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PubMed Journals Articles About "A Prospective Study Of Human Bone Adaptation Using A Novel In Vivo Loading Model" RSS

21:16 EST 27th February 2020 | BioPortfolio

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Showing "Prospective Study Human Bone Adaptation Using Novel Vivo" PubMed Articles 1–25 of 78,000+

A new method to monitor bone geometry changes at different spatial scales in the longitudinal in vivo μCT studies of mice bones.

Longitudinal studies of bone adaptation in mice using in vivo micro-computed tomography (μCT) have been commonly used for pre-clinical evaluation of physical and pharmacological interventions. The main advantage of this approach is to use each mouse as its own control, reducing considerably the sample size required by statistical power analysis. To date, multi-scale estimation of bone adaptations become essential since the bone activity that takes place at different scales may be associated with different ...


A review on computer modeling of bone piezoelectricity and its application to bone adaptation and regeneration.

Bone is a hierarchical, multiphasic and anisotropic structure which in addition possess piezoelectric properties. The generation of piezoelectricity in bone is a complex process which has been shown to play a key role both in bone adaptation and regeneration. In order to understand the complex biological, mechanical and electrical interactions that take place during these processes, several computer models have been developed and used to test hypothesis on potential mechanisms behind experimental observatio...

Human adaptation to invasive species: A conceptual framework based on a case study metasynthesis.

Species invasions are a major driver of ecological change, are very difficult to control or reverse, and will increase with climate change and global trade. Invasion sciences consider how species in invaded environments adapt, but neither scientists nor policy makers consider human adaptation to invasive species and how this affects ecosystems and well-being. To address this, a framework conceptualising autochthonous human adaptation to invasions was developed based on the Human Adaptation to Biodiversity C...


Ex vivo gene therapy using human bone marrow cells overexpressing BMP-2: "Next-day" gene therapy versus standard "two-step" approach.

Traditionally, ex vivo gene therapy involves a two-step approach, with culture expansion of cells prior to transduction and implantation. We have tried to simplify this strategy and eliminate the time and cost associated with culture expansion, by introducing "next-day" regional gene therapy using human bone marrow cells. The purpose of this study was to determine whether a lentiviral vector (LV) carrying the cDNA for BMP-2 can transduce freshly isolated human BM cells, leading to abundant BMP production an...

In vivo analysis of subchondral trabecular bone in patients with osteoarthritis of the knee using second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT).

Subchondral bone plays an important role in the pathological mechanisms of knee osteoarthritis (OA). High-resolution peripheral quantitative computed tomography (HR-pQCT) is an imaging modality allowing noninvasive microstructural analysis of human bone, and the second generation enables scanning of the knee. The purpose of this study was to perform in vivo analysis of subchondral trabecular bone in patients with medial knee OA, to elucidate features of bone microstructure in medial knee OA, and to investig...

DNA aptamer immobilized hydroxyapatite for enhancing angiogenesis and bone regeneration.

In this study, we developed aptamer-conjugated hydroxyapatite (Apt-HA) that promotes bone regeneration and angiogenesis. The 3R02 bivalent aptamer specific to vascular endothelial growth factor (VEGF) was grafted to the hydroxyapatite (HA) surface. Apt-HA was tested for its VEGF protein capture ability to determine the optimal aptamer concentration immobilized on the HA. Apt-HA showed higher VEGF protein capture ability, and faster growth of human umbilical vein endothelial cell (HUVEC) compared to a neat H...

Autogenous Dentin Shell Grafts Versus Bone Shell Grafts for Alveolar Ridge Reconstruction: A Novel Technique with Preliminary Results of a Prospective Clinical Study.

This prospective pilot study presents a novel method using the dentin shell technique for the three-dimensional reconstruction of alveolar bone defects. Autogenous dentin shell (≤ 2 mm) harvested from impacted third molars was fixed at the recipient site as an external barrier. The space between the dentin shell and residual bone was filled with deproteinized bovine bone mineral particles mixed with concentrated growth factor (CGF) pieces. Autogenous bone (gold standard for bone graft) was applied to prep...

Melatonin prevents cadmium-induced bone damage: first evidence on an improved osteogenic/adipogenic differentiation balance of mesenchymal stem cells as underlying mechanism.

