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PubMed Journal Database | Ugeskrift for laeger RSS

13:13 EDT 20th March 2019 | BioPortfolio

The US National Library of Medicine and National Institutes of Health manage PubMed.gov which comprises of more than 29 million records, papers, reports for biomedical literature, including MEDLINE, life science and medical journals, articles, reviews, reports and  books.

BioPortfolio aims to cross reference relevant information on published papers, clinical trials and news associated with selected topics - speciality.

For example view all recent relevant publications on Epigenetics and associated publications and clincial trials.

Showing PubMed Articles 1–25 of 143 from Ugeskrift for laeger

Tinnitus and hyperacusis in Danish children and adolescents.

Although prevalence studies on tinnitus and hyperacusis indicate, that these symptoms are very common in children, data vary considerably according to study design, study population and the research question posed. Only a small number are seen in specialised centres with an established tinnitus programme, suggesting that either the children are seen at general practitioners or not being referred at all, or that the incidence of troublesome tinnitus in childhood is lower, than the epidemiological data propos...

Severe reversible penile ischaemia after terlipressin treatment of hepatorenal syndrome.

This case report presents a 70-year-old man with alcoholic liver cirrhosis, who was hospitalised due to pulmonary oedema, and who developed acute renal injury. Though the criteria were not fulfilled, hepatorenal syndrome was suspected and treated with terlipressin, after which the patient developed severe penile ischaemia. Hepatorenal syndrome is one of many potential causes of acute kidney injury in patients with acute or chronic liver disease. The syndrome is an exclusion diagnosis, and other causes of li...

Laryngeal traumas in children caused by trampoline accidents.

Laryngeal trauma is rare in children due to the anatomical placement and the trauma mechanisms required for injury. Recently the trampoline has become frequent in Danish households leading to more high-energy laryngeal traumas. This case report is about two incidents occurring within a year. The first patient had a laryngeal fracture despite minimum objective findings. The second patient had a compromised airway and needed acute intubation, although she only presented with light hoarseness. We strive to und...

Health-related register-based research in Denmark.

Danish researchers have a unique possibility for producing high-quality observational studies through the Danish registers. The intention of this review is to provide an introduction to data sources, access and linkage of the Danish registers, primarily from Statistics Denmark, the Danish Health Data Authority and the Danish clinical quality databases. Authorisation to data access is given by each institution separately and requires permission by the Danish Data Protection Agency. Data can be linked by the ...

Parinaud syndrome caused by corpus pineale tumour in a 14-year-old boy.

Parinaud syndrome (PS) can manifest in a pineal tumour. Major components of PS include restriction of gazing upwards, light-near dissociation and convergence retraction nystagmus. A 14-year-old boy presented with diplopia and restricted ability to gaze upwards. The objective examination revealed signs, which were compatible with the major manifestations of PS. A magnetic resonance scan (MRI) of cerebrum indicated pinealoma, and a pathological examination identified the lesion as a germ cell carcinoma. The p...

Colonoscopy following acute diverticulitis mandatory.

According to international guidelines, patients presenting with acute diverticulitis are offered lower endoscopy to rule out colorectal cancer. This practice is based on weak evidence. Recent studies have established that the incidence of colorectal cancer after acute diverticulitis is low. In case of complicated diverticulitis, with abscess or perforation, the incidence of colorectal cancer is higher. There is, thus, a lack of evidence supporting colonoscopy by uncomplicated diverticulitis, but if a patien...

Child mortality for children under five years of age declined seven fold in Guinea-Bissau over the latest 40 years.

Observations on child mortality in Guinea-Bissau developed the idea of vaccines having non-specific effects (NSEs) not being explained by the prevention of the targeted infections. The live vaccines against measles, tuberculosis, polio and smallpox have beneficial NSEs, but the inactivated vaccines are associated with negative effects for female survival. The repeated campaigns with polio and measles vaccines have been particularly effective in reducing child mortality. Hence, stopping live vaccines after e...

Treatment of HIV, tuberculosis and malaria in Guinea-Bissau.

For 40 years, Bandim Health Project in Guinea-Bissau has been working on mapping epidemics, uncovering the impact of health interventions and trying to improve the health of the population in one of the world's poorest countries. The primary focus has been on child mortality and vaccine effects, but considerable effort has also been made in many other fields. This review describes the work with the three major infectious diseases: HIV, tuberculosis and malaria, and the most important findings are reviewed f...

Limited knowledge of the effect on child mortality of vaccinations and vitamin A supplementation.

Preventive health interventions, including the vaccination and vitamin A supplementation programmes, are implemented in low-income countries with little assessment of the real-life effects on child mortality. Nevertheless, the programmes are frequently credited with large, finite numbers of deaths prevented. Forty years of demographic surveillance in Guinea-Bissau indicates, that vaccines and vitamin A supplementation have effects beyond what can be explained by preventing the target infections and vitamin ...

