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11:58 EDT 20th June 2019 | BioPortfolio

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Showing "Bayer auch noch Daten Skandal" PubMed Articles, all 24

Die Patientenaufklärung ist mittlerweile auch in Arztkreisen zu einer allseits anerkannten und zentralen ärztlichen Verpflichtung geworden. Die Patientenaufklärung in Klinik und Praxis zählt neben der standardgemäßen Behandlung und der Dokumentation zu den Kardinalpflichten des ärztlichen Berufes. Auch der Gesetzgeber hat die Patientenaufklärung mit den Bestimmungen des Patientenrechtegesetzes zu einem zentralen Element der ärztlichen Behandlung erhoben. Ungeachtet dessen gibt es nach wie vor eine ...


Fairchild and Bayer Respond.

An approach towards enhancement of a screening library: The Next Generation Library Initiative (NGLI) at Bayer - against all odds?

Pharmaceutical companies often refer to 'screening their library' when performing high-throughput screening (HTS) on a corporate compound collection to identify lead structures for small-molecule drug discovery programs. Characteristics of such a library, including the size, chemical space covered, and physicochemical properties, often determine the success of a screening campaign. Therefore, strategies to maintain and enhance the overall quality of screening collections are crucial to stay competitive and ...


Meditation in Deutschland: Eine national repräsentative Umfrage.

Hintergrund: Zunehmende Evidenz weist auf positive Wirkungen der Meditation bei psychischen und körperlichen Symptomen hin. Ziel dieser national repräsentativen Umfrage war die Erhebung der Lebenszeitprävalenz und Punktprävalenz der Meditations-Praxis in Deutschland, der Gründe für Meditation und der wahrgenommenen Veränderungen durch die Meditation. Methoden: In dieser national repräsentativen Umfrage mit 2'126 TeilnehmerInnen ab 14 Jahren wurde im April und Mai 2018 die derzeitige und frühere Med...

Hochregulation der SLURP1-Immunfärbung in Läsionen von Psoriasis-vulgaris-Patienten entspricht dem Schweregrad der Erkrankung.

Die genaue Pathogenese der Psoriasis ist immer noch ungeklärt. Da SLURP1 wichtig ist für die normale Differenzierung von Keratinozyten, könnte es bei Psoriasis eine Rolle spielen. In dieser Studie untersuchten wir die immunhistochemische Färbung von SLURP1 bei Patienten mit Psoriasis vulgaris und deren möglichen Zusammenhang mit der Pathogenese der Erkrankung.

Stadien des Prostatakarzinoms und Unmet Medical Need.

Männer mit Prostatakarzinom haben eine gute Prognose, wenn die Erkrankung in einem frühen Stadium erkannt und behandelt wird. In späteren Stadien steigt das Progressions- und Mortalitätsrisiko hingegen deutlich. Das gilt auch für das nicht-metastasierte kastrationsresistente Prostatakarzinom (M0CRPC, nm-CRPC), bei dem das Progressionsrisiko insbesondere bei kurzer PSA-Verdopplungszeit deutlich erhöht ist. Für entsprechende Patienten gab es lange - außer der klassischen Androgendeprivation - keine Th...

High ISO JPEG Image Denoising by Deep Fusion of Collaborative and Convolutional Filtering.

Capturing images at high ISO modes will introduce much realistic noise, which is difficult to be removed by traditional denoising methods. In this paper, we propose a novel denoising method for high ISO JPEG images via deep fusion of collaborative and convolutional filtering. Collaborative filtering explores the non-local similarity prior of natural images, while convolutional filtering takes advantage of the large capacity of convolutional neural network (CNN) to infer noise from noisy images. We observe t...

Imaging of toxocariasis.

Parasitäre Erkrankungen werden in Europa relativ selten diagnostiziert und behandelt. Somit sind auch klinische Besonderheiten und bildgebende Merkmale weniger bekannt. In den heutigen Zeiten von Migration und weltweiter Flüchtlingsströme ist die Kenntnis parasitärer Infektionen zunehmend von Bedeutung. Anhand von klinischen Beschreibungen der Echinokokkose, Schistosomiasis, Fasciolosis und Ascariasis wurden entsprechende Berichte in der Zeitschrift für Gastroenterologie publiziert. In der hier präsen...

Technical note: Evaluation of kV CBCT enhancement using a liver specific contrast agent for stereotactic body radiation therapy image guidance.

