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PubMed Journals Articles About "Approves Nucala Mepolizumab Year Children With Severe Eosinophilic" RSS

16:16 EDT 17th October 2019 | BioPortfolio

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Showing "Approves Nucala mepolizumab Year Children with Severe Eosinophilic" PubMed Articles 1–25 of 18,000+

Proportion of Severe Asthma Patients Eligible for Mepolizumab Therapy by Age and Age of Onset of Asthma.

Mepolizumab is an anti-IL-5 antibody approved for the treatment of severe eosinophilic asthma. However, the prevalence of patients with severe asthma eligible for mepolizumab remains unknown, especially among children.


Long-term safety and pharmacodynamics of mepolizumab in children with severe asthma with an eosinophilic phenotype.

Mepolizumab is approved for patients with severe asthma with an eosinophilic phenotype aged ≥12 (US) or ≥6 (EU) years, but its long-term use in children aged 6-11 years has not yet been assessed.

Efficacy of mepolizumab for patients with severe asthma and eosinophilic chronic rhinosinusitis.

Several major randomized control studies have demonstrated that mepolizumab, an anti-IL-5 monoclonal antibody, is effective for patients with severe eosinophilic asthma who show exacerbation or require systemic corticosteroid maintenance therapy. However, the predictive factors of the response to mepolizumab other than blood eosinophil count are unclear in clinical practice.


Efficacy and safety of mepolizumab in a real-world cohort of patients with severe eosinophilic asthma.

The interleukin 5 (IL-5) pathway is an important component in the pathophysiology of severe eosinophilic asthma. Mepolizumab is a monoclonal antibody that targets the IL-5 pathway. Clinical trials showed efficacy of Mepolizumab in patients with severe eosinophilic asthma. However, reports on experience with treatment in a real-world cohort are limited. Evaluation of the efficacy and safety of Mepolizumab for treatment of severe eosinophilic asthma in a real-world cohort of patients. A clinical prospective...

The clinical benefit of mepolizumab replacing omalizumab in uncontrolled severe eosinophilic asthma.

Mepolizumab and omalizumab are treatments for distinct but overlapping severe asthma phenotypes.

Effect of mepolizumab in severe eosinophilic asthma according to omalizumab eligibility.

Patients with severe asthma can present with overlapping eosinophilic and allergic phenotypes, which makes it challenging when deciding which biologic therapy is most appropriate to reduce exacerbations and help achieve asthma control.

An Evaluation of Mepolizumab for the Treatment of Severe Asthma.

Introduction Asthma is considered one of the most common chronic conditions globally, characterized by variable airflow obstruction and symptoms. Severe asthma is diagnosed when asthma control requires high-intensity therapy or continues to remain uncontrolled despite treatment. Eosinophilic inflammation is known to be perpetuated by the activity of IL-5 in a proportion of severe asthma subjects, and targeting IL-5 may offer a therapeutic option. Areas covered In this review we discuss the role and pathogen...

Update: Mepolizumab treatment in patients with severe eosinophilic asthma and prior omalizumab use.

One year of mepolizumab. Efficacy and safety in real-life in Italy.

Severe asthma is a disease with a heavy socio-economic burden and a relevant impact on the life of patients. Mepolizumab (MEP) was recently introduced in practice. The previous data were favourable as efficacy and safety are concerned. Nowadays, we can report the clinical data after more than one year of use of MEP in the real-life setting.

Severe asthma in children-a review of definitions, epidemiology, and treatment options in 2019.

Severe asthma is a relatively uncommon condition in children but one which causes morbidity, occasionally mortality, and is a challenging condition to manage. There are several definitions of severe asthma, which have a common theme of poor control despite high dose inhaled corticosteroid treatment. Depending on the definition chosen, the prevalence of severe childhood asthma may be up to 5% within populations with asthma. Collectively, there is some evidence that the treatments used in severe asthma are be...

Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives.

Severe asthma in children remains a significant issue. It places a heavy burden on affected individuals and society as a whole in terms of high morbidity, mortality, consumption of healthcare resources, and side effects from high-dose corticosteroid therapy. New, targeted biologic therapies for asthma have emerged as effective add-on options, complementing our expanding understanding of asthma phenotypes/endotypes and the underlying immunopathology of the disease spectrum. They include omalizumab, mepolizum...

Mepolizumab in patients with eosinophilic granulomatosis with polyangiitis.

