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PubMed Journals Articles About "A Randomized Controlled Trial Assessing The Safety And Feasibility Of Respiratory Muscle Training And Exercise Training In Children And Adolescents With Persistent Asthma" RSS

08:28 EDT 20th May 2019 | BioPortfolio

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Showing "Randomized Controlled Trial Assessing Safety Feasibility Respiratory Muscle" PubMed Articles 1–25 of 23,000+

The Protective Effects of Levetiracetam on a Human iPSCs-Derived Spinal Muscular Atrophy Model.

Spinal muscular atrophy (SMA) is an inherited disease characterized by progressive motor neuron death and subsequent muscle weakness and is caused by deletion or mutation of survival motor neuron (SMN) 1 gene. Protecting spinal motor neuron is an effective clinical strategy for SMA. The purpose of this study was to investigate the potential effect of an anti-epileptic drug levetiracetam on SMA. In the present study, we used differentiated spinal motor neurons (MNs) from SMA patient-derived induced pluripote...


Comparison of laser- and bur-prepared class I cavities restored with two different low-shrinkage composite resins: a randomized, controlled 60-month clinical trial.

The aim of this study was to compare the clinical performances of two low-shrinkage composite resins (silorane-based and methacrylate-based) in class I cavities prepared by Er,Cr:YSGG laser or conventional diamond bur over 60 months.

Oxaliplatin-desensitization procedure is safe and feasible in an outpatient cancer unit in France.

This study was undertaken to assess the previously unevaluated safety and feasibility of oxaliplatin-desensitization procedure add a French ambulatory cancer unit, which is a current topic in oncology. Our findings demonstrated that oxaliplatin-desensitization was safe and feasible in our ambulatory cancer unit. In routine practice, all these procedures are done on an inpatient basis starting at least the day before. Those results could change oncological practices in France and improve patients' quality of...


Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience.

Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.

Latent Profiles of Cognitive and Interpersonal Risk Factors for Adolescent Depression and Implications for Personalized Treatment.

A personalized approach to treatment with patients being matched to the best-fit treatment has been proposed as one possible solution to the currently modest treatment response rates for adolescent depression. Personalized treatment involves identifying and characterizing subgroups likely to respond differently to different treatments. We investigated the feasibility of this approach, by focusing on two key risk factors that are the purported treatment targets of cognitive behavioral therapy (CBT) and inter...

On a three-dimensional constitutive model for history effects in skeletal muscles.

An exceptional property of skeletal muscles that distinguishes them from other soft tissues is their ability to contract by generating active forces, which in turn are initiated by an electrochemical trigger. Some of these so-called active material properties are generally characterised using isometric contraction experiments at various muscle lengths. In this context, experimental observations revealed that unlike the widespread assumption in muscle modelling, reaction forces indeed depend on so-called his...

Correction to: Effect of endometrial mechanical stimulation in an unselected population undergoing in vitro fertilization: futility analysis of a double-blind randomized controlled trial.

The original version of this article unfortunately contained mistakes. The complete list of corrections is given below.

Regulation of growth performance and lipid metabolism in juvenile grass carp (Ctenopharyngodon idella) with honeysuckle (Lonicera japonica) extract.

This study investigated the effects of honeysuckle extract (Lonicera japonica, HE) on the growth performance and lipid metabolism of juvenile grass carp (Ctenopharyngodon idella). HE at doses of 10 g kg (LHE), 20 g kg (MHE), and 40 g kg (HHE) were individually mixed with the basal diet and fed to grass carp for 10 weeks, and ginseng extract (20 g kg, GSE) was used as a positive control. The results showed that HE administration exerted no effect on growth performance, but the hepatosomatic index (H...

The Effects of Sleep Loss on Military Physical Performance.

As part of both training and active service, military members can be exposed to prolonged periods of sleep loss. Given the extent of physical and cognitive performances viewed as critical to successful military performance, such sleep disruption may present risk to health and performance. The primary aim of this narrative review was to investigate evidence on the effect of inadequate sleep on measures of aerobic capacity, anaerobic capacity, muscular strength and muscular endurance in military personnel. Sl...

Psychotria leiocarpa Extract and Vincosamide Reduce Chemically-Induced Inflammation in Mice and Inhibit the Acetylcholinesterase Activity.

Species from Psychotria are used in folk medicine against inflammatory diseases, respiratory disturbances, and anti-hallucinogenic. In the present study, the compound vincosamide (PL-1) was identified for the first time in methanolic extract of the Psychotria leiocarpa (ME-PL) leaves, as well as the anti-inflammatory and anticholinesteric effects in rodents and molecular docking simulations. The fractionation of the chloroform fraction (CF-PL) through chromatographic methods afforded the known compound PL-1...

Exclusion criteria and adverse events in perioperative trials of tranexamic acid in cardiac surgery: a systematic review and meta-analysis.

Tranexamic acid (TXA) reduces perioperative blood loss and transfusion requirement following cardiac surgery. Nevertheless, TXA remains underutilized because of concerns regarding development of adverse events. We conducted a systematic review to determine which patients are commonly excluded from TXA cardiac surgery clinical trials to determine if there are patient groups lacking safety data on TXA.

Safety margin of radiofrequency ablation for hepatocellular carcinoma: a prospective study using magnetic resonance imaging with superparamagnetic iron oxide.

In radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC), it is difficult to assess the ablative margin (AM) precisely by comparing pre- and post-RFA CT images. We prospectively studied the AMs using magnetic resonance imaging (MRI) with pre-administered superparamagnetic iron oxide (SPIO). SPIO is safe for kidney disease patients.

Long-Term Safety and Tolerability of OnabotulinumtoxinA Treatment in Patients with Chronic Migraine: Results of the COMPEL Study.

