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PubMed Journals Articles About "Bayer Aktie Aktivistischer Investor Elliott Eingestiegen" RSS

12:46 EDT 19th March 2019 | BioPortfolio

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Showing "Bayer Aktie Aktivistischer Investor Elliott eingestiegen" PubMed Articles, all 18

Time-varying and asymmetric effects of the oil-specific demand shock on investor sentiment.

The relationship between oil price and investor sentiment is crucial to economic activity. Disentangling the shocks in crude oil price by structural VAR model, this paper analyzes the interaction between oil price shocks and investor sentiment by linear and nonlinear causality approach, TVP-VAR mode and NARDL model. The results reveal that changes of oil-specific demand shock not only linearly but also nonlinearly cause changes of investor sentiment while there is no significant link between other oil shock...


Biochemistry and Molecular Biology, 6th edition. Edited by Despo Papachristodoulou, Alison Snape, William H. Elliott and Daphne C. Elliott. Oxford University Press, 2018. Pp. 640. Price GBP 39.99, paperback, ISBN 9780198768111.

The ASPHO 2019 distinguished career award goes to Dr. Elliott P. Vichinsky.


An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer - against all odds?

Pharmaceutical companies often refer to 'screening their library' when performing high-throughput screening (HTS) on a corporate compound collection to identify lead structures for small-molecule drug discovery programs. Characteristics of such a library, including the size, chemical space covered, and physicochemical properties, often determine the success of a screening campaign. Therefore, strategies to maintain and enhance the overall quality of screening collections are crucial to stay competitive and ...

Snapshot multi-wavelength interference microscope.

A snapshot multi-wavelength interference microscope is proposed for high-speed measurement of large vertical range discontinuous microstructures and surface roughness. A polarization CMOS camera with a linear micro-polarizer array and Bayer filter accomplishes snapshot multi-wavelength phase-shifting measurement. Four interferograms with ๐œ‹/2 phase shift are captured at each wavelength for phase measurement, the 2๐œ‹ ambiguities are removed by using two or three wavelengths.

Technical note: Evaluation of kV CBCT enhancement using a liver specific contrast agent for stereotactic body radiation therapy image guidance.

To evaluate possible use for cone-beam CT guidance, this phantom study evaluated the contrast enhancement provided by Gadoxetate Disodium (Primovist CAN/EU, or Eovist USA, Bayer Healthcare), a contrast agent that is taken up selectively by liver cells and is retained for up to an hour. Image quality from CBCT was benchmarked against helical fan-beam computed tomography for two phantom geometries.

Acyl atractyligenin and carboxyatractyligenin glycosides from Antennaria rosea subsp. confinis.

Eight previously undescribed acyl atractyligenin and carboxyatractyligenin glycosides were isolated from whole Antennaria rosea subsp. confinis (Greene) R. J. Bayer (Compositae) [syn. Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae)] plants and their structures were determined by spectroscopic and chemical methods. The compounds were trivially named leontopodiosides F-M. Seven of the compounds showed potent in vitro inhibitory activity toward pancreatic lipase with IC values ranging from 3.4 to 52....

Life cycle greenhouse gas emissions and costs of production of diesel and jet fuel from municipal solid waste.

This paper quantifies and compares the life cycle GHG emissions and costs of production of diesel and jet fuel derived from municipal solid waste (MSW) in the United States via three thermochemical conversion pathways: conventional gasification and Fischer-Tropsch (FT MD), plasma gasification and Fischer-Tropsch (Plasma FT MD) and, conventional gasification, catalytic alcohol synthesis and alcohol-to-jet upgrading (ATJ MD). We use expanded system boundaries to capture the change in existing MSW use and disp...

Solriamfetol for the treatment of daytime sleepiness in obstructive sleep apnea.

Obstructive sleep apnea (OSA) is highly prevalent and constitutes a major health hazard. Current pharmacotherapy is ineffective in correcting sleep-disordered breathing and is used adjunctively to address residual sleepiness. A new drug, solriamfetol, a selective norepinephrine-dopamine reuptake inhibitor, is the first drug of its class that is being considered by the US Food and Drug Administration (FDA) to treat excessive sleepiness in OSA and narcolepsy patients. Areas Covered: This review covers drug ch...

Another look at the relationship between energy consumption, carbon dioxide emissions, and economic growth in South Africa.

