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PubMed Journals Articles About "Alles Palette Zwar Automatisch Automatisierung Logistik Verpackungsprozess Bayer" RSS

15:46 EST 21st January 2019 | BioPortfolio

Alles Palette Zwar Automatisch Automatisierung Logistik Verpackungsprozess Bayer PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Alles Palette Zwar Automatisch Automatisierung Logistik Verpackungsprozess Bayer articles that have been published worldwide.

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Showing "Alles Palette zwar automatisch Automatisierung Logistik Verpackungsprozess Bayer" PubMed Articles, all 23

Jochen Block Prize for Andreas Vorholt / Otto Bayer Award for Tobias Erb.


An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer - against all odds?

Pharmaceutical companies often refer to 'screening their library' when performing high-throughput screening (HTS) on a corporate compound collection to identify lead structures for small-molecule drug discovery programs. Characteristics of such a library, including the size, chemical space covered, and physicochemical properties, often determine the success of a screening campaign. Therefore, strategies to maintain and enhance the overall quality of screening collections are crucial to stay competitive and ...

Adjuvante Behandlung des schweren/refraktären bullösen Pemphigoids mit Protein-A-Immunadsorption.

Mittels Immunadsorption (IA) können Immunglobuline und Immunkomplexe aus dem Plasma entfernt werden. Während dieses therapeutische Verfahren beim Pemphigus vulgaris bereits etabliert ist, wird es bei anderen blasenbildenden Autoimmundermatosen bislang nur sporadisch eingesetzt. Das bullöse Pemphigoid (BP) spricht zwar meist gut auf eine Therapie mit topischen und systemischen Kortikosteroiden an, jedoch könnte bei Patienten mit ausgedehnten Läsionen oder bei einem Rezidiv die rasche Reduktion der patho...


Snapshot multi-wavelength interference microscope.

A snapshot multi-wavelength interference microscope is proposed for high-speed measurement of large vertical range discontinuous microstructures and surface roughness. A polarization CMOS camera with a linear micro-polarizer array and Bayer filter accomplishes snapshot multi-wavelength phase-shifting measurement. Four interferograms with 𝜋/2 phase shift are captured at each wavelength for phase measurement, the 2𝜋 ambiguities are removed by using two or three wavelengths.

Technical note: Evaluation of kV CBCT enhancement using a liver specific contrast agent for stereotactic body radiation therapy image guidance.

To evaluate possible use for cone-beam CT guidance, this phantom study evaluated the contrast enhancement provided by Gadoxetate Disodium (Primovist CAN/EU, or Eovist USA, Bayer Healthcare), a contrast agent that is taken up selectively by liver cells and is retained for up to an hour. Image quality from CBCT was benchmarked against helical fan-beam computed tomography for two phantom geometries.

Acyl atractyligenin and carboxyatractyligenin glycosides from Antennaria rosea subsp. confinis.

Eight previously undescribed acyl atractyligenin and carboxyatractyligenin glycosides were isolated from whole Antennaria rosea subsp. confinis (Greene) R. J. Bayer (Compositae) [syn. Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae)] plants and their structures were determined by spectroscopic and chemical methods. The compounds were trivially named leontopodiosides F-M. Seven of the compounds showed potent in vitro inhibitory activity toward pancreatic lipase with IC values ranging from 3.4 to 52....

Reaching Biocompatibility with Nanoclays: Eliminating the Cytotoxicity of Ir(III) Complexes.

Cyclometalated IrIII complexes are promising candidates for biomedical applications but high cytotoxicity limits their use as imaging and sensing agents. We herein introduce the use of Laponite® as carrier for triplet-emitting cyclometalated IrIII complexes. Laponite® is a versatile nanoplatform due to its biocompatibility, dispersion stability and large surface area that readily adsorbs functional non-polar and cationic molecules. These inorganic-organic hybrid nanomaterials mask cytotoxicity, show effic...

Pigmento: Pigment-Based Image Analysis and Editing.

The colorful appearance of a physical painting is determined by the distribution of paint pigments across the canvas, which we model as a per-pixel mixture of a small number of pigments with multispectral absorption and scattering coefficients. We present an algorithm to efficiently recover this structure from an RGB image, yielding a plausible set of pigments and a low RGB reconstruction error. We show that under certain circumstances we are able to recover pigments that are close to ground truth, while in...

