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PubMed Journals Articles About "Awards Grant Battle Sepsis Diego Allele Biotechnology Pharmaceuticals" RSS

16:00 EDT 20th March 2019 | BioPortfolio

Awards Grant Battle Sepsis Diego Allele Biotechnology Pharmaceuticals PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Awards Grant Battle Sepsis Diego Allele Biotechnology Pharmaceuticals articles that have been published worldwide.

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Showing "Awards Grant Battle Sepsis Diego Allele Biotechnology Pharmaceuticals" PubMed Articles 1–25 of 3,300+

Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.

DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 496 healthy adult donors from San Diego, California, to characterize allele frequencies in support of studies of T cell responses to common allergens. Deviations from Hardy Weinberg proportions were detected at each locus except A and C. Several alleles were found in more than 15% of individuals, including the class II alleles DPB1∗02:01, DPB1∗04:01, DQA1∗01:02, DQA1∗05:01, DQB1∗03:01, and the clas...


A Retrospective Review of the Sepsis Definition after Publication of Sepsis-3.

To determine if the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) was being utilized in defining sepsis in the clinical setting.

ASPEN NUTRITION SCIENCE AND PRACTICE CONFERENCE: Phoenix, Arizona, March 23 - 26, 2019: Vars Candidates, Trainee Awards, Best of ASPEN (Topic Awards), International Awards, Abstracts of Distinction, Posters of Distinction and Other Abstracts.


Intra-abdominal sepsis: new definitions and current clinical standards.

The abdomen is the second most common source of sepsis and is associated with unacceptably high morbidity and mortality. Recently, the essential definitions of sepsis and septic shock were updated (Third International Consensus Definitions for Sepsis and Septic Shock, Sepsis-3) and modified. The purpose of this review is to provide an overview of the changes introduced by Sepsis-3 and the current state of the art regarding the treatment of abdominal sepsis.

Respiratory Viral Infections in Infants with Possible Sepsis.

Knowledge of infections leading sepsis is needed to develop comprehensive infection prevention and sepsis early recognition and treatment strategies.The aim of this study was to investigate the etiology of sepsis and evaluate the proportion of respiratory viral pathogens in infants under two years of age with possible sepsis.

Recent advances in biosensors for diagnosis and detection of sepsis: A comprehensive review.

Sepsis is one of the leading causes of mortality among critically ill patients globally. According to WHO report 2018, it is estimated to affect beyond 30 million people worldwide every year. It causes loss of human lives, which arise from infection and inflammation and long term stay in intensive care unit (ICU) in hospitals. Despite the availability of satisfactory prognostic markers contributing to the diagnosis of sepsis, millions of people die even after admission to the hospitals. Correct and early di...

Admission characteristics predictive of in-hospital death from hospital-acquired sepsis: A comparison to community-acquired sepsis.

Healthcare associated (HA) sepsis is associated with increased resource utilization and mortality compared with community acquired (CA) sepsis. The purpose of this study was to identify independent predictors of in-hospital mortality from HA-sepsis.

Paths into Sepsis: Trajectories of Pre-Sepsis Healthcare Use.

Sepsis is a leading cause of death and disability whose heterogeneity is often cited as a key impediment to translational progress.

New Definitions of Sepsis and the Quest for Specific Biomarkers. Are the miRNAs the Answer?

Sepsis represents a systemic illness, characterized by life-threatening organ dysfunction induced by infection. Early diagnostic, evaluation of severity of sepsis with aggressive resuscitation and administration of appropriate antibiotics are associated with improved outcomes. In 2016 a new definition of sepsis (Sepsis-3) was proposed. The key element of sepsis-induced organ dysfunction is defined by "an acute change in total SOFA score >= 2 points consequent to infection". The use of SIRS criteria as ident...

Characterization of a novel variant allele, HLA-C*08:125, identified in a Chinese Han individual.

The novel HLA-C*08:125 allele differs from the closest allele C*08:02:01:01 in exon 3. This article is protected by copyright. All rights reserved.

A novel HLA-A allele, HLA-A*68:01:42, identified by next-generation sequencing in a Chinese individual.

The novel HLA-A*68:01:42 allele differs from the closest matching allele, HLA-A*68:01:02:02 by one nucleotide substitution. This article is protected by copyright. All rights reserved.

Delivery-associated sepsis: trends in prevalence and mortality.

Sepsis is a leading cause of pregnancy-related mortality. Previous studies have reported an increased prevalence of sepsis during pregnancy. Despite national campaigns to increase sepsis awareness, there is a lack of pregnancy-specific guidelines.

Rules of anti-infection therapy for sepsis and septic shock.

Sepsis is a deadly infection that causes injury to tissues and organs. Infection and anti-infective treatment are the eternal themes of sepsis. The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. This evidence is combined with clinical experiments to reveal the rules and a standard flowchart of anti-infection therapy for sepsis.

Rules of anti-infection therapy for sepsis and septic shock.

Sepsis is a deadly infection that causes injury to tissues and organs. Infection and anti-infective treatment are the eternal themes of sepsis. The successful control of infection is a key factor of resuscitation for sepsis and septic shock. This review examines evidence for the treatment of sepsis. This evidence is combined with clinical experiments to reveal the rules and a standard flowchart of anti-infection therapy for sepsis.

External Validation of the Two Newly Proposed Criteria for Assessing Coagulopathy in Sepsis.