To evaluate possible use for cone-beam CT guidance, this phantom study evaluated the contrast enhancement provided by Gadoxetate Disodium (Primovist CAN/EU, or Eovist USA, Bayer Healthcare), a contrast agent that is taken up selectively by liver cells and is retained for up to an hour. Image quality from CBCT was benchmarked against helical fan-beam computed tomography for two phantom geometries.

Acyl atractyligenin and carboxyatractyligenin glycosides from Antennaria rosea subsp. confinis.

Eight previously undescribed acyl atractyligenin and carboxyatractyligenin glycosides were isolated from whole Antennaria rosea subsp. confinis (Greene) R. J. Bayer (Compositae) [syn. Leontopodium leontopodioides (Willd.) Beauv. (Asteraceae)] plants and their structures were determined by spectroscopic and chemical methods. The compounds were trivially named leontopodiosides F-M. Seven of the compounds showed potent in vitro inhibitory activity toward pancreatic lipase with IC values ranging from 3.4 to 52....

Erfolgreiche therapeutische endoskopisch-endoluminale Procaininstillation in eine Anastomosenregion bei chronischem Symptomkomplex nach operativer Versorgung einer angeborenen Ösophagusatresie.

Hintergrund: Wir berichten über eine 27-jährige Patientin, die nach operativem Magenhochzug bei Ösophagusatresie unter massiv einschränkenden Symptomen wie Sodbrennen, Erbrechen, Regurgitation, Übelkeit und Magenkrämpfen litt, trotz maximaler konservativer Therapie. Falldarstellung: Die Patientin erhielt im Rahmen einer Gastroskopie eine endoluminale Procaininfiltration in die narbige Anastomosenregion, woraufhin sich die klinische Symptomatik deutlich reduzierte und auch im Langzeitverlauf stabil ver...

Another look at the relationship between energy consumption, carbon dioxide emissions, and economic growth in South Africa.

This study explores the energy use and economic growth nexus from 1960 to 2016 in South Africa while accounting for capital, labour, and carbon dioxide emissions. We applied Bayer and Hanck (2013) combined co-integration approach, Pesaran et al. (2001) bounds test and Kripfganz and Schneider (2018) critical values and approximate p-values. The empirical evidence finds support for a long-run equilibrium relationship among investigated variables. The Granger causality test indicates one-way causality from ene...

Larotrectinib: First Global Approval.

Larotrectinib (VITRAKVI) is an orally administered, small molecule, highly-selective, tropomyosin receptor kinase (TRK) inhibitor that was developed by Loxo Oncology in collaboration with Bayer AG as a treatment for adult and paediatric patients whose cancers harbour neurotrophic receptor tyrosine kinase (NTRK) gene fusions. In November 2018 larotrectinib received its first global approval in the USA for the treatment of adult and paediatric patients with solid tumours that have a NTRK gene fusion without a...

Der SV12: Entwicklung eines klinischen Inventars zur Erfassung von Sensibilität und deren Verarbeitungsproblematiken.

Hintergrund: Zur Erfassung einer erhöhten Verarbeitungssensibilität bei Patienten in der stationären psychosomatischen Behandlung wurde ein Fragebogen entwickelt, der anders als Fragebögen zur Messung von Hochsensibilität die Konstrukte der Wahrnehmungssensibilität und Verarbeitungsproblematik trennen soll. Methoden: Zunächst wurde eine 30 Items umfassende Version an einer klinischen und einer nichtklinischen Stichprobe mit jeweils 1'103 Patienten erhoben und faktoranalytisch ausgewertet. Daraus konn...

Improved bauxite residue dealkalization by combination of aerated washing and electrodialysis.

Bauxite residue, a major by-product of the alumina-producing Bayer process, is a serious environmental pollutant due to its high alkalinity. Here, we reported an operation system designed in our laboratory that included washing and electrodialysis dealkalization systems with aeration pipes. Washing with aeration releases a substantial amount of free alkali and attached alkali into water and increases the dealkalization efficiency. The washing liquid was treated with five steps of batch-mode electrodialysis....

Mechanistic Reactivity Descriptors for the Prediction of Ames Mutagenicity of Primary Aromatic Amines.

Pharmaceutical products are often synthesized by the use of reactive starting materials and intermediates. These can, either as impurities or through metabolic activation, bind to the DNA. Primary aromatic amines belong to the critical classes that are considered potentially mutagenic in the Ames test so there is a great need of good prediction models for risk assessment. How primary aromatic amines exert their mutagenic potential can be rationalized by the widely accepted nitrenium ion hypothesis of covale...