Extending the 'Open-Closed Principle' to Automated Algorithm Configuration.

Metaheuristics are an effective and diverse class of optimization algorithms: a means of obtaining solutions of acceptable quality for otherwise intractable problems. The selection, construction, and configuration of a metaheuristic for a given problem has historically been a manually intensive process based on experience, experimentation, and reasoning by metaphor. More recently, there has been interest in automating the process of algorithm configuration. In this paper, we identify shared state as an inhi...

Structural insights into the substrate promiscuity of a laboratory-evolved peroxygenase.

Due to their minimal requirements, substrate promiscuity and product selectivity, fungal peroxygenases are now considered to be the jewel in the crown of C-H oxyfunctionalization biocatalysts. In this work, the crystal structure of the first laboratory evolved peroxygenase expressed by yeast was solved at a resolution of 1.5 Å. Notable differences were detected between evolved and native peroxygenase from Agrocybe aegerita, including the presence of a full N-terminus and a broader heme access channel due t...

Highly transmissive subtractive color filters based on an all-dielectric metasurface incorporating TiO nanopillars.

Transmissive subtractive color filters are proposed and demonstrated that take advantage of an all-dielectric metasurface based on a lattice of TiO nanopillars (NPs), rendering a high transmission efficiency that exceeds 90%. TiO NP elements have been created that exhibit a high aspect ratio. Specifically, a series of lithographic processes are conducted to form a narrow and deep hole in the photoresist, which is accompanied by atomic layer deposition of TiO. A broad palette of vivid colors encompassing the...

Another look at the relationship between energy consumption, carbon dioxide emissions, and economic growth in South Africa.

This study explores the energy use and economic growth nexus from 1960 to 2016 in South Africa while accounting for capital, labour, and carbon dioxide emissions. We applied Bayer and Hanck (2013) combined co-integration approach, Pesaran et al. (2001) bounds test and Kripfganz and Schneider (2018) critical values and approximate p-values. The empirical evidence finds support for a long-run equilibrium relationship among investigated variables. The Granger causality test indicates one-way causality from ene...

Atherosclerosis in cholesterol-fed rabbits and in homozygous and heterozygous LDL receptor-deficient humans.

A phenocopy is an environmentally-defined phenotype that mimics another, genetically-determined phenotype. The severity of hypercholesterolaemia, extent of down regulation of LDL receptor expression and aortic root localisation of atherosclerosis in cholesterol-fed rabbits strikingly resemble the cardinal features of homozygous familial hypercholesterolaemia (FH) in humans, suggesting that the former is a phenocopy of the latter. This review compares the metabolic and pathological consequences of induced hy...

Larotrectinib: First Global Approval.

Larotrectinib (VITRAKVI) is an orally administered, small molecule, highly-selective, tropomyosin receptor kinase (TRK) inhibitor that was developed by Loxo Oncology in collaboration with Bayer AG as a treatment for adult and paediatric patients whose cancers harbour neurotrophic receptor tyrosine kinase (NTRK) gene fusions. In November 2018 larotrectinib received its first global approval in the USA for the treatment of adult and paediatric patients with solid tumours that have a NTRK gene fusion without a...

Fluorescence Multiplexing with Spectral Imaging and Combinatorics.

Ultraviolet-to-infrared fluorescence is a versatile and accessible assay modality, but is notoriously hard to multiplex due to overlap of wide emission spectra. We present an approach for fluorescence multiplexing using spectral imaging and combinatorics (MuSIC). MuSIC consists of creating new independent probes from covalently-linked combinations of individual fluorophores, leveraging the wide palette of currently available probes with the mathematical power of combinatorics. Probe levels in a mixture can ...

Novel flavin-based fluorescent proteins with red-shifted emission bands: a computational study.

The iLOV protein is a promising member of the class of flavin mononucleotide (FMN) based fluorescent proteins (FbFPs). It is becoming a popular tool for bioanalytical applications and bioimaging as a competitor of the well-known green fluorescent protein and its analogues. The main limitation of FbFPs is that all the members have close values of their absorption and emission band maxima. Therefore the upcoming challenge is to introduce novel variants of FbFPs to extend their color palette. We report the res...

