PubMed Journals Articles About "Anteros Enters Market Powered BioMotiv Bristol Myers Squibb" RSS

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Showing "Anteros enters market powered BioMotiv Bristol Myers Squibb" PubMed Articles 1–25 of 1,100+

Lumateperone: First Approval.

Lumateperone (Caplyta) is a novel, orally available agent developed by Intra-Cellular Therapies (under a license from Bristol-Myers Squibb) for the treatment of schizophrenia and other neuropsychiatric and neurological disorders. Lumateperone is a first-in-class selective and simultaneous modulator of serotonin, dopamine and glutamate. In December 2019, lumateperone received its first global approval in the USA for the treatment of schizophrenia in adults. The drug is also under clinical development for bip...

A multi-national trial of a direct oral anticoagulant in children with cardiac disease: Design and rationale of the Safety of ApiXaban On Pediatric Heart disease On the preventioN of Embolism (SAXOPHONE) study.

Anticoagulation in children is problematic for multiple reasons. Currently used anticoagulants have significant disadvantages and may negatively affect quality of life (QOL). This manuscript describes the design, rationale, and methods of a prospective, randomized, open label phase II multi-national clinical trial of a direct oral anticoagulant (DOAC), apixaban, in children and infants with congenital and acquired heart disease. This trial is designed to gather preliminary safety and pharmacokinetics (PK) d...

Immune Checkpoint Blockade Mediated by a Small-Molecule Nanoinhibitor Targeting the PD-1/PD-L1 Pathway Synergizes with Photodynamic Therapy to Elicit Antitumor Immunity and Antimetastatic Effects on Breast Cancer.

Targeting programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immunologic checkpoint blockade with monoclonal antibodies has achieved recent clinical success in antitumor therapy. However, therapeutic antibodies exhibit several issues such as limited tumor penetration, immunogenicity, and costly production. Here, Bristol-Myers Squibb nanoparticles (NPs) are prepared using a reprecipitation method. The NPs have advantages including passive targeting, hydrophilic and nontoxic features, an...

John King, the Bristol surgeon and friend of artists and poets.

The Bristol School of Artists developed between 1800 and 1840 and was a collaboration between professional and amateur artists, one of whom was Dr John King. King started his professional life in Bristol as assistant to Thomas Beddoes where one of his colleagues was Humphry Davy and the three of them worked in the Pneumatic Institute, attempting to cure tuberculosis with gases. King subsequently became a popular general practitioner in Clifton and his correspondence with patrons of art, romantic poets and h...

Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use.

When a new drug or biologic product enters the market, its full spectrum of side effects is not yet fully understood, as use in the real world often uncovers nuances not suggested within the relatively narrow confines of preapproval preclinical and trial work.

When the market drives you crazy: Stock market returns and fatal car accidents.

This paper provides evidence that daily fluctuations in the stock market have important - and hitherto neglected - spillover effects on fatal car accidents. Using the universe of fatal car accidents in the United States from 1990 to 2015, we find that a one standard deviation reduction in daily stock market returns is associated with a 0.6% increase in fatal car accidents that happen after the stock market opening. A battery of falsification tests supports a causal interpretation of this finding. Our result...

Myers et al. Respond.

Pain is a Limiting Factor in Patients Suitable for Transilluminated Powered Phlebectomy.

To analyze, perioperatively and in follow-up, transilluminated powered phlebectomy (TIPP), a surgical technique for the treatment of varicose veins.

Diagnosing Conductive Dysfunction in Infants Using Wideband Acoustic Immittance: Validation and Development of Predictive Models.

Purpose The aims of this study were (a) to validate the wideband acoustic immittance (WAI) model developed by Myers et al. (2018a) in a new sample of neonates and (b) to develop a prediction model for diagnosing middle ear dysfunction in infants aged 6-18 months using wideband absorbance, controlling for the effect of age. Method Tympanometry, distortion product otoacoustic emissions, and WAI were measured in 124 neonates and longitudinally in 357 infants at 6, 12, and 18 months of age. Results of tympanome...

The Quaternary evolutionary history of Bristol rock cress (Arabis scabra, Brassicaceae), a Mediterranean element with an outpost in the north-western Atlantic region.

Bristol rock cress is among the few plant species on the British Isles considered to have Mediterranean-montane element. Spatiotemporal patterns of colonization of the British Isles since the last interglacial and after Last Glacial Maximum (LGM) from mainland Europe are underexplored and have not yet included such floristic elements. Herewith we shed light on the evolutionary history of a relic and outpost metapopulation of Bristol rock cress in the southwestern United Kingdom.

The analysis of medical market in Russia in 2016-2018: main economic indices and research results.

The article presents the main indicators of development of Russian medical market in 2016-2018. The basic data concerning main activities in market of medical services and goods, key figures on patterns and trends of market of medical sphere, pricing policy, organizational forms of medical institutions is presented. The conclusions on the research oт supply and demand in medical market are made. The conclusions related to forecasting and planning of development of Russian medical market in Russia, its pers...

Assessment of miniaturized ultrasound-powered implants: an in vivo study.

Therapeutic applications of implantable active medical devices have improved the quality of patient life. Numerous on-going research in the field of neuromodulation and bioelectronics medicine are exploring the use of these implants for treating diseases and conditions. Miniaturized implantable medical devices that are wirelessly powered by ultrasound (US) can be placed close to the target sites deep inside the body for effective therapy with less invasiveness. In this study, we assessed the long-term in vi...

