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Showing "Abdominal Aortic Aneurysms Pipeline Review 2015" PubMed Articles 1–25 of 21,000+

Cellular Mechanisms of Aortic Aneurysm Formation.

Aortic aneurysms are a common vascular disease in Western populations that can involve virtually any portion of the aorta. Abdominal aortic aneurysms are much more common than thoracic aortic aneurysms and combined they account for >25 000 deaths in the United States annually. Although thoracic and abdominal aortic aneurysms share some common characteristics, including the gross anatomic appearance, alterations in extracellular matrix, and loss of smooth muscle cells, they are distinct diseases. In recent...

Evolution of practices in Treatment of abdominal aortic aneurysm in France between 2006 and 2015.

The main objective of this study was to identify the changes that have occurred in the treatment of abdominal aortic aneurysms (AAA) in France over a period of 10 years.

Genetics of Thoracic and Abdominal Aortic Diseases.

Dissections or ruptures of aortic aneurysms remain a leading cause of death in the developed world, with the majority of deaths being preventable if individuals at risk are identified and properly managed. Genetic variants predispose individuals to these aortic diseases. In the case of thoracic aortic aneurysm and dissections (thoracic aortic disease), genetic data can be used to identify some at-risk individuals and dictate management of the associated vascular disease. For abdominal aortic aneurysms, gene...

The association between diabetes and thoracic aortic aneurysms.

The negative correlation between diabetes mellitus (DM) and abdominal aortic aneurysms (AAAs) is well described. The etiologic similarities and differences between AAAs and thoracic aortic aneurysms (TAAs) have also been documented. We aimed to evaluate the relationship between DM and TAA by performing a meta-analysis of contemporary clinical studies.

Infra-renal vs supra-renal abdominal aortic aneurysms: Comparison of associated aneurysms and renal artery stenosis.

The aim of our study was to assess the prevalence of concomitant arterial abnormalities (true aneurysms of iliac, common femoral, renal, visceral arteries and stenoses of iliac and renal arteries) in patients with abdominal aortic aneurysm, and to evaluate whether the type of the aneurysm (suprarenal versus solely infrarenal) is associated with this prevalence.

Mid-term follow-up geometrical analysis of thoraco-abdominal aortic aneurysms treated with multilayer flow modulator.

Aim of our study is the analysis of clinical results and aneurysmal sac evolution after Multilayer Flow Modulator (MFM) placement, in patients with thoraco-abdominal aortic aneurysms (TAA).

Additional value of biomechanical indices based on CTa for rupture risk assessment of abdominal aortic aneurysms.

Biomechanics for rupture risk prediction in abdominal aortic aneurysms (AAA) are gaining popularity. However, their clinical applicability is still doubtful as there is lack of standardization. This study evaluates the added value of biomechanical indices in rupture risk assessment.

Abdominal Aortic Aneurysm Screening: A Systematic Review and Meta-analysis of Efficacy and Cost.

Abdominal aortic aneurysms (AAA) can cause significant mortality when ruptured but are often undiagnosed before this time. Population screening of high risk individuals and early intervention may mitigate AAA-related mortality. Large trials have demonstrated a mortality benefit for AAA screening but adoption is not ubiquitous. This study sought to systematically review and consolidate the most recent randomised trial evidence on AAA screening in mend and its cost effectiveness.

Impact of polar renal artery coverage following fenestrated endovascular aortic repair (FEVAR) for juxta-renal and type IV thoraco-abdominal aortic aneurysms.

Fenestrated endovascular aortic repair (FEVAR) of complex aneurysm can require the coverage of polar renal artery. The aim of this study was to investigate the impact of the procedure on post-operative outcomes in patients with juxta-renal or thoraco-abdominal aortic aneurysms.

Analysis of The Correlation Between Central Obesity And Abdominal Aortic Diseases.

atherosclerosis and Abdominal Aortic Aneurysms (AAA) have several similar risk factors but different pathogenesis. Inflammation of the arteries is common to both. Central obesity can act as an endocrine organ through the secretion of inflammatory cytokines and the perivascular fat has a local effect that could contributes to diseases of the abdominal aorta. While the relation between central obesity and atherosclerosis occlusive arterial disease has been demonstrated, the correlation with AAA has conflictin...

Anemia and postoperative outcomes after open and endovascular repair of intact abdominal aortic aneurysms.

Anemia is associated with increased cardiac adverse events during the early postoperative period because of high physiologic stress and increased cardiac demand. The aim of this study was to assess the surgical outcomes and prognostic implications of anemia in patients undergoing repair of intact abdominal aortic aneurysms (AAAs).

Ruptured Abdominal Aortic Aneurysm with a Suprarenal Tumor.

This paper presents a case study of a patient that underwent surgery for a ruptured abdominal aneurysm. The postoperative course was complicated by resistant hypertension and tachycardia. A suprarenal mass was detected in the computed tomography scan with radiological suspicion of pheochromocytoma. Few cases of pheochromocytoma coexisting with aneurysms have been reported. Management of cardiovascular stability is crucial in such cases. Despite the lack of evidence, pheochromocytomas might have a role in th...

Preoperative Predictors of Discharge Destination Following Endovascular Repair of Abdominal Aortic Aneurysms.

There is a paucity of data guiding preoperative counselling on the need for discharge to a facility or non-home discharge (NHD) following elective endovascular repair of abdominal aortic aneurysms (EVAR). This study seeks to determine the preoperative predictors of NHD following EVAR in baseline home-dwelling patients and to determine whether NHD is associated with major post-discharge complications and readmission.

