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A Study To Assess The Safety And Efficacy Of Treprostinil To Facilitate Liver Transplantation In Patients With Portopulmonary Hypertension PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest A Study To Assess The Safety And Efficacy Of Treprostinil To Facilitate Liver Transplantation In Patients With Portopulmonary Hypertension articles that have been published worldwide.
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Nonalcoholic Steatohepatitis(NASH) is one of the top three indications for liver transplantation in western countries. It is unknown whether renal dysfunction at the time of liver transplantation has any effect on post-liver transplantation outcomes in recipients with NASH.
Split liver transplantation (SLT) is a valuable option for optimizing the use of good quality deceased donor grafts. It is not routinely reported outside the West due to limited deceased donor numbers, technical and organizational constraints, lack of experience, and predominant living donor liver transplant (LDLT) practice. Twenty percent of the liver transplants at our centre are from deceased donors. We report our experience of SLT and compare outcomes with pediatric and adult LDLT recipients.
Either liver transplantation or surgical resection is available for selected patients with hilar cholangiocarcinoma. However, the comparative effectiveness between liver transplantation and liver resection remains unknown. The aim of our study is to evaluate the relative effectiveness between liver transplantation and surgical resection in patients with hilar cholangiocarcinoma.
Intraoperative hyperglycemia during liver transplantation can induce infectious bacterial complications after surgery. The aim of this study was to evaluate the efficacy of the artificial endocrine pancreas in achieving perioperative blood glucose control and preventing infection in patients undergoing living donor liver transplantation.
We thank Rammohan et cols for the comment on our paper entitled "The Role of Liver Transplantation in Propionic Acidemia". As the authors highlight, the reported rates of Hepatic Arterial Thrombosis (HAT) in Propionic Acidemia (PA) patients that undergo Liver Transplantation (LT) are higher than in other indications of LT (1). As described in the paper, the rate of HAT in our series is 33% (2/6) similar to those reported by other groups (1-2). The overall incidence of HAT in the last 10 years in our centre ...
Acceptance criteria for liver allografts are ever more expanding because of a persisting waiting list mortality. Older livers are therefore offered and used more frequently for transplantation. This study aims to analyze the use and long-term outcome of these transplantations.
Limitations to the use of long-term Hepatitis B Immunoglobulin (HBIg) following liver transplantation for hepatitis B (HBV) have led to the substitution of HBIg with oral nucleo(s)tide analogue prophylaxis. We prospectively assessed the long-term safety and efficacy of switching to tenofovir disoproxil fumarate (TDF) from HBIg.
The recent years have been full of remarkable innovation and progress in the field of liver transplant. Importantly, 2017 will always be most significantly remembered, for the loss of the man that paved the way for liver transplantation. On March 4, 2017, Dr. Thomas Starzl passed away at the age of 90, leaving a legacy of unprecedented creativity, bravery, and innovation leading the way for the era of modern transplantation. His impact on patients with end stage organ disease has changed the face of modern ...
Severe acute liver injury (sALI) is a grave complication of exertional heatstroke (EH). Liver transplantation (LT) may be a therapeutic option, but the criteria for, and timing of transplantation have not been clearly established. The aim of this study was to define the profile of patients who require transplantation in this context.
Auxiliary partial orthotopic liver transplantation (APOLT) was initially explored for potentially reversible acute liver failure and noncirrhotic metabolic liver disease (NCMLD)(1, 2). The rationale for APOLT for acute liver failure is native liver regeneration facilitating discontinuation of immunosuppressive therapy(3). This article is protected by copyright. All rights reserved.
Auxiliary Partial Orthotopic Liver Transplantation (APOLT) in selected non-cirrhotic metabolic liver diseases (NCMLD) is a viable alternative to orthotopic liver transplantation as it supplements the function of the native liver with the missing functional protein. APOLT for NCMLD is not universally accepted due to concerns of increased technical complications and long-term graft atrophy.
"Hard cases make bad law." The legal maxim comes to mind as we read the interesting review by Shekhtman et al. on simultaneous dual-kidney liver transplantation (DLKT) in the United States. The first thing that strikes us is the very rarity of the procedure. This article is protected by copyright. All rights reserved.
Highly effective direct acting antiviral (DAA) therapy has transformed outcomes of liver transplantation in HCV patients. We examined longer-term outcomes in HCV-positive recipients in the DAA era.
Dexmedetomidine (DEX) is a sedative and analgesic medication that is frequently used postoperatively in children after liver transplantation. Hepatic dysfunction, including alterations in drug clearance, is common immediately after liver transplantation. However, the pharmacokinetics (PK) of DEX in this population is unknown. The objective of this study was to determine the PK profile of DEX in children after liver transplantation.
Liver biopsy is the gold standard for assessing liver fibrosis (LF) after liver transplantation (LT), but its invasiveness limits its utility. This study aimed to evaluate the usefulness of liver stiffness measurement (LSM) via acoustic radiation force impulse (ARFI) imaging to assess LF after LT.
A recent study using US national registry data has reported that split liver transplant (SLT) has improved over-time and no more hazardous than whole liver transplant using Cox proportional hazard (PH) models. However, the study methods violated PH assumption, the fundamental assumption of Cox modeling. As a result, the reported HR are biased and unreliable. This study aimed to investigate whether the risk of graft survival (GS) in SLT has really improved over-time, ensuring attention to the PH assumption.
To investigate the safety and efficacy of somatostatin as liver inflow modulator in patients with end-stage liver disease (ESLD) and clinically significant portal hypertension (CSPH) undergoing liver transplantation (LT) (ClinicalTrials.gov number,01290172).
Early studies reported poor survival rates following liver transplantation for metastatic colorectal cancer to the liver and liver transplantation has thus traditionally been contraindicated for these patients. However, improvements in liver transplantation outcomes, immunosuppression and the treatment of colorectal cancer warrant a reassessment of the role of liver transplantation for metastatic colorectal cancer.
Recombinant soluble human thrombomodulin (ART-123) is an anticoagulant and anti-inflammatory agent clinically used for treatment of disseminated intravascular coagulation. Preclinical studies have shown that ART-123 reduces hepatic ischemia/reperfusion. Although ART-123 may therefore have clinical benefit in orthotopic liver transplantation the substantial alterations in the hemostatic system may complicate its use in this setting.
Pulmonary arterial hypertension (PAH) is a life-threatening disease that leads to progressive pulmonary hypertension, right heart failure and death. Parenteral prostaglandins, including treprostinil, a prostacyclin analogue, represent the most effective medical treatment for severe PAH. We investigated the effect of treprostinil on established severe PAH and underlying mechanisms using the rat SU5416 (SU, a vascular endothelial growth factor receptor-2 inhibitor)-chronic hypoxia (Hx) model of PAH.