Improved bauxite residue dealkalization by combination of aerated washing and electrodialysis.

Bauxite residue, a major by-product of the alumina-producing Bayer process, is a serious environmental pollutant due to its high alkalinity. Here, we reported an operation system designed in our laboratory that included washing and electrodialysis dealkalization systems with aeration pipes. Washing with aeration releases a substantial amount of free alkali and attached alkali into water and increases the dealkalization efficiency. The washing liquid was treated with five steps of batch-mode electrodialysis....

MetScore: Site of Metabolism Prediction Beyond CYP P450 Enzymes.

The metabolism of xenobiotics by humans and other organisms is a complex process involving numerous enzymes that catalyze phase I (functionalization) and phase II (conjugation) reactions. We here introduce MetScore, a machine learning model that can predict both phase I and phase II reaction sites of drugs. We developed cheminformatics workflows to filter and process reactions to obtain suitable phase I and phase II data sets for model training. Employing a recently developed molecular representation based ...

Enantiomeric separation of prothioconazole and prothioconazole-desthio on chiral stationary phases.

Prothioconazole is a type of broad-spectrum triazole thione fungicide developed by the Bayer Company. Prothioconazole-desthio is the main metabolite of prothioconazole in the environment. In our study, enantiomeric separation of prothioconazole and prothioconazole-desthio was performed on various chiral stationary phases (CSPs) by high-performance liquid chromatography (HPLC). It was found that polysaccharide CSPs showed better ability than brushing CSPs in enantiomeric separation. The successful chiral sep...

Diagnostik blasenbildender Autoimmundermatosen.

Blasenbildende Autoimmundermatosen (BAIDs) sind eine heterogene Gruppe seltener Erkrankungen, die klinisch durch Erosionen und/oder Blasen an Haut und Schleimhäuten charakterisiert sind. BAIDs können in zwei Gruppen eingeteilt werden: Pemphigus-Erkrankungen, die durch intraepidermale Blasenbildung und Autoantikörper gegen desmosomale Proteine wie Desmoglein (Dsg) 1, Dsg3 und Mitglieder der Plakin-Familie charakterisiert sind, sowie subepidermale BAIDs, die Pemphigoid-Erkrankungen und die Dermatitis herp...

Selective Sequestration of Aromatics from Aqueous Mixtures with Sugars by Hydrophobic Molecular Calixarene Cavities Grafted on Silica.

The separation of aromatic contaminants from sugar-aromatic aqueous mixtures is required in second-generation biorefineries because aromatic compounds deactivate (bio)catalysts typically involved in upgrading lignocellulosic biomass to fuels and chemicals. This separation remains challenging, however, because of the degree of molecular recognition needed to sequester dilute aromatic impurities from concentrated sugar streams. Herein, we demonstrate that hydrophobic cavities of p- tert-butylcalix[4]arene mac...

Efficacy and safety of a combination of selamectin plus sarolaner for the treatment and prevention of flea infestations and the treatment of ear mites in cats presented as veterinary patients in the United States.

Two randomised, single-masked, multi-center field studies were conducted in the United States in cats presented as veterinary patients. The first study evaluated the efficacy and safety of a topically applied formulation of selamectin plus sarolaner (Revolution Plus/Stronghold Plus, Zoetis) against natural flea infestations; the second study evaluated its efficacy against natural ear mite infestations. The product was administered topically by the cats' owners at the dose range provided in the market produc...

DNA Templated Metal Nanoclusters: From Emergent Properties to Unique Applications.

Metal nanoclusters containing a few to several hundred atoms with sizes ranging from sub-nanometer to ∼2 nm occupy an intermediate size regime that bridges larger plasmonic nanoparticles and smaller metal complexes. With strong quantum confinement, metal nanoclusters exhibit molecule-like properties. This Account focuses on noble metal nanoclusters that are synthesized within a single stranded DNA template. Compared to other ligand protected metal nanoclusters, DNA-templated metal nanoclusters manifest in...


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