Non-specific effects of vaccination in Denmark.

Studies from low-income countries show, that vaccines may have effects on overall mortality, so-called non-specific effects, which cannot be explained by the effect on the targeted infection. We investigated if vaccines have non-specific effects on infectious disease morbidity in Denmark, and we found beneficial non-specific effects of measles-mumps-rubella vaccine, which have now been confirmed in other high-income settings. Danish investment in research in low-income countries may lead to important new in...

Smoking cessation and lung cancer treatment.

Many resources have been spent to successfully improve the outcome and prognosis of lung cancer during the last decade. However, surprisingly few studies and real-life settings deal with smoking cessation as an integrated part of screening and treatment for lung cancer even though the evidence is compelling - these events offer a window of opportunity, as smokers are motivated to quit. Furthermore, the effect of smoking cessation with respect to survival, prognosis and quality of life equals the established...

Hypochondriacal paranoia is a differential diagnostic challenge.

Patients with persistent complaints about somatic symptoms, which cannot be explained by somatic disease, constitute a major healthcare problem. Hypochondriacal paranoia is an important subset of paranoid conditions, which should not be overlooked in patients with persistent hypochondriacal complaints. It is rare, in contrast to illness anxiety disorder or body dysmorphic disorder optionally with insufficient insight. Recent research indicates, that hypochondriacal complaints present a spectrum of evident p...

Post-partum ovarian vein thrombosis.

In this case report a 38-year-old woman presented with lower abdominal pain three weeks postpartum. She had been delivered by caesarean section after twin pregnancy and was given low-molecular heparin prophylaxis to be taken six weeks post caesarean. The initial clinical examination was normal. A CT scan revealed thrombosis in the right ovarian vein. Therapeutic dosage of low-molecular heparin was initiated, and the patient was further referred for thrombophilia workup. Post-partum ovarian vein thrombosis i...

Diabetes mellitus caused by cannabis oil.

The effects and side effects of medical cannabis are not well-established. In 2018, cannabis was approved as a medical drug in Denmark - giving all doctors the opportunity to subscribe medical cannabis to their patients. In this case report a 64-year-old kidney-transplanted woman started cannabis droplets due to chronic back pain, which resulted in increased appetite, weight gain and development of diabetes mellitus. Patients with an increased risk of developing diabetes may be more prone to this under the ...

Fasciola hepatica infection acquired in Denmark.

In this case report, a 64-year-old woman with symptoms of lethargy, nausea, fluctuating temperature, and weight loss was suspected of a disease of cardiological or haematological aetiology. She was diagnosed with liver fluke infection based on serological evidence, eosinophilia, relevant exposure, and clinical presentation. High-dose triclabendazole led to symptom resolution. On several occasions, she had been eating watercress from a meadow with grazing sheep. The tendency of eating raw watercress and othe...

Diagnosing and treating rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic, autoimmune joint disease associated with increased risk of multiorgan involvement and comorbidities such as osteoporosis, cardiovascular disease, and infections. Therefore, doctors in other specialities should have knowledge of RA. No diagnostic criteria are available, but the classification criteria are often used as a diagnostic tool. Early initiation of effective immunosuppressive treatment is essential to improve outcome. The cornerstone of treatment is intra-arti...

Measuring doctors competencies.

Competency-based medical education relies on the use of assessment tools, which can describe and/or measure medical competencies and are supported by validity evidence. The exploration of validity evidence ensures, that the assessment tool not only measures what is intended, but also that the interpretation and decisions made are fair and just. In this review, we have described a contemporary approach to validity used in Kane's framework. We have also used an example to illuminate, how the exploration of va...

Creativity and psychosis.

This review provides a brief overview of key historical, conceptual and empirical aspects of the link between creativity and psychosis. The genius and his or her tendency to madness constitute the historical backbone of this link, although ambiguous interpretations and substantial conceptual change characterise this mad genius hypothesis. Some empirical findings show high levels of creativity among first-degree relatives of patients with psychotic illness. For schizophrenia, this could be seen as support of...

Adverse events with oral anticoagulants.

Anticoagulant therapy is widely used for prevention and treatment of cardiovascular disease and is frequently prescribed both in primary and secondary care. In comparison to other drugs, the frequency of medication errors is high for anticoagulant therapy. In Denmark, 4,383 adverse events with vitamin K antagonists and 3,234 adverse events with non-vitamin K antagonist oral anticoagulants were reported to the Danish Patient Safety Authority in 2014-2017. In this review, we provide an overview of medication ...

Electroconvulsive therapy.

Within psychiatry, no treatment is as effective - or controversial - as electroconvulsive therapy (ECT), and ECT is the only non-pharmacological treatment in widespread clinical psychiatry. The history of ECT as a psychiatric treatment is outlined in this review, and the efficacy in four diagnostic entities is reviewed along with side effects. The evidence shows compelling effect of ECT when administered within affective disorders, delirium and psychotic states.


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