Melatonin (MLT) plays a role in preserving bone health, a function that may depend on homeostatic effects on both mature osteoblasts and mesenchymal stem cells (MSCs) of the bone tissue. In this study, these functions of MLT have been investigated in rat bone (femur) and in human adipose MSC (hMSC) during chronic exposure to low-grade cadmium (Cd) toxicity, a serious public health concern. The in vivo findings demonstrate that MLT protects against Cd-induced bone metabolism disruption and accumulation of bo...

Are we crying Wolff? 3D printed replicas of trabecular bone structure demonstrate higher stiffness and strength during off-axis loading.

Roux's principle of bone functional adaptation postulates that bone tissue, and particularly trabecular bone tissue, responds to mechanical stimuli by adjusting (modeling) its architecture accordingly. Hence, it predicts that the new modeled trabecular structure is mechanically improved (stiffer and stronger) in line with the habitual in vivo loading direction. While previous studies found indirect evidence to support this theory, direct support was so far unattainable. This is attributed to the fact that e...

Autologous Iliac Bone Graft Compared with Biphasic Hydroxyapatite and Calcium Sulfate Cement for the Treatment of Bone Defects in Tibial Plateau Fractures: A Prospective, Randomized, Open-Label, Multicenter Study.

Bone-graft substitutes are commonly used for the augmentation of traumatic bone defects in tibial plateau fractures. However, their clinical performance compared with that of autologous bone-grafting, the gold standard in bone defect reconstruction, still remains under debate. This study investigates the differences in quality of life, pain, and radiographic outcomes in the treatment of tibial plateau fracture-associated bone defects with either autologous bone grafts or a bioresorbable hydroxyapatite and c...

Dispersion of ceramic granules within human fractionated adipose tissue to enhance endochondral bone formation: Engineering a bone organ using fat tissue.

Engineering of materials consisting of hypertrophic cartilage, as physiological template for de novo bone formation through endochondral ossification (ECO), holds promise as a new class of biological bone substitutes. Here, we assessed the efficiency and reproducibility of bone formation induced by the combination of ceramic granules with fractionated human adipose tissue ("nanofat"), followed by in vitro priming to hypertrophic cartilage. Human nanofat was mixed with different volumetric ratios of ceramic ...

Weekly Teriparatide versus Bisphosphonate for Bone Union during Six Months after Multi-Level Lumbar Interbody Fusion for Osteoporotic Patients: A Multicenter, Prospective, Randomized Study.

Multicenter, prospective randomized study.

Human adaptation to biodiversity change: An adaptation process approach applied to a case study from southern India.

Adaptation to environmental change, including biodiversity change, is both a new imperative in the face of global climate change and the oldest problem in human history. Humans have evolved a wide range of adaptation strategies in response to localised environmental changes, which have contributed strongly to both biological and cultural diversity. The evolving set of locally driven, 'bottom-up' responses to environmental change is collectively termed 'autonomous adaptation,' while its obverse, 'planned ada...

Bone Formation of Titanium Implant Surfaces Treated with Submicron Poly(lactide-co-glycolide)/Recombinant Human Transforming Growth Factor- β2 Particles by the Electrospray Method: An In Vivo Study.

This study evaluated the effect of anodized titanium implants coated with submicron-sized poly(lactide-co-glycolide) (PLGA)/recombinant human transforming growth factor- β2 (rhTGF- β2) particles via electrospray on osseointegration in an in vivo model.

Single-cell characterization and metabolic profiling of in vitro cultured human skeletal progenitors with enhanced in vivo bone forming capacity.

Cell populations and their interplay provide the basis of a cell-based regenerative construct. Serum-free preconditioning can overcome the less predictable behavior of serum expanded progenitor cells, but the underlying mechanism and how this is reflected in vivo remains unknown. Herein, the cellular and molecular changes associated with a cellular phenotype shift induced by serum-free preconditioning of human periosteum derived cells were investigated. Following BMP-2 stimulation, preconditioned cells disp...

Early-predictors of marginal bone loss around morse taper connection implants loaded with single crowns: A prospective longitudinal study.

Few studies estimated the joint effect of implant design (length and diameter), peri-implant, and occlusal variables on early marginal bone loss. The monitoring of these factors during the first year after implant loading may be effective in preventing early implant failure. This prospective longitudinal study aimed to identify early-predictors of marginal bone loss around morse-tapered connection implants 12 months after implant loading.

