PubMed Journal Database | Therapeutic delivery RSS

09:21 EDT 27th May 2019 | BioPortfolio

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Showing PubMed Articles, all 17 from Therapeutic delivery


An industry update: the latest developments in therapeutic delivery covering September 2018.

The present industry update covers the period 1-30 September 2018, with information sourced from company press releases, regulatory and patent agencies as well as scientific literature. Various technologies using reformulations of know drugs with nanoparticles, hydrogels, aerosols, etc. emerged in new financing rounds (BioTime; CA, USA, SiSaf; Guildford, UK, Cassion Biotech; TX, USA), intellectual property protection (TFF Pharmaceuticals; TX, USA), repackaging (Leiters; CA, USA) and reformulation (Virpax Ph...

α-fetoprotein-binding toxins and teratogens against cancer.

A novel method for conjugating the terminal amine of peptide ligands to cholesterol: synthesis iRGD-cholesterol.

Conventional conjugation reactions often involve the use of activated PEG as a linker, but concerns about PEG-mediated reduction in intracellular delivery and enhanced immunogenicity have generated interest in developing methods that eliminate the need for a PEG linker.

Exosomes: fighting cancer with cancer.

Exosomes are nanovesicles secreted by many cells, including cancer cells. Extensive research has been carried out to validate potential applications of exosomes and to evaluate their efficiency in a wide range of diseases, including cancer. The current knowledge on the origin, biogenesis and composition of exosomes is described. This review then focuses on the use of exosomes in cancer diagnostics and therapeutics.

Mefenamic acid-loaded solid SMEDDS: an innovative aspect for dose reduction and improved pharmacodynamic profile.

The current investigation is focused on solid self-microemulsifying drug-delivery systems (S-SMEDDS) of mefenamic acid (MFA) for improving pharmacodynamic activity. Methodology & results: Solubility assessment in various lipid excipients and optimization of pseudoternary plots were carried out for development of liquid SMEDDS. The optimized liquid SMEDD formulation was spray dried to solid dosage form and observed with enhanced amorphization or molecular dispersion of MFA in S-SMEDDS, as evident from x-ray ...

Understanding the basis of transcutaneous vaccine delivery.

Under many circumstances, prophylactic immunizations are considered as the only possible strategy to control infectious diseases. Considerable efforts are typically invested in immunogen selection but, erroneously, the route of administration is not usually a major concern despite the fact that it can strongly influence efficacy. The skin is now considered a key component of the lymphatic system with tremendous potential as a target for vaccination. The purpose of this review is to present the immunological...

Bacterial nanocellulose: the future of controlled drug delivery?

Although bacterial nanocellulose (BNC), a natural nanostructured biopolymer network, offers unique material characteristics, the number of drug-loaded BNC-based carriers in clinical trials or on the market is still low. This report provides an overview of aspects still limiting the broad application of BNC as drug-delivery system and the challenges for its future applications. Continuous large-scale production, storability, the loading and controlled release of critical drugs, for example, with high molar m...

Challenges in realizing selectivity for nanoparticle biodistribution and clearance: lessons from gold nanoparticles.

The field of nanomedicine has received much attention for its potential to allow for targeted identification and treatment of tumors, while sparing healthy tissue. This promise has yet to be clinically realized; instead nanomedicine has translated into clinical benefit via formulations that improve the pharmacokinetics and toxicity profiles of toxic chemotherapeutic agents. In this perspective, we highlight that several of the defining strategies for using nanoparticles intravenously to target solid tumors ...

How can microneedles overcome challenges facing transdermal drug delivery?

Patient-centered drug delivery and its potential applications for unmet medical needs.

Pharmaceutical dosage forms address diverse key components but satisfying unmet patient needs to enhance patient adherence is a major challenge. The desired design of patient-centered drug products should be based on characteristics of various components, such as patients, disease, routes of administration, drug delivery technologies and active pharmaceutical ingredients. Understanding of targeting patients and their physiological and biological environments is pivotal for developing suitable patient-center...

Printable nanomedicines: the future of customized drug delivery?

Designing and developing suppository formulations for anti-HIV drug delivery.

Despite a long history of use for rectal and vaginal drug delivery, the current worldwide market for suppositories is limited primarily due to a lack of user acceptability. Therefore, virtually no rational pharmaceutical development of antiviral suppositories has been performed. However, suppositories offer several advantages over other antiviral dosage forms. Current suppository designs have integrated active pharmaceutical ingredients into existing formulation designs without optimization. As such, emergi...

An industry update: what is new in the field of therapeutic delivery?

Applying nanotherapeutics to improve chemoradiotherapy treatment for cancer.

Chemoradiotherapy (CRT) plays a key role in the curative treatment of many human cancers. The full utility of this paradigm is often restricted by limitations of conventional drug delivery. Nanotherapeutics have demonstrated great potential to overcome many of these issues. The potential benefits of nanotherapeutics in CRT include improved therapeutic efficacy, decreased toxicity, enhanced real-time in vivo tumor imaging, and the translation of novel small molecule drugs or nucleic acid therapies. Additiona...

Spherulites: onion-like vesicles as nanomedicines.

Spherulites are onion-like structures composed of phospholipids and excipients. Initially discovered in an academic laboratory, these autoassembled nano-objects have been developed further by the start-up Capsulis (Bordeaux, France), and commercialized for veterinary and dermatological applications. Owing to economical strategies, the development of these objects have not been pursued, however, they are very interesting systems, which should be exploited further. The autoassembly of amphiphiles followed by ...

Oral delivery of liposomes.

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