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00:41 EDT 24th October 2018 | BioPortfolio

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Showing "Athera Biotechnologies" PubMed Articles, all 20

Dental, Oral, and Craniofacial Regenerative Medicine: Transforming Biotechnologies for Innovating Patient Care.


Biological sulfur oxidation in wastewater treatment: A review of emerging opportunities.

Sulfide prevails in both industrial and municipal waste streams and is one of the most troublesome issues with waste handling. Various technologies and strategies have been developed and used to deal with sulfide for decades, among which biological means make up a considerable portion due to their low operation requirements and flexibility. Sulfur bacteria play a vital role in these biotechnologies. In this article, conventional biological approaches dealing with sulfide and functional microorganisms are sy...

High-throughput optimisation of light-driven microalgae biotechnologies.

Microalgae biotechnologies are rapidly developing into new commercial settings. Several high value products already exist on the market, and systems development is focused on cost reduction to open up future economic opportunities for food, fuel and freshwater production. Light is a key environmental driver for photosynthesis and optimising light capture is therefore critical for low cost, high efficiency systems. Here a novel high-throughput screen that simulates fluctuating light regimes in mass cultures ...


Integrating Proteins in Layer-by-Layer Assemblies Independently of their Electrical Charge.

Layer-by-layer (LbL) assembly is an attractive method for proteins immobilization at interfaces, a much wanted step for e.g. biotechnologies and biomedicine. Integrating proteins in LbL thin films is however very challenging due to their low conformational entropy, heterogeneous spatial distribution of charges and polyampholyte nature. Protein-polyelectrolyte complexes (PPCs) are promising building blocks for LbL construction owing to their standardized charge and polyelectrolyte (PE) corona. In this work, ...

Recent Advances in Liquid Metal Manipulation toward Soft Robotics and Biotechnologies.

Interest has grown significantly in the field of soft robotics, which seeks to develop machinery capable of duplicating the elastic and rheological properties of typically polymeric or elastomeric biological tissues and organs. As a result of a number of unique properties, gallium-based liquid metals (LMs) are emerging as materials used in the forefront of soft robotics research. Finding methods to enable the sophisticated manipulation of LMs will be essential for further progress in the field. This review ...

Enhancing Yeast Alcoholic Fermentations.

The production of ethanol by yeast fermentation represents the largest of all global biotechnologies. Consequently, the yeast Saccharomyces cerevisiae is the world's premier industrial microorganism, which is responsible not only for the production of alcoholic beverages, including beer, wine, and distilled spirits, but also for the billions of liters of bioethanol produced annually for use as a renewable transportation fuel. Although humankind has exploited the fermentative activities of yeasts for millenn...

Preparation of magnetic microspheres functionalized by lanthanide oxides for selective isolation of bovine hemoglobin.

The isolation and depletion of highly-abundant proteins and peptides is of vital importance for the screening and monitoring of biomarkers which are low stoichiometry in proteomics and protein-based biotechnologies. Here we have designed and synthesized a series of magnetic microspheres MnFeO @SiO @ Lanthanide Oxides (La= Ce, Sm, Er, Tm, Yb) whose surface were functionalized by lanthanide oxides that could successfully isolate bovine hemoglobin (BHb), and MnFeO @SiO @ErO microspheres were found to be most...

Conceptus loss in Santa Inês ewes carrying twin pregnancies by natural mating or embryo transfer.

Commercial application of reproductive biotechnologies such as multiple ovulation and embryo transfer depends on its overall efficiency. Sheep embryo transfer is gradually gaining wider adoption, but pregnancy rates after embryo transfer remain lower than those derived from natural mating for most breeds. The work was aimed to evaluate embryonic and fetal losses in Santa Inês ewes carrying twin pregnancies by natural mating or embryo transfer. Ewes were subjected to synchronized natural mating by ram effec...

A biochemical framework for anaerobic oxidation of methane driven by Fe(III)-dependent respiration.

Consumption of methane by aerobic and anaerobic microbes governs the atmospheric level of this powerful greenhouse gas. Whereas a biochemical understanding of aerobic methanotrophy is well developed, a mechanistic understanding of anaerobic methanotrophy has been prevented by the unavailability of pure cultures. Here we report a biochemical investigation of Methanosarcina acetivorans, a methane-producing species capable of anaerobic methanotrophic growth dependent on reduction of Fe(III). Our findings suppo...

Endoscopy robotics: current and future applications.

Many different types of endoscopy robots have been developed or are under development. Some of these innovative biotechnologies are dedicated to complex endoscopic procedures as endoscopic submucosal dissection while others are purely diagnostic. In endoscopy robotics there are still several problems that need a solution. These problems concern basically robotic locomotion and instrument control from on hand and clinical application on the other. In most of the cases the technology is still under developmen...

Hydrophobicity-driven unfolding of Trp-cage encapsulated between graphene sheets.

