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PubMed Journals Articles About "Amgen Says Kyprolis Darzalex Combination Hits Main Goal" RSS

03:40 EDT 19th October 2019 | BioPortfolio

Amgen Says Kyprolis Darzalex Combination Hits Main Goal PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Amgen Says Kyprolis Darzalex Combination Hits Main Goal articles that have been published worldwide.

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Showing "Amgen says Kyprolis Darzalex combination hits main goal" PubMed Articles 1–25 of 9,000+

Combination of pharmacophore modeling and 3D-QSAR analysis of potential glyoxalase-I inhibitors as anticancer agents.

Glyoxalase system is an ubiquitous system in human cells which has been examined thoroughly for its role in different diseases. It comprises two enzymes; Glyoxalase I (Glo-I) and Glyoxalase II (Glo-II) which perform detoxifying endogenous harmful metabolites, mainly methylglyoxal (MG) into non-toxic bystanders. In silico computer Aided Drug Design approaches were used and ninety two diverse pharmacophore models were generated from eighteen Glyoxalase I crystallographic complexes. Subsequent QSAR modeling fo...


A longitudinal investigation of trait-goal concordance on goal progress: The mediating role of autonomous goal motivation.

The present study investigated the benefits of matching personality traits with goal type (i.e., agentic or communal) for goal progress. Autonomous motivation was examined as a mediator.

Fragment hits: What do they look like and how do they bind?

A "fragment hit"-a molecule of low molecular weight that has been validated to bind to a target protein-can be an effective chemical starting point for a drug discovery project. Our ability to find and progress fragment hits could potentially be improved by enhancing our understanding of their binding properties, which to date has largely been based on tacit knowledge and reports from individual projects. In the work reported here, we systematically analyzed the molecular and binding properties of fragment ...


Employing virtual screening and molecular dynamics simulations for identifying hits against the active cholera toxin.

Cholera is a major global threat, affecting millions each year. The ADP ribosyltransferase activity of the active cholera toxin catalyses the massive loss of water and electrolytes during cholera infections. The active toxin heterodimer comprises the A1 subunit from Vibrio cholerae and ARF (ADP Ribosylation Factor) from the human host. Although the active toxin is a potential target for drug discovery against cholera, it has been scarcely targeted to date. The A1-ARF interface contains a potential druggable...

The National Cancer Institute's Plated Compound Sets Can Be a Valuable Resource for Academic Researchers.

Academic researchers looking for material to screen may benefit from plated compound collections provided at no cost except shipping by the U.S. National Cancer Institute (NCI). Four plated sets are available, two of which comprise diverse synthetic compounds. These collections, of ~900 and ~1500 compounds, are a convenient size to screen without automated equipment, and a great deal of data about the compounds is available that increases their usefulness. Despite these positive attributes, the collections ...

The Rise of Molecules Able to Regenerate the Central Nervous System.

Injury to the adult central nervous system (CNS) usually leads to permanent deficits of cognitive, sensory and/or motor functions. The failure of axonal regeneration in the damaged CNS limits functional recovery. The lack of information concerning the biological mechanism of axonal regeneration and its complexity has delayed the process of drug discovery for many years compared to other drug classes. Starting in the early 2000s, the ability of many molecules to stimulate axonal regrowth was evaluated throug...

The role of goal cueing in kindergarteners' working memory.

Goal neglect has been shown to contribute to kindergarteners' poor executive control. Hence, presenting goal cues during a task improves children's performance in inhibition and switching tasks. The current study aimed at extending these findings to working memory (WM) by examining the extent to which kindergarteners' poor WM performance can result from neglecting the goal to recall memoranda at the end of the retention interval. This question was addressed by introducing goal cues, either visual (Experimen...

Neural circuits in goal-directed and habitual behavior: Implications for circuit dysfunction in obsessive-compulsive disorder.

Goal-directed and habitual actions are essential for normal functioning in everyday life. Goal-directed behaviors are actions that are executed to achieve specific goals. With repetition, such as a daily routine, these goal-directed actions become automatized and habitual. However, these useful behaviors can become aberrant, manifesting as key symptoms in several psychiatric disorders, including obsessive-compulsive disorder (OCD). A comprehensive understanding of the neural circuits underlying both aberran...

Primaquine derivatives: Modifications of the terminal amino group.

Numerous modifications of the well-known antimalarial drug primaquine, both at the quinoline ring and at the primary amino group, have been reported, mostly to obtain antimalarial agents with improved bioavailability, reduced toxicity and/or prolonged activity. Modifications of the terminal amino group were made with the main idea to prevent the metabolic pathway leading to inactive and toxic carboxyprimaquine (follow-on strategy), but also to get compounds with different activity (repurposing strategy). Th...

Hippocampus-nidopallium caudolaterale interactions exist in the goal-directed behavior of pigeon.

Avian hippocampus (Hp) and nidopallium caudolaterale (NCL) are believed to play key roles in goal-directed behavior. However, it is still unclear whether there are interactions between the two brain regions in the goal-directed behavior of pigeons. To investigate the interactions between the Hp and the NCL in the goal-directed behavior, we recorded local field potential (LFP) signals from the two regions simultaneously when the pigeons performed a goal-directed decision-making task. Amplitude-amplitude coup...

Does goal congruence dilate the pupil over and above goal relevance?

