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PubMed Journals Articles About "Bioverativ Taps Manufacturer Steps Biogen Shadow" RSS

04:48 EDT 16th October 2018 | BioPortfolio

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Showing "Bioverativ taps manufacturer steps Biogen shadow" PubMed Articles 1–25 of 1,600+

In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence.

Monochorionic twin pregnancies are at risk of unique complications due to placental sharing and vascular connections between placental territories assigned for each twin. Twin anemia-polycythemia sequence (TAPS) is an infrequent but potentially dangerous complication of abnormal placental vascular connections. TAPS occurs due to very-small-caliber (< 1 mm) abnormal placental vascular connections which lead to chronic anemia in the donor twin and polycythemia in the recipient twin. TAPS may occur spontaneous...


Egocentric Temporal Action Proposals.

We present an approach to localize generic actions in egocentric videos, called temporal action proposals (TAPs), for accelerating the action recognition step. An egocentric TAP refers to a sequence of frames that may contain a generic action performed by the wearer of a head-mounted camera, e.g., taking a knife, spreading jam, pouring milk, or cutting carrots. Inspired by object proposals, this paper aims at generating a small number of TAPs, thereby replacing the popular sliding window strategy, for local...

Carbon Emission Reduction with Capital Constraint under Greening Financing and Cost Sharing Contract.

Motivated by the industrial practices, this work explores the carbon emission reductions for the manufacturer, while taking into account the capital constraint and the cap-and-trade regulation. To alleviate the capital constraint, two contracts are analyzed: greening financing and cost sharing. We use the Stackelberg game to model four cases as follows: (1) in Case A1, the manufacturer has no greening financing and no cost sharing; (2) in Case A2, the manufacturer has greening financing, but no cost sharing...


Quantitative shadow compensated optical coherence tomography of choroidal vasculature.

Conventionally rendered optical coherence tomography (OCT) images of the posterior segment contain shadows which influence the visualization of deep structures such as the choroid. The purpose of this study was to determine whether OCT shadow compensation (SC) alters the appearance of the choroid and the apparent choroidal vascularity index (CVI), an OCT-derived estimated ratio of luminal to total choroidal volume. All scans were shadow compensated using a previously published algorithm, binarized using a n...

Retailer Stackelberg game in a supply chain with pricing and service decisions and simple price discount contract.

This paper studies the Retailer Stackelberg game in a supply chain consisting of two manufacturers and one retailer where they compete simultaneously under three factors including price, service and simple price discount contract. It is assumed that the second manufacturer provides service directly to his customers, and the retailer provides service for the first product's customers, while the retailer buys the first product under price discount from the first manufacturer. The analysis of the optimal equil...

Convolutional Neural Network-Based Shadow Detection in Images Using Visible Light Camera Sensor.

Recent developments in intelligence surveillance camera systems have enabled more research on the detection, tracking, and recognition of humans. Such systems typically use visible light cameras and images, in which shadows make it difficult to detect and recognize the exact human area. Near-infrared (NIR) light cameras and thermal cameras are used to mitigate this problem. However, such instruments require a separate NIR illuminator, or are prohibitively expensive. Existing research on shadow detection in ...

Who is my Jung? A personal and symbolic history.

Identifying the reality of Jung in my life requires first of all a historical examination. How Jung first came into my life through my reading a book by P.W.Martin, Experiment in Depth, stands as a metaphor for the conscious unravelling of psychological development. His further appearance in a sequence of dreams demonstrated the significance of both the instinctual and the numinous in Jung's life and in my personal individuation. Finally, through a consideration of light and shadow, particularly in two phot...

Four Key Steps Control Glycolytic Flux in Mammalian Cells.

Altered glycolysis is a hallmark of diseases including diabetes and cancer. Despite intensive study of the contributions of individual glycolytic enzymes, systems-level analyses of flux control through glycolysis remain limited. Here, we overexpress in two mammalian cell lines the individual enzymes catalyzing each of the 12 steps linking extracellular glucose to excreted lactate, and find substantial flux control at four steps: glucose import, hexokinase, phosphofructokinase, and lactate export (and not a...

Ocular Blood Volume Index Based on Scattering Properties of Retinal Vessels Using Spectral Domain Optical Coherence Tomography.

Introduction The evaluation of retinal vessels and the retinal blood flow is important for ocular diseases. We introduce a spectral domain optical coherence tomography (SD-OCT) based method for facilitating a retinal blood vessel analysis using the scattering properties of retinal vessels. The intensity of the distal shadow of vessels caused by the scattered signal is measured, correlated with the pulsatile ocular blood flow (POBF), and its repeatability is analysed. Methods 20 eyes of 20 healthy, young par...

My People, 2014.

A nurse with a gravely injured family member taps a hidden network of support.

Leveraging EUnetHTA's conceptual framework to compare HTA decision drivers in France, Italy, and Germany from a manufacturer's point of view.

Health Technology Assessments (HTA) procedures differ substantially across the various European countries. We reviewed recent appraisals of a pharmaceutical manufacturer in three major European markets (France; Italy; Germany) and identified and categorized related decision drivers.

