PubMed Journals Articles About "Acute Spinal Cord Injury Global Clinical Trials Review" RSS

16:24 EDT 15th September 2019 | BioPortfolio

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Showing "Acute Spinal Cord Injury Global Clinical Trials Review" PubMed Articles 1–25 of 57,000+

Acute Adverse Events After Spinal Cord Injury and Their Relationship to Long-term Neurologic and Functional Outcomes: Analysis From the North American Clinical Trials Network for Spinal Cord Injury.

There are few contemporary, prospective multicenter series on the spectrum of acute adverse events and their relationship to long-term outcomes after traumatic spinal cord injury. The goal of this study is to assess the prevalence of adverse events after traumatic spinal cord injury and to evaluate the effects on long-term clinical outcome.

The role of prophylactic hypothermia on neurophysiological and functional measures in the setting of an iatrogenic spinal cord impact injury.

Iatrogenic spinal cord injury (iSCI) during spinal corrective surgery can result in devastating complications such as paraplegia or paraparesis. Perioperatively, iSCI often occurs as a direct injury during spinal cord instrumentation placement. To date, treatment of iSCI remains contented with post-traumatic hypothermic treatment demonstrating some value in recent clinical trials. Here, we illustrate the outcomes of pre-injury hypothermia initiated pre-procedurally and lasting for a considerable period of t...

Development of a Traumatic Cervical Dislocation Spinal Cord Injury Model with Residual Compression in the Rat.

Pre-clinical spinal cord injury models do not represent the wide range of biomechanical factors seen in human injuries, such as spinal level, injury mechanism, velocity of spinal cord impact, and residual compression. These factors may be responsible for differences observed between experimental and clinical study results, especially related to the controversial issue of timing of surgical decompression.

Therapeutic Potential of Wnt-3a in Neurological Recovery after Spinal Cord Injury.

Spinal cord injury (SCI) is a constant challenge in medical research and a global therapeutic problem. Treatment of this condition remains difficult in clinical practice. Hence, prevention, treatment, and rehabilitation of SCI have become imminent tasks in the medical field.

Acute spinal cord injury is associated with mitochondrial dysfunction in mouse urothelium.

To characterize the effects of acute spinal cord injury (SCI) on mitochondrial morphology and function in bladder urothelium and to test the therapeutic efficacy of early treatment with the mitochondrially targeted antioxidant, MitoTempo.

Stem cell therapies for acute spinal cord injury in humans: a review.

Recent advances in stem cell biology present significant opportunities to advance clinical applications of stem cell-based therapies for spinal cord injury (SCI). In this review, the authors critically analyze the basic science and translational evidence that supports the use of various stem cell sources, including induced pluripotent stem cells, oligodendrocyte precursor cells, and mesenchymal stem cells. They subsequently explore recent advances in stem cell biology and discuss ongoing clinical translatio...

Proprioception: Bottom-up directive for motor recovery after spinal cord injury.

Proprioceptive feedback provides movement-matched sensory information essential for motor control and recovery after spinal cord injury. While it is understood that the fundamental contribution of proprioceptive feedback circuits in locomotor recovery is to activate the local spinal cord interneurons and motor neurons in a context-dependent manner, the precise mechanisms by which proprioception enables motor recovery after a spinal cord injury remain elusive. Furthermore, how proprioception contributes to m...

Spinal Cord Protection for Thoracic Aortic Surgery: Bench to Bedside.

In this article, we review the anatomically driven pathophysiology of spinal cord injury, the impact of ischemia reperfusion on the cellular level, current research in developing neuronal ischemic tolerance, and promotion of collateralization. We also discuss neuro-protective strategies in modern clinical practice, current pharmacologic interventions, and continued challenges in the management of complex aortic disease. The pathophysiology of spinal cord injury includes disruption and recovery of collateral...

Neuroprotective Effects of Combined Treatment with Minocycline and Olfactory Ensheathing Cells Transplantation against Inflammation and Oxidative Stress after Spinal Cord Injury.

Traumatic spinal cord injury (SCI) is considered one of the most devastating injuries leading to neuronal disruption. Olfactory ensheathing cells (OECs) and minocycline have been shown to promote locomotor function after spinal cord injury. In this study, we have tested the efficacy of combined treatment with minocycline and OECs after contusive spinal cord injury.

Duplex ultrasound surveillance for deep vein thrombosis after acute traumatic spinal cord injury at rehabilitation admission.

To determine the prevalence of deep vein thrombosis (DVT) detected through routine duplex screening and factors associated with DVT in spinal cord injury (SCI) patients on admission to rehabilitation.

miR-940 promotes spinal cord injury recovery by inhibiting TLR4/NF-κB pathway-mediated inflammation.

The aim of this study was to investigate the effects of miR-940 and Toll-like receptor 4/Nuclear Factor κB (TLR4/NF-κB) pathways on inflammatory responses and spinal cord injury (SCI).

Current Agents and Related Therapeutic Targets for Inflammation Following Acute Traumatic Spinal Cord Injury.

