Track topics on Twitter Track topics that are important to you
The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and books.
BioPortfolio aims to cross reference relevant information on published papers, clinical trials and news associated with selected topics - speciality.
For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.
We read with interest the recently published paper by Pandeya et al. , which assessed the association between aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) and incident keratinocyte cancers (KC) in a cohort study and reported a weak and inconsistent association between aspirin and NSAID use and KC. However, this study design and especially exposure definition, i.e. extent of aspirin and NSAID use, may have led to misclassification of exposure, and thereby to biased results. This article is pro...
The p.V600E mutation in the BRAF gene (BRAF ) is the most frequent mutation in cutaneous melanoma and is a recurrent alteration found in common benign naevi. The analysis of cell-free BRAF mutation (cfBRAF ) in plasma has emerged as a biomarker for monitoring prognosis and treatment response in melanoma patients.
Secukinumab is a fully human monoclonal antibody that selectively binds to and neutralises interleukin-17A.
Thank you for the opportunity to respond to the letter from Abtahi and colleagues on our recent paper describing the association between Aspirin and non-steroidal anti-inflammatory drug use and keratinocyte cancer (KC). It allows us to clarify several important points. Firstly, we reiterate that we assessed cross-sectional exposure prevalence of aspirin and NSAID use at study baseline (within 1 year prior) and our results should be interpreted in that context. This article is protected by copyright. All r...
Since psoriasis is associated with substantial impairment in health-related quality of life (HRQoL), this outcome has become an important endpoint in clinical trials and indicator of disease severity in clinical practice. HRQoL can be measured using either generic instruments, such as the EuroQol 5-Dimension 3-Level (EQ-5D-3L), or dermatology-specific HRQoL instruments, such as the Dermatology Life Quality Index (DLQI). While generic HRQoL instruments are typically more extensively validated and allow for c...
Identifying idiopathic inflammatory myopathies (IIM), including dermatomyositis (DM), clinically amyopathic dermatomyositis (CADM), and polymyositis (PM), remains clinically challenging. Testing for myositis-associated (MAA) and myositis-specific (MSA) autoantibodies is an increasingly important tool to aid in IIM diagnosis and phenotyping. This article is protected by copyright. All rights reserved.
Alopecia areata (AA) and alopecia totalis/alopecia universalis (AT/AU) manifest as chronic patchy hair loss. AA is characterized by distinct round patches of hair in the body. AT affects the whole scalp, and AU the whole body. In the early 1970s, the incidence of AA was around 2 per 1,000 persons in a US. The cumulative lifetime incidence of AA since the 1990s has been around 2.1%. The incidence of AA varies geographically and among ethnicities, but most studies of the incidence of AA were conducted in the ...
Xeroderma pigmentosum (XP) is an autosomal recessive disorder of nucleotide excision repair, characterized by hypersensitivity to ultraviolet light (UV) radiation. In individuals with XP, the incidence of non-melanoma skin cancers prior to the age of 20 years is approximately 10,000 times that seen in the general population. The most common cause of death in this patient population is skin cancer, including metastatic melanoma and metastatic cutaneous squamous cell carcinoma (cSCC). Sun avoidance is the mai...
Dermatophytes are unique keratinophilic filamentous fungi that can obtain nutrients from keratinized material. They usually cause benign superficial infections limited to keratin-rich tissues, whereas are occasionally responsible for deep infections. Studies have shown that Caspase recruitment domain protein 9 (CARD9) deficiency predisposes individuals to severe dermatophytosis caused by species belonging to the genus Trichophyton. Here, we report a patient with deep dermatophytosis caused by a relatively u...
Hidradenitis Suppurativa (HS) can negatively impact on patients' quality of life (QoL) and is associated with a higher risk of depression, as well as difficulties in employment and relationships OBJECTIVES: This study sought to evaluate the lived experience of psychological distress in hidradenitis suppurativa (HS).
Sentinel lymph node biopsy (SLNB) is usually performed using a triple technique that includes lymphoscintigraphy (LSG), which involves the injection of a radiolabelled tracer, blue dye injection, and a detection radioisotope with a gamma probe. However, blue dye injection may cause pathologic misinterpretation and obscure clinical margins, especially when combined with Mohs micrographic surgery (MMS) for cutaneous melanoma.