The identification of small molecule inhibitors of the plant inositol phosphorylceramide synthase which demonstrate herbicidal activity.

Resistance to 157 different herbicides and 88% of known sites of action has been observed, with many weeds resistant to two or more modes. Coupled with tighter environmental regulation, this demonstrates the need to identify new modes of action and novel herbicides. The plant sphingolipid biosynthetic enzyme, inositol phosphorylceramide synthase (IPCS), has been identified as a novel, putative herbicide target. The non-mammalian nature of this enzyme offers the potential of discovering plant specific inhibi...

Enantiomeric separation of prothioconazole and prothioconazole-desthio on chiral stationary phases.

Prothioconazole is a type of broad-spectrum triazole thione fungicide developed by the Bayer Company. Prothioconazole-desthio is the main metabolite of prothioconazole in the environment. In our study, enantiomeric separation of prothioconazole and prothioconazole-desthio was performed on various chiral stationary phases (CSPs) by high-performance liquid chromatography (HPLC). It was found that polysaccharide CSPs showed better ability than brushing CSPs in enantiomeric separation. The successful chiral sep...

The role of globalization, real income, tourism in environmental sustainability target. Evidence from Turkey.

In this study, we examine the role of real income, globalization and tourism on environmental sustainability target by applying Autoregressive Distributed Lag (ARDL) bounds testing approach that controls for structural breaks and Vector Error Correction Model (VECM) Granger causality approach that produces robust, efficient and reliable short-run and long-run estimates in the case of Turkey over the periods 1970-2014. To achieve our research objective, we examine stationarity properties of the series via un...

Therapeutisches Management bei Vitiligo.

Vitiligo ist eine erworbene Hauterkrankung, an der weltweit 0,5 % der Bevölkerung erkranken und die eine große Herausforderung in der dermatologischen Versorgung darstellt. Die Erkrankung geht für Betroffene oftmals aufgrund der fleckigen Depigmentierung mit einer kosmetischen Entstellung und großem Leidensdruck einher. Pathophysiologisch werden als Hauptursachen für den Verlust funktionierender Melanozyten eine genetische Prädisposition, autoimmune Mechanismen und oxidativer Stress angesehen. Vorges...

The novel pesticide flupyradifurone (Sivanto) affects honeybee motor abilities.

Honeybees and other pollinators are threatened by changing landscapes and pesticides resulting from intensified agriculture. In 2018 the European Union prohibited the outdoor use of three neonicotinoid insecticides due to concerns about pollinators. A new pesticide by the name of "Sivanto" was recently released by Bayer AG. Its active ingredient flupyradifurone binds to the nicotinic acetylcholine receptor (AchR) in the honeybee brain, similar to neonicotinoids. Nevertheless, flupyradifurone is assumed to b...

Menstrual suppression in paediatric and adolescent patients with disabilities ranging from developmental to acquired conditions: A population study in an Australian Quaternary Paediatric and Adolescent Gynaecology Service from January 2005 to December 2015.

The aim of this study was to review the efficacy of different medical modalities for menstrual suppression in the cohort of patients with disabilities presenting to the Queensland Paediatric and Adolescent (PAG) Gynaecology Service between January 2005 and December 2015. Menstrual suppression in adolescents with disabilities is an important aspect of care to support the patient and their carers in managing the complexities of menstrual hygiene, pain and other discomfort associated with menses. It is importa...

Efficacy and safety of a combination of selamectin plus sarolaner for the treatment and prevention of flea infestations and the treatment of ear mites in cats presented as veterinary patients in the United States.

Two randomised, single-masked, multi-center field studies were conducted in the United States in cats presented as veterinary patients. The first study evaluated the efficacy and safety of a topically applied formulation of selamectin plus sarolaner (Revolution Plus/Stronghold Plus, Zoetis) against natural flea infestations; the second study evaluated its efficacy against natural ear mite infestations. The product was administered topically by the cats' owners at the dose range provided in the market produc...

Muscle-strain injury exudate favors acute tissue healing and prolonged connective tissue formation in humans.

Traumatic strain injury in skeletal muscle is often associated with fluid accumulation at the site of rupture, but the role of this injury exudate (EX) in cellular responses and healing is unknown. We aimed to characterize the EX sampled from human hamstring or calf muscles following a strain injury ( = 12). The cytokine and growth-factor profile, gene expression, and transcriptome analysis of EX-derived cells were compared with blood taken simultaneously from the same individuals. Cellular responses to the...


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