 Two different criteria for evaluating coagulopathy in sepsis were recently released: sepsis-induced coagulopathy (SIC) and sepsis-associated coagulopathy (SAC). Although both use universal haemostatic markers of platelet count and pro-thrombin time, significance and usefulness of these criteria remain unclear.

Swimming activity in zebrafish larvae exposed to veterinary antiparasitic pharmaceuticals.

Veterinary antiparasitic pharmaceuticals have been detected in surface waters and several of these pharmaceuticals act on the nervous system on the target organisms implying that neurological effects also might be of concern in non-target animals such as fish. We tested if exposure to antiparasitic pharmaceuticals affect swimming activity in 6 days old zebrafish larvae. The results revealed that most pharmaceuticals did not cause any effects in swimming activity. However, larvae exposed to 0.58 mg/L doram...

Sepsis Update: Definition and Epidemiology.

Sepsis is a common disease in intensive care units worldwide, which is associated with relevant morbidity and mortality. Although massive research efforts have been made for decades, there is no specific therapy for sepsis to date. Decisive in the treatment of sepsis is the early diagnosis, because the outcome of the treated patients can be significantly improved by early elimination of the infection focus, the fastest possible administration of a broad, calculated antibiosis as well as the stabilization of...

A Young Man with Trisomy 21 and Sudden Behavioral Changes.

Grant is a 13-year-old boy with trisomy 21 who presents with his mother for concerns regarding the emergence of several new disruptive behaviors. While he is verbal, he also communicates through an augmentative communication device. He currently attends a residential school. Over the past 2 months, he has begun spitting at the staff, engaging in self-injurious behaviors, placing his hands in his pants and frequently talking about "pee and poop." Notably, Grant has undergone several changes to his educationa...

Genetic polymorphisms in sepsis and cardiovascular disease Do similar risk genes suggest similar drug targets?

Genetic variants are associated with altered clinical outcome of patients with sepsis and cardiovascular diseases. Common gene signaling pathways may be involved in the pathophysiology of these diseases. A better understanding of genetic commonality among these diseases may enable the discovery of important genes, signaling pathways and therapeutic targets for these diseases. We investigated the common genetic factors by a systematic search of the literature. 24 genes (ADRB2, CD14, FGB, FV, HMOX1, IL1B, IL1...

Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study.

Given the significant morbidity and mortality of maternal sepsis, early identification is key to improve outcomes. This study aims to evaluate the performance characteristics of the systemic inflammatory response syndrome (SIRS), quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA), and maternal early warning (MEW) criteria for identifying cases of impending sepsis in parturients. The secondary objective of this study is to identify etiologies and risk factors for maternal sepsis and to assess...

Portfolio Analysis on Preeclampsia and Pregnancy-associated Hypertension Research Funded by the National Heart, Lung and Blood Institute.

Chronic hypertension and preeclampsia are the most common complications of pregnancy. To clarify the contributions of the National Heart, Lung and Blood Institute (NHLBI) to the field and identify potential research gaps, we performed portfolio analysis of awards related to preeclampsia and pregnancy-associated hypertension. A list of National Institutes of Health-funded awards between fiscal years 2008-present was obtained through an NIH RePORTER search using the following terms: "preeclampsia" and "pregna...

Biomarker Phenotype for Early Diagnosis and Triage of Sepsis to the Pediatric Intensive Care Unit.

Early diagnosis and triage of sepsis improves outcomes. We aimed to identify biomarkers that may advance diagnosis and triage of pediatric sepsis. Serum and plasma samples were collected from young children (1-23 months old) with sepsis on presentation to the Pediatric Intensive Care Unit (PICU-sepsis, n = 46) or Pediatric Emergency Department (PED-sepsis, n = 58) and PED-non-sepsis patients (n = 19). Multivariate analysis was applied to distinguish between patient groups. Results were compared ...

Anti-PF4/heparin antibodies are increased in hospitalized patients with bacterial sepsis.

Heparin-induced thrombocytopenia (HIT) is caused by antibodies targeting platelet factor 4 (PF4)/heparin complexes. The immune response leading to HIT remains perplexing with many paradoxes. Unlike other drug induced reactions, anti-PF4/heparin antibody generation does not follow the classic immunologic response. Research in murine models suggests that that there is close interplay among infection, PF4 and the immune system. We hypothesized there would be a relatively higher prevalence of anti-PF4/heparin a...

Combined quantification of procalcitonin and HLA-DR improves sepsis detection in surgical patients.

Early recognition of sepsis is a key factor to improve survival to this disease in surgical patients, since it allows prompt control of the infectious source. Combining pro-inflammatory and immunosupression biomarkers could represent a good strategy to improve sepsis detection. Here we evaluated the combination of procalcitonin (PCT) with gene expression levels of HLA-DRA to detect sepsis in a cohort of 154 surgical patients (101 with sepsis and 53 with no infection). HLA-DRA expression was quantified using...

Understandability and Actionability of the CDC'S Printable Sepsis Patient Education Material.

Quality improvement efforts in sepsis management have increased patients' survival rates. Many sepsis survivors experience sequelae leading to unplanned hospital readmissions and subsequent mortality, especially when survivors delay seeking medical attention because they do not recognize the signs and symptoms of recurrent sepsis. Thus, increasing knowledge of sepsis among patients and caregivers before initial hospital discharge is essential.


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