Infliction of a traumatic spinal cord injury propagates damage that is seen in two stages. The first phase of trauma occurs from the initial mechanical insult, while the second phase involves the degradation of nervous tissue but is likely not affected by the initial insult. Thus therapeutic targets with a high specificity for these secondary injury processes are of increasing interest. The pathophysiologic cascades of inflammation after spinal cord injuries and potential therapeutic targets are reviewed.

Employment and job benefits among those with spinal cord dysfunction: A comparison of people with spinal cord injury and multiple sclerosis.

(1) Identify the proportion of participants with spinal cord dysfunction (SCD) reporting each of 10 job benefits and compare the proportions between participants with spinal cord injury (SCI) and multiple sclerosis (MS), and (2) examine if diagnostic criteria, demographics, education level, and functional limitations are associated with the number of job benefits received.

Thromboprophylaxis in Patients with Acute Spinal Cord Injury: A Narrative Review.

Patients with acute spinal cord injury (SCI) have the highest risk of venous thromboembolism (VTE) among hospitalized patients. The incidence of total deep vein thrombosis ranges from 50 to 100% in untreated patients and pulmonary embolism is the third most common cause of mortality in these patients. The pathophysiology of the increased risk of VTE is explained by venous stasis after injury, endothelial vessel wall injury from surgery, and a hypercoagulable state associated with trauma. The current thrombo...

Leuprolide Acetate, a GnRH Agonist, Improves the Neurogenic Bowel in Ovariectomized Rats with Spinal Cord Injury.

Electromyographic studies have shown that external anal sphincter activity is modified in response to distension in animals with spinal cord injury. Gonadotropin-releasing hormone and its agonist leuprolide acetate have neurotrophic properties in animals with spinal cord injury.

Recent advances in the therapeutic uses of chondroitinase ABC.

Many studies, using pre-clinical models of SCI, have demonstrated the efficacy of chondroitinase ABC as a treatment for spinal cord injury and this has been confirmed in laboratories worldwide and in several animal models. The aim of this review is report the current state of research in the field and to compare the relative efficacies of these new interventions to improve outcomes in both acute and chronic models of SCI. We also report new methods of chondroitinase delivery and the outcomes of two clinical...

Traumatic vs non-traumatic spinal cord injury: A comparison of primary rehabilitation outcomes and complications during hospitalization.

To compare outcome for patients with traumatic (TSCI) and non-traumatic spinal cord injuries (NTSCI) after primary rehabilitation regarding neurological improvement measured by the American Spinal Injury Association Impairment Scale (AIS), length of stay and complications.

Education provision for patients following a spinal cord injury.

approximately 40 000 people in the UK live with spinal cord injury.

Assessing spinal cord injury area in patients with Tethered Cord Syndrome by Diffusion tensor imaging.

To evaluate the spinal cord injury range in the patients with tethered cord syndrome who have urinary incontinence.

The origin, fate, and contribution of macrophages to spinal cord injury pathology.

Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell proliferation and differentiation, as well as tissue remodeling, are mediated in part by infiltrating monocyte-derived macrophages. It is now clear that these infiltrating macrophages have distinct functions from resident microglia and are capable of mediating both harmful and beneficial effects after injury. These divergent effects have been largely attributed to environmental cues, such as specific cytokines, that influe...

Nanovector-Mediated Drug Delivery in Spinal Cord Injury: A Multitarget Approach.

Many pre-clinical studies seek cures for spinal cord injury (SCI) but when the results are translated to clinical trials they give scant efficacy. One possible reason is that most strategies use treatments directed toward a single pathological mechanism, while a multitherapeutic approach needs to be tested to significantly improve outcomes after SCI. Most of the pre-clinical reports gave better outcomes when a combination of different compounds was used instead of a single drug. This promising approach, how...

Ziconotide for spinal cord injury related pain.

Central neuropathic pain related to spinal cord injury is notoriously difficult to treat. So far most pharmacological and surgical options have shown but poor results. Recently ziconotide has been approved for use both neuropathic and non-neuropathic pain. In this cohort study, we assessed responder rate and long term efficacy of intrathecal ziconotide in patients with pain related to spinal cord injury.

Reliability and validity of the function in sitting test among non-ambulatory individuals with spinal cord injury.

Trunk impairment among non-ambulatory individuals with spinal cord injury (SCI) reduces the ability to maintain a functional sitting position and perform activities of daily living. Measuring functional sitting balance is complex and difficult in a clinical setting. The function in sitting test (FIST) is a clinical measure that includes the assessment of all the components of sitting balance. The purpose of this study is to assess the reliability and validity of the 14-item FIST among non-ambulatory individ...

Health, functioning and accessibility among spinal cord injury population in Finland: Protocol for the FinSCI study.

The purpose of the Finnish Spinal Cord Injury Study (FinSCI) is to identify factors related to the health and functioning of people with spinal cord injury, their challenges with accessibility, and how such factors are interconnected. The International Classification of Functioning, Disability and Health (ICF) is used as a structured framework in the study.

MicroRNA-204-5p targets SOX11 to regulate the inflammatory response in spinal cord injury.

The purpose of this study was to investigate whether microRNA-204-5p can regulate the inflammatory response of spinal cord injury (SCI) by targeting SOX11.

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