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PubMed Journals Articles About "AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated" RSS

07:32 EDT 20th June 2018 | BioPortfolio

AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated articles that have been published worldwide.

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Showing "AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated" PubMed Articles 1–25 of 33,000+

Organocatalyst-assisted Ar-(18)F bond formation: a universal procedure for direct aromatic radiofluorination.

A metal free, phosphane-catalysed protocol for C-F bond formation based on ipso-elimination of iodanes is described. The reaction proceeds in significantly higher yield and with markedly reduced variability of yields (yield range) than previously described procedures. Rapid and efficient radiofluorination is achieved using unobjectionable chemical reagents with precedence in routine radiotracer production. With operational ease and mild conditions, the method promises a high potential for radiolabelling of ...


Efficient NIR Emission from Nd, Er, and Tm Complexes with Fluorinated Selenolate Ligands.

(DME)2Ln(SeC6F5)3 (Ln = Nd, Er, Tm) can be isolated in high yield by reductive cleavage of the Se-Se bond in (SeC6F5)2 with elemental Ln in DME. All three Ln compounds are isostructural, with 8 coordinate Ln bound to four O from DME, three terminally bound Se(C6F5), and a dative bond from an arene fluoride to a fluorine at the ortho position of one selenolate. Emission measurements indicate that these compounds are bright NIR sources.

Genetics of familial hypercholesterolemia: a tool for development of novel lipid lowering pharmaceuticals?

Familial hypercholesterolemia is characterized by high LDL cholesterol and an elevated risk to develop coronary heart disease. Mutations in LDL receptor-mediated cholesterol uptake are the main cause of familial hypercholesterolemia. However, multiple mutations in various other genes are also associated with high LDL cholesterol and even familial hypercholesterolemia. Thus, pharmaceuticals that target these genes and proteins might be attractive treatment options to reduce LDL cholesterol. This review provi...


A Ter-Ionic Complex that Forms a Bond Upon Visible Light Absorption.

A "ter-ionic complex" comprised of a tetracationic Ru(II) complex and two iodide ions was found to yield a covalent I-I bond upon visible light excita-tion in acetone solution. H NMR, visible absorp-tion, and DFT studies revealed that one iodide was associated with a ligand while the other was closer to the Ru metal center. Standard Stern-Volmer quenching of the excited state by iodide revealed upward curvature with a novel saturation at high concentrations. The data were fully consistent with a mechanism i...

Effect of Magnesium Bond on the Competition between Hydrogen Bond and Halogen Bond and the Induction of Proton and Halogen Transfer.

HOX (X = Cl, Br, I, and At) can engage in either a H-bond (HB) or halogen bond (XB) with a base like HCN, NH3, and imidazole. While the former is energetically preferred for X=Cl and Br, it is the XB that is more stable for At, with I showing little preference. MgY2 forms a Mg-bond with the O atom of HOX, which grows stronger in the order X= Cl < Br < I < At and Y= F< Cl < Br. When all three molecules are combined together, both the Mg and the H/X bonds are cooperatively strengthened to a large degree. Rath...

Policosanol fabrication from insect wax and optimization by response surface methodology.

Insect wax is a famous biological resource for the role in economic production in China. Insect wax is a good source of policosanol, which may is a candidate supplement in foodstuff and pharmaceuticals that has important physiological activities. Therefore, this work aims to investigate a high-yield and rapid method for policosanol fabrication from insect wax.

Olefin Cyclopropanation via Radical Carbene Transfer Reaction Promoted by Co(II)porphyrinates for the Active-Metal-Template Synthesis of 2Rotaxanes.

A Co(II)porphyrinate-based macrocycle in the presence of 3,5-diphenylpyridine axial ligand functions as an endotopic ligand to direct the assembly of [2]rotaxanes from diazo and styrene half-threads via radical carbene transfer reactions in excellent 95% yield. The method reported herein applies the active-metal template strategy to include radical-type activation of ligands by the metal-template ion during the organometallic process that ultimately yield the mechanical bond. A careful quantitative analysis...

A General Strategy for Site-Selective Incorporation of Deuterium and Tritium into Pyridines, Diazines and Pharmaceuticals.

Methods to incorporate deuterium and tritium atoms into organic molecules are valuable for medicinal chemistry. The prevalence of pyridines and diazines in pharmaceuticals means that new ways to label these heterocycles will present opportunities in drug design and facilitate absorption, distribution, metabolism and excretion (ADME) studies. A broadly applicable protocol is presented wherein pyridines, diazines and pharmaceuticals are converted into heterocyclic phosphonium salts and then isotopically label...

Disilenyl silylene reactivity of a cyclotrisilene.