This study explores the energy use and economic growth nexus from 1960 to 2016 in South Africa while accounting for capital, labour, and carbon dioxide emissions. We applied Bayer and Hanck (2013) combined co-integration approach, Pesaran et al. (2001) bounds test and Kripfganz and Schneider (2018) critical values and approximate p-values. The empirical evidence finds support for a long-run equilibrium relationship among investigated variables. The Granger causality test indicates one-way causality from ene...

Larotrectinib: First Global Approval.

Larotrectinib (VITRAKVI) is an orally administered, small molecule, highly-selective, tropomyosin receptor kinase (TRK) inhibitor that was developed by Loxo Oncology in collaboration with Bayer AG as a treatment for adult and paediatric patients whose cancers harbour neurotrophic receptor tyrosine kinase (NTRK) gene fusions. In November 2018 larotrectinib received its first global approval in the USA for the treatment of adult and paediatric patients with solid tumours that have a NTRK gene fusion without a...

Improved bauxite residue dealkalization by combination of aerated washing and electrodialysis.

Bauxite residue, a major by-product of the alumina-producing Bayer process, is a serious environmental pollutant due to its high alkalinity. Here, we reported an operation system designed in our laboratory that included washing and electrodialysis dealkalization systems with aeration pipes. Washing with aeration releases a substantial amount of free alkali and attached alkali into water and increases the dealkalization efficiency. The washing liquid was treated with five steps of batch-mode electrodialysis....

Mechanistic Reactivity Descriptors for the Prediction of Ames Mutagenicity of Primary Aromatic Amines.

Pharmaceutical products are often synthesized by the use of reactive starting materials and intermediates. These can, either as impurities or through metabolic activation, bind to the DNA. Primary aromatic amines belong to the critical classes that are considered potentially mutagenic in the Ames test so there is a great need of good prediction models for risk assessment. How primary aromatic amines exert their mutagenic potential can be rationalized by the widely accepted nitrenium ion hypothesis of covale...

MetScore: Site of Metabolism Prediction Beyond CYP P450 Enzymes.

The metabolism of xenobiotics by humans and other organisms is a complex process involving numerous enzymes that catalyze phase I (functionalization) and phase II (conjugation) reactions. We here introduce MetScore, a machine learning model that can predict both phase I and phase II reaction sites of drugs. We developed cheminformatics workflows to filter and process reactions to obtain suitable phase I and phase II data sets for model training. Employing a recently developed molecular representation based ...

Enantiomeric separation of prothioconazole and prothioconazole-desthio on chiral stationary phases.

Prothioconazole is a type of broad-spectrum triazole thione fungicide developed by the Bayer Company. Prothioconazole-desthio is the main metabolite of prothioconazole in the environment. In our study, enantiomeric separation of prothioconazole and prothioconazole-desthio was performed on various chiral stationary phases (CSPs) by high-performance liquid chromatography (HPLC). It was found that polysaccharide CSPs showed better ability than brushing CSPs in enantiomeric separation. The successful chiral sep...

Occupancy and detectability modelling of vertebrates in northern Australia using multiple sampling methods.

Understanding where species occur and how difficult they are to detect during surveys is crucial for designing and evaluating monitoring programs, and has broader applications for conservation planning and management. In this study, we modelled occupancy and the effectiveness of six sampling methods at detecting vertebrates across the Top End of northern Australia. We fitted occupancy-detection models to 136 species (83 birds, 33 reptiles, 20 mammals) of 242 recorded during surveys of 333 sites in eight con...

The novel pesticide flupyradifurone (Sivanto) affects honeybee motor abilities.

Honeybees and other pollinators are threatened by changing landscapes and pesticides resulting from intensified agriculture. In 2018 the European Union prohibited the outdoor use of three neonicotinoid insecticides due to concerns about pollinators. A new pesticide by the name of "Sivanto" was recently released by Bayer AG. Its active ingredient flupyradifurone binds to the nicotinic acetylcholine receptor (AchR) in the honeybee brain, similar to neonicotinoids. Nevertheless, flupyradifurone is assumed to b...

Efficacy and safety of a combination of selamectin plus sarolaner for the treatment and prevention of flea infestations and the treatment of ear mites in cats presented as veterinary patients in the United States.

Two randomised, single-masked, multi-center field studies were conducted in the United States in cats presented as veterinary patients. The first study evaluated the efficacy and safety of a topically applied formulation of selamectin plus sarolaner (Revolution Plus/Stronghold Plus, Zoetis) against natural flea infestations; the second study evaluated its efficacy against natural ear mite infestations. The product was administered topically by the cats' owners at the dose range provided in the market produc...


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