Retrospective study of budesonide in children with eosinophilic gastroenteritis.

The effectiveness of budesonide (BUD), a locally active steroid, on eosinophilic gastroenteritis (EGE) is not well understood. This study is to retrospectively evaluate the efficacy of BUD in children with EGE.

Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: A prospective cohort study.

Africa has the highest rates of child mortality. Little is known about outcomes after hospitalization for children with very severe anemia.

Evaluation of Long-term Course in Children with Eosinophilic Esophagitis Reveals Distinct Histologic Patterns and Clinical Characteristics.

Eosinophilic esophagitis (EoE) is a chronic, increasingly prevalent antigen driven disease. There is a paucity of information on long-term course in children.

Non-severe eosinophilic granulomatosis with polyangiitis: long-term outcomes after remission-induction trial.

In a previous controlled trial, 1-year adjunction of AZA to glucocorticoids (GC) for patients with non-severe, newly diagnosed eosinophilic granulomatosis with polyangiitis (EGPA) failed to lower remission failure, vasculitis relapse and isolated asthma/rhinosinus exacerbation rates, or cumulative GC use at month (M) 24. The aim of this study was to analyse longer-term outcomes to determine whether subsequent vasculitis relapse or isolated asthma/rhinosinus exacerbation (IARE) rates differed.

Efficacy of Epicutaneous Immunotherapy in Children with Milk-Induced Eosinophilic Esophagitis.

Eosinophilic esophagitis (EoE) is caused by an immune response to specific food allergens. There are no approved therapies beyond avoidance of the allergen(s) or treatment of inflammation. Epicutaneous immunotherapy (EPIT) reduces features of eosinophilic gastrointestinal disease in mice and pigs. We performed randomized, placebo-controlled study to determine the safety and efficacy of EPIT with Viaskin milk in children with milk-induced EoE.

The Salivary Microbiome Is Altered in Children With Eosinophilic Esophagitis and Correlates With Disease Activity.

Eosinophilic esophagitis (EoE) is an allergen-mediated inflammatory disease affecting the esophagus. Although microbial communities may affect the host immune responses, little is known about the role of the microbiome in EoE. We compared the composition of the salivary microbiome in children with EoE with that of non-EoE controls to test the hypotheses that the salivary microbiome is altered in children with EoE and is associated with disease activity.

Mepolizumab and reslizumab, two different options for severe asthma patients with prior failure to omalizumab.

Update on immunogenicity in severe asthma: experience with mepolizumab.

A Unique Presentation of Infantile-Onset Colitis and Eosinophilic Disease without Recurrent Infections Resulting from a Novel Homozygous CARMIL2 Variant.

This study aimed to characterize the clinical phenotype, genetic basis, and consequent immunological phenotype of a boy with severe infantile-onset colitis and eosinophilic gastrointestinal disease, and no evidence of recurrent or severe infections.

No genetic associations with mepolizumab efficacy in COPD with peripheral blood eosinophilia.

Improved understanding of genetic effects on response to treatments with novel approaches for COPD with peripheral blood eosinophilia, such as mepolizumab (a humanized monoclonal antibody to IL-5), may improve treatment outcomes. We conducted a study to identify genetic variants associated with efficacy of mepolizumab COPD.

The role of type 2 innate lymphoid cells in eosinophilic asthma.

Eosinophilic asthma has conventionally been proposed to be a T helper 2 driven disease but emerging evidence supports a central role of type 2 innate lymphoid cells (ILC2s). These are non-T, non-B cells that lack antigen specificity and produce more IL-5 and IL-13 than CD4 T lymphocytes, on a cell per cell basis, in vitro. Although it is clear that ILC2s and CD4 T cells work in concert with each other to drive type 2 immune responses, kinetic studies in allergic asthma suggest that ILC2s may act locally wit...

The spectrum of viral pathogens in children with severe acute lower respiratory tract infection: A 3-year prospective study in the pediatric intensive care unit.

No comprehensive analysis is available on the viral etiology and clinical characterization among children with severe acute lower respiratory tract infection (SALRTI) in Southern China.

Diagnosis of Eosinophilic Esophagitis in Children - A Serbian Single Center Experience from 2010 to 2017.

The aim of this study was to assess the epidemiological, clinical, endoscopic and pathohistological characteristics of pediatric eosinophilic esophagitis (EoE) in Serbia.


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