Trilayered Lead-Chloride Perovskite Ferroelectric Affording Self-Powered Visible-Blind Ultraviolet Photodetection with Giant Zero-Bias Photocurrent.

Perovskite ferroelectrics, in which the spontaneous polarization (Ps) is conducive to the separation of photoexcited charge carriers, have shown great potential for self-powered photodetection. Nevertheless, such self-powered ferroelectric photodetectors are mostly dominated by traditional inorganic oxides and exhibit relatively small zero-bias photocurrent, which limit their further application. Herein, we present a wide bandgap 2D trilayered lead-chloride hybrid perovskite ferroelectric, EA4Pb3Cl10 (1, EA...

Stock Market Prediction Using Optimized Deep-ConvLSTM Model.

Stock market prediction acts as a challenging area for the investors for obtaining the profits in the financial markets. A greater number of models used in stock market forecasting is not capable of providing an accurate prediction. This article proposes a stock market prediction system that effectively predicts the state of the stock market. The deep convolutional long short-term memory (Deep-ConvLSTM) model acts as the prediction module, which is trained by using the proposed Rider-based monarch butterfly...


To characterize evolution of macular injury from a high-powered blue handheld laser using multimodal imaging and describe successful surgical treatment.

Ocular Injuries Associated With Air-Powered Salt Guns.

This report discusses the potential ocular injuries associated with an air-powered salt gun, a new product that may appeal to children. The authors hope to inform both providers and patients of the potential risks and treatment considerations if an injury of this type is sustained. [J Pediatr Ophthalmol Strabismus. 2019;56:e65-e67.].

Impedance Control Strategies for Enhancing Sloped and Level Walking Capabilities for Individuals with Transfemoral Amputation Using a Powered Multi-Joint Prosthesis.

Powered prostheses are a promising new technology that may help people with lower-limb loss improve their ability to perform locomotion tasks. Developing active prostheses requires robust design methodologies and intelligent controllers to appropriately provide assistance to the user for varied tasks in different environments. The purpose of this study was to validate an impedance control strategy for a powered knee and ankle prosthesis using an embedded sensor suite of encoders and a six-axis load cell tha...

Convergently evolved muscle architecture enables high-performance ballistic movement in salamanders.

Elastically powered ballistic movements, such as tongue projection, are common in nature, likely due to benefits such as increased acceleration and distance of movement, and decreased thermal sensitivity imparted by elastic mechanisms. Within Plethodontidae, both muscle-powered and elastically powered ballistic tongue projection occur. Thus, we examine how elastically powered ballistic tongue projection morphology has evolved from muscle powered projection at the level of the projector muscles (m. subarcual...

Classification of position management strategies at the order-book level and their influences on future market-price formation.

Financial prices fluctuate as a results of the market impact of the flow of transactions between traders. Reciprocally, several studies of market microstructure have shown how decisions of individual traders or banks, implemented in their trading strategies, are affected by historical market information. However, little is known about the detailed processes of how such trading strategies at the micro level recursively affect future market information at the macro level. Using a special fined-grained dataset...

A self-powered photoelectrochemical aptamer probe for oxytetracycline based on the use of a NiO nanocrystal/g-CN heterojunction.

A self-powered photoelectrochemical (PEC) aptamer probe is presented for the determination of oxytetracycline (OTC). The assay is based on the use of g-CN and NiO nanocrystals (NCs) which form a heterojunction. The latter was prepared by two-step hydrothermal pyrolysis by using the ionic liquid 1-hydroxyethyl-3-methylimidazole chloride which functions as a morphological template to form NiO NCs. The heterojunction exhibits much better electronic conductivity, wider absorption range, higher electron-hole-sep...

Bristol rheumatoid arthritis fatigue scale is valid in patients with psoriatic arthritis and is associated with overall severe disease and higher comorbidities.

To (1) determine the reliability and validity of the Bristol Rheumatoid Arthritis Fatigue scale (BRAF-NRS) in patients with psoriatic arthritis (PsA) and (2) examine possible clinical associations of worse fatigue in PsA.

Impact of market misallocations on green TFP: evidence from countries along the Belt and Road.

Based on the idea of a "Community of Human Destiny," the Chinese government proposed the "Belt and Road" initiative, and clearly proposed to promote green development and strengthen ecological environmental protection. However, a considerable number of countries are resource-rich economies with serious market misallocations. Using the stochastic frontier analysis (SFA) combined with the directional distance function (DDF) framework, this paper measures the green total factor productivity (GTFP) and its item...

A photocontrolled and self-powered bipedal DNA walking machine for intracellular microRNA imaging.

In this work, we report a photocontrolled and self-powered DNA walking machine with bipedal DNAzyme walkers for intracellular microRNA imaging.

Will I Need to Move to Get My First Job?: Geographic Relocation and Other Trends in the Pathology Job Market.

There is an ongoing perception that the pathology job market is poor, which may be discouraging medical students from pursuing the specialty. Academic pathologists believe that jobs are available but relocation may be necessary.

Sleep assessment devices: types, market analysis, and a critical view on accuracy and validation.

: Sleep assessment devices are essential for the detection, diagnosis, and monitoring of sleep disorders. This paper provides a state-of-the-art review and comparison of sleep assessment devices and a market analysis.: Hardware devices are classified into contact and contactless devices. For each group, the underlying technologies are presented, paying special attention to their limitations. A systematic literature review has been carried out by comparing the most important validation studies of sleep track...

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