynamic therapy in the treatment of necrotizing ulcerative periodontitis among HIV seropositive patients: A randomized controlled clinical trial.

To evaluate clinical periodontal and microbiological parameters after the treatment with adjunctive antimicrobial photodynamic therapy (APDT) among HIV seropositive and seronegative patients with necrotizing ulcerative periodontitis (NUP).

Low-level PDT treatment modulated photoaging mediated by UVA irradiation through regulating Bach2.

To investigate low-level ALA-PDT (Aminolevulinic acid photodynamic therapy) effects on photorejuvenation in vitro and in vivo, exploring the basic mechanism of Bach2 involved in PDT treatment in photoaging.

Choriocapillary vascular density in central serous chorioretinopathy complicated by choroidal neovascularization.

To evaluate choriocapillary vascular density (CVD) in eyes with central serous chorioretinopathy (CSC) complicated by choroidal neovascularization (CNV), at baseline and after intravitreal injections (IVR) of Ranibizumab, using optical coherence tomography angiography (OCTA).

Enhanced radiosensitivity of LNCaP prostate cancer cell line by gold-photoactive nanoparticles modified with folic acid.

Conventional cancer treatment methods suffer from many limitations such as non-specificity in discrimination between healthy and cancer cells. The aim of this study was to investigate the role of polymeric gold-photoactive nanoparticles (PGPNPs) conjugated with folic acid (FA) as theranostic nanoparticles for active targeting, real-time fluorescence tracing and radiosensitivity inducing in LNCaP prostate cancer cells.

Use of dermograph for improvement of PpIX precursor's delivery in Photodynamic Therapy: experimental and clinical pilot studies.

Photodynamic Therapy (PDT) is an alternative treatment for non-melanoma skin cancer. One of the main challenges of topical PDT is to increase the precursor penetration when applied on the lesion. Protoporphyrin IX (PpIX) is an endogenous photosensitizer (PS) widely used, obtained by the administration of precursors such as aminolevulinic acid and methyl aminolevulinate. Aiming for the technique improvement by providing greater PS penetration in skin lesions, we tested a new approach for drug delivery with a...

Photodynamic therapy inhibits cell growth and enhances the histone deacetylase-mediated viability impairment in Cryptococcus spp. in vitro.

Cryptococcosis is a disseminated infection caused mainly by C. neoformans and C. gattii. Limitations for the treatment involve the selection of isolates resistant to conventional antifungal drugs, prolonged treatment time and drugs side effects. This study evaluated the combined effect of histone deacetylase inhibitors (HDACi) and photodynamic therapy (PDT) on the growth of C. neoformans and C. gattii in vitro. Results showed that PDT inhibited yeasts proliferation and enhanced the HDACi-mediated cell viabi...

Desmoplastic neurotropic melanoma of the buccal sulcus invading the inferior alveolar nerve subjected to interstitial photodynamic therapy.

Detection of hemophilia by fluorescence spectroscopy: A photodiagnosis approach.

Hemophilia (HP), the deficiency of clotting factors such as VIII (FVIII) and IX, is an inherited blood disorder which is due to the lack of clotting protein. Conventional techniques for detecting hemophilia are based on clotting factor tests such as hemostasis assays to determine various types of hemophilia and its severity. In the current study, we propose a new approach involving a spectral technique to discriminate normal controls from hemophilia patients with an accuracy above 80%. This accuracy is calc...

Investigating the mechanisms behind extensive cell death in human cancer cells following nanoparticle assisted photo-thermo-radiotherapy.

We have recently reported the synthesis and characterization of gold-coated iron oxide nanoparticle and demonstrated such a nanoparticle (Au@FeO NP) was able to significantly enhance the lethal effects of photo-thermo-radiotherapy. The purpose of this study was to determine the mechanisms behind such an enhancement by investigating the changes induced in cancer cell viability, proliferation, and morphology as well as monitoring the alteration of some genes which play important role in the process of cell de...

The Combination of Photodynamic Therapy and Fractional CO2 Laser for Oral Leukoplakia: Case Series.

Oral leukoplakia (OL), a predominantly white change to the oral mucosa, is the most common potentially malignant lesion. Elimination of this condition, especially the high risk OL, is advisable, even necessary as an attempt to avoid malignant transformation. Here we presented three cases of OL successfully treated by photodynamic therapy (PDT) following pretreatment with CO laser. After a series of one to three sessions the patients were monitored for 12 months. All the lesions showed completed remission, b...

Energy analysis of PDT using thermography during the treatment of basal cell carcinoma.

