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PubMed Journals Articles About "AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated" RSS

12:14 EST 16th December 2018 | BioPortfolio

AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated articles that have been published worldwide.

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Showing "AMAG Pharmaceuticals Participate Barclays High Yield Bond Syndicated" PubMed Articles 1–25 of 34,000+

A Ter-Ionic Complex that Forms a Bond Upon Visible Light Absorption.

A "ter-ionic complex" comprised of a tetracationic Ru(II) complex and two iodide ions was found to yield a covalent I-I bond upon visible light excita-tion in acetone solution. H NMR, visible absorp-tion, and DFT studies revealed that one iodide was associated with a ligand while the other was closer to the Ru metal center. Standard Stern-Volmer quenching of the excited state by iodide revealed upward curvature with a novel saturation at high concentrations. The data were fully consistent with a mechanism i...


Motivation to participate in high-intensity functional exercise compared with a social activity in older people with dementia in nursing homes.

Motivation to participate in exercise among people with dementia has not been well studied. The symptoms of dementia, including apathy, may lead to low motivation to participate in exercise. The aim of this study was to evaluate the motivation of older people with dementia to participate in a high-intensity exercise program compared with motivation of those participating in a social group activity.

Synthesis of highly potent Lymphocyte Function-Associated Antigen-1 Antagonists Labeled with Carbon-14 and with Stable Isotopes, Part 3.

The drug candidates (2) and (3) are highly potent LFA-1 inhibitors. They were efficiently prepared labeled with carbon-14 using a palladium-catalyzed carboxylation of an iodo-precursor (5) and sodium formate- C to afford acid [ C]-(6), which was coupled via an amide bond to chiral amines (7) and (8) in 52% and 48% overall yield respectively and with specific activities higher than 56 mCi/mmol and radiochemical purities of 99%. For stable isotopes synthesis, the amine [ H ]-(7) was synthesized in three steps...


Policosanol fabrication from insect wax and optimization by response surface methodology.

Insect wax is a famous biological resource for the role in economic production in China. Insect wax is a good source of policosanol, which may is a candidate supplement in foodstuff and pharmaceuticals that has important physiological activities. Therefore, this work aims to investigate a high-yield and rapid method for policosanol fabrication from insect wax.

Swimming activity in zebrafish larvae exposed to veterinary antiparasitic pharmaceuticals.

Veterinary antiparasitic pharmaceuticals have been detected in surface waters and several of these pharmaceuticals act on the nervous system on the target organisms implying that neurological effects also might be of concern in non-target animals such as fish. We tested if exposure to antiparasitic pharmaceuticals affect swimming activity in 6 days old zebrafish larvae. The results revealed that most pharmaceuticals did not cause any effects in swimming activity. However, larvae exposed to 0.58 mg/L doram...

Olefin Cyclopropanation via Radical Carbene Transfer Reaction Promoted by Co(II)porphyrinates for the Active-Metal-Template Synthesis of 2Rotaxanes.

A Co(II)porphyrinate-based macrocycle in the presence of 3,5-diphenylpyridine axial ligand functions as an endotopic ligand to direct the assembly of [2]rotaxanes from diazo and styrene half-threads via radical carbene transfer reactions in excellent 95% yield. The method reported herein applies the active-metal template strategy to include radical-type activation of ligands by the metal-template ion during the organometallic process that ultimately yield the mechanical bond. A careful quantitative analysis...

Cycloaddition versus Cleavage of C=S Bond of Isothiocyanates Promoted by Digallane Compounds with Non-Innocent a-Diimine Ligands.

While the chemistry of single-bond activation by main-group element compounds has gained some development in recent years, the cleavage of multiple bonds remains underexplored. Here we report the reactions of two digallanes bearing α-diimine ligands, [L1Ga-GaL1] (1, L1 = dpp-dad = [(2,6-iPr2C6H3)NC(CH3)]2) and [L2Ga-GaL2] (2, L2 = dpp-bian = 1,2-[(2,6-iPr2C6H3)NC]2C10H6), with isothiocyanates. Reactions of 1 or 2 with isothiocyanates in 1:2 molar ratio proceeded via [2+4] cycloaddition of C=S bond across t...

Effects of NOx, SO and RH on the SOA formation from cyclohexene photooxidation.

We performed a laboratory investigation of the secondary organic aerosol (SOA) formation from cyclohexene photooxidation with different initial NOx and SO concentrations at low and high relative humidity (RH). Both SOA yield and number concentration first increase drastically and then, decreased when the [VOC]/[NOx] ratio changed from 30 to 10 and from 10 to 3. Though the presence of SO could increase the SOA number concentration, the SOA yield could only increase under [VOC]/[NOx] = 10 and high RH, and...

Effects of pharmaceuticals on microbial communities and activity of soil enzymes in mesocosm-scale constructed wetlands.