Rats offer a superior model of human stress erythropoiesis.

Mouse models are widely used to study human erythropoiesis in vivo. One important caveat using mouse models is that mice often develop significant extramedullary erythropoiesis with anemia, which could mask important phenotypes. To overcome this drawback in mice, here we established in vitro and in vivo rat models for the studies of stress erythropoiesis. Using flow cytometry-based assays, we can monitor terminal erythropoiesis in rats during fetal and adult erythropoiesis under steady state and stress cond...

Crestal Bone Changes in Different Implants Designs: A Prospective Clinical Trial.

 Several modifications, such as changes in the implant-abutment connection, have been suggested in studies on dental implants to better preserve the peri-implant bone level. The aim of this study was to prospectively compare crestal bone level changes between two different implant designs-tissue level (TL) and bone level (BL).

Tauroursodeoxycholic acid induces angiogenic activity in endothelial cells and accelerates bone regeneration.

Angiogenesis is a crucial process during bone tissue regeneration. The aim of this study was to investigate the angiogenic activity and the potentiation of bone regeneration via angiogenesis using tauroursodeoxycholic acid (TUDCA) in vitro and in vivo. We investigated the effect of TUDCA on proliferation and angiogenic differentiation in human umbilical vein endothelial cells (HUVECs) and the associated signaling pathway. Proliferation was determined using crystal violet assay. Angiogenic effects were evalu...

An Ultra-Short Femoral Neck-Preserving Hip Prosthesis: A 2-Year Follow-up Study with Radiostereometric Analysis and Dual X-Ray Absorptiometry in a Stepwise Introduction.

Total hip arthroplasty (THA) with a diaphyseal stem may risk bone loss. In order to save proximal bone stock in young patients with a high activity level and a long life expectancy, the interest in short stems has evolved. The purpose of this prospective observational cohort study was to evaluate the fixation of, and bone remodeling around, the Primoris femoral neck-preserving hip implant.

Dengue viruses infect human megakaryocytes, with probable clinical consequences.

One of the most important clinical signs of dengue virus infection is the reduction of white blood cells and platelets in human peripheral blood (leukopenia and thrombocytopenia, respectively), which may significantly impair the clearance of dengue virus by the immune system. The cause of thrombocytopenia and leukopenia during dengue infection is still unknown, but may be related to severe suppression of bone marrow populations including hematopoietic stem cells and megakaryocytes, the progenitors of white ...

Eight to eleven-year follow-up of immediately loaded implants placed in edentulous maxillae with compromised bone volume and poor bone quality: A prospective cohort study.

There is a lack of long-term evaluations of immediately loaded implants in patients with compromised maxillary bone.

Effects of the selective GPER-1 agonist G1 on bone growth.

Estrogens may affect bone growth locally or systemically via the known estrogen receptors ERα, ERβ and G protein-coupled estrogen receptor 1 (GPER-1). Mouse and human growth plate chondrocytes have been demonstrated to express GPER-1 and ablation of this receptor increased bone length in mice. Therefore, GPER-1 is an attractive target for therapeutic modulation of bone growth, which has never been explored. To investigate the effects of activated GPER-1 on the growth plate, we locally exposed mouse metata...

The long-term behaviors and differences in bone reconstruction of three polymer-based scaffolds with different degradability.

Scaffolds composed of polymers and nano-hydroxyapatite (n-HA) have received extensive attention in bone reconstructive repair; however there is a lack of in-depth and long-term comparative study on the effect of scaffold degradability on bone reconstruction. In this study, the osteogenic behaviors of three polymeric composite scaffolds based on fast degradable poly(lactic-co-glycolic acid) (PLGA), slowly degradable polycaprolactone (PCL) and non-degradable polyamide 66 (PA66) were investigated and compared ...

Activin A and BMP chimera (AB204) induced bone fusion in osteoporotic spine using an ovariectomized rat model.

Recombinant human bone morphogenic protein 2 (rhBMP2) has been used to induce bone fusion in patients with spinal fusion surgery. However, the effectiveness of rhBMP2 in the bone fusion process is limited in osteoporosis patients, and a high dose of rhBMP2 for enough bone fusion sometimes provokes side effects. Therefore, substitutes for rhBMP2 with a higher therapeutic potency are needed, and already several studies have published the effectiveness of Activin A/Bone morphogenic protein 2 chimera (AB204) in...


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