Understanding the interaction between proteins and graphene not only helps elucidate the behaviors of proteins in confined geometries, but is also imperative to the development of a plethora of graphene-based biotechnologies, such as the graphene liquid cell transmission electron microscopy. To discuss the overall geometrical-thermal effects on proteins, we performed molecular dynamics simulations of hydrated Trp-cage miniprotein sandwiched between two graphene sheets and in the bulk environment at the temp...

Considerations for the governance of gene drive organisms.

Governance is a broader and more flexible concept than statute-driven regulations as it incorporates components outside the latter's remit. Considerations of governance are critical in the development of emerging biotechnologies such as gene drive organisms. These have been proposed or are being developed to address public and environmental health issues not addressed easily by conventional means. Here, we consider how the concept of governance differs from statute-driven regulation with reference to the ro...

Biotechnological strategies for the recovery of valuable and critical raw materials from waste electrical and electronic equipment (WEEE) - A review.

Critical raw materials (CRMs) are essential in the development of novel high-tech applications. They are essential in sustainable materials and green technologies, including renewable energy, emissionfree electric vehicles and energy-efficient lighting. However, the sustainable supply of CRMs is a major concern. Recycling end-of-life devices is an integral element of the CRMs supply policy of many countries. Waste electrical and electronic equipment (WEEE) is an important secondary source of CRMs. Currently...

Food supply and bioenergy production within the global cropland planetary boundary.

Supplying food for the anticipated global population of over 9 billion in 2050 under changing climate conditions is one of the major challenges of the 21st century. Agricultural expansion and intensification contributes to global environmental change and risks the long-term sustainability of the planet. It has been proposed that no more than 15% of the global ice-free land surface should be converted to cropland. Bioenergy production for land-based climate mitigation places additional pressure on limited la...

Encapsulating microorganisms inside electrospun microfibers as a living material enables room-temperature storage of microorganisms.

Room-temperature storage and transportation of microorganisms maximize the power of microorganisms in healthcare, energy and environment. Recently, paper-based biotechnologies have been developed to enable room-temperature storage of a variety of non-living biosystems such as diagnostic devices and cell-free systems. Herein, room-temperature storage of living microorganisms is realized by an electrospun nonwoven paper containing convex region, which is composed of coiled microfibers with dense distribution ...

Quantitative analysis of methane monooxygenase (MMO) explains process robustness in continuous and feast-famine bioreactors treating methane.

The ability of methanotrophs to rapidly respond to intentional or accidental stress conditions caused by operational failures or process fluctuations is of utmost importance to guarantee the robustness of CH abatement biotechnologies. In this study, the performance of a continuous and two feast-famine (5:5 days feast-famine cycles) stirred tank reactors treating diluted CH emissions (4-5% v/v) was comparatively assessed for 149 days. The robustness of the three bioreactors towards a 5 days CH deprivation ep...

ADReCS-Target: target profiles for aiding drug safety research and application.

Delivering safe and effective therapeutic treatment to patients is one of the grand challenges in modern medicine. However, drug safety research has been progressing slowly in recent years, compared to other fields such as biotechnologies and precision medicine, due to the mechanistic complexity of adverse drug reactions (ADRs). To fill up this gap, we develop a new database, the Adverse Drug Reaction Classification System-Target Profile (ADReCS-Target, http://bioinf.xmu.edu.cn/ADReCS-Target), which provide...

Mapping of the early intrauterine morphogenesis in the alpaca (Vicugna pacos): External features and development of the cephalic vesicle in comparison with the progressive Carnegie scale.

In this study we characterized the morphological aspects of the early development of the head of the alpaca (Vicugna pacos) and identified the main structures of the central nervous system during the first trimester of pregnancy. The topography and the cytoarchitecture of the fetal brain regions were described by histological analysis of the brain sections. We performed this analysis on alpaca embryos and fetuses presumably aged 20, 30, 45, and 90 days. For the description of the external body structures we...

Expression of a thermo- and alkali-philic fungal laccase in Pichia pastoris and its application.

The fungal laccase Lcc9 from Coprinopsis cinerea is a promising candidate for biotechnological applications due to its distinct biochemical properties. In the present work, Lcc9 cDNA was cloned from C. cinerea using reverse transcription polymerase chain reaction and heterologously expressed in Pichia pastoris GS115. The recombinant laccase was found to be a heavily hyperglycoprotein, with the molecular weight of 60.2 kDa as determined by MALDI-TOF. Laccase activity in the culture supernatant was 1750 ...

The Growing U.S. Bioeconomy: Drivers, Development and Constraints.

Bioeconomy refers to economic activities using renewable biological resources to produce energy and domestic consumables. The U.S. bioeconomy emerged in the early 2000s as a result of the societal pursuit of energy independence and security, greenhouse gas emission mitigation and sustainable development. Founded on biotechnologies and stimulated by federal policies, the U.S. bioeconomy has been growing rapidly over the past decade. Intensive research and development endeavors have been carried out to explor...


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