Cyperus alternifolius based mesocosm-scale constructed wetland was employed to remove pharmaceuticals. We investigated the microbial community composition using phosphor lipid fatty acids (PFLAs) analysis and substrate enzyme activity during long-term exposure to pharmaceuticals in mesocosm-scale constructed wetlands. The results showed that there was no visible inhibition effect of pharmaceuticals on CW substrate enzymes activities in the experimental range (0-500 μg/L). Microbial communities, as reveal...

Gold-Catalyzed Formal C-C Bond Insertion Reaction of 2-Aryl-2-diazoesters with 1,3-Diketones.

The transition-metal-catalyzed formal C-C bond insertion reaction of diazo compounds with monocarbonyl compounds is well established, but the related reaction of 1,3-diketones instead gives C-H bond insertion products. Herein, we report a protocol for a gold-catalyzed formal C-C bond insertion reaction of 2-aryl-2-diazoesters with 1,3-diketones, which provides efficient access to polycarbonyl compounds with an all-carbon quaternary center. The aryl ester moiety plays a crucial role in the unusual chemoselec...

Illumina sequencing analysis of the ruminal microbiota in high-yield and low-yield lactating dairy cows.

In this study, differences in the ruminal bacterial community between high-yield and low-yield lactating dairy cows under the same dietary conditions were investigated. Sixteen lactating dairy cows with similar parity and days in milk were divided into high-yield (HY) and low-yield (LY) groups based on their milk yield. On day 21, rumen content samples were collected, and their microbiota compositions were determined using high-throughput sequencing of the 16S rRNA gene by the Illumina MiSeq platform. Durin...

Chiral pharmaceuticals: Environment sources, potential human health impacts, remediation technologies and future perspective.

Chiral pharmaceuticals (CPs), including non-steroid anti-inflammatory drugs (NSAIDs), β-blockers and some herbicide and pesticides, are widely used in aquaculture, clinical treatment and many other fields. However, people are increasingly concerned about such ubiquitous pollutants, which can frequently be detected in contaminated soil and water. In large part, the significant sources of chiral pharmaceuticals stem from industrial processes, such as the direct discharge of untreated or incompletely treated ...

Inter/intramolecular Bonds in TH (T = C/Si/Ge): H as Tetrel Bond Acceptor and the Uniqueness of Carbon Bonds.

Atoms in Molecules (AIM), Natural Bond Orbital (NBO), and normal coordinate analysis have been carried out at the global minimum structures of TH5+ (T = C/Si/Ge). All these analyses lead to a consistent structure for these three protonated TH4 molecules. The CH5+ has a structure with three short and two long C-H covalent bonds and no H-H bond. Hence, the popular characterization of protonated methane as a weakly bound CH3+ and H2 is inconsistent with these results. However, SiH5+ and GeH5+ are both indeed a...

Direct Photocatalytic S-H Bond Cyanation with Green "CN" Source.

Herein we report a novel C-S bond cleavage and reconstruction strategy for the synthesis of thiocyanates through direct photocatalytic S-H bond cyanation from thiols and inorganic thiocyanate salts. In our strategy, the unprecedented example of cutting off C-S bond of SCN- to deliver the green "CN" sources is demonstrated. This transformation features nontoxic and inexpensive "CN" sources, available starting materials, metal-/base-/ligand-/peroxide-free, high step economy and mild conditions. It leads to th...

Copper-Catalyzed Intermolecular Reductive Radical Difluoroalkylation-Thiolation of Aryl Alkenes.

A novel radical-involved alkene difunctionalization catalyzed by the copper/Bpin system has been developed, leading to the difluoroalkylation-thiolation of aryl alkenes. The use of Bpin as an organic reductant enables the simultaneous installation of a C(sp)-C(FR) bond and a C(sp)-S(R) bond across the C═C bond of aryl alkenes by utilizing two electrophilic reactants. The reaction exhibits broad substrate scope, excellent diastereoselectivity, and moderate to good yields. Moreover, the reaction can be cond...

Assessment of 83 pharmaceuticals in WWTP influent and effluent samples by UHPLC-MS/MS: Hourly variation.

The removal efficiency of pharmaceuticals in wastewater treatment plants (WWTPs) is variable and some of these compounds pass these plants almost intact and others presenting a removal efficiency close to 100%. Their incomplete removal results in a continuous discharge of pharmaceuticals into the environment. To assess the profile of contamination of influents and effluents over a day, a set of 83 pharmaceuticals were evaluated hourly in a WWTP in Leiria, Portugal. The composite samples of the influent and ...

A Modified System for the Synthesis of Enantioenriched N-Arylamines through Copper-Catalyzed Hydroamination.