The changes in tissue temperature of basal cell carcinoma lesions were investigated during photodynamic therapy in order to better understand the effects and mechanisms of PDT in tissue. In this study, the monitoring of 40 lesions of basal cell carcinoma was performed during photodynamic therapy. The lesion region becomes thermally evident throughout the procedure, and there is an improved contrast of the lesion edges after the end of the irradiation. The comparison between thermal and fluorescence images s...

"Efficacy of photodynamic therapy on the treatment of herpes labialis: a systematic review".

Therefore, we conducted a systematic review to evaluate the efficacy of PDT in the management of RHL.

The role of ABCG2 in modulating responses to anti-cancer photodynamic therapy.

The ATP-binding cassette (ABC) superfamily G member 2 (ABCG2) transmembrane protein transporter is known for conferring resistance to treatment in cancers. Photodynamic therapy (PDT) is a promising anti-cancer method involving the use of light-activated photosensitisers to precisely induce oxidative stress and cell death in cancers. ABCG2 can efflux photosensitisers from out of cells, reducing the capacity of PDT and limiting the efficacy of treatment. Many studies have attempted to elucidate the relationsh...

Antimicrobial action of photoactivated C-Phycocyanin against Enterococcus faecalis biofilms: Attenuation of quorum-sensing system.

The limitations of conventional chemo-mechanic therapy in endodontic have given rise to introduce and develop photoactivated disinfection (PAD) as an adjunctive treatment. The objective of this ex vivo study was to evaluate the effects of PAD using C-Phycocyanin, as a natural photosensitizer, on biological activities and expression of quorum-sensing system gene fsrB of Enterococcus faecalis.

Multimodal imaging of a choroidal granuloma as a first sign of tuberculosis.

Choroidal granuloma is rarely seen as the first sign of tuberculosis(TB). Here we report a case of a 34-year old male with a choroidal mass which was associated with serous retinal detachment on EDI-OCT and the "contact sign" between the neurosensory retina and the retinal pigment epithelium. We analysed the macular microvascular features of tuberculoma with Optical Coherence Tomography Angiography(OCTA). After 3 months of antituberculosis treatment, we observed the shrinkage of granuloma with permanent cha...

Significance of in vitro photodynamic cytodiagnosis using 5-aminolevulinic acid in solid pancreatic tumors extracted by endoscopic ultrasound-guided fine-needle aspiration.

Recently, photodynamic diagnosis using 5-aminolevulinic acid (5-ALA) has gained attention for the diagnosis of neoplastic diseases. In the present study, anin vitro method of photodynamic cytodiagnosis (PDCD) performed using the reagent 5-ALA in the cytodiagnosis of solid pancreatic tumors was developed. Here, we assess the accuracy of PDCD for malignancy.

Photodynamic therapy for atherosclerosis. The potential of Indocyanine Green.

The aim of this article is to summarize and review the use of photodynamic therapy for the treatment of atherosclerotic plaque and the prevention of intimal hyperplasia. Different photosensitizers are discussed and more specifically the role of indocyanine green as a potential photosensitizer.

A case report of Ramsay Hunt syndrome in a patient with HIV treated by dual-wavelength photodynamic therapy.

In this paper we report on the application of the dual-wavelength photodynamic therapy with chlorin-based photosensitizer for treatment of Ramsay Hunt syndrome in a patient with HIV. Traditional treatment approach (combination of acyclovir and a glucocorticosteroid) failed to provide a significant outcome, while photodynamic therapy resulted in fast positive dynamics. No recurrence was observed in a 5-month-long follow-up.

Antibacterial Photodynamic Therapy Mediated by 5-aminolevulinic acid on methicillin-resistant Staphylococcus aureus.

In recent years, the emergence of drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), has brought great difficulties to clinical treatment. Antibacterial photodynamic therapy (aPDT) is a new non-antibiotic treatment strategy for a variety of drug-resistant bacteria. However, there are few studies on the antimicrobial mechanism of aPDT mediated by 5-aminolevulinic acid (ALA-PDT) for MRSA. In this study, we observed the bactericidal effect of ALA-PDT on MRSA. We found that ALA...

Newly formulated 5% 5-aminolevulinic acid phototherapy on Candida albicans.

A large number of systemic diseases can be linked to oral candida pathogenicity. Virtually as the fungal infections, the global trend of invasive candidiasis has increased progressively of late. This tendency is often accentuated by increasing Candida albicans resistance to the most common antifungal medications. Photodynamic therapy (PT) is a promising alternative therapeutic approach for oral microbial infections. A new formulation of 5-aminolevulinic acid (5%ALA) in a thermosetting gel (t) (5%ALA-PTt) wa...


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