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PubMed Journals Articles About "Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc" RSS

18:45 EDT 19th July 2019 | BioPortfolio

Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Adalimumab Biosimilar Idacio Launched Germany∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "Adalimumab biosimilar Idacio launched Germany derfield score derval" PubMed Articles 1–25 of 4,300+

Gestational age-related reference values for Apgar score and umbilical cord arterial and venous pH in preterm and term newborns.

Despite much literature on reference values of acid-base status in umbilical cord blood at birth, there are yet no studies performed to determine gestational age-dependent references in cord venous blood and no studies on preterm acid-base standards. Similarly, the normal reference range of Apgar score for term and preterm infants has not yet been determined.


Consecutive transperineal prostatic template biopsies employing cognitive and systematic approach: a single center study.

The role of transperineal template biopsy for prostate cancer diagnosis is well established. Pre-biopsy multiparametric magnetic resonance imaging (MRI) is used in most centers for planning of prostate biopsies and staging. Cognitive and software fusion techniques are increasingly getting popular. We retrospectively reviewed patients who underwent transperineal template biopsies from January 2016 till December 2018. This included patients on active surveillance, previous negative transrectal ultrasonograph...

Evidence that Tenecteplase Is Noninferior to Alteplase for Acute Ischemic Stroke.

Background and Purpose- TNK (tenecteplase), a newer fibrinolytic agent, has practical delivery advantages over ALT (alteplase) that would make it a useful agent if noninferior in acute ischemic stroke treatment outcome. Accordingly, the most recent US American Heart Association/American Stroke Association acute ischemic stroke guideline recognized TNK as an alternative to ALT, but only based on informal consideration, rather than formal meta-analysis, of completed randomized control trials. Methods- Systema...


Blood Pressure and Outcome After Mechanical Thrombectomy With Successful Revascularization.

Background and Purpose- Successful reperfusion can be achieved in more than two-thirds of patients treated with mechanical thrombectomy. Therefore, it is important to understand the effect of blood pressure (BP) on clinical outcomes after successful reperfusion. In this study, we investigated the relationship between BP on admission and during the first 24 hours after successful reperfusion with clinical outcomes. Methods- This was a multicenter study from 10 comprehensive stroke centers. To ensure homogene...

Association of Psychache and Alexithymia With Suicide in Patients With Schizophrenia.

Suicide is a leading cause of death in patients with schizophrenia. Previous studies have mostly investigated the association between suicide and sociodemographics, positive and negative symptoms, and depressive symptoms. This study evaluated psychache and alexithymia in patients with schizophrenia, which have both been associated with suicide attempts and thoughts in patients with other psychiatric disorders. Positive and Negative Syndrome Scale (PANSS), Psychache Scale (PAS), Beck Scale for Suicidal Ideat...

Minimal Clinically Important Difference of Shoulder Outcome Measures and Diagnoses: A Systematic Review.

Patient-reported outcome scales determine response to treatment. The minimal clinically important difference of these scales is a measure of responsiveness: the smallest change in a score associated with a clinically important change to the patient. This study sought to summarize the literature on minimal clinically important difference for the most commonly reported shoulder outcome scales.

One Year Mortality in Geriatric Trauma Patients: Improving Upon the Geriatric Trauma Outcomes Score Utilizing the Social Security Death Index.

GTOS predicts in-patient mortality in geriatric trauma patients and has been validated in a prospective multicenter trial and expanded to predict adverse discharge (GTOS II). We hypothesized that these formulations actually underestimate the downstream sequelae of injury and sought to predict longer-term mortality in geriatric trauma patients.

The Significance of Visceral Protection in Preventing Enteroatmospheric Fistulae During Open Abdomen Treatment in Patients With Secondary Peritonitis: A Propensity Score-matched Case-control Analysis.

To evaluate the influence of a visceral protective layer (VPL) on the formation of enteroatmospheric fistulae (EAF) in open abdomen treatment (OAT) for peritonitis.

An Aging-Related Single-Nucleotide Polymorphism is Associated with Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients.