To better understand the mechanisms underlying preferential processing of affective stimuli (i.e., affective attention), it is useful to ask which appraisal dimensions characterize stimuli that capture affective attention. Viewed from such appraisal perspective, most accounts of affective attention predict that the appraisal of goal relevance (i.e. the overall relevance of a stimulus/event to one's current goals) should attract attention whereas some accounts also implicate the appraisal of goal congruence ...

Impact of Arterial Procedures on Coagulation and Fibrinolysis - A Pilot Study.

The main goal of our study was to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways.

Endpoint accuracy of goal-directed ankle movements correlates to over-ground walking in stroke.

Goal-directed movements are essential for voluntary motor control. The inability to execute precise goal-directed movements after stroke can impair the ability to perform voluntary functions, learn new skills, and hinder rehabilitation. However, little is known about how the accuracy of single-joint, goal-directed ankle movements relates to multi-joint, lower limb function in stroke. Here, we determined the impact of stroke on the accuracy of goal-directed ankle movements and its relation to over-ground wal...

Identification of Fatty Acid Binding Protein 5 Inhibitors Through Similarity-based Screening.

Fatty acid binding protein 5 (FABP5) is a promising target for development of inhibitors to help control pain and inflammation. In this work, computer-based docking (DOCK6 program) was employed to screen ~2M commercially available compounds to FABP5 based on an x-ray structure complexed with the small molecule inhibitor SBFI-26 previously identified by our group (also through virtual screening). The goal was discovery of additional chemotypes. The screen resulted in the purchase of 78 candidates which led t...

Does antibiotic use accelerate or retard cutaneous repair? A systematic review in animal models.

The presence of infections is one of the main factors that leads to delays in healing or non-closure of cutaneous wounds. Although the goal of antibiotic use is to treat or prevent infection, there is currently no agreement on the effectiveness of these products.

How to Save a Life From Macroscopic Fat Embolism: A Narrative Review of Treatment Options.

Macroscopic fat embolism (MAFE) has grabbed the attention of the plastic surgery community through recent years owing to its high mortality rate. A good number of articles on its prevention during gluteal fat grafting are available in the literature. However, total prevention of this complication is a difficult goal to achieve and encountering MAFE is still a possible scenario owing to many variable factors and human elements. This review is written with the main goal of providing a treatment plan. MAFE sha...

Subconcussive Football Hits May Leave a Telltale Signature of Brain Damage.

GIVE me your attention: Differentiating goal identification and goal execution components of the anti-saccade effect.

The anti-saccade task is a commonly used method of assessing individual differences in cognitive control. It has been shown that a number of clinical disorders are characterised by increased anti-saccade cost. However, it remains unknown whether this reflects impaired goal identification or impaired goal execution, because, to date, no procedure has been developed to independently assess these two components of anti-saccade cost. The aim of the present study was to develop such an assessment task, which we ...

Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening.

Mast cells (MCs) are known to regulate innate and adaptive immunity. MC activators have recently been described as safe and effective vaccine adjuvants. Many currently known MC activators are inadequate for in vivo applications, however, and research on identifying novel MC activators is limited. In this study, we identified novel MC activators by using high-throughput screening (HTS) assays using approximately 55,000 small molecules. Data sets obtained by the primary HTS assays were statistically evaluated...

Electrophysiology of goal-directed versus habitual control during outcome devaluation.

Dual-system accounts posit that instrumental behavior is controlled by both a goal-directed and a habitual system. In this study, we aimed to identify the electrophysiological components associated with goal-directed versus habitual performance using an outcome devaluation procedure. Datasets from 35 healthy participants were analyzed. Behaviorally, in line with previous research, participants displayed sensitivity to outcome devaluation, a hallmark of goal-directed control. Electrophysiologically, decrease...

Exclusive: Battle to wipe out debilitating Guinea worm parasite hits 10 year delay.

A Network Activity Reconfiguration Underlies the Transition from Goal to Action.

Neurons in prefrontal cortex (PF) represent mnemonic information about current goals until the action can be selected and executed. However, the neuronal dynamics underlying the transition from goal into specific actions are poorly understood. Here, we show that the goal-coding PF network is dynamically reconfigured from mnemonic to action selection states and that such reconfiguration is mediated by cell assemblies with heterogeneous excitability. We recorded neuronal activity from PF while monkeys selecte...

Factors Related to Medication Self-Management in African American Older Women.

Individuals with multiple chronic diseases are often prescribed medications for each condition and thus must manage a drug regimen. Medication self-management is challenging for most individuals with chronic diseases, but it can be especially difficult for African American older women. This study investigated how medical mistrust, caregiver role strain, and other relevant variables may be associated with medication self-management behaviors (MSMB) among African American older women, and whether goal congrue...

The environmental condition of an estuarine ecosystem disturbed by pesticides.

Knowledge regarding the concentration levels resulting from the use of agricultural pesticides may indicate the nature of the controls necessary to reduce environmental and human health risks to an acceptable level. Therefore, the main goal of the present work was to assess the spatial and temporal occurrence of 35 pesticides in the River Sado estuary (Portugal) in 2017 and evaluate its environmental condition, as data for estuarine ecosystems is scarce. Since pesticides are very susceptible to matrix effec...

Activin Receptor II Ligand Traps: New Treatment Paradigm for Low-Risk MDS.

Alleviating cytopenias, namely anemia, is the main goal of therapy in lower-risk myelodysplastic syndromes (MDS). Current available treatment options remain limited. We review the role of TGF-B pathway in MDS, the current available data on luspatercept and sotatercept development.


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