PubMed Journals Articles About "23andMe Working Drug Based Users Genetics" RSS

04:12 EDT 4th April 2020 | BioPortfolio

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Showing "23andMe Working Drug Based Users Genetics" PubMed Articles 1–25 of 44,000+

Treatment Status and Use of Psychoactive Substances in Deceased Drug Users.

Studies on drug use are limited by the study populations available, which usually only include drug users in treatment settings. Therefore, the knowledge base is limited on drug users not entering treatment for drug use disorder (DUD). Using registers from departments of forensic medicine enables research on decedents with DUD, irrespective of treatment status.

Being 'in place', being 'out of place': Problematising marginalised drug users in two cities.

Socially marginalised drug users when congregating in the public space on so-called 'open drug scenes' are often problematised, especially in post-industrial cities which increasingly are engaged in attempts to attract those that are considered to be promoters of economic activity through processes of 'beautification' and 'gentrification'. The different punitive practices that target homeless and marginalised drug users in the public space have been rendered visible in a range of influential accounts since ...

Identifying subtypes of cannabis users based on simultaneous polysubstance use.

Cannabis use patterns vary considerably, with many users reporting simultaneous and non-simultaneous use (co-use) of other substances. Despite this, little research has examined the extent to which subtypes of cannabis users may be identified based on their simultaneous and co-use behaviors.

23andMe Develops First Drug Compound Using Consumer Data.

Illegal drug use and prospective memory: A systematic review.

Illegal drug use is proposed to interfere with neurobiological functioning by damaging the neurotransmitter communication systems that are believed to be responsible for cognitive abilities, including perception, attention, and memory. This review specifically examined effects of illegal drug use on prospective memory (PM) - memory for future actions. Twenty- seven studies spanning 14 years were included in this review which were divided into two broad categories based on testing methods used: self-report a...

Next-generation drug repurposing using human genetics and network biology.

Drug repurposing has attracted increased attention, especially in the context of drug discovery rates that remain too low despite a recent wave of approvals for biological therapeutics (e.g. gene therapy). These new biological entities-based treatments have high costs that are difficult to justify for small markets that include rare diseases. Drug repurposing, involving the identification of single or combinations of existing drugs based on human genetics data and network biology approaches represents a nex...

What do HIV-positive drug users' experience tell us about their antiretroviral medications taking? An international integrated literature review.

HIV-positive drug users' poor adherence to antiretroviral regimens can pose a significant and negative impact on individual and global health. This review aims to identify knowledge gaps and inconsistencies within the current evidence base and to measure HIV-positive drug users' adherence rates and the factors that influence their adherence.

An institutional ethnography of prevention and treatment services for substance use disorders in the Dominican Republic.

The Dominican Republic is thought to have significant epidemics of illicit drug use but lacks surveillance and formal analyses of the policy context of drug prevention and treatment services. We conducted an institutional ethnography of 15 drug service organisations in Santo Domingo and Boca Chica, Dominican Republic, to explore barriers and resources for drug abuse prevention and treatment. Here, we present a typology of drug service organisations based on their services, methods, and approach. We then dra...

Study on HIV-1 genetics and drug resistance among HIV infected individuals who initiated antiretroviral therapy in Dehong Dai and Jingpo autonomous prefecture, 2017.

To understand the distribution of HIV-1 genotypes and the status of drug resistance among people living with HIV who had prepared to initiate antiretroviral therapy (ART) in Dehong Dai and Jingpo autonomous prefecture (Dehong). A total of 170 adults with HIV were recruited in Dehong from January to June 2017, before initiating ART. HIV-1 genes were amplified and used to analyze the HIV-1 genotypes and drug resistance. A total of 147 samples were successfully sequenced. Based on the phylogenetic analysis,...

Linking intravenous drug users to treatment through non-governmental organizations in Ukraine: how well is it working?

Alliance for Public Health, the International Charitable Foundation, coordinates HIV prevention in Non-Governmental Organizations (NGO) working with people who inject drugs (PWID) in Ukraine. We aimed to describe the performance of the differential model of linking PWID to HIV care and treatment (Community Initiated Treatment Intervention - CITI).

Risk of Hepatitis C Virus Infection in Injecting and Non-Injecting Drug Users Receiving Opioid Substitution Therapy.

Hepatitis C virus (HCV) is the most common viral infection among illicit drug users in the world. Although intervention of needle and syringe program and opioid substitution therapy had engaged to prevent HCV infection, the prevalence of HCV infection seem not declined. The aim of this study was to estimate risk of HCV infection in injection drug uses (IDUs) and non-injection drug users (NIDUs) receiving opioid substitution therapy.

Physician's obligations to inform about complications based on a recent warning from drug authorities.

Based on a recent warning from the drug authorities about increased suicidality among users of hormonal contraceptives, this article discusses the legal consequences of translating novel findings from clinical trials into altered contents of gaining informed consent during the medical consultation.

Estimating the size of crack cocaine users in France: Methods for an elusive population with high heterogeneity.

Despite several sources corroborating an expanding market and increased visibility and greater diversity in users' profiles, very little is known about the number of crack cocaine users in France.

The off-prescription use of modafinil: An online survey of perceived risks and benefits.

Cognitive enhancing drugs are claimed to improve cognitive functions such as learning and attention. However, little is known presently about the characteristics of off-prescription cognitive enhancing drug users or their perceived everyday experience with these drugs. As modafinil is the most commonly used off-prescription cognitive enhancing drug, the current study aimed to provide a detailed profile of modafinil users and their experiences and perceptions of this drug. To this end, an online survey, targ...

Pneumonia: host susceptibility and shared genetics with pulmonary function and other traits.

Pneumonia is a common and severe infectious lung disease. Host genetics along with underlying medical and lifestyle conditions determines pneumonia susceptibility. We performed a secondary analysis of the results of two genome-wide studies for pneumonia in 23andme participants (40600 cases/ 90039 controls) (Tian et al., 2017) and UK Biobank (BB) participants (12614 cases/ 324585 controls) (via the Global Biobank Engine) and used GTEx database to correlate the results with expression quantitative trait loci ...

Stimulant Use and Study Protocol Completion: Assessing the Ability of Men Who Have Sex with Men to Collect Dried Blood Spots for Laboratory Measurement of HIV Viral Load.

Stimulant use is associated with higher HIV viral load (VL) and sexual HIV transmission risk among men who have sex with men (MSM) living with HIV. There is little research on willingness of drug users living with HIV to fully participate in studies, especially those involving self-collection of biomarker data. This study presents findings from an at-home dried blood spot collection study measuring laboratory-quantified VL among U.S. HIV-positive MSM who reported high-risk sexual behavior and/or suboptimal ...

Self-Report Data on Regular Consumption of Illicit Drugs and HIV Risk Behaviors after Kratom ( korth.) Initiation among Illicit Drug Users in Malaysia.

This study sought to determine the relationship between kratom () initiation and regular consumption of illicit drugs and HIV risk behaviors in a cohort of illicit drug users in Malaysia. 260 illicit drug users with current kratom use were recruited through convenience sampling for this cross-sectional study. All were male, with the majority being Malays (95%, n = 246/260). Results suggest that kratom initiation was associated with significant decrease in the regular use of heroin (odds ratio (OR) = 0.50, 9...

Patterns and reasons for kratom (Mitragyna speciosa) use among current and former opioid poly-drug users.

Kratom (Mitragyna speciosa) is a native medicinal plant of Southeast Asia widely reported to be used to reduce opioid dependence and mitigate withdrawal symptoms. There is also evidence to suggest that opioid poly-drug users were using kratom to abstain from opioids.

Risk of myocardial infarction among new users of calcium supplements alone or combined with vitamin d: a population-based case-control study.

A population-based case-control study was conducted to evaluate the risk of acute myocardial infarction among new users of calcium supplements, alone (CaM) or in combination with vitamin D (CaD). A total of 23025 cases and 114851 controls randomly sampled from the underlying cohort and matched with cases by age, sex and index date were included. New users of CaM and CaD were categorized as current-, recent-, past- and non-users. We computed adjusted odds ratios (AOR) and their 95%CI among current users as c...

Persistent frequent emergency department users with chronic conditions: A population-based cohort study.

Frequent emergency department users are patients cumulating at least four visits per year. Few studies have focused on persistent frequent users, who maintain their frequent user status for multiple consecutive years. This study targets an adult population with chronic conditions, and its aims are: 1) to estimate the prevalence of persistent frequent ED use; 2) to identify factors associated with persistent frequent ED use (frequent use for three consecutive years) and compare their importance with those as...

A Latent Class Analysis of Parental Alcohol and Drug Use: Findings from the Avon Longitudinal Study of Parents and Children.

Previous measures of parental substance use have often paid limited attention to the co-occurrence of alcohol and drugs, or to the between-parent dynamics in the use of substances. These shortcomings may have important implications for our understandings of the relationship between parental substance use and child wellbeing. Using data from the Avon Longitudinal Study of Parents and Children, a UK community-based cohort study from 1990 onwards (n = 9,451), we identified groups of parental substance use us...

Hearing aid experience and background noise affect the robust relationship between working memory and speech recognition in noise.

The aim of this study was to examine how background noise and hearing aid experience affect the robust relationship between working memory and speech recognition. Matrix sentences were used to measure speech recognition in noise. Three measures of working memory were administered. Study sample: 148 participants with at least 2 years of hearing aid experience. A stronger overall correlation between working memory and speech recognition performance was found in a four-talker babble than in a stationary noise ...

Gender differences in diversion among non-medical users of prescription opioids and sedatives.

: Non-medical use of prescription drugs is a major public health concern in the United States. Prescription opioids and sedatives are among the most widely abused drugs and their combined use can be lethal. Increasingly rigid prescribing guidelines may contribute to the changing context of opioid use and increase drug diversion.: To examine gender differences in diversion of prescription opioids and sedatives among non-medical prescription opioid and sedative polysubstance users. We hypothesize that men wil...

The practitioners' perspective on the upside and downside of applying social capital concept in therapeutic settings.

Social capital, and more particularly the social networks that define its existence, is said to benefit health and well-being. In individuals recovering from alcohol and drug addiction, social capital accruing from social networks support treatment, recovery and maintenance. Therefore, the concept of social capital is important for public health practitioners working in recovery interventions. This qualitative study seeks to explore what practitioners perceive as the importance of social capital and how the...

Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users.

Cannabis is the most commonly used illicit drug in the world. However, because of a changing legal landscape and rising interest in therapeutic utility, there is an increasing trend in (long-term) use and possibly cannabis impairment. Importantly, a growing body of evidence suggests that regular cannabis users develop tolerance to the impairing, as well as the rewarding, effects of the drug. However, the neuroadaptations that may underlie cannabis tolerance remain unclear. Therefore, this double-blind, rand...

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