The contribution of individual genetic determinants of aging to the adverse clinical outcomes and altered inflammation mediator networks characteristic of aged trauma patients is unknown. The AA genotype of the aging-related single-nucleotide polymorphism (SNP) rs2075650 in TOMM40 has been associated with longevity, while the AG and GG genotypes are associated with an increased risk of Alzheimer's disease. Here, we studied the effect of rs2075650 on clinical outcomes and dynamic biomarker patterns after tra...

Awareness of residents about kala-azar and its related practices in two endemic areas of Bangladesh.

Kala-azar, a worldwide disease, is caused by the parasitic protozoan species of genus Leishmania and transmitted by species of sandflies. Awareness of the population about the disease is essential to run a successful control-strategies program. This cross-sectional study was conducted to assess the awareness of residents about it and related practices in two highly-endemic areas of Bangladesh. In total, 511 household respondents were selected conveniently from two unions (Kushmail and Kanihari) under two su...

Long survival of patients with metastatic clear cell renal cell carcinoma. Results of real life study of 344 patients.

The treatment landscape in metastatic renal cell carcinoma has changed fundamentally over the last decade by the development of anti-angiogenic agents, mTOR inhibitors, and immunotherapy. Outside of the context of a clinical trial the treatments are used sequentially. We describe results under real life conditions of a sequential treatment strategy, before the era of immunotherapy. All patients were treated according to their prognostic score (either MSKCC or IMDC) for advanced renal cell carcinoma. A treat...

Asymmetric Synthesis of Adjacent Tri- and Tetrasubstituted Carbon Stereocenters. Organocatalytic Aldol Reaction of an Hydantoin Surrogate with Azaarene 2-Carbaldehydes.

Bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford aldol adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (dr up to >20:1; ee up to 98%) is reported. Acid hydrolysis of adducts followed by reduction of the N-oxide group yields enantiopure carbinol-tethered quaternary hydantoin-azaarene conjugates with densely functionalized skeletons. DFT studies of the potential energy...

Temperature Control of Sequential Nucleation-Growth Mechanisms in Hierarchical Supramolecular Polymers.

Upon cooling in various solvents, chiral triarylamine tris-amide unimers produce organogels by stacking into helical supramolecular polymers which subsequently bundle into larger fibers. Interestingly, AFM imaging, circular dichroism, and vibrational circular dichroism of the chiral self-assemblies reveal that, while monocolumnar P-helical fibrils are formed upon fast cooling, bundled M-superhelical fibers are formed upon slow cooling. The mechanistic study of this structural bifurcation demonstrate the pre...

Ligand Effect in Alkali Metal-Catalyzed Transfer Hydrogenation of Ketones Iryna D. Alshakova, Hayden C. Foy, Travis Dudding, and Georgii I. Nikonov*a.

This paper unveils the reactivity patterns, as well as ligand and additive effect on alkali metal base catalyzed transfer hydrogenation of ketones. Crucially to this reactivity is the presence of a Lewis acid (alkali cation), as opposed to a simple base effect. With aryl ketones, the observed reactivity order is Na+ > Li+ > K+, whereas for aliphatic substrates it follows the expected Lewis acidity, Li+ > Na+ > K+. Importantly, the reactivity pattern can be drastically changed by adding ligands and additives...

Interest of plasma microvesicles to monitor pancreatic islet graft dysfunction: beta cell- and leukocyte-derived microvesicles as specific features in a pilot longitudinal study.

Markers of early pancreatic islet graft dysfunction and its causes are lacking. We monitored 19 T1D islet-transplanted patients for up to 36 months following last islet injection. Patients were categorized as Partial (PS) or complete (S) Success, or Graft Failure (F), using the β-score as an indicator of graft function. F was the subset reference of maximum worsened graft outcome. To identify the immune, pancreatic, and liver contribution to the graft dysfunction, the cell origin and concentration of circu...

Early ALT response to corticosteroid treatment distinguishes idiosyncratic Drug-induced Liver Injury from Autoimmune Hepatitis.

Drug-induced liver injury (DILI) and idiopathic autoimmune hepatitis (AIH) are competing diagnoses in patients with acute liver injury and drug intake. In absence of unequivocal markers, scores like RUCAM and the AIH score are used to distinguish both entities. However, in some cases the diagnosis remains ambiguous. Our aim was to identify a simple parameter to discriminate DILI and AIH shortly after starting corticosteroid treatment.