OnabotulinumtoxinA is approved in the USA for the prevention of headache in adults with chronic migraine, a debilitating neurologic disease characterized by headaches occurring on ≥ 15 days per month for > 3 months and including migraine features on ≥ 8 days per month.

Stromal organization as predictive biomarker for the treatment of colon cancer with adjuvant bevacizumab; a post-hoc analysis of the AVANT trial.

Intra-tumoral stroma has become increasingly important in understanding tumor biology, tumor progression and clinical outcome. The amount itself, quantified as the tumor-stroma ratio (TSR), has proven to be prognostic in stage I-III colon cancer. Also, alterations in stromal organization have been found to provide prognostic and predictive information in certain cancers. Here, we evaluated the predictive value of stromal organization in high-risk stage II and III colon cancer with respect to adjuvant bevaci...

Pain Control in Latin America: The Optimized Role of Buprenorphine in the Treatment of Cancer and Noncancer Pain.

Pain is a terrible health problem that transcends borders and nationalities, although there may be significant differences among regions regarding pain management. In Latin America (LatAm, composed of the many nations of Central America, South America, Mexico, and the Caribbean), access to healthcare, pain management, and opioid analgesics can vary. Despite an international U.S.-led trend toward greater control in opioid prescribing, the role of opioids in the management of severe pain in LatAm is probably ...

Recovery-Oriented Outcomes Associated with Long-Acting Injectable Antipsychotics in an Urban Safety-Net Population.

This study examined whether transitioning patients from oral antipsychotics (POs) to long-acting injectable antipsychotics (LAIs) helps patients achieve recovery-oriented goals. Data was extracted from San Francisco County's electronic medical record system for this retrospective pre-post observational study. Patients reflect a safety-net population treated in community-based mental health settings during 2015. The San Francisco Adult Strengths and Needs Assessment (SF ANSA), a measure of psychosocial funct...

Assessing young consumers' awareness and participation in sustainable e-waste management practices: a survey study in Northwest China.

The massive generation of electronic waste (e-waste) and the informal recycling of e-waste are serious concerns in China. As a hazardous waste stream, e-waste calls for sustainable management practices to avoid adverse effects on environment and health. However, consumers' awareness and active participation are needed to make e-waste management successful. Therefore, this study is an exploratory attempt to investigate young consumer awareness, knowledge, and participation in sustainable e-waste management p...

An experimental investigation on waste fishing net as an alternate fuel source for diesel engine.

In this experimental study, the feasibility of using the oil obtained from waste fishing net as a substitute for diesel fuel was investigated. Waste fishing net oil (WFNO) was obtained through pyrolysis process on a laboratory scale setup and used as a fuel in diesel engine. The properties of oil obtained from waste fishing net were examined and compared with conventional diesel fuel. Results indicated that the WFNO possesses excellent fuel properties. The calorific value of WFNO is 44,450 kJ/kg, which is h...

An Introduction to the Book.

Chitin is a linear biopolymer composed of β-1,4-linked N-acetylglucosamine (GlcNAc), and an essential component in exoskeleton of insects and crustaceans, the egg shells of parasitic nematodes, and the fungal cell wall. Since the chitin-containing organisms often threaten human health, food safety, and agricultural production, it has been highly desirable to control the hazardous chitin-containing organisms. This book will provide researchers and students with information on the recent research progress ab...

Computational Design and Optimization of Novel D-peptide TNFα Inhibitors.

Compared to small molecule drugs, peptide therapeutics provide greater efficacy, selectivity, and safety. The intrinsic disadvantages of peptides are their sensitivity to proteases. To overcome this, we have developed a general computational strategy for de novo design of proteins binding helical D-peptides. A D-helical fragment library was established and used in generating flexible D-helical conformations, which were then used to generate suitable sequences with the required structural and binding propert...

Method of Levels Not Limits for Assessment of Cooling Detection Thresholds.

New emerging roles of CD133 in cancer stem cell: Signaling pathway and miRNA regulation.

Cancer stem cells (CSC) are rare immortal cells within a tumor that are able to initiate tumor progression, development, and resistance. Advances studies show that, like normal stem cells, CSCs can be both self-renewed and given rise to many cell types, therefore form tumors. A number of cell surface markers, such as CD44, CD24, and CD133 are frequently used to identify CSCs. CD133, a transmembrane glycoprotein, either alone or in collaboration with other markers, has been mainly considered to identify CSC...

Comparing the effect of the novel ionic cocrystal of lithium salicylate proline (LISPRO) with lithium carbonate and lithium salicylate on memory and behavior in female APPswe/PS1dE9 Alzheimer's mice.

Alzheimer's disease (AD) is characterized by progressive decline of cognition and associated neuropsychiatric signs including weight loss, anxiety, depression, agitation, and aggression, which is particularly pronounced in the female gender. Previously, we have shown that a novel ionic co-crystal of lithium salicylate proline (LISPRO) is an improved lithium formulation compared to the carbonate or salicylate form of lithium in terms of safety and efficacy in reducing AD pathology in Alzheimer's mice. The cu...

On the development of equivalent medium for active implantable device radiofrequency safety assessment.

To develop the equivalent medium theorem that can be used to perform accurate evaluation of implantable device safety under MRI exposure.

Piriformis Syndrome: A narrative review of the anatomy, diagnosis, and treatment.

Piriformis syndrome is a form of sciatica caused by compression of the sciatic nerve by the piriformis muscle. It is a relatively uncommon, but not insignificant, cause of sciatica. The diagnosis of piriformis syndrome is complicated by the large differential diagnosis of low back and buttock pain with many diagnoses having overlapping symptoms. This narrative review highlights the relevant anatomy, history, physical exam maneuvers, electrodiagnostic findings, and imaging findings that are used to diagnose ...


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