Ipilimumab does carry a survival advantage in the adjuvant setting but was considered too toxic for routine use. Other adjuvant studies have demonstrated benefits in terms of recurrence-free survival, but are not yet sufficiently mature to demonstrate an advantage in terms of overall survival. As the editorial contends, it is likely that disease-free survival will be followed by an improvement in overall survival, particularly as nivolumab is already known to be more effective than ipilimumab in the adjuvan...
Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non-neoplastic dermatoses): an expert consensus on behalf of the International Dermoscopy Society.
Over the last few years, several articles on dermoscopy of non-neoplastic dermatoses have been published, yet there is poor consistency in the terminology among different studies.
Immune checkpoint inhibitors (ICIs) are now the standard of care in the treatment of several cancer types. Cutaneous immune-related adverse events (irAEs) are usually of low grade and reversible, while endocrine irAEs are generally irreversible and managed with hormone replacement therapy. We report a 47-year-old patient treated with the anti-programmed cell death 1 (anti-PD1) antibody pembrolizumab for a metastatic melanoma who developed severe lipodystrophy after 10 months of treatment, characterized by t...
Basket-weave structure in the stratum corneum is an important factor for maintaining physiological properties of human skin as studied using reconstructed human epidermis and tape-stripping of human cheek skin.
The normal stratum corneum (SC) has two layers, an upper basket-weave (B-W) pattern layer and a lower compact layer when examined by hematoxylin/eosin microscopy. It is known that the transition from the compact layer to the B-W SC is well associated with the transition from diffuse to peripheral distributions of corneodesmosomes (CDs), i.e., digestion of CDs. However, the functional meaning of this maturation is not yet clear, although the loss of this transition from compact SC to B-W SC appears to cause ...
We would like to present an update reporting the successful management of a patient previously described, who presented with severe oral mucosal abnormalities following long-term vemurafenib therapy. A 74-year old male commenced vemurafenib therapy for BRAF mutant-positive metastatic melanoma in March 2012. Within six months, he developed four cutaneous squamous cell carcinomas. This article is protected by copyright. All rights reserved.
Chi et al. (Am J Clin Dermatol; 31(5): 798-807) and Singh et al (J Am Acad Dermatol; 77(3): 425-440.e2) each conducted a systematic review and meta-analysis of observational studies examining the relationship between suicidality and psoriasis.
Despite the recent update to the AJCC staging criteria for melanoma, this system is still unable to identify truly high-risk stage I tumour subsets.
Sebaceous glands (SGs) are appendages of mammalian skin that produce a mixture of lipids known as sebum. Acne vulgaris is an exceptionally common skin condition, characterized by elevated sebum production, altered sebum composition, and the formation of infundibular cysts, called comedones. Comedo-associated SGs are atrophic, suggesting that comedo formation involves abnormal differentiation of progenitor cells that generate the SG and infundibulum: the 'comedo switch'. Understanding the biological processe...
Commensal bacteria are a major factor in human health and disease pathogenesis. Interest has recently expanded beyond the gastrointestinal microflora to include the skin microbiome and its impact on various skin diseases.
Hidradenitis suppurativa (HS) is associated with bacterial colonization, skin-barrier disruption, immune dysregulation, and treatments that can increase infection risk.
Mycosis fungoides (MF) and Sézary Syndrome (SS) are the most common cutaneous T-cell lymphomas. MF/SS is accompanied by considerable morbidity from pain, itching and disfigurement.
Validated scoring measures in morphea can facilitate clinical trials.
The European League Against Rheumatism / American College of Rheumatology (EULAR / ACR) classification criteria for inflammatory myopathies are able to classify patients with skin-predominant dermatomyositis (DM). However, approximately 25% of patients with skin-predominant DM do not meet 2 out of the 3 hallmark skin signs and fail to meet the criteria.
Itch is one of the cardinal symptoms of polymorphic light eruption (PLE), the most common form of photodermatosis known to be mediated immunologically. Indeed, very often itch precedes the skin lesions of the condition or may be even the only symptom in PLE, which sometimes is aggravated to a burning sensation. There have been reports of a variant called PLE sine eruption, with intense pruritus on the sun-exposed parts without any visible skin changes. This article is protected by copyright. All rights res...