Chronic Cannabis Use and Circulating Biomarkers of Neural Health, Stress, and Inflammation in Physically Active Individuals.

Previous research has associated cannabis use with altered circulating neurotrophins and biomarkers of immune health, but these relationships have yet to be fully explored in physically active individuals. The specific aim of this study was to explore the relationships between biomarkers of neural health: nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), immune health: interleukin 6 (IL-6), c-reactive protein (CRP), and cortisol, as well as the presence of depression, in physically act...

Lifestyle and occupational factors associated with participation in colorectal cancer screening among men and women in Australia.

This study explores the associations between lifestyle and occupational factors and participation in colorectal cancer (CRC) screening among men and women aged 50 and over and living in Australia. We used weighted data from the Australian National Health Survey 2014-15 to produce population estimates. Lifestyle variables investigated were smoking, physical activity, alcohol consumption, fruit and vegetable consumption, and body mass index, while the occupational variables were labour force status, occupatio...

Albumin-to-alkaline phosphatase ratio as a novel prognostic indicator for patients undergoing minimally invasive lung cancer surgery: A prospective propensity score matching study.

To evaluate prognostic significance of albumin-to-alkaline phosphatase ratio (AAPR) for patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for non-small-cell lung cancer (NSCLC) by a propensity score-matching (PSM) analysis.

Enzyme Mimic Basing on Self-assembled Chitosan/DNA Hybrid Exhibits Superior Activity and Tolerance.

Nature has evolved exquisite active sites with which enzymes catalyze biotransformations with high efficiency. However, the exploitation of natural enzymes is often hampered by poor stability and natural enzyme production and purification are costly. Supramolecular self-assembly allows one to construct biomimetic active sites, although it is challenging to produce such artificial enzymes with catalytic activity and stability that rivals those of natural enzymes. In this work, we report a modular strategy to...

Recent Progress in Construction of Natural De-O-sulfonated Sulfonium Sugars with Antidiabetic Activities.

A group of sulfonium salts equipped with a poly hydroxylated side chain structure have been isolated and identified as potent alpha-glycosidase inhibitors. Consequently, they became attractive target in diverse research disciplines including organic synthesis, drug discovery and chemical biology. To this end, the development practical and effective synthetic strategies especially for more bioactive de-Osulfonated sulfonium salts is one of significant research areas in organic synthesis. An ideal synthetic m...

Sunlight selectively modifies Maillard reaction products in a wide array of chemical reactions.

We report the photochemical transformation of Maillard reaction products (MRPs) under simulated sunlight into mostly unexplored photoproducts. Non-enzymatic glycation of amino acids leads to a heterogeneous class of intermediates with extreme chemical diversity, which is of particular relevance in processed and stored food products as well as in diabetic and age-related protein damage. We here reacted three amino acids (lysine, arginine, and histidine) with ribose at 100 °C for ten hours. Exposing these mo...

Magnetically Driven Undulatory Microswimmers Integrating Multiple Rigid Segments.

Mimicking biological locomotion strategies offers important possibilities and motivations for robot design and control methods. Among bioinspired microrobots, flexible microrobots exhibit remarkable efficiency and agility. These microrobots traditionally rely on soft material components to achieve undulatory propulsion, which may encounter challenges in design and manufacture including the complex fabrication processes and the interfacing of rigid and soft components. Herein, a bioinspired magnetically driv...

Fresh and Savory: Integrating Teaching Kitchens with Shared Medical Appointments.

In the fall of 2017, Fresh and Savory, a Culinary and Lifestyle Medicine Teaching Kitchen (TK) program proved systematically feasible as a Shared Medical Appointment (SMA). A portable TK complemented physician consultations, interactive didactic presentations, nutritious cooking, and mind-body exercises. A series of SMAs were launched to develop a system for physicians to address patients' nutritional and lifestyle needs. MedStar Health implemented three TK SMA programs to improve patients culinary and lif...

Center for Epidemiological Studies-Depression Scale: Evaluation of a New Cutoff Score for Women Living with HIV.


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