The highly reactive silicon congeners of cyclopropene, cyclotrisilenes (c-Si₃R₄), typically undergo either π-addition to the Si=Si double bond or σ-insertion into the Si-Si single bond. In contrast, treatment of c-Si₃Tip₄ (Tip = 2,4,6-iPr₃C₆H₂) with styrene and benzil results in ring opening of the three-membered ring to formally yield the [1+2] and [1+4] cycloaddition product of the isomeric disilenyl silylene to the C=C bond and the 1,2-diketone π system, respectively. At elevated tempera...

Urbanization gradient of selected pharmaceuticals in surface water at a watershed scale.

Ubiquitous detection of pharmaceuticals in the aquatic environment around the world raises a great public concern. Aquatic residuals of pharmaceuticals have been assumed to relate to land use patterns and various human activities within a catchment or watershed. This study generated a gradient of human activity in the Jiulong River watershed, southeastern China by urban land use percentage in 20 research subwatersheds. Thirty-three compounds from three-category pharmaceuticals [26 compounds of 5 antibiotic ...

Visible Light Photoinitiator for 3D-Printing of Tough Methacrylate Resins.

Lithography-based additive manufacturing was introduced in the 1980s, and is still the method of choice for printing accurate plastic parts with high surface quality. Recent progress in this field has made tough photopolymer resins and cheap LED light engines available. This study presents the influence of photoinitiator selection and post-processing on the thermomechanical properties of various tough photopolymers. The influence of three photoinitiators (Ivocerin, BAPO, and TPO-L) on the double-bond conver...

Potassium Amide-Catalyzed Benzylic C-H Bond Addition of Alkylpyridines to Styrenes.

The benzylic functionalization of alkylpyridines is an important pathway for pyridine derivate synthesis. The reaction partners, however, were mostly limited to highly reactive polar electrophiles. Herein, we report a potassium amide-catalyzed selective benzylic C-H bond addition of alkylpyridines to styrenes. Potassium bis(trimethylsilyl)amide (KHMDS), a readily available Brønsted base, showed excellent catalytic activity and chemoselectivity. A series of alkylpyridine derivatives, including benzylic quat...

Hydrogen-Bonding Effects in Five-Coordinate High-Spin Imidazole-Ligated Iron(II) Porphyrinates.

The influence of hydrogen binding to the N-H group of coordinated imidazole in high-spin iron(II) porphyrinates has been studied. The preparation and characterization of new complexes based on [Fe(TPP)(2-MeHIm)] (TPP is the dianion of tetraphenylporphyrin) are reported. The hydrogen bond acceptors are ethanol, tetramethylene sulfoxide, and 2-methylimidazole. The last acceptor, 2-MeHIm, was found in a crystalline complex with two [Fe(TPP)(2-MeHIm)] sites, only one of which has the 2-methylimidazole hydrogen ...

Direct Photocatalytic S-H Bond Cyanation with Green "CN" Source.

Herein we report a novel C-S bond cleavage and reconstruction strategy for the synthesis of thiocyanates through direct photocatalytic S-H bond cyanation from thiols and inorganic thiocyanate salts. In our strategy, the unprecedented example of cutting off C-S bond of SCN- to deliver the green "CN" sources is demonstrated. This transformation features nontoxic and inexpensive "CN" sources, available starting materials, metal-/base-/ligand-/peroxide-free, high step economy and mild conditions. It leads to th...

A Modified System for the Synthesis of Enantioenriched N-Arylamines through Copper-Catalyzed Hydroamination.

Despite significant recent progress in the copper-catalyzed enantioselective hydroamination chemistry, the synthesis of chiral N-arylamines, which are frequently found in natural products and pharmaceuticals, has not been realized. Initial experiments with N-arylhydroxylamine ester electrophiles were unsuccessful and, instead, their reduction, in the presence of copper hydride (CuH) catalysts, was observed. Herein, we report key modifications of our previously reported hydroamination protocols that lead to ...

Letter--Incorporating Real-World Evidence and Patient Value Criteria into Value-Based Frameworks for Relapsed/Refractory Multiple Myeloma.

Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Janssen, Millennium Pharmaceuticals, and Onyx Pharmaceuticals; and is a member of advisory boards for Amgen, Bristol-Myers Squibb, Celgene Corporation, Incyte, Kite, Legend Biotech, Sanofi-Aventis, and Takeda Pharmaceuticals.

Widely Applicable Hydrofluorination of Alkenes via Bifunctional Activation of Hydrogen Fluoride.

