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The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books.
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To examine the association between social isolation, change in the severity of depression, and subsequent recurrence of peptic ulcer disease (PUD) in older adults with mild cognitive impairment (MCI).
Results from twin studies examining the genetic overlap between type 2 diabetes and depression are currently inconclusive. This question has not been addressed in non-western populations. We aimed to examine whether there are common genetic factors between type 2 diabetes and depression in a Sri-Lankan population, using genetic model-fitting analysis.
Emerging evidence suggests that handgrip strength (a proxy for muscular fitness) is associated with better cognitive performance in people with major depressive disorder (MDD). The underlying processes are unclear, although hippocampal volume (HCV) reductions and white matter hyperintensities (WMHs) have been implicated. Therefore, we investigated the associations between handgrip strength and various brain region volumes and WMHs in MDD and healthy controls (HCs).
Losing a spouse is a distressing life event that can negatively impact both mental and physical health. Stress-induced health consequences often include increased risk for cardiovascular disease (CVD) and altered immune system functioning marked by increased inflammation. Here, we sought to identify individual difference factors that co-vary with problematic inflammatory outcomes.
Post-traumatic stress disorder (PTSD) and lower respiratory symptoms (LRS) often co-exist among survivors of the September 11, 2001 (9/11) World Trade Center (WTC) attacks. Research in police and nontraditional responders suggests PTSD mediates the relationship between 9/11 physical exposures and LRS, but not vice versa. We replicated these findings in WTC rescue/recovery workers (R/R workers), extended them to exposed community members, and explored the interplay between both physical and psychological 9/1...
Hospital readmission following acute coronary syndrome (ACS) is associated with worsened patient outcomes and financial burden. Short sleep duration is a risk factor for cardiovascular events, and may therefore represent a behavioral factor that increases risk of adverse post-hospitalization outcomes. This study examined whether short sleep duration in the month after hospital evaluation for ACS is associated with 6-month all-cause emergency department (ED) and hospital readmission.
To examine the association between racial discrimination and allostatic load (AL), and whether this association was moderated by cultural continuity among Indigenous adults.
Evidence exists that placebo effects may influence hormone secretion. However, only few studies examined placebo effects in the endocrine system, including oxytocin placebo effects. We studied whether it is possible to trigger oxytocin placebo effects using a classical conditioning paradigm.
Acute pain has an evolutionary role for the detection of and response to physical harm. In some cases, however, acute pain can impair function and lead to other morbidities. Chronic pain, meanwhile, can present as a psychopathological condition that significantly interferes with daily living. Most basic and translational pain research has focused on the molecular and cellular mechanisms in the spinal and peripheral nervous systems. In contrast, the brain plays a key role in the affective manifestation and c...
Positive mood has been associated with enhanced immune function. Interventions that improve mood could, therefore, provide a mechanism for optimising immune related health outcomes. Brief interventions that improve mood, also known as mood inductions, potentially offer a pragmatic approach to enhancing immune function for suor surgery). This review sought to systematically examine the evidence regarding the effects of brief, single-session positive mood interventions on immunity.
Personality traits have been associated with an increased risk of cardiovascular disease (CVD) mortality as well as lifestyle-related cardiovascular risk factors. However, the mediating effects of lifestyle behaviors in the association between personality factors and CVD mortality remain insufficiently understood. The aim of the present study was to examine the mediating effect of lifestyle behaviors on the association between personality traits and CVD mortality.
Few studies have investigated associations between alexithymia and physiological mechanisms in psychosomatic diseases. We examined associations between alexithymia and 1) perception and brain processing of visceral stimulation and 2) the endocrine responses to corticotrophin-releasing hormone (CRH) in healthy individuals and patients with irritable bowel syndrome (IBS).
Social relationships can both influence and be influenced by immune processes. Past work implicates two distinct pathways along which this interaction may occur: inflammatory processes and antiviral processes. This article reviews how social behavior is modulated by these two immune processes and how such processes may in turn regulate social behavior.
Allergic rhinitis symptoms can be reduced by behaviorally conditioning antihistamine. It is unclear whether these findings extend to histamine-induced itch, or work when participants are informed about the conditioning procedure (open-label conditioning). The current study aims to investigate the efficacy of (open-label) antipruritic behavioral conditioning for histamine-induced itch.
Neuroticism is associated with poor health outcomes, but its contribution to the accumulation of health deficits in old age, i.e. the frailty index, is largely unknown. We aimed to explore associations between neuroticism and frailty cross-sectionally and longitudinally, and to investigate the contribution of shared genetic influences.
Exposure to high levels of fine particle air pollution (PM2.5) is associated with adolescent pathophysiology. It is unclear, however, if PM2.5 is associated with physiology within psychosocial contexts, such as social stress, and whether some adolescents are particularly vulnerable to PM2.5-related adverse effects. This study examined the association between PM2.5 and autonomic reactivity to social stress in adolescents and tested whether symptoms of anxiety and depression moderated this association.
Sleep disruption contributes to the pathophysiology of mental disorders, particularly bipolar illness, but the biobehavioral mechanisms of this relationship are insufficiently understood. This study evaluated sleep duration, timing, and variability as prospective predictors of parasympathetic nervous system activity during rest and social stress in adolescents with bipolar disorder, reflecting sleep-related interference in stress regulatory systems that may confer vulnerability to mood episodes.
Social role-related stress and social role-related reward as related to subsequent subclinical cardiovascular disease in a longitudinal study of mid-life women: The Study of Women's Health Across the Nation.
The purpose of this study was to determine if mid-life social role quality, defined by the stress and rewards associated with four social roles, is related to later-life subclinical cardiovascular disease (SCVD) in a cohort of women transitioning through menopause.
Mindfulness-based interventions (MBIs) target novel pain relief mechanisms not captured by legacy pain scales, including 1) cultivating awareness of pleasant and neutral sensations proximal to unpleasant sensations and 2) interoceptively mapping sensation locations and spatial distributions.
Using an integrative view of psychology, neuroscience, immunology and psychophysiology, the present review of literature curates the findings that have had an impact on the field of bereavement research, and shaped its development.
Individual studies have reported conflicting effects of selective serotonin reuptake inhibitors (SSRIs) on glycaemia. We systematically reviewed the effects of SSRIs on glycemia and whether metabolic and psychological factors moderated these effects.