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For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.
Natural killer T (NKT) cells express a T cell receptor that recognises endogenous and environmental glycolipid antigens. Several subsets of NKT cells have been identified, including IFNγ-producing NKT1 cells, IL-4-producing NKT2 cells and IL-17-producing NKT17 cells. However, little is known about the factors that regulate their differentiation and respective functions within the immune system.
Three-week, short-course of adjuvant-free hydrolysates of Lolium perenne peptide (LPP) immunotherapy for rhinoconjunctivitis with/without asthma over 4 physician visits is safe, well-tolerated and effective.
Predominantly antibody deficiencies (PAD) are the most prevalent primary immune deficiencies, but their B-cell defects and underlying genetic alterations remain largely unknown.
This study delineates the mitochondrial defects in DOCK2-deficient T cells contributing to the T cell lymphopenia characteristic of this primary immunodeficiency.
We report a kindred deficient in IRF9. The absence of this factor inactivates the interferon response and provokes a marked susceptibility to infection with both RNA and DNA viruses.
Weather and climate change are constant and ever-changing processes that impact allergy and asthma. The purpose of this report is to provide information since the last climate change review with focus on asthmatic disease. PubMed and internet searches for topics included climate and weather change, air pollution, particulate, greenhouse gasses, traffic, insect habitat, and mitigation, in addition to references contributed by the individual authors. Changes in patterns of outdoor aeroallergens due to increas...
We identified a strong association between peanut allergy and the MALT1 locus in LEAP participants in the peanut avoidance group with 58.6% of carriers developing peanut allergy at 60 months as compared to 12.7% of non-carriers.
Fevipiprant is a potent inhibitor of PGD-mediated ILC2 activation. The findings support further development as a therapeutic intervention for asthma.
We explored gene expression profile of circulating helper-like innate lymphoid cells (ILC). In addition to identifying novel gene signatures, we discovered abnormal T cell receptor expression in ILC, suggesting a link between these cell types.
FCHO1 deficiency is a novel autosomal recessive combined immune deficiency with impaired clathrin-mediated endocytosis.
We demonstrate that blocking the mevalonate pathway and protein prenylation in human monocytes leads to enhanced activity of an NLRP3-dependent, but not Pyrin-dependent, inflammasome, suggesting a prominent role for NLRP3 in the pathogenesis of mevalonate kinase deficiency.
The function of follicular regulatory T (Tfr) cells, especially in regulating IgE production in allergic diseases, is poorly understood.
This mouse study demonstrates that repetitive inhalation of a single major house dust mite (HDM) allergen prevents HDM-induced allergic asthma development through suppressing the function of lung dendritic cells, thus providing an alternative to classical allergen-specific immunotherapy.
Aggressive mature B-cell LPD can occur in WAS as in XLT pediatric and adult patients. Immunochemotherapy is applicable to all WAS/XLT patients, while transplantation still remains controversial for adult patients.
Methanogenic archaea are a key part of the gut microbiota alongside bacteria. However there is comparatively little research on the role of archaea in health.
Humoral immune defects are described in 9 patients from 5 families with STK4 deficiency. A mouse model carrying the novel p.Y88del show that these defects are intrinsic to the B cells.
Vancomycin is a prevalent cause of the severe hypersensitivity syndrome drug reaction with eosinophilia and systemic symptoms (DRESS) which leads to significant morbidity and mortality and commonly occurs in the setting of combination antibiotic therapy which impacts future treatment choices. Variations in human leukocyte antigen (HLA) class I in particular have been associated with serious T-cell mediated adverse drug reactions which has led to preventive screening strategies for some drugs.
Several treatment options for cold urticaria (ColdU) have been studied and reported, but systematic reviews and meta-analyses are limited.
Mast cells, best known for their detrimental role in allergic diseases, act in a diverse array of physiological and pathological functions, made possible by the plurality of mast cell types. Their various developmental avenues and their distinct sensitivity to (micro-) environmental conditions convey extensive heterogeneity, resulting in diverse functions. We briefly summarize this heterogeneity, elaborate on molecular determinants that allow mast cells to communicate with their environment to fulfill their...
Monogenic interferonopathies are thought to be mediated by type I interferon (IFN). For example, a gain-of-function mutation in STING (STING N153S) up-regulates type I IFN-stimulated genes (ISGs) and causes perivascular inflammatory lung disease in mice. The equivalent mutation in humans also causes lung disease, which is thought to require signaling through the cGAS-STING pathway and subsequent activation of IFN regulatory factors (IRF) 3/7, type I IFN, and ISGs.
We report the natural history, clinical manifestations, genetics, and immunohematological findings in 14 patients from 11 families with ARPC1B deficiency, delineating the spectrum of the disease that appears progressive and challenging to manage clinically.
Nasal epithelial transcriptome is altered by the season. Birch pollen allergen immunotherapy recovers microbial community diversity and alters expression of allergy related genes.