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Biogen Inks Deals With Therapeutics Skyhawk Develop Drugs PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Biogen Inks Deals With Therapeutics Skyhawk Develop Drugs articles that have been published worldwide.
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Tattoo inks represent a growing market in the world economy, but this growth is associated with an increase in reports of adverse effects caused by the use of this product. In this study, four commercial tattoo inks (blue, green, red and black) were studied to characterize the composition and particle size and identify possible in vivo and in vitro toxicological effects on Daphnia magna and HaCaT cells, respectively. Compositional analysis confirmed the functional groups in the vehicles and organic pigments...
In order to expedite the availability of drugs to treat cancers in a cost-effective manner, repurposing of old drugs for oncological indications is gathering momentum. Revolutionary advances in pharmacology and genomics have demonstrated many old drugs to have activity at novel antioncogenic pharmacological targets. We decided to investigate whether prospective studies support the promises of nonclinical and retrospective clinical studies on repurposing three old drugs, namely metformin, valproate and astem...
Nowadays, practice of tattooing is very common worldwide and, along with this increasing trend, there is also an increased risk of adverse reactions to tattoo pigments that are well known and described in literature. Previous studies have reported that cutaneous and allergic reactions to a particular pigment can manifest in several ways (allergic contact dermatitis and photo-allergic dermatitis). In this paper, a new high-throughput method is presented, in order to achieve a new system for the quality contr...
Conductive inks based on nickel nanoparticles (NPs) have attracted much attention as a low-cost replacement for the currently used silver and gold inks for fabrication of printed electronic circuits and devices. Nickel NPs as a component of conductive inks should be stable against oxidation process at all stages of preparation of conductive patterns: ink formulation and storage, printing, and post-printing treatment. In the present study, the oxidation resistance of the Ag layer and the conductive propertie...
Bone substitute fabrication is of interest to meet the worldwide incidence of bone disorders. Physical chitosan hydrogels with intertwined apatite particles were chosen to meet the bio-physical and mechanical properties required by a potential bone substitute. A set up for 3-D printing by robocasting was found adequate to fabricate scaffolds. Inks consisted of suspensions of calcium phosphate particles in chitosan acidic aqueous solution. The inks are shear-thinning and consist of a suspension of dispersed ...
Protein therapeutics play a significant role in treating many diseases. They, however, suffer from patient's proteases degradation and antibody neutralization which lead to short plasma half-lives. One of the ways to overcome these pitfalls is the frequent injection of the drug albeit at the cost of patient compliance which affects the quality of life of patients. There are several techniques available to extend the half-life of therapeutics. Two of the most common protocols are PEGylation and fusion with h...
We report a new class of MOF inks with a water-repellent, photocurable fluoropolymer (PFPE) having up to 90 wt% MOF loading. These MOF inks enable to process various MOFs through spray coating, pen writing, stencil printing, and moulding at room temperature. Upon UV-curing, the hydrophobic PFPE matrix efficiently blocks water permeation but allows accessibility of chemicals into MOF pores, thereby freeing the MOF to perform its unique function. Moreover, by introducing functional MOFs we successfully demons...
Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a moiety of great significance. It forms an important intermediate in many industrial and organic syntheses. Morpholine containing drugs are of high therapeutic value. Its wide array of pharmacological activity includes anti-diabetic, anti-emetic, growth stimulant, anti-depressant, bronchodilator and anticancer. Multi-drug resistance in cancer cases have emerged in the last few years and have led to the failure of many ch...
Tattoos have become increasingly common in the United States. Historically, tattoo inks were comprised of metallic pigments which had the potential to cause allergic contact dermatitis. Data have been lacking on the current use of these pigments in tattoo ink.
Psychotropic drugs are frequently used to treat postpartum women with psychiatric diagnoses, especially psychotic disorder, major depression, and bipolar mood episodes. Pharmacotherapy in breastfeeding mothers is a major challenge.
During the second quarter of 2018, Cortellis Competitive Intelligence registered 985 new deals (excluding mergers and acquisitions) with a total disclosed deal value of USD 19.5 billion as part of its ongoing coverage of licensing activity in the life sciences sector compared to 964 and USD 35.6 billion in the first quarter and 1,104 and USD 13.6 billion in the second quarter of 2017. Total deal value in the second quarter did not quite reach the peak of 2014 (paced by Novartis' USD 16 billion purchase of G...
This study assessed whether five health technology assessment (HTA) bodies in Europe were more negative about drugs with a conditional marketing authorisation (CMA) that are approved without controlled studies compared to CMA drugs that are approved based on controlled studies. HTA recommendations were categorized into positive, restricted and negative. A total of 92 HTA recommendations were available for 27 drugs. 30/62 (48%) and 17/30 (57%) of recommendations were negative for drugs with and without contr...