Despite significant recent progress in the copper-catalyzed enantioselective hydroamination chemistry, the synthesis of chiral N-arylamines, which are frequently found in natural products and pharmaceuticals, has not been realized. Initial experiments with N-arylhydroxylamine ester electrophiles were unsuccessful and, instead, their reduction, in the presence of copper hydride (CuH) catalysts, was observed. Herein, we report key modifications of our previously reported hydroamination protocols that lead to ...

RuHCl(CO)(PPh3)3-Catalyzed Direct Amidation of Arene C-H Bond with Azides.

We first report the direct ortho C-H amidation of arenes with azides by using a novel and inexpensive RuHCl(CO)(PPh3)3 catalyst. The reaction proceeds efficiently in high yield over a broad range of substrates without requirement of any additional silver salt or additive.

Detection of Quantitative Trait Loci Underlying Yield-Related Traits in Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes).

Increasing yield is a principal goal when breeding Lentinus edodes. The detection of quantitative trait loci (QTLs) underlying yield and its related traits, precocity and the number of fruiting bodies (NFs), is important in order to breed high-yield cultivars. Using composite interval mapping (CIM), we mapped a total of 25 QTLs responsible for precocity, NFs, and yield in 2 segregating populations of L. edodes. QTLs for the 3 traits were mapped on 5 different linkage groups, contributing 5.9% to 15.4% of th...

Asymmetric Rh(I)-Catalyzed Functionalization of the 3-C( sp)-H Bond of Benzofuranones with α-Diazoesters.

An asymmetric Rh(I)-catalyzed functionalization of the 3-C( sp)-H bond of benzofuranones with α-diazoesters has been developed, providing a new strategy for the stereoselective 3-alkylation of benzofuranones. With low catalyst loadings (low to 0.02 mol % Rh), a number of benzofuranones bearing consecutive quaternary and tertiary stereogenic centers have been synthesized (up to 94% yield, 95:5 dr, and >99% ee). The synthetic utilities of this methodology have been demonstrated by elaborating the model produ...

Advanced oxidation process-mediated removal of pharmaceuticals from water: A review.

Pharmaceuticals, which are frequently detected in natural and wastewater bodies as well as drinking water have attracted considerable attention, because they do not readily biodegrade and may persist and remain toxic. As a result, pharmaceutical residues pose on-going and potential health and environmental risks. To tackle these emerging contaminants, advanced oxidation processes (AOPs) such as photo-Fenton, sonolysis, electrochemical oxidation, radiation and ozonation etc. have been applied to remove pharm...

Strong pH-Dependent Near-Infrared Fluorescence in a Microbial Rhodopsin Reconstituted with a Red-Shifting Retinal Analogue.

Near-infrared (NIR)-driven rhodopsins are of great interest in optogenetics and other optobiotechnological developments such as artificial photosynthesis and deep-tissue voltage imaging. Here we report that the proton pump proteorhodopsin (PR) containing a NIR-active retinal analogue (PR:MMAR) exhibits intense NIR fluorescence at a quantum yield of 3.3%. This is 130 times higher than native PR (Lenz, M.O. et al., Biophys J 2006, 91, 255-62) and 3-8 times higher than the QuasAr and PROPS voltage sensors (Kra...

Adsorptive interaction of cationic pharmaceuticals on activated charcoal: Experimental determination and QSAR modelling.

Due to high mobility and specific toxic actions of the ionizable pharmaceuticals in surface water with a normal range of pH, the pharmaceuticals should be removed before being discharged. Therefore, this study investigated the adsorptive interactions between cationic pharmaceuticals and a popular adsorbent (i.e., activated charcoal) frequently used in water treatment processes. For that, we performed isotherm experiments and then the results were plotted by Langmuir model to determine the adsorption affinit...

Application of liquid-liquid microextraction for the effective separation and simultaneous determination of 11 pharmaceuticals in wastewater samples using HPLC-MS/MS.

A dispersive liquid-liquid microextraction method for the simultaneous determination of 11 pharmaceuticals has been developed. The method is based on a microextraction procedure applied to wastewater samples from different regions of Hungary followed by high performance liquid chromatography with mass spectrometry. The effect of the nature of the extractant, dispersive solvent, different additives and extraction time were examined on the extraction efficiently of the dispersive liquid-liquid microextraction...

Fabrication of graphene-oxide/β-BiO/TiO/BiTiO heterojuncted nanocomposite and its sonocatalytic degradation for selected pharmaceuticals.

A graphene-oxide (GO)/β-BiO/TiO/BiTiO heterojuncted nanocomposite, designated as GBT, was synthesized via a two-step hydrothermal process. The sonocatalytic activity of the GBT was evaluated at several frequencies (28, 580, and 970 kHz) and compared with Bi-doped GO (GB) and Ti-doped GO (GT). Transmission electron microscopy images showed heterojuncted crystal structures of Bi and Ti on GO, and X-ray diffraction patterns verified that the crystal structures consisted of β-BiO, TiO, and BiTiO nanocomposi...


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