Pipeline Embolization of Vertebrobasilar Aneurysms - a Multicenter Case Series.

and purpose: The Pipeline Embolization Device (PED) is being increasingly utilized for treatment of posterior circulation aneurysms. The purpose of this study was to examine the clinical and angiographic outcomes of patients with vertebrobasilar aneurysms treated with the PED.

The Intra-rater and Inter-rater Reliability of measures derived from Cardiopulmonary Exercise Testing (CPET) in patients with Abdominal Aortic Aneurysms (AAA).

Patients with abdominal aortic aneurysms (AAA) often have low exercise tolerance due to comorbidities and advance age. Cardiopulmonary exercise testing (CPET) is predictive of post-operative morbidity and mortality in patients with AAA. We aimed to assess the intra- and inter-rater reliability of both treadmill and cycle ergometer based CPET variables.

Pharmacologic Management of Aneurysms.

Current management of aortic aneurysms relies exclusively on prophylactic operative repair of larger aneurysms. Great potential exists for successful medical therapy that halts or reduces aneurysm progression and hence alleviates or postpones the need for surgical repair. Preclinical studies in the context of abdominal aortic aneurysm identified hundreds of candidate strategies for stabilization, and data from preoperative clinical intervention studies show that interventions in the pathways of the activate...

Validation of abdominal aortic aneurysm repair codes in Ontario administrative data.

To determine the positive predictive values (PPV) of Ontario administrative data codes for the identification of open (OSR) and endovascular (EVAR) repairs of elective (eAAA) and ruptured (rAAA) abdominal aortic aneurysms.

Psoas muscle area and quality are independent predictors of survival in patients treated for abdominal aortic aneurysms.

Sarcopenia is associated with mortality after abdominal aortic aneurysm (AAA) repair. The reliability of computed tomography (CT) core muscle areas and quality i.e. densities and their association with postoperative survival in patients undergoing AAA treatment were retrospectively studied.

Blunt abdominal aortic injury may accompany bowel transection.

Blunt abdominal aortic injury is an extremely rare condition. In the past, when blunt abdominal aortic injury was managed with open surgery, intra-abdominal injury was identified more easily, while in the era of endovascular surgery, intra-abdominal injury might potentially be found after vascular reconstruction. We present a case of blunt abdominal aortic injury treated using a parallel graft-stent and simultaneous laparoscopy which revealed an occult bowel perforation.

Outcomes and cost of fenestrated versus standard endovascular repair of intact abdominal aortic aneurysm in the United States.

Fenestrated endovascular aneurysm repair (FEVAR) has expanded the indications of this minimally invasive procedure to include patients with pararenal aneurysms. The actual cost of this relatively newer technology compared with standard endovascular aneurysm repair (EVAR) has not been studied before. Thus, the aim of this study was to analyze in-hospital costs and adverse outcomes in patients undergoing FEVAR vs EVAR for intact abdominal aortic aneurysms (AAAs).

Biomechanical research progress on sex differences of abdominal aortic aneurysm.

The phenomenon of sex differences exists in patients who have abdominal aortic aneurysms (AAA). The occurrence rate of AAA is higher in male, while the rates of rupture and postoperative mortality are higher for female. This phenomenon of sex differences would affect the diagnosis, treatment and postoperative rehabilitation for AAA patients. This article reviewed the recent research status of sex differences on AAA, and explored the phenomenon of sex differences from the aspects of threshold determination, ...

Fenestrated endovascular aneurysm repair is associated with lower perioperative morbidity and mortality compared with open repair for complex abdominal aortic aneurysms.

The Zenith Fenestrated Endovascular Graft (ZFEN; Cook Medical, Bloomington, Ind) has expanded the anatomic eligibility of endovascular aneurysm repair (EVAR) for complex abdominal aortic aneurysms (AAAs). Current data on ZFEN mainly consist of single-institution experiences and show conflicting results. Therefore, we compared perioperative outcomes after repair using ZFEN with open complex AAA repair and infrarenal EVAR in a nationwide multicenter registry.

Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates.

The Asp358Ala variant (rs2228145; A>C) in the interleukin-6 receptor ( IL6R) gene has been implicated in the development of abdominal aortic aneurysms (AAAs), but its effect on AAA growth over time is not known. We aimed to investigate the clinical association between the IL6R-Asp358Ala variant and AAA growth, and to assess the effect of blocking the IL-6 signalling pathway in mouse models of aortic aneurysm rupture or dissection.

Type of Anesthesia for Endovascular Abdominal Aortic Aneurysm Repair.

Endovascular aneurysm repair (EVAR) is used increasingly in the management of patients with abdominal aortic aneurysms (AAAs), including in the emergency setting for ruptured AAA. The lower mortality among patients undergoing emergency EVAR under local anesthesia (LA) observed in the Immediate Management of Patients with Rupture: Open Versus Endovascular Repair trial has sparked renewed interest in the anesthesia choice for EVAR. This systematic review evaluates the effect of mode of anesthesia on outcomes ...

pathogenic variants: risk for thoracic aortic disease and associated complications from the Montalcino Aortic Consortium.

Pathogenic variants in cause thoracic aortic aneurysms and dissections, along with aneurysms and rupture of other arteries. Here, we examined differences in clinical presentation of aortic events (dissection or surgical repair of an aneurysm) with respect to age and variant type in an international cohort of individuals with variants.

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