Expanding the use of fluorine in pharmaceuticals, agrochemicals and materials requires a widely applicable and more efficient protocol for the preparation of fluorinated compounds. We have developed a new generation nucleophilic fluorination reagent--KHSO4-13HF, HF 68 wt/wt%--that is not only easily-handled and inexpensive but also capable of hydrofluorinating diverse, highly functionalized alkenes, including natural products. The high efficiency observed in this reaction hinges on the activation of HF usin...

Accelerated Forced Degradation of Pharmaceuticals in Levitated Microdroplet Reactors.

Forced degradation is a method of studying the stability of pharmaceuticals in order to design stable formulations and predict drug product shelf life. Traditional methods of reaction and analysis usually take multiple days, and include LC-UV and LC-MS product analysis. In this study, the reaction/analysis sequence was accelerated to be completed within minutes using Leidenfrost droplets as reactors (acceleration factor: 23 - 188) and nanoelectrospray ionization MS analysis. The Leidenfrost droplets underwe...

Deep Eutectic Solvents (DESs) for the Isolation of Willow Lignin (Salix matsudana cv. Zhuliu).

Deep eutectic solvents (DESs) are a potentially high-value lignin extraction methodology. DESs prepared from choline chloride (ChCl) and three hydrogen-bond donors (HBD)-lactic acid (Lac), glycerol, and urea-were evaluated for isolation of willow (Salix matsudana cv. Zhuliu) lignin. DESs types, mole ratio of ChCl to HBD, extraction temperature, and time on the fractionated DES-lignin yield demonstrated that the optimal DES-lignin yield (91.8 wt % based on the initial lignin in willow) with high purity of 94...

Incorporation of TiOnanotubes in a polycrystalline zirconia: Synthesis of nanotubes, surface characterization, and bond strength.

Despite numerous advantages such as high strength, the bond of yttria-stabilized zirconia polycrystal (Y-TZP) to tooth structure requires improvement.

Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.

Prioritizing the risk posed by thousands of chemicals potentially present in the environment requires exposure, toxicity, and toxicokinetic (TK) data, which are often unavailable. Relatively high throughput, in vitro TK (HTTK) assays and in vitro-to-in vivo extrapolation (IVIVE) methods have been developed to predict TK, but most of the in vivo TK data available to benchmark these methods are from pharmaceuticals. Here we report on new, in vivo rat TK experiments for 26 non-pharmaceutical chemicals with env...

Regio- and Chemoselective Hydrogenation of Dienes to Monoenes Governed by a Well-Structured Bimetallic Surface.

Unprecedented surface chemistry, governed by specific atomic arrangements and the steric effect of ordered alloys, is reported. Rh-based ordered alloys supported on SiO2 (RhxMy/SiO2, M = Bi, Cu, Fe, Ga, In, Pb, Sn, and Zn) were prepared and tested as catalysts for selective hydrogenation of trans-1,4-hexadiene to trans-2-hexene. RhBi/SiO2 exhibited excellent regioselectivity for the terminal C=C bond and chemoselective hydrogenation to the monoene, not to the overhydrogenated alkane, resulting in a high tra...

Production of highly efficient activated carbons from industrial wastes for the removal of pharmaceuticals from water-A full factorial design.

The wide occurrence of pharmaceuticals in aquatic environments urges the development of cost-effective solutions for their removal from water. In a circular economy context, primary paper mill sludge (PS) was used to produce activated carbon (AC) aiming the adsorptive removal of these contaminants. The use of low-cost precursors for the preparation of ACs capable of competing with commercial ACs continues to be a challenge. A full factorial design of four factors (pyrolysis temperature, residence time, prec...

High loading solubilization and upgrading of poly(ethylene terephthalate) in low cost bifunctional ionic liquid.

High loading solubilization and efficient upgrading polyethylene terephthalate (PET) is of significant importance but challenging and most solvents for PET are highly toxic. In this work, we demonstrate for the first time that a low cost (~$1.2/kg) and biocompatible ionic liquid (IL), cholinium phosphate ([Ch]3[PO4]) can play bifunctional roles in PET solubilization and glycolytic degradation. High loading of PET (10 wt%) is readily dissolved in [Ch]3[PO4] at relatively low temperatures (120 °C, 3h) and ev...

Optimization, chain conformation and characterization of exopolysaccharide isolated from Leuconostoc mesenteroides DRP105.

Response surface methodology (RSM) was used to optimize the fermentation condition of exopolysaccharide (EPS) producing strain Leuconostoc mesenteroides DRP105. Result showed that the optimum condition was sucrose 86.83 g/L, tryptone 15.47 g/L, initial pH 7.18 and maximum yield was 53.79 ± 0.78 g/L in 36 h fermentation. Chain conformation was characterized by Congo red test, β-elimination and circular dichroism (CD), which indicated that the EPS was O-linkage and exhibited random coil struct...


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