Denial: in its own shadow.

Differences in Word and Phoneme Recognition in Quiet, Sentence Recognition in Noise, and Subjective Outcomes between Manufacturer First-Fit and Hearing Aids Programmed to NAL-NL2 Using Real-Ear Measures.

The American Speech-Language-Hearing Association (ASHA) and American Academy of Audiology (AAA) have created Best Practice Guidelines for fitting hearing aids to adult patients. These guidelines recommend using real-ear measures (REM) to verify that measured output/gain of hearing aid(s) match a validated prescriptive target. Unfortunately, approximately 70-80% of audiologists do not routinely use REM when fitting hearing aids, instead relying on a manufacturer default "first-fit" setting. This is problemat...

Congenital Syphilis-Still a Shadow on the Land.

Setbacks shadow microRNA therapies in the clinic.

Denial: in its own shadow (a clinical response).

Pharmacy Costs of Systemic Medications for Hidradenitis Suppurativa in the United States.

Considerable work has been done to characterize the economic burdens of atopic dermatitis, psoriasis, and skin cancers, but the long-term medication costs of hidradenitis suppurativa remain unknown. Manufacturer-reported benchmarks such as Average Wholesale Price (AWP) and Wholesale Acquisition Cost (WAC) are commonly used to estimate medication costs in dermatology, but do not account for manufacturer-to-pharmacy price reductions, which are commonplace in prescription medication pricing. This manuscript us...

Chemoenzymatic Approach to Tetrodotoxin: Synthesis of Fukuyama's, Alonso's, and Sato's Advanced Intermediates.

The advanced intermediates in the syntheses of tetrodotoxin reported by Fukuyama, Alonso, and Sato were prepared. The key steps in the synthesis of the title compounds involved the toluene dioxygenase-mediated dihydroxylation of either iodobenzene or benzyl acetate. The resulting diene diols were transformed to Fukuyama's intermediate in seven steps, to Alonso's intermediate in nine steps and to Sato's intermediate in ten steps, respectively.

Effects of Anti-IL-5 on Virus Induced Exacerbation in Asthma: Light and Shadow.

Shadow Mask Templates for Site-Selective Metal Exchange in Magnesium Porphyrin Nanorings.

Molecular templates can be used in many different ways to control the outcome of chemical reactions. Here we present a new type of template-directed synthesis. We show that templates can be used as shadow masks: the shape of the template becomes imprinted on the product because reaction only occurs at sites not masked by the template. We demonstrate this effect by using oligopyridine templates to dictate the sites of demetallation when a magnesium porphyrin nanoring is treated with acid. Magnesium centers t...

Electrocardiogram failure in the operating room - manufacturer's comment.

Reference intervals and diagnostic ranges for serum free κ and free λ immunoglobulin light chains vary by instrument platform: Implications for classification of patient results in a multi-center study.

Serum free light chain (FLC) immunoglobulins are key biomarkers that aid in the diagnosis, prognosis and assessment of treatment response in patients with plasma cell disorders (PCD). Here we investigated the transference of manufacturer's reported κFLC, λFLC and κ to λ FLC reference intervals (RI) and established de novo FLC RI and diagnostic ranges on four instruments at three academic medical centers. In addition, we also compared the classification of patient FLC results using manufacturer's versus ...

Quantification of vitamin D in commercial dog foods and comparison with Association of American Feed Control Officials recommendations and manufacturer-reported concentrations.

OBJECTIVE To quantify vitamin D (VitD) concentrations in commercial dog foods and compare those concentrations with Association of American Feed Control Officials (AAFCO) recommendations and manufacturer-reported concentrations. DESIGN Cross-sectional study. SAMPLE 82 commercial dog foods. PROCEDURES Samples of commercially available dog foods were obtained from owners of healthy dogs in the Guelph, ON, Canada, area and owners of dogs that were patients at the Ontario Veterinary College Health Sciences Cent...

Qualitative Exploration of the Feasibility and Acceptability of Workplace-based Microgrants to Improve Physical Activity: The 10,000 Steps Pedometer Microgrant Scheme.

Despite the benefits associated with workplace health programs, many organisations are unable to offer them due to financial constraints. To address this barrier, the existing 10,000 Steps program trialled the 10,000 Steps Pedometer Microgrant Scheme. This study assessed the feasibility and acceptability of the Microgrant Scheme.

A unified approach for the assembly of atisine- and hetidine-type diterpenoid alkaloids: Total syntheses of azitine and the proposed structure of navirine C.

A tetracyclic dinitrile was synthesized in 12 steps from cyclohex-2-en-1-one by using a chelation-triggered conjugate addition to g-hydroxy a,b-unsaturated nitrile and oxidative-dearomatization/Diels-Alder cycloaddition as the key steps. The first total synthesis of azitine (in 17 steps) was achieved through a simple reductive cyclization of this intermediate and subsequent transformations, while total synthesis of the proposed structure of navirine C (in 19 steps) was accomplished via a HAT reaction of the...


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