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4SC AG PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest 4SC AG articles that have been published worldwide.
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The accurate diagnosis of Alzheimer's disease (AD) and its early stage, e.g., mild cognitive impairment (MCI), is essential for timely treatment or possible intervention to slow down AD progression. Recent studies have demonstrated that multiple neuroimaging and biological measures contain complementary information for diagnosis and prognosis. Therefore, information fusion strategies with multi-modal neuroimaging data, such as voxel-based measures extracted from structural MRI (VBM-MRI) and fluorodeoxygluco...
We regret to inform about an error in the above-mentioned paper, i.e., the raw Raman spectrum of copper-carbon DC arc discharge product prepared with 10% of CH4 in the gas mixture of CH4/He as shown in figure 5c. This raw spectrum and its deconvoluted components are replaced. The corresponding text about Raman results is re-described. These errors do not affect the discussion or interpretation of the results. We would like to apologize for any inconvenience caused.
To conduct a proof-of-concept pilot evaluation of the self-directed format of Walk With Ease (WWE), a 6-week walking program developed for adults with arthritis, in patients with systemic lupus erythematosus (SLE).
Headaches are common in patients with systemic lupus erythematosus (SLE). It is important to identify the exact cause of headaches in SLE to avoid unnecessary steroid or immunosuppressive therapy like in neuropsychiatric SLE. A 35-year-old woman with SLE suddenly developed severe headache. Magnetic resonance angiography showed multifocal segmental narrowing of cerebral arteries, suggestive of central nervous system vasculitis. However, lack of abnormal enhancement in vessel wall imaging indicated reversible...
Cutaneous lupus erythematosus (CLE)-a common presentation of lupus erythematosus-may exist independently or as a part of the systemic manifestations of systemic lupus erythematosus. The effects of living with and treating a chronic condition such as CLE can be debilitating to a patient's health and finances. The management of patients with CLE is made particularly challenging by poor compliance, limited therapeutic options, scarcity of evidence supporting their use, and significant differences in costs of m...
In Italy medical cannabis is a prescription drug since 1998. Even though it could not be considered a therapy as such, it is indicated as a symptomatic treatment also in cancer patients, to cure iatrogenic nausea/vomiting and chronic pain.
In the UK, pharmacist independent prescribers can prescribe for any condition within their clinical competence including systemic anti-cancer therapy. Competency frameworks have been developed but contain little detail on the patient assessment skills pharmacist independent prescribers require to prescribe systemic anti-cancer therapy with concern in the literature over current training on these skills.
Recurrent or metastatic disease occurs in two-thirds of head and neck squamous cell carcinomas and it is associated with poor prognosis. Systemic treatment with platinum-based chemotherapy in combination with the epidermal growth factor receptor-targeting monoclonal antibody cetuximab represents a preferred option for these patients. Upon the achievement of tumor response by combined treatment, maintenance with single-agent cetuximab is usually administered with the aim of prolonging disease control at the ...
The optimal timing of initiating granulocyte-colony stimulating factor following chemotherapy in pediatric patients has not been clearly defined. This study aimed to compare the administration of granulocyte-colony stimulating factor on day 1 versus day 3 postchemotherapy in pediatric patients with Ewing sarcoma.
Based on technological and analytical advances, the capability to more accurately and finitely examine biomechanical and skill characteristics of movement has improved. The purpose of this study was to use Inertial Measurement Units (IMUs) and Functional Principal Components Analysis (fPCA) to examine the role of movement variability (assessed via angular velocity), on 2 divers (1 international level; 1 national) performing the forward 3½ pike somersault dive. Analysis of angular velocity curves during ive...
Training to reduce landing forces is a common component of anterior cruciate ligament injury prevention programmes. The purpose of this study was to compare the effects of training incorporating instructions promoting an internal versus external attentional focus on landing forces in adolescent rugby athletes. Twenty-two rugby athletes were randomly allocated to groups that received instructions promoting an internal versus an external focus during a two week training programme. Landing forces were recorded...
During sidestep cutting, the pelvis is supported only on one side; this affects the athlete's posture. This study investigated the mechanism to avoid excessive pelvic obliquity during sidestep cutting. Ten physically active men performed sidestep cutting with maximal effort, and we captured the kinematics and kinetics with force platforms and an eight-camera motion capture system. Our results indicated that the stance hip exerted little abduction torque; however, lumbosacral lateral flexion torque was exert...
The purposes of this study were to characterise the golfer-ground interactions during the swing and to identify meaningful associations between the golfer-ground interaction force/moment parameters and the maximum clubhead speed in 63 highly skilled male golfers (handicap ≤ 3). Golfers performed shots in 3 club conditions (driver, 5-iron and pitching wedge) which were captured by an optical motion capture system and 2 force plates. In addition to the ground reaction forces (GRFs), 3 different golfer-groun...
Irritable bowel syndrome (IBS) affects 10-22% of people in the UK. Abdominal pain, bloating and altered bowel habits affect quality of life and can lead to time off work. Current treatment relies on a positive diagnosis, reassurance, lifestyle advice and drug therapies, but many people suffer ongoing symptoms. Cognitive-behavioural therapy (CBT) is recommended in guidelines for patients with ongoing symptoms but its availability is limited.
Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis. We show here that emperipolesis is a dynamic process mediated actively by both lineages, in part through the β2-integrin/ICAM-1/ezrin pathway. Tethered neutrophils enter in membrane-bound vesicles before penetrating into the megakaryocyte cytoplasm. Intracytoplasmic neutrophils develop membrane contiguity with the demarcation membrane system, thereby transferring membrane to the megakaryocyte and to daughter platelets. This...
Axon degeneration sculpts neuronal connectivity patterns during development and is an early hallmark of several adult-onset neurodegenerative disorders. Substantial progress has been made in identifying effector mechanisms driving axon fragmentation, but less is known about the upstream signaling pathways that initiate this process. Here, we investigate the behavior of the actin-spectrin-based Membrane-associated Periodic Skeleton (MPS), and effects of actin and spectrin manipulations in sensory axon degene...
The concept of objects is fundamental to cognition and is defined by a consistent set of sensory properties and physical affordances. Although it is unknown how the abstract concept of an object emerges, most accounts assume that visual or haptic boundaries are crucial in this process. Here, we tested an alternative hypothesis that boundaries are not essential but simply reflect a more fundamental principle: consistent visual or haptic statistical properties. Using a novel visuo-haptic statistical learning ...
Sedentary behavior is a major concern among patients with multiple sclerosis (MS), as it may accelerate disease progression and exacerbate physical disability. This is especially concerning among African Americans, a segment of the MS population who present with greater neurological disability and higher odds of physical